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Irsenontrine

3 trials in this asset. Source: ClinicalTrials.gov, as of July 21, 2026.

Trials

3

Ongoing

0

Recruiting

0

Completed

3

Sites

67

Countries

8

Endpoints

63

Composite endpoints

0

Distinct sites and countries across this asset's trials. A site running several of its trials counts once, matching the map. All 63 linked ClinicalTrials.gov endpoints are classified into the categories below. Trial and endpoint linkage does not by itself establish treatment attribution for every endpoint.

Development

Where the program stands

Trials by phase

Phase 1
1
Phase 2
2

Trials by status

Completed
3

Evidence coverage

What this asset has been measured on

Endpoints grouped into outcome categories, ranked by how often they are measured across this asset's trials.

Safety / tolerability / PK
20
Behavior / neuropsychiatric
12
Other (unclassified)
11
Global cognition
6
Executive function / language
6
Other clinical outcomes
4
Function / daily living
2
Fluid / digital biomarkers
2

Most-measured metrics

Top 20 metrics across this asset's endpoints

Normalized metric codes are available for 12 of 63 classified ClinicalTrials.gov endpoints for this asset; the ranking below covers that coded subset.

Neuropsychiatric Inventory (NPI)Behavior

8

Montreal Cognitive Assessment (MoCA)Cognition

2

Mini-Mental State Examination (MMSE)Cognition

2

Trials

Trials for this asset

Every trial for this asset, with the same search, filters, and sort as the Trials tab.

3 of 3

Alzheimer’s disease and related dementias trials
Asset / Disease areaKey I/E criterionEvidence
NCT03467152Study To Evaluate the Efficacy, Safety and Tolerability of E2027 (Hereinafter Referred to as Irsenontrine) in Participants With Dementia With Lewy Bodies

Irsenontrine

Lewy body dementia

Dementia with Lewy bodiesPh 2Completed74Apr 20201results
NCT04764669A Study of E2027 in Participants With Dementia With Lewy Bodies (DLB) or Parkinson's Disease Dementia (PDD) With or Without Amyloid Copathology

Irsenontrine

Lewy body dementia

Parkinson's disease dementiaPh 2Completed14Dec 2021-results
NCT04023877A Study to Determine the Metabolism and Elimination of [14C]E2027 in Healthy Male Participants

Irsenontrine

Lewy body dementia

Age 18-55Ph 1Completed1Oct 2019-

Showing 1-3 of 3 trials