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Methylphenidate

11 trials in this asset. Source: ClinicalTrials.gov, as of July 21, 2026.

Trials

11

Ongoing

2

Recruiting

2

Completed

6

Sites

18

Countries

4

Endpoints

68

Composite endpoints

0

Distinct sites and countries across this asset's trials. A site running several of its trials counts once, matching the map. All 68 linked ClinicalTrials.gov endpoints are classified into the categories below. Trial and endpoint linkage does not by itself establish treatment attribution for every endpoint.

Development

Where the program stands

Trials by phase

Phase 2
3
Phase 2/3
1
Phase 3
1
Phase 4
5
Not applicable
1

Trials by status

Recruiting
2
Completed
6
Terminated
1
Withdrawn
1
Unknown
1

Evidence coverage

What this asset has been measured on

Endpoints grouped into outcome categories, ranked by how often they are measured across this asset's trials.

Behavior / neuropsychiatric
21
Other (unclassified)
13
Other clinical outcomes
11
Global cognition
6
Memory
6
Neuroimaging
4
Safety / tolerability / PK
4
Executive function / language
1
Function / daily living
1
Fluid / digital biomarkers
1

Most-measured metrics

Top 20 metrics across this asset's endpoints

Normalized metric codes are available for 11 of 68 classified ClinicalTrials.gov endpoints for this asset; the ranking below covers that coded subset.

Neuropsychiatric Inventory (NPI)Behavior

7

Mini-Mental State Examination (MMSE)Cognition

4

Trials

Trials for this asset

Every trial for this asset, with the same search, filters, and sort as the Trials tab.

11 of 11

Alzheimer’s disease and related dementias trials
Asset / Disease areaKey I/E criterionEvidence
ADMET2Apathy in Dementia Methylphenidate Trial 2

Methylphenidate

Alzheimer’s disease

Alzheimer's diseasePh 3Completed10Jul 20204results
ADMETApathy in Dementia Methylphenidate Trial (ADMET)

Methylphenidate

Alzheimer’s disease

Alzheimer's diseasePh 2Completed3Aug 20121results
NCT00254033Apathy Associated With Alzheimer's Disease

Dextroamphetamine, Methylphenidate

Alzheimer’s disease

Alzheimer's diseasePh 4Completed1Oct 20061
PRIMECombined Brain Stimulation and Methylphenidate Treatment for Apathy in Dementia

Methylphenidate

Alzheimer’s disease, Vascular cognitive impairment / dementia, Mixed / unspecified dementia

Multiple dementia etiologiesPh 2Recruiting1Oct 2027-
NCT03811847A Pilot of Methylphenidate in Mild Cognitive Impairment and Dementia Participants.

Methylphenidate

Alzheimer’s disease, MCI / preclinical Alzheimer’s

Alzheimer's diseasePh 4Completed1Aug 20211results
PACTE-1Methylphenidate and Cognitive Training in Elderly

Methylphenidate

Mixed / unspecified dementia

Healthy volunteersPh 2Completed1Mar 2020-
NCT00495820Methylphenidate for Apathy in Alzheimer's Dementia: A Controlled Study

Methylphenidate

Alzheimer’s disease

Alzheimer's diseasePh 4Completed1Mar 20102results
REACTrTMS for Apathy Clinical Trial

Methylphenidate

Alzheimer’s disease, MCI / preclinical Alzheimer’s

-Not applicableRecruiting1Dec 2026-
NCT01825577Exploring the Use of Transdermal Methylphenidate to Reduce Fall Risk in Patients With Dementia.

Methylphenidate

Mixed / unspecified dementia

Age 65-95Ph 4Terminated1Feb 2015-results
STREAM-VCISymptomatic Treatment of Vascular Cognitive Impairment

Galantamine, Methylphenidate

Vascular cognitive impairment / dementia

MMSE ≥16Ph 2/3Unknown1Dec 20162
NCT00792662Improving Function, Quality of Life, Glycemia in Diabetics With Dementia

Methylphenidate

Alzheimer’s disease

mild-to-moderate AD / moderate AD dementiaPh 4Withdrawn0Dec 2011-

Showing 1-11 of 11 trials