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Semaglutide

7 trials in this asset. Source: ClinicalTrials.gov, as of July 21, 2026.

Trials

7

Ongoing

4

Recruiting

2

Completed

3

Sites

500

Countries

40

Endpoints

102

Composite endpoints

0

Distinct sites and countries across this asset's trials. A site running several of its trials counts once, matching the map. All 102 linked ClinicalTrials.gov endpoints are classified into the categories below. Trial and endpoint linkage does not by itself establish treatment attribution for every endpoint.

Development

Where the program stands

Trials by phase

Phase 1/2
1
Phase 2
3
Phase 3
3

Trials by status

Not yet recruiting
2
Recruiting
2
Completed
3

Evidence coverage

What this asset has been measured on

Endpoints grouped into outcome categories, ranked by how often they are measured across this asset's trials.

Global cognition
33
Other (unclassified)
21
Behavior / neuropsychiatric
10
Safety / tolerability / PK
9
Neuroimaging
6
Function / daily living
5
Other clinical outcomes
5
Amyloid biomarkers
3
Neurodegeneration biomarkers
3
Fluid / digital biomarkers
3
Memory
2
Tau biomarkers
1
Caregiver / quality of life
1

Most-measured metrics

Top 20 metrics across this asset's endpoints

Normalized metric codes are available for 41 of 102 classified ClinicalTrials.gov endpoints for this asset; the ranking below covers that coded subset.

ADAS-CogCognition

14

Clinical Dementia Rating-Sum of Boxes (CDR-SB)Cognition

6

Mini-Mental State Examination (MMSE)Cognition

5

Neuropsychiatric Inventory (NPI)Behavior

5

ADCS-Activities of Daily Living (ADCS-ADL)Function

4

Montreal Cognitive Assessment (MoCA)Cognition

4

Phosphorylated tau 217 (p-tau217)Fluid/digital

1

Phosphorylated tau 181 (p-tau181)Other

1

Neurofilament light (NfL)Neurodeg.

1

Trials

Trials for this asset

Every trial for this asset, with the same search, filters, and sort as the Trials tab.

7 of 7

Alzheimer’s disease and related dementias trials
Asset / Disease areaKey I/E criterionEvidence
EVOKE PlusA Research Study Investigating Semaglutide in People With Early Alzheimer's Disease (EVOKE Plus)

Semaglutide

Alzheimer’s disease

CDR global 0.5Ph 3Completed498Sep 20254
EVOKEA Research Study Investigating Semaglutide in People With Early Alzheimer's Disease (EVOKE)

Semaglutide

Alzheimer’s disease

CDR global 0.5Ph 3Completed447Sep 20253
NCT05891496A Research Study Looking at the Effect of Semaglutide on the Immune System and Other Biological Processes in People With Alzheimer's Disease

Semaglutide

Alzheimer’s disease

CDR global 0.5Ph 3Completed11Aug 2024-results
NCT07651319Interleukine-2 (IL-2) Plus Semaglutide in Alzheimer's Disease

Aldesleukin, Semaglutide

Alzheimer’s disease

Alzheimer's diseasePh 1/2Recruiting1Jun 2029-
NCT06072963COMMETS- Combination MCI Metabolic Syndrome

Insulin, Semaglutide

Alzheimer’s disease, MCI / preclinical Alzheimer’s

MoCA ≤27Ph 2Recruiting1Dec 202758
NCT07135245Improved Treatment and Monitoring of Alzheimer's Disease

Semaglutide

Alzheimer’s disease

-Ph 2Not yet recruiting0Sep 2030-
NCT07200622Oral Semaglutide in Patients With Alzheimer's Disease

Semaglutide

Alzheimer’s disease

Alzheimer's diseasePh 2Not yet recruiting0Dec 2027-

Showing 1-7 of 7 trials