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Sirolimus

3 trials in this asset. Source: ClinicalTrials.gov, as of July 21, 2026.

Trials

3

Ongoing

1

Recruiting

0

Completed

2

Sites

3

Countries

2

Endpoints

116

Composite endpoints

0

Distinct sites and countries across this asset's trials. A site running several of its trials counts once, matching the map. All 116 linked ClinicalTrials.gov endpoints are classified into the categories below. Trial and endpoint linkage does not by itself establish treatment attribution for every endpoint.

Development

Where the program stands

Trials by phase

Early Phase 1
1
Phase 1/2
1
Phase 2
1

Trials by status

Active, not recruiting
1
Completed
2

Evidence coverage

What this asset has been measured on

Endpoints grouped into outcome categories, ranked by how often they are measured across this asset's trials.

Safety / tolerability / PK
31
Other (unclassified)
26
Memory
12
Executive function / language
11
Fluid / digital biomarkers
7
Other clinical outcomes
7
Global cognition
5
Behavior / neuropsychiatric
5
Function / daily living
3
Amyloid biomarkers
3
Neuroimaging
3
Tau biomarkers
2
Neurodegeneration biomarkers
1

Most-measured metrics

Top 20 metrics across this asset's endpoints

Normalized metric codes are available for 7 of 116 classified ClinicalTrials.gov endpoints for this asset; the ranking below covers that coded subset.

Montreal Cognitive Assessment (MoCA)Cognition

3

Neuropsychiatric Inventory (NPI)Behavior

2

Clinical Dementia Rating-Sum of Boxes (CDR-SB)Cognition

1

Neurofilament light (NfL)Neurodeg.

1

Trials

Trials for this asset

Every trial for this asset, with the same search, filters, and sort as the Trials tab.

3 of 3

Alzheimer’s disease and related dementias trials
Asset / Disease areaKey I/E criterionEvidence
CARPE_DIEMCognition, Age, and RaPamycin Effectiveness - DownregulatIon of thE mTor Pathway

Sirolimus

Alzheimer’s disease

Alzheimer's diseaseEarly Ph 1Completed1Jan 20221results
REACHRapamycin - Effects on Alzheimer's and Cognitive Health

Sirolimus

Alzheimer’s disease, MCI / preclinical Alzheimer’s

Alzheimer's diseasePh 2Active, not recruiting1Mar 2026-
ERAPEvaluating Rapamycin Treatment in Alzheimer's Disease Using Positron Emission Tomography

Sirolimus

Alzheimer’s disease

Alzheimer's diseasePh 1/2Completed1Dec 20242

Showing 1-3 of 3 trials