CompletedPhase 3

Alzheimer's Disease Prevention Trial

Alzheimer's Disease Prevention Trial. A Multi-center, Randomized, Double-blind Placebo Controlled Trial of Estrogens to Prevent Alzheimer's Disease and Loss of Memory in Women.

Lead sponsor

National Institute on Aging (NIA)

Assets

estrogen / Estrogen and Progesterone

Listed sites

Recruiting sites

Enrollment

Study population

Alzheimer’s disease

Key I/E criteria

•Age ≥65•Female

Primary endpoint

Footprint

Where this trial recruits

Site locations as reported to ClinicalTrials.gov. Site count is not enrollment count; per-site enrollment is not available from source.

Identifiers

Registered as

Org study IDIA0018

NCT IDNCT00000176

SecondaryRO 1AG15922-01

Timeline

Milestones

Study first posted1999-11-01estimated

Primary completion2007-09actual (month precision)

Study completion2007-09actual (month precision)

Last update posted2010-11-05estimated

Assets

Drug assets

estrogen Estrogen and Progesterone

Study populations

Who this study enrolls

Alzheimer’s disease

Eligibility

Who can enroll

Minimum age65 Years

SexFemale

Healthy volunteersAccepted

Inclusion criteria

•Healthy women 65 or older with a family history of memory problems not currently on estrogen

Exclusion criteria

•Significant neurological impairment

•Current estrogen use

•History of breast cancer

Endpoints (0)

What's being measured

Protocol endpoints and posted registry outcome measures, grouped into outcome categories. Composite endpoints show their component event types. Standard codes (LOINC, SNOMED CT) are shown where available.

No endpoints recorded for this trial.

Publications (4)

Bibliography

Records linked to this trial through ClinicalTrials.gov references, PubMed NCT search, and curated study seeds. 'Canonical' marks design/result papers; others are registry references or candidates.

Registry references + supporting bibliography

Provenance

Sources

Trial identity, design, statusClinicalTrials.gov API v2

Snapshot dateJuly 21, 2026

Endpoint classificationDelfa ADRD endpoint taxonomy

Results tableno registry results posted yet

Trial facts come from public ClinicalTrials.gov records. Endpoint categories are Delfa's classification of those records, not a ClinicalTrials.gov field. All figures reflect the July 21, 2026 snapshot.