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CompletedPhase 4

The Effect of Short-Term Statins and NSAIDs on Levels of Beta-Amyloid, a Protein Associated With Alzheimer's Disease

The Effect of Short-Term Statin and NSAID Treatment on CSF Beta-Amyloid

Assets

Ibuprofen / Lovastatin

Listed sites

1

Recruiting sites

-

Enrollment

50

Study population

Alzheimer’s disease

Key I/E criterion

-

Primary endpoint

-

Footprint

Where this trial recruits

Site locations as reported to ClinicalTrials.gov. Site count is not enrollment count; per-site enrollment is not available from source.

Identifiers

Registered as

Secondary02-M-0305
Org study ID020305
NCT IDNCT00046358

Timeline

Milestones

Study start2002-09 (month precision)
Study first posted2002-09-27estimated
Study completion2005-08 (month precision)
Last update posted2008-03-04estimated

Assets

Drug assets

IbuprofenLovastatin

Study populations

Who this study enrolls

Alzheimer’s disease

Eligibility

Who can enroll

SexAll
Healthy volunteersAccepted

Inclusion criteria

1. Normal volunteer over the age of 18

2. Cognitively within normal limits at baseline evaluation

3. Previously evaluated in Protocol 95-M-0096

4. Women of child-bearing potential will be advised not to become pregnant during the treatment period

Exclusion criteria

1. Known allergies to lovastatin or ibuprofen

2. Use of regular dosing of NSAID or statin during the previous month

3. Concurrent use of cyclosporine, itraconazole, ketoconazole, gemfibrozil, niacin, erythromycin, clarithromycin, HIV protease inhibitors or nefazodone because of possible drug interactions with lovastatin.

4. Women who are currently pregnant

5. Concurrent use of anticoagulants, aspirin, beta-adrenergic agents, cimetidine, digoxin and oral hypoglycemics because of possible drug interactions with ibuprofen.

6. Peptic ulcer disease by history

7. Autoimmune disease by history

Endpoints (0)

What's being measured

Protocol endpoints and posted registry outcome measures, grouped into outcome categories. Composite endpoints show their component event types. Standard codes (LOINC, SNOMED CT) are shown where available.

No endpoints recorded for this trial.

Publications (3)

Bibliography

Records linked to this trial through ClinicalTrials.gov references, PubMed NCT search, and curated study seeds. 'Canonical' marks design/result papers; others are registry references or candidates.

Registry references + supporting bibliography

Provenance

Sources

Trial identity, design, statusClinicalTrials.gov API v2
Snapshot dateJuly 21, 2026
Endpoint classificationDelfa ADRD endpoint taxonomy
Results tableno registry results posted yet

Trial facts come from public ClinicalTrials.gov records. Endpoint categories are Delfa's classification of those records, not a ClinicalTrials.gov field. All figures reflect the July 21, 2026 snapshot.