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CompletedPhase 4

A 52 Week Open Label Trial of Memantine for Frontotemporal Lobar Degeneration

Lead sponsor

University of California, San Francisco

Asset

Memantine

Listed sites

Recruiting sites

Enrollment

Study population

Frontotemporal dementia

Key I/E criterion

•MMSE ≥15

Primary endpoint

Identifiers

Registered as

Org study IDNAM-02A

NCT IDNCT00187525

Timeline

Milestones

Study start2004-05 (month precision)

Study first posted2005-09-16estimated

Primary completion2005-10actual (month precision)

Study completion2006-10actual (month precision)

Last update posted2012-11-12estimated

Assets

Drug assets

Memantine

Study populations

Who this study enrolls

Frontotemporal dementia

Eligibility

Who can enroll

Minimum age40 Years

Maximum age80 Years

SexAll

Healthy volunteersNot accepted

Inclusion criteria

•Neary et al. Criteria for Frontotemporal Lobar Degeneration

•Age 40 -80

•CDR < 3 or MMSE > 15

•English Speaking

•Study Partner

Exclusion criteria

•Concurrent use of antipsychotic drugs or acetylcholinesterase inhibitors

Endpoints (0)

What's being measured

Protocol endpoints and posted registry outcome measures, grouped into outcome categories. Composite endpoints show their component event types. Standard codes (LOINC, SNOMED CT) are shown where available.

No endpoints recorded for this trial.

Publications (1)

Bibliography

Records linked to this trial through ClinicalTrials.gov references, PubMed NCT search, and curated study seeds. 'Canonical' marks design/result papers; others are registry references or candidates.

Registry references + supporting bibliography

Boxer AL, Lipton AM, Womack K, Merrilees J, Neuhaus J, Pavlic D, Gandhi A, Red D, Martin-Cook K, Svetlik D, Miller BL. An open-label study of memantine treatment in 3 subtypes of frontotemporal lobar degeneration. Alzheimer Dis Assoc Disord. 2009 Jul-Sep;23(3):211-7. doi: 10.1097/WAD.0b013e318197852f.
PMID19812461via DERIVED

Provenance

Sources

Trial identity, design, statusClinicalTrials.gov API v2

Snapshot dateJuly 21, 2026

Endpoint classificationDelfa ADRD endpoint taxonomy

Results tableno registry results posted yet

Trial facts come from public ClinicalTrials.gov records. Endpoint categories are Delfa's classification of those records, not a ClinicalTrials.gov field. All figures reflect the July 21, 2026 snapshot.