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CompletedPhase 2

Trial of Valproic Acid in Patients With Progressive Supranuclear Palsy (Depakine)

Randomized Placebo-controlled Trial of Valproic Acid in Patients With Progressive Supranuclear Palsy

Lead sponsor

Nantes University Hospital

Asset

Valproic Acid

Listed sites

Recruiting sites

Enrollment

actual

Study population

Frontotemporal dementia

Key I/E criterion

•Age 45-75

Primary endpoint

•PSPRS score

Footprint

Where this trial recruits

Site locations as reported to ClinicalTrials.gov. Site count is not enrollment count; per-site enrollment is not available from source.

Identifiers

Registered as

Org study ID05/10-H

NCT IDNCT00385710

Timeline

Milestones

Study first posted2006-10-11estimated

Study start2006-11 (month precision)

Primary completion2010-07actual (month precision)

Study completion2010-07actual (month precision)

Last update posted2012-11-05estimated

Assets

Drug assets

Valproic Acid

Study populations

Who this study enrolls

Frontotemporal dementia

Eligibility

Who can enroll

Minimum age45 Years

Maximum age75 Years

SexAll

Healthy volunteersNot accepted

Eligibility criteria

•Patients with possible or probable PSP

•from 45 to 75 year of age

Endpoints (2)

What's being measured

Protocol endpoints and posted registry outcome measures, grouped into outcome categories. Composite endpoints show their component event types. Standard codes (LOINC, SNOMED CT) are shown where available.

Other (unclassified)

2 endpoints

Primary/protocol endpoint/low confidence

PSPRS score (specific score for PSP)

Time frame:This score will be measured every three months during the two-year follow up of the study

descriptive

Secondary/protocol endpoint/low confidence

Neuropsychological evaluation

Time frame:inclusion, one year and two years follow up

descriptive

Provenance

Sources

Trial identity, design, statusClinicalTrials.gov API v2

Snapshot dateJuly 21, 2026

Endpoint classificationDelfa ADRD endpoint taxonomy

Results tableno registry results posted yet

Trial facts come from public ClinicalTrials.gov records. Endpoint categories are Delfa's classification of those records, not a ClinicalTrials.gov field. All figures reflect the July 21, 2026 snapshot.