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Oral · GLP-1 agonist

Aleniglipron / GSBR-1290

9 trials in this molecule. Source: ClinicalTrials.gov, as of July 1, 2026.

Trials

9

Active

5

Recruiting

0

Completed

3

Sites

207

Countries

1

Endpoints

121

Composite endpoints

8

Distinct sites and countries across this molecule's trials. A site running several of its trials counts once, matching the map.

Development

Where the program stands

Trials by phase

Phase 1
2
Phase 1/2
1
Phase 2
4
Phase 3
2

Trials by status

Not yet recruiting
2
Active, not recruiting
3
Completed
3
Unknown
1

Evidence coverage

What this asset has been measured on

Endpoints grouped into outcome categories, ranked by how often they are measured across this asset's trials.

Safety / tolerability / PK
59
Weight & body composition
44
Cardiometabolic biomarkers
8
Glycemic / diabetes
6
Patient-reported / QoL
4

Most-measured metrics

Top 20 metrics across this asset's endpoints

Treatment-emergent AEs (any)Safety/PK

6

AUC₀–∞Safety/PK

6

CmaxSafety/PK

6

TmaxSafety/PK

6

Body weight, % changeWeight

5

Body weight, absolute change (kg)Weight

5

Waist circumference, changeWeight

4

Serious AEs (any)Safety/PK

4

Plasma concentration (steady state)Safety/PK

3

Half-lifeSafety/PK

3

≥5% weight-loss respondersWeight

3

≥10% weight-loss respondersWeight

3

≥15% weight-loss respondersWeight

3

BMI, changeWeight

2

HbA1c, changeGlycemic

1

Fasting glucose, changeGlycemic

1

Total fat massWeight

1

Visceral fat, changeWeight

1

Lean massWeight

1

SF-36 totalPRO/QoL

1

Trials

Programs for this asset

Every trial for this molecule, with the same search, filters, and sort as the Trials tab.

9 of 9

Asset / PopulationKey I/E criterionEvidence
NCT07654374A Study of Aleniglipron in Adults With Obesity or Overweight and Type 2 Diabetes Mellitus (ACCOMPLISH-2)

Aleniglipron / GSBR-1290

Obesity / overweight, Type 2 diabetes

BMI ≥27Ph 3Not yet recruiting74Sep 2028
NCT07654361Efficacy and Safety of Aleniglipron in Participants With Obesity or Overweight With a Weight-Related Comorbidity (ACCOMPLISH-1)

Aleniglipron / GSBR-1290

Obesity / overweight

BMI ≥30Ph 3Not yet recruiting71Sep 2028
ACCESSA Phase 2b, Dose-range Finding Study of the Efficacy and Safety of Multiple Doses of Aleniglipron (GSBR-1290) in Participants Living With Obesity or Overweight With at Least One Weight-related Comorbidity

Aleniglipron / GSBR-1290

Obesity / overweight

BMI ≥30Ph 2Active, not recruiting39Oct 2025
GSBR-1290Aleniglipron Phase 2 in Type 2 Diabetes Mellitus

Aleniglipron / GSBR-1290

Obesity / overweight, Type 2 diabetes

BMI ≥27Ph 2Active, not recruiting16Sep 2026
NCT07169942Aleniglipron Phase 2 Body Composition Study

Aleniglipron / GSBR-1290

Obesity / overweight

BMI ≥30Ph 2Active, not recruiting11Aug 2026
ACCESS IIA Dose-Range Study of Aleniglipron (GSBR-1290) in Participants Living With Obesity or Overweight With at Least One Weight-related Comorbidity

Aleniglipron / GSBR-1290

Obesity / overweight

BMI ≥30Ph 2Completed10Jan 2026
NCT05762471Phase 1b/2a Study of GSBR-1290 in Adult Overweight or Obese Healthy Subjects and Subjects With Type 2 Diabetes Mellitus

Aleniglipron / GSBR-1290

Obesity / overweight, Type 2 diabetes

BMI 27-40Ph 1/2Completed4Apr 2024
NCT06139055A Study of Multiple-ascending Doses of GSBR-1290 in Healthy Overweight/Obese Participants

Aleniglipron / GSBR-1290

Healthy volunteers, Obesity / overweight

BMI ≥27Ph 1Unknown3Mar 2024
NCT05893043A Study of Multiple Ascending Doses of GSBR-1290 in Japanese and Non-Japanese Healthy Participants

Aleniglipron / GSBR-1290

Healthy volunteers

Ph 1Completed1Jun 2023