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Oral · GLP-1 / amylin

Amycretin / zenagamtide

21 trials in this molecule. Source: ClinicalTrials.gov, as of July 1, 2026.

Trials

21

Active

12

Recruiting

9

Completed

9

Sites

1,279

Countries

34

Endpoints

368

Composite endpoints

4

Distinct sites and countries across this molecule's trials. A site running several of its trials counts once, matching the map.

Development

Where the program stands

Trials by phase

Phase 1
10
Phase 2
2
Phase 3
9

Trials by status

Not yet recruiting
3
Recruiting
9
Completed
9

Evidence coverage

What this asset has been measured on

Endpoints grouped into outcome categories, ranked by how often they are measured across this asset's trials.

Safety / tolerability / PK
96
Cardiometabolic biomarkers
88
Weight & body composition
50
Other clinical outcomes
49
Glycemic / diabetes
47
Patient-reported / QoL
22
Renal / kidney
6
Other (unclassified)
5
Cardiovascular outcomes
3
Heart failure
2

Most-measured metrics

Top 20 metrics across this asset's endpoints

Treatment-emergent AEs (any)Safety/PK

19

AUC₀–∞Safety/PK

18

Body weight, % changeWeight

18

CmaxSafety/PK

16

Fasting glucose, changeGlycemic

14

OSA responderOther clin.

13

Systolic BP, changeBiomarker

11

Waist circumference, changeWeight

10

Body weight, absolute change (kg)Weight

10

BMI, changeWeight

10

Total cholesterol, changeBiomarker

10

HDL-C, changeBiomarker

10

LDL-C, changeBiomarker

10

Triglycerides, changeBiomarker

10

hs-CRP, changeBiomarker

10

HbA1c, changeGlycemic

10

Diastolic BP, changeBiomarker

9

VLDL, changeBiomarker

9

Non-HDL cholesterol, changeBiomarker

9

Serious AEs (any)Safety/PK

9

Trials

Programs for this asset

Every trial for this molecule, with the same search, filters, and sort as the Trials tab.

21 of 21

Asset / PopulationKey I/E criterionEvidence
HF-POLARISA Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity

Amycretin / zenagamtide

Heart failure, Obesity / overweight

Ph 3Not yet recruiting825Jul 2029
AMAZE 8AMAZE 8: A Research Study Investigating How Well the Medicine NNC0487-0111 Compared to Semaglutide Helps People With Excess Body Weight and Type 2 Diabetes Lose Weight

Amycretin / zenagamtide, Semaglutide

Obesity / overweight, Type 2 diabetes

HbA1c 7-10%Ph 3Not yet recruiting120Dec 2028
NCT06542874A Research Study Comparing How Well Different Doses of the Medicine NNC0487-0111 Lower Blood Sugar in People With Type 2 Diabetes

Amycretin / zenagamtide

Type 2 diabetes

BMI ≤50Ph 2Completed119Oct 2025
AMAZE 4AMAZE 4: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea

Amycretin / zenagamtide

Obesity / overweight, Sleep apnea

Ph 3Recruiting91Jun 2028
AMAZE 5A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain

Amycretin / zenagamtide

Obesity / overweight, Osteoarthritis

Ph 3Recruiting82Aug 2028
AMAZE 6AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain

Amycretin / zenagamtide

Obesity / overweight, Osteoarthritis

Ph 3Recruiting81Aug 2028
AMAZE 3AMAZE 3: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Not Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea

Amycretin / zenagamtide

Obesity / overweight, Sleep apnea

Ph 3Recruiting80Jul 2028
AMAZE 2AMAZE 2: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Type 2 Diabetes Lose Weight

Amycretin / zenagamtide

Obesity / overweight, Type 2 diabetes

HbA1c 7-10%Ph 3Recruiting74Aug 2028
AMAZE 1AMAZE 1: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Lose Weight

Amycretin / zenagamtide

Obesity / overweight

Ph 3Recruiting72Jun 2029
AMAZE 12AMAZE 12: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Maintain Their Weight Loss

Amycretin / zenagamtide

Obesity / overweight

Ph 3Recruiting72Jun 2028
NCT06064006A Research Study to See How a New Medicine (NNC0487-0111) Works in People With Overweight or Obesity When Injected Under the Skin

Amycretin / zenagamtide

Obesity / overweight

BMI 27-39.9Ph 2Completed2Nov 20241
NCT07587710A Research Study Looking Into Blood Levels of the Medicine NNC0487-0111 in the Body and How Well it is Tolerated in People With Reduced Liver Function and Normal Liver Function

Amycretin / zenagamtide

Healthy volunteers, Hepatic impairment

Ph 1Not yet recruiting2Dec 2027
NCT06820476A Research Study on How NNC0487-0111, a New Medicine, Works in Chinese Participants After 10 Days of Oral Dosing

Amycretin / zenagamtide

Obesity / overweight

BMI 24-34.9Ph 1Completed2May 2025
NCT05369390A Research Study on How NNC0487-0111 Works in People With Overweight or Obesity

Amycretin / zenagamtide

Obesity / overweight

BMI 25-34.9Ph 1Completed2Jan 20241
NCT06049329A Research Study of How a New Medicine Called Amycretin, Given as Tablets, Works in Japanese Men With Obesity

Amycretin / zenagamtide

Obesity / overweight

BMI 25-34.9Ph 1Completed1Dec 2023
NCT06478563A Research Study Looking at Different Oral Formulations and the Effect of Food Intake on How the Medicine NNC0487-0111 Behaves in the Body of Participants Living With Overweight or Obesity

Amycretin / zenagamtide

Obesity / overweight

BMI 27-39.9Ph 1Completed1Jun 2025
NCT07121153A Research Study on How NNC0487-0111, a New Medicine, Works in Chinese Participants When Injected Under the Skin.

Amycretin / zenagamtide

Obesity / overweight

BMI 24-34.9Ph 1Completed1Dec 2025
NCT07535307Investigating How NNC0487-0111 Regulates Insulin of Adults With Type 2 Diabetes

Amycretin / zenagamtide

Type 2 diabetes

HbA1c 6.5-9.5%Ph 1Recruiting1Nov 2027
NCT06461039A Research Study Looking at How the Compound NNC0487-0111 Works With Birth Control Pills and Affects Emptying of the Stomach in Women Not Able to Become Pregnant

Amycretin / zenagamtide

Healthy volunteers, Obesity / overweight

BMI 25-39.9Ph 1Completed1Mar 2025
NCT06559527A Research Study Looking Into Blood Levels of the Medicine NNC0487-0111 in the Body and How Well it is Tolerated in Participants With Reduced Kidney Function and Normal Kidney Function

Amycretin / zenagamtide

Healthy volunteers, Renal impairment

BMI 20-39.9Ph 1Completed1Feb 2025
NCT07508020A Research Study Looking at How NNC0487-0111 Affects Food Intake, Appetite and Metabolism After Meals in People With Obesity

Amycretin / zenagamtide

Obesity / overweight

Ph 1Recruiting1Jan 2028