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Oral · GLP-1 agonist

AZD5004 / ECC5004

16 trials in this molecule. Source: ClinicalTrials.gov, as of July 1, 2026.

Trials

16

Active

2

Recruiting

0

Completed

14

Sites

155

Countries

12

Endpoints

256

Composite endpoints

12

Distinct sites and countries across this molecule's trials. A site running several of its trials counts once, matching the map.

Development

Where the program stands

Trials by phase

Phase 1
14
Phase 2
2

Trials by status

Active, not recruiting
2
Completed
14

Evidence coverage

What this asset has been measured on

Endpoints grouped into outcome categories, ranked by how often they are measured across this asset's trials.

Safety / tolerability / PK
225
Weight & body composition
16
Glycemic / diabetes
15

Most-measured metrics

Top 20 metrics across this asset's endpoints

AUC₀–∞Safety/PK

48

CmaxSafety/PK

25

Treatment-emergent AEs (any)Safety/PK

18

TmaxSafety/PK

17

Half-lifeSafety/PK

15

Plasma concentration (steady state)Safety/PK

7

Body weight, % changeWeight

5

Serious AEs (any)Safety/PK

4

Body weight, absolute change (kg)Weight

3

Fasting glucose, changeGlycemic

3

HOMA-IR (insulin sensitivity)Glycemic

3

BMI, changeWeight

2

≥5% weight-loss respondersWeight

2

Waist circumference, changeWeight

1

tlagSafety/PK

1

Postprandial glucoseGlycemic

1

C-peptide AUCGlycemic

1

≥10% weight-loss respondersWeight

1

HbA1c, changeGlycemic

1

HbA1c <6.5% achievementGlycemic

1

Trials

Programs for this asset

Every trial for this molecule, with the same search, filters, and sort as the Trials tab.

16 of 16

Asset / PopulationKey I/E criterionEvidence
SOLSTICEEfficacy, Safety, and Tolerability of Once Daily Oral Administration of AZD5004 Versus Placebo for 26 Weeks in Adults With Type 2 Diabetes Mellitus.

AZD5004 / ECC5004, Semaglutide

Type 2 diabetes

BMI ≥23Ph 2Completed97Dec 2025
VISTAEffects of AZD5004 in Adults Who Are Living With Obesity or Overweight With at Least 1 Weight-related Comorbidity

AZD5004 / ECC5004

Obesity / overweight

BMI ≥30Ph 2Completed62Nov 2025
NCT06988553A Phase Ib Study of AZD5004 in Chinese Participants With Overweight/Obesity With or Without Type 2 Diabetes Mellitus

AZD5004 / ECC5004

Obesity / overweight, Type 2 diabetes

BMI ≤35Ph 1Completed6Nov 2025
NCT06813781Study to Investigate the Effect of Hepatic Impairment on the Pharmacokinetics, Safety, and Tolerability of AZD5004

AZD5004 / ECC5004

Healthy volunteers, Hepatic impairment

BMI 18-40Ph 1Completed5Oct 2025
NCT06742762A Phase I Study to Investigate the Effect of Renal Impairment on the Pharmacokinetics, Safety, and Tolerability of AZD5004

AZD5004 / ECC5004

Healthy volunteers, Renal impairment

BMI 18-40Ph 1Completed3Apr 2025
NCT06942936A Study to Investigate the Impact of Multiple Doses of Itraconazole on AZD5004 in Healthy Participants and Multiple Doses of AZD5004 on Combined Oral Ethinyl Oestradiol and Levonorgestrel in Healthy Female Participants

AZD5004 / ECC5004

Healthy volunteers

BMI 18.5-35Ph 1Completed2Jan 2026
NCT07455825A Study to Investigate the Pharmacokinetics of Different Formulations and Safety of AZD5004 in Healthy Participants Aged 18 to 55 Years

AZD5004 / ECC5004

Healthy volunteers

BMI ≥23Ph 1Active, not recruiting2Jun 2026
NCT06555822A Study to Investigate Multiple Ascending Doses and Relative Bioavailability of AZD5004 in Healthy Participants

AZD5004 / ECC5004

Healthy volunteers

BMI ≥23Ph 1Completed1Mar 2025
NCT06703658A Study to Investigate Multiple Ascending Doses of AZD5004 in Healthy Japanese Participants and Participants With Type 2 Diabetes Mellitus

AZD5004 / ECC5004

Healthy volunteers, Type 2 diabetes

BMI 18-32Ph 1Completed1Mar 2025
NCT05654831FTIH of ECC5004 in Healthy and Diabetic Participants

AZD5004 / ECC5004

Healthy volunteers, Type 2 diabetes

BMI 18-32Ph 1Completed1Nov 20231
NCT06857695A Study to Assess the Mass Balance and ADME of [14C]AZD5004 and the Absolute Bioavailability of AZD5004

AZD5004 / ECC5004

Healthy volunteers

BMI 18-35Ph 1Completed1May 2025
NCT07444424A Study to Investigate the Effect of AZD5004 on Mitiglinide and Pioglitazone in Healthy Participants

AZD5004 / ECC5004

Healthy volunteers

BMI 18-35Ph 1Active, not recruiting1Jul 2026
NCT06996886A Study in Healthy Participants to Investigate Relative Bioavailability of AZD5004 in Three Solid Oral Formulations

AZD5004 / ECC5004

Healthy volunteers

BMI ≥23Ph 1Completed1Jul 2025
NCT06948747A Study to Investigate the Effect of AZD5004 on Rosuvastatin, Atorvastatin, Simvastatin, Repaglinide and the Effect of Erythromycin on AZD5004 in Healthy Participants

AZD5004 / ECC5004

Healthy volunteers

BMI 20-35Ph 1Completed1Oct 2025
NCT06293742ECC5004 DDI Study With Atorvastatin, Rosuvastatin, Digoxin and Midazolam in Healthy Participants

AZD5004 / ECC5004

Healthy volunteers

BMI 18-32Ph 1Completed1Apr 2024
NCT06268145ECC5004 RBA FE Study in Healthy Participants

AZD5004 / ECC5004

Healthy volunteers

BMI 18-32Ph 1Completed1Mar 2024