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Subcutaneous · Amylin analog

AZD6234

11 trials in this molecule. Source: ClinicalTrials.gov, as of July 1, 2026.

Trials

11

Active

7

Recruiting

5

Completed

4

Sites

123

Countries

9

Endpoints

207

Composite endpoints

0

Distinct sites and countries across this molecule's trials. A site running several of its trials counts once, matching the map.

Development

Where the program stands

Trials by phase

Phase 1
6
Phase 1/2
1
Phase 2
4

Trials by status

Recruiting
5
Active, not recruiting
2
Completed
4

Evidence coverage

What this asset has been measured on

Endpoints grouped into outcome categories, ranked by how often they are measured across this asset's trials.

Safety / tolerability / PK
106
Weight & body composition
31
Glycemic / diabetes
27
Other (unclassified)
24
MASH / liver
10
Other clinical outcomes
6
Cardiometabolic biomarkers
3

Most-measured metrics

Top 20 metrics across this asset's endpoints

Body weight, % changeWeight

1

≥5% weight-loss respondersWeight

1

≥10% weight-loss respondersWeight

1

Body weight, absolute change (kg)Weight

1

HbA1c, changeGlycemic

1

Plasma concentration (steady state)Safety/PK

1

Fasting glucose, changeGlycemic

1

Trials

Programs for this asset

Every trial for this molecule, with the same search, filters, and sort as the Trials tab.

11 of 11

Asset / PopulationKey I/E criterionEvidence
ASCENDA Weight Loss Study Evaluating Subcutaneous Treatment With AZD9550 and AZD6234 in Combination Against Placebo or Each of the Drugs Alone

AZD6234, AZD9550

Obesity / overweight

BMI ≥30Ph 2Active, not recruiting53May 2026
APRICUSA Study in Participants With Obesity or Overweight With at Least One Weight-related Comorbidity

AZD6234

Obesity / overweight

BMI ≥30Ph 2Completed41Aug 2025
ARAYEfficacy, Safety and Tolerability of AZD6234 in Participants Living With Overweight or Obesity With Type 2 Diabetes Who Are on a Stable Dose of GLP-1 Receptor Agonist

AZD6234

Obesity / overweight, Type 2 diabetes

BMI ≥27Ph 2Active, not recruiting18May 2026
CONTEMPOA Trial to Learn How Safe AZD9550 Monotherapy and Combined With AZD6234 is in People With or Without Type 2 Diabetes Who Are Living With Obesity and Overweight

AZD6234, AZD9550

Obesity / overweight, Type 2 diabetes

BMI 27-39.9Ph 1/2Recruiting15Jan 2027
NCT07546760A Phase I Study to Investigate the Effect of Hepatic Impairment of AZD9550 and AZD6234

AZD6234, AZD9550

Healthy volunteers, Hepatic impairment

BMI 18-42Ph 1Recruiting4Feb 2027
NCT07017179This is a Multi-centre, Multi-drug, Platform Study in Chinese Participants Living With Obesity / Overweight

AZD6234, AZD9550

Obesity / overweight

BMI ≥27Ph 2Recruiting3Aug 2026
NCT06845813Study to Investigate the Effect of Renal Impairment on the Pharmacokinetics, Safety, and Tolerability of AZD6234

AZD6234

Healthy volunteers, Renal impairment

BMI 18-40Ph 1Completed3Sep 2025
NCT06132841A Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD6234 After Repeat Dose Administration in Participants Who Are Overweight or Obese

AZD6234

Healthy volunteers, Obesity / overweight

BMI 25-40Ph 1Completed3Feb 2026
NCT05511025Assess the Safety, Tolerability, and Pharmacokinetics of AZD6234 Following Single Ascending Dose Administration to Healthy Subjects Who Are Overweight or Obese

AZD6234

Healthy volunteers, Obesity / overweight

BMI 25-35Ph 1Completed2Dec 2023
NCT07013643A Study to Investigate the Effect of AZD6234, AZD9550, and a Combination of AZD9550 and AZD6234 on Pharmacokinetics of Combined Oral Contraceptive Ethinyl Estradiol/Levonorgestrel in Healthy Female Participants Living With Overweight or Obesity

AZD6234, AZD9550

Healthy volunteers, Obesity / overweight

BMI 25-40Ph 1Recruiting2Dec 2026
NCT07220954A Study to Assess the Relative Bioavailability of Different Subcutaneous Formulations ofAZD6234

AZD6234

Healthy volunteers, Obesity / overweight

BMI 25-35Ph 1Recruiting1Sep 2026