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Subcutaneous · GLP-1 / glucagon dual

Cotadutide

24 trials in this molecule. Source: ClinicalTrials.gov, as of July 1, 2026.

Trials

24

Active

0

Recruiting

0

Completed

22

Sites

341

Countries

31

Endpoints

450

Composite endpoints

15

Distinct sites and countries across this molecule's trials. A site running several of its trials counts once, matching the map.

Development

Where the program stands

Trials by phase

Phase 1
12
Phase 1/2
1
Phase 2
11

Trials by status

Completed
22
Terminated
2

Evidence coverage

What this asset has been measured on

Endpoints grouped into outcome categories, ranked by how often they are measured across this asset's trials.

Safety / tolerability / PK
264
Glycemic / diabetes
87
Weight & body composition
50
Cardiometabolic biomarkers
28
MASH / liver
13
Renal / kidney
4
Other clinical outcomes
2
Other (unclassified)
2

Most-measured metrics

Top 20 metrics across this asset's endpoints

Treatment-emergent AEs (any)Safety/PK

60

AUC₀–∞Safety/PK

35

Immunogenicity (ADA)Safety/PK

30

CmaxSafety/PK

21

Body weight, % changeWeight

19

TmaxSafety/PK

18

HbA1c, changeGlycemic

13

Body weight, absolute change (kg)Weight

13

Fasting glucose, changeGlycemic

12

Half-lifeSafety/PK

11

Postprandial glucoseGlycemic

11

Plasma concentration (steady state)Safety/PK

11

Heart rate, changeBiomarker

11

CGM time-above-rangeGlycemic

10

HbA1c, % changeGlycemic

5

≥5% weight-loss respondersWeight

4

CGM time-below-rangeGlycemic

4

CGM time-in-rangeGlycemic

4

Systolic BP, changeBiomarker

4

uACR, % changeRenal

4

Trials

Programs for this asset

Every trial for this molecule, with the same search, filters, and sort as the Trials tab.

24 of 24

Asset / PopulationKey I/E criterionEvidence
NCT03235050A Study to Evaluate the Efficacy and Safety of MEDI0382 in the Treatment of Overweight and Obese Subjects With Type 2 Diabetes

Cotadutide, Liraglutide

Obesity / overweight, Type 2 diabetes

BMI ≥25Ph 2Completed119May 20181results
PROXYMO-ADVA Study to Evaluate the Safety and Efficacy of Cotadutide Given by Subcutaneous Injection in Adult Participants With Non-cirrhotic Non-alcoholic Steatohepatitis With Fibrosis

Cotadutide

MASH / NAFLD / liver fibrosis

Ph 2Completed115Apr 2024results
NCT04515849A Study of Cotadutide in Participants Who Have Chronic Kidney Disease With Type 2 Diabetes Mellitus

Cotadutide, Semaglutide

Chronic kidney disease, Type 2 diabetes

BMI ≥25Ph 2Completed83Mar 20223results
NCT04019561A Study to Evaluate Safety and Pharmacodynamic Efficacy of 0382 in Obese Subjects With NAFLD/NASH.

Cotadutide

MASH / NAFLD / liver fibrosis, Obesity / overweight

BMI ≥30Ph 2Completed27May 20211results
NCT02548585A Multiple-ascending-dose Study to Evaluate the Efficacy, Safety, and Pharmacokinetics (PK) of MEDI0382 in Overweight and Obese Participants With Type 2 Diabetes Mellitus

Cotadutide

Obesity / overweight, Type 2 diabetes

Ph 1/2Completed11Feb 20172results
NCT03444584Study of MEDI0382 in Combination With Dapagliflozin and Metformin in Overweight/Obese Participants With Type 2 Diabetes

Cotadutide

Obesity / overweight, Type 2 diabetes

BMI 25-40Ph 2Completed8Dec 2018results
NCT03550378A Study to Look at the Effect MEDI0382 Has on Blood Sugar in People With Type 2 Diabetes and Kidney Problems and Also to Check That MEDI0382 is Well Tolerated

Cotadutide

Renal impairment, Type 2 diabetes

BMI 25-45Ph 2Completed7Feb 20192results
NCT03244800A Study to Investigate Different Doses of 0382 in Overweight and Obese Subjects With Type 2 Diabetes Mellitus.

Cotadutide

Obesity / overweight, Type 2 diabetes

BMI 27-40Ph 2Completed5Jan 20181results
NCT03645421Safety and Tolerability Study of MEDI0382 in Japanese Preobese or Obese Subjects With Type 2 Diabetes

Cotadutide

Obesity / overweight, Type 2 diabetes

BMI 24-40Ph 2Completed5Jan 2019results
NCT03235375A Study to Evaluate Pharmacokinetics, Safety and Tolerability of MEDI0382 in Renal Impairment Subjects

Cotadutide

Healthy volunteers, Renal impairment

BMI ≥17Ph 1Completed4Apr 20181
NCT03555994A Study to Investigate the Effect of MEDI0382 on Hepatic Glycogen Metabolism in Overweight and Obese Subjects With Type 2 Diabetes Mellitus.

Cotadutide, Liraglutide

Obesity / overweight, Type 2 diabetes

BMI 27-40Ph 2Completed3Apr 20211results
NCT05517226Pharmacokinetics of Cotadutide in Participants With Hepatic Impairment

Cotadutide

Healthy volunteers, Hepatic impairment

BMI 18-40Ph 1Terminated3Feb 2023
NCT04208620Safety and Tolerability Study of Cotadutide in Japanese Obese Subjects With Type 2 Diabetes Melitus

Cotadutide

Obesity / overweight, Type 2 diabetes

BMI 25-35Ph 1Completed3Jul 2020
COTA China PKChinese Multiple Dose Escalation (MDE) High Dose Study

Cotadutide

Obesity / overweight, Type 2 diabetes

BMI 25-35Ph 1Completed2Dec 2022
NCT03625778A Study to Assess Safety, Tolerability, and Pharmacokinetics of MEDI0382 in Non-diabetic Obese Participants

Cotadutide

Obesity / overweight

BMI ≥35Ph 1Completed2Aug 2019
NCT04091373A Study Investigating the Pharmacokinetics of a Single Dose Administration of Cotadutide

Cotadutide

Healthy volunteers

BMI 19-30Ph 1Completed1Mar 2020
NCT05668936A Thorough QTC Study to Assess the Effect of Cotadutide on Cardiac Repolarization in Healthy Participants

Cotadutide

Healthy volunteers

BMI 18-29.9Ph 1Terminated1Mar 2023
NCT05294458A Randomised, Open-Label Study to Evaluate the Relative and Absolute Bioavailability of Cotadutide in Healthy Subjects

Cotadutide

Healthy volunteers

BMI 18-30Ph 1Completed1Sep 2022
NCT03347968Study to Compare Pharmacokinetics & Pharmacodynamics of Warfarin & Esmolol in the Absence & Presence of MEDI0382

Cotadutide

Healthy volunteers

BMI 18-30Ph 1Completed1Apr 2018
NCT03596177A Study to Evaluate the Effect of MEDI0382 on Energy Balance in Overweight and Obese Participants With Type 2 Diabetes Mellitus

Cotadutide

Obesity / overweight, Type 2 diabetes

BMI 28-40Ph 2Completed1Dec 2019results
NCT03745937A Study to Evaluate the Safety and Tolerability of MEDI0382 in Overweight and Obese Participants With Type 2 Diabetes Mellitus

Cotadutide

Obesity / overweight, Type 2 diabetes

BMI 27-35Ph 2Completed1May 2019results
NCT03341013A Pilot Study Investigating Bioequivalence Between a Single Dose of Formulation 2 and Formulation 3 of MEDI0382

Cotadutide

Healthy volunteers

BMI 19-30Ph 1Completed1Jan 2018
NCT02394314A Phase 1, Single Dose Study to Evaluate the Safety and Pharmacokinetics of MEDI0382 in Healthy Volunteers

Cotadutide

Healthy volunteers

BMI 22-30Ph 1Completed1Aug 2015
NCT03385369A Study to Evaluate the Safety and Pharmacokinetics of MEDI0382 in Overweight/Obese Subjects of Japanese or Chinese Descent

Cotadutide

Healthy volunteers, Obesity / overweight

BMI 23-40Ph 1Completed1Apr 2018