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Oral · GLP-1 agonist

CT-996 / RO7795081

6 trials in this molecule. Source: ClinicalTrials.gov, as of July 1, 2026.

Trials

6

Active

4

Recruiting

2

Completed

2

Sites

72

Countries

8

Endpoints

76

Composite endpoints

1

Distinct sites and countries across this molecule's trials. A site running several of its trials counts once, matching the map.

Development

Where the program stands

Trials by phase

Phase 1
4
Phase 2
2

Trials by status

Recruiting
2
Active, not recruiting
2
Completed
2

Evidence coverage

What this asset has been measured on

Endpoints grouped into outcome categories, ranked by how often they are measured across this asset's trials.

Safety / tolerability / PK
58
Weight & body composition
11
Glycemic / diabetes
4
Patient-reported / QoL
1
Other clinical outcomes
1
Other (unclassified)
1

Most-measured metrics

Top 20 metrics across this asset's endpoints

HbA1c, changeGlycemic

2

HbA1c <5.7% achievementGlycemic

1

Fasting glucose, changeGlycemic

1

Body weight, % changeWeight

1

Body weight, absolute change (kg)Weight

1

≥15% weight-loss respondersWeight

1

Treatment-emergent AEs (any)Safety/PK

1

Documented hypoglycemiaSafety/PK

1

Plasma concentration (steady state)Safety/PK

1

Trials

Programs for this asset

Every trial for this molecule, with the same search, filters, and sort as the Trials tab.

6 of 6

Asset / PopulationKey I/E criterionEvidence
NCT07112872A Study to Compare Different Doses of RO7795081 With a Placebo or Semaglutide in People With Type 2 Diabetes

CT-996 / RO7795081, Semaglutide

Type 2 diabetes

BMI ≥23Ph 2Active, not recruiting50Nov 2026
NCT07081958A Study Evaluating the Effect of Daily Oral RO7795081 in Participants With Obesity or Overweight With at Least One Weight-Related Comorbidity

CT-996 / RO7795081

Obesity / overweight

Ph 2Active, not recruiting36Apr 2026
NCT05814107Phase 1 Study of CT-996 in Overweight/Obese Participants and Patients With Type 2 Diabetes Mellitus

CT-996 / RO7795081

Obesity / overweight, Type 2 diabetes

BMI 25-40Ph 1Completed2Nov 2025
NCT07499050A Study of Multiple Doses of Orally Administered RO7795081 in Otherwise Healthy Chinese Adult Participants With Obesity or Overweight

CT-996 / RO7795081

Obesity / overweight

BMI ≥24Ph 1Recruiting2Dec 2026
NCT06982131A Study Investigating the Safety of RO7795081 and the Effect of RO7795081 on How the Body Processes Pitavastatin and Rosuvastatin in Otherwise Healthy Overweight or Obese Adult Participants

CT-996 / RO7795081

Healthy volunteers, Obesity / overweight

BMI ≥27Ph 1Recruiting1Dec 2026
NCT06809608A Study Investigating the Effect of Different Approved Medications on How the Body Processes the Study Compound RO7795081

CT-996 / RO7795081

Healthy volunteers

BMI 18-32Ph 1Completed1Jun 2025