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Subcutaneous · GLP-1 / glucagon dual

Efinopegdutide

15 trials in this molecule. Source: ClinicalTrials.gov, as of July 1, 2026.

Trials

15

Active

1

Recruiting

0

Completed

12

Sites

336

Countries

34

Endpoints

244

Composite endpoints

0

Distinct sites and countries across this molecule's trials. A site running several of its trials counts once, matching the map.

Development

Where the program stands

Trials by phase

Phase 1
9
Phase 2
6

Trials by status

Active, not recruiting
1
Completed
12
Terminated
2

Evidence coverage

What this asset has been measured on

Endpoints grouped into outcome categories, ranked by how often they are measured across this asset's trials.

Safety / tolerability / PK
151
Cardiometabolic biomarkers
36
Weight & body composition
23
Glycemic / diabetes
19
MASH / liver
14
Other (unclassified)
1

Most-measured metrics

Top 20 metrics across this asset's endpoints

AUC₀–∞Safety/PK

25

Treatment-emergent AEs (any)Safety/PK

19

CmaxSafety/PK

15

TmaxSafety/PK

12

Half-lifeSafety/PK

11

Discontinuation due to AESafety/PK

9

Body weight, absolute change (kg)Weight

8

Body weight, % changeWeight

8

Immunogenicity (ADA)Safety/PK

7

Plasma concentration (steady state)Safety/PK

5

HDL-C, changeBiomarker

5

LDL-C, changeBiomarker

5

Total cholesterol, changeBiomarker

5

Triglycerides, changeBiomarker

5

Liver fat content, changeMASH

5

Fasting glucose, changeGlycemic

4

Heart rate, changeBiomarker

3

≥5% weight-loss respondersWeight

3

Non-HDL cholesterol, changeBiomarker

2

ApoB, changeBiomarker

2

Trials

Programs for this asset

Every trial for this molecule, with the same search, filters, and sort as the Trials tab.

15 of 15

Asset / PopulationKey I/E criterionEvidence
NCT05877547A Clinical Study of Efinopegdutide in Participants With Precirrhotic Nonalcoholic Steatohepatitis (NASH) (MK-6024-013)

Efinopegdutide, Semaglutide

MASH / NAFLD / liver fibrosis

HbA1c ≤9%Ph 2Completed175Dec 2025
NCT04944992A Study of Efinopegdutide (MK-6024) in Participants With Nonalcoholic Fatty Liver Disease (NAFLD) (MK-6024-001)

Efinopegdutide, Semaglutide

MASH / NAFLD / liver fibrosis, Obesity / overweight

BMI ≥25Ph 2Completed69Oct 20221results
NCT06465186A Clinical Study of Efinopegdutide in People With Compensated Cirrhosis Due to Steatohepatitis (MK-6024-017)

Efinopegdutide

MASH / NAFLD / liver fibrosis

Ph 2Active, not recruiting68Aug 2026
NCT03486392A Study to Evaluate the Safety and Efficacy of JNJ-64565111 in Non-diabetic Severely Obese Participants

Efinopegdutide, Liraglutide

Obesity / overweight

Ph 2Completed51Mar 2019results
NCT06482112Alternate Dosing Study of MK-6024 in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) (MK-6024-016)

Efinopegdutide

MASH / NAFLD / liver fibrosis, Obesity / overweight

BMI ≥25Ph 2Completed39Jun 2025results
NCT03586830A Study to Evaluate the Safety and Efficacy of JNJ-64565111 in Severely Obese Participants With Type 2 Diabetes Mellitus

Efinopegdutide

Obesity / overweight, Type 2 diabetes

HbA1c 6.5-9.5%Ph 2Completed27Apr 2019results
NCT06052566A Study of Efinopegdutide in Participants With Hepatic Impairment (MK-6024-014)

Efinopegdutide

Healthy volunteers, Hepatic impairment

Healthy volunteersPh 1Completed4Dec 2024results
NCT03235219A Phase 1b Study to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Doses of JNJ-64565111 in Participants With Type 2 Diabetes Mellitus

Efinopegdutide

Obesity / overweight, Type 2 diabetes

BMI 25-40Ph 1Completed2Feb 2018
NCT03546205A Study to Evaluate JNJ-64565111 Pharmacokinetics and Safety in Adult Participants With Varying Degrees of Renal Function

Efinopegdutide

Healthy volunteers, Renal impairment

BMI 18-40Ph 1Completed2Dec 2018
NCT03618160A Study to Assess the Safety, Tolerability and Pharmacokinetics of Subcutaneous (SC) Injections of JNJ-64565111 in Healthy Male Japanese Participants and to Assess Pharmacokinetics Following Subcutaneous Injections of JNJ-64565111 in Healthy Male Caucasian Participants

Efinopegdutide

Healthy volunteers, Obesity / overweight

BMI 25-40Ph 1Terminated2Jun 2019
NCT06836037A Clinical Study of Efinopegdutide (MK-6024) in Healthy Chinese Volunteers (MK-6024-011)

Efinopegdutide

Healthy volunteers, Obesity / overweight

BMI 25-35Ph 1Completed1Feb 2023
NCT03606057A Study to Investigate the Effect of JNJ-64565111 on Cardiac Repolarization (Corrected QT Interval) Compared With Placebo in Healthy Adults: a Thorough ECG Study Employing Placebo, JNJ-64565111, and a Positive Control (Moxifloxacin)

Efinopegdutide

Healthy volunteers, Obesity / overweight

BMI 25-40Ph 1Completed1Feb 2019
NCT03586843A Study of JNJ-64565111 After Single Subcutaneous Administration at Different Injection Sites in Otherwise Healthy Overweight/Obese Adult Participants and a Study of JNJ-6456511 in Otherwise Healthy Obese Adult Participants After Multiple Dose

Efinopegdutide

Obesity / overweight

BMI 25-40Ph 1Completed1Mar 2019
NCT02862431Study to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of JNJ-64565111 in Type 2 Diabetes Mellitus (T2DM)

Efinopegdutide

Type 2 diabetes

HbA1c ≥6.5%Ph 1Terminated1Nov 2016
NCT06701305A Study of Efinopegdutide in Healthy Obese Participants (MK-6024-015)

Efinopegdutide

Healthy volunteers, Obesity / overweight

BMI 29-38Ph 1Completed1Feb 2025