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Subcutaneous · Amylin analog

Eloralintide

17 trials in this molecule. Source: ClinicalTrials.gov, as of July 1, 2026.

Trials

17

Active

11

Recruiting

9

Completed

6

Sites

678

Countries

24

Endpoints

153

Composite endpoints

5

Distinct sites and countries across this molecule's trials. A site running several of its trials counts once, matching the map.

Development

Where the program stands

Trials by phase

Phase 1
7
Phase 2
5
Phase 3
5

Trials by status

Not yet recruiting
1
Recruiting
9
Active, not recruiting
1
Completed
6

Evidence coverage

What this asset has been measured on

Endpoints grouped into outcome categories, ranked by how often they are measured across this asset's trials.

Safety / tolerability / PK
41
Weight & body composition
39
Patient-reported / QoL
22
Cardiometabolic biomarkers
16
Glycemic / diabetes
14
Other clinical outcomes
11
Other (unclassified)
6
Renal / kidney
3
Heart failure
1

Most-measured metrics

Top 20 metrics across this asset's endpoints

CmaxSafety/PK

17

AUC₀–∞Safety/PK

17

Body weight, % changeWeight

12

BMI, changeWeight

8

PGI, changePRO/QoL

6

Body weight, absolute change (kg)Weight

6

Waist circumference, changeWeight

5

Triglycerides, changeBiomarker

5

Systolic BP, changeBiomarker

5

hs-CRP, changeBiomarker

5

EQ-5D indexPRO/QoL

5

HbA1c, changeGlycemic

4

SF-36 totalPRO/QoL

4

eGFR, changeRenal

3

Serious AEs (any)Safety/PK

3

Fasting glucose, changeGlycemic

3

≥5% weight-loss respondersWeight

3

≥10% weight-loss respondersWeight

3

Treatment-emergent AEs (any)Safety/PK

3

Total fat massWeight

2

Trials

Programs for this asset

Every trial for this molecule, with the same search, filters, and sort as the Trials tab.

17 of 17

Asset / PopulationKey I/E criterionEvidence
ENLIGHTEN-6A Study of Eloralintide (LY3841136) in Participants With Persistent Obesity Who Are Treated With a Weekly Incretin

Eloralintide

Obesity / overweight

Ph 3Recruiting178Jun 2028
ENLIGHTEN-1A Study of Eloralintide (LY3841136) in Participants With Obesity, or Overweight Without Type 2 Diabetes

Eloralintide

Obesity / overweight, Prediabetes / glucose intolerance

Ph 3Recruiting170Mar 2028
ENLIGHTEN-4Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight

Eloralintide

Obesity / overweight, Osteoarthritis

Ph 3Recruiting160Mar 2028
ENLIGHTEN-2A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight, and Type 2 Diabetes

Eloralintide

Obesity / overweight, Type 2 diabetes

BMI ≥27Ph 3Recruiting159Jan 2028
ENLIGHTEN-3A Study of Eloralintide (LY3841136) in Participants With Obstructive Sleep Apnea and Obesity or Overweight

Eloralintide

Obesity / overweight, Sleep apnea

BMI ≥27Ph 3Recruiting131Mar 2028
NCT06143956A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight

Eloralintide, Macupatide, Mazdutide, Tirzepatide

Obesity / overweight

Ph 2Recruiting53Sep 2027
NCT06603571A Study to Investigate Weight Management With LY3841136 and Tirzepatide (LY3298176), Alone or in Combination, in Adult Participants With Obesity or Overweight With Type 2 Diabetes

Eloralintide, Tirzepatide

Obesity / overweight, Type 2 diabetes

BMI ≥27Ph 2Active, not recruiting52Jun 2026
NCT06230523A Study of LY3841136 Compared With Placebo in Adult Participants With Obesity or Overweight

Eloralintide

Obesity / overweight

BMI ≥27Ph 2Completed46May 20251
NCT07589608A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight

Eloralintide, Macupatide

Obesity / overweight

Ph 2Not yet recruiting40Sep 2027
NCT07215559A Study of Macupatide (LY3532226) and Eloralintide (LY3841136), Alone or in Combination, in Adults With Obesity or Overweight and With Type 2 Diabetes

Eloralintide, Macupatide

Obesity / overweight, Type 2 diabetes

HbA1c 7.5-10.5%Ph 2Recruiting38Mar 2027
NCT06297616A Study of LY3841136 in Japanese Participants With Obesity or Overweight

Eloralintide, Tirzepatide

Obesity / overweight

BMI 27-40Ph 1Completed3Nov 2025
NCT06345066A Study of LY3841136 in Overweight and Obese Participants

Eloralintide, Tirzepatide

Obesity / overweight

BMI 27-45Ph 1Completed3Sep 2025
NCT06916065A Study of Eloralintide (LY3841136) and Eloralintide With Tirzepatide in Participants With Overweight or Obesity

Eloralintide, Tirzepatide

Obesity / overweight

BMI 27-40Ph 1Completed3Jan 2026
NCT07401862A Study of Eloralintide (LY3841136) in Participants With Different Levels of Liver Damage and in Participants With Healthy Livers.

Eloralintide

Healthy volunteers, Hepatic impairment

BMI 19-40Ph 1Recruiting3Mar 2027
NCT05295940A Study of LY3841136 in Healthy and Overweight Participants

Eloralintide

Healthy volunteers, Obesity / overweight

BMI 18.5-32Ph 1Completed3Jan 20241
NCT07426380A Study of Eloralintide (LY3841136) in Participants With Renal Impairment and in Participants With Normal Renal Function

Eloralintide

Healthy volunteers, Renal impairment

BMI 19-40Ph 1Recruiting2Oct 2026
NCT06916091A Study of Eloralintide (LY3841136) in Chinese Participants With Obesity or Overweight

Eloralintide

Obesity / overweight

BMI 27-40Ph 1Completed1Sep 2025