← All assets

Subcutaneous · GLP-1 agonist

GZR18

26 trials in this molecule. Source: ClinicalTrials.gov, as of July 1, 2026.

Trials

26

Active

18

Recruiting

6

Completed

7

Sites

38

Countries

3

Endpoints

217

Composite endpoints

1

Distinct sites and countries across this molecule's trials. A site running several of its trials counts once, matching the map.

Development

Where the program stands

Trials by phase

Phase 1
11
Phase 1/2
2
Phase 2
4
Phase 3
9

Trials by status

Not yet recruiting
7
Recruiting
6
Active, not recruiting
5
Completed
7
Unknown
1

Evidence coverage

What this asset has been measured on

Endpoints grouped into outcome categories, ranked by how often they are measured across this asset's trials.

Safety / tolerability / PK
92
Weight & body composition
51
Other (unclassified)
33
Glycemic / diabetes
19
Cardiometabolic biomarkers
19
Patient-reported / QoL
3

Most-measured metrics

Top 20 metrics across this asset's endpoints

Body weight, % changeWeight

3

HbA1c, changeGlycemic

3

≥5% weight-loss respondersWeight

2

Body weight, absolute change (kg)Weight

2

Treatment-emergent AEs (any)Safety/PK

2

≥10% weight-loss respondersWeight

1

≥15% weight-loss respondersWeight

1

≥20% weight-loss respondersWeight

1

≥25% weight-loss respondersWeight

1

BMI, changeWeight

1

Waist circumference, changeWeight

1

Fasting glucose, changeGlycemic

1

Systolic BP, changeBiomarker

1

Diastolic BP, changeBiomarker

1

Total cholesterol, changeBiomarker

1

LDL-C, changeBiomarker

1

HDL-C, changeBiomarker

1

Triglycerides, changeBiomarker

1

HbA1c <7.0% achievementGlycemic

1

Trials

Programs for this asset

Every trial for this molecule, with the same search, filters, and sort as the Trials tab.

26 of 26

Asset / PopulationKey I/E criterionEvidence
NCT06737042Efficacy and Safety of GZR18 Every 2 Weeks Versus Tirzepatide and Placebo in Obese or Overweight Participants

GZR18, Tirzepatide

Obesity / overweight

BMI ≥30Ph 2Not yet recruiting20Feb 2026
NCT07628985BALANCE-DM2 Study of Bofanglutide in Adults With Type 2 Diabetes

GZR18, Semaglutide

Obesity / overweight, Type 2 diabetes

BMI ≥27Ph 3Not yet recruiting7Oct 20272
NCT07622810BALANCE-OBS: Bofanglutide (GZR18) Versus Semaglutide in Latin American Adults With Overweight or Obesity

GZR18, Semaglutide

Obesity / overweight

BMI ≥30Ph 3Not yet recruiting6Dec 2027
GZR18-BWM-303Extension Study of the Phase 3 Clinical Study of GZR18 Injection for Weight Loss

GZR18

Obesity / overweight

BMI ≥18.5Ph 3Recruiting2Sep 2027
NCT07150975Phase III Clinical Study Comparing the Efficacy and Safety of GZR18 Injection and Semaglutide (Wegovy®) in Adult Obese or Overweight Subjects

GZR18, Semaglutide

Obesity / overweight, Type 2 diabetes

BMI ≥28Ph 3Recruiting1Jun 2027
NCT06974487A Phase I Study to Evaluate the PK and PD Profiles of GZR102 Injection Versus GZR4 Injection and GZR18 Injection Given Separately in Chinese Adult Overweight Subjects

GZR18

Obesity / overweight

BMI 24-28Ph 1Not yet recruiting1Sep 2025
NCT06256562A Study of GZR18 Injection in Obese/Overweight Patients

GZR18

Obesity / overweight

BMI ≥28Ph 2Completed1Jun 20241
NCT06728124A Phase III Clinical Study to Evaluate the Efficacy and Safety of GZR18 Injection in Adult Obese/Overweight Subjects

GZR18

Obesity / overweight

BMI ≥28Ph 3Active, not recruiting1May 2026
NCT07119450The Study of [14C] GZR18

GZR18

Obesity / overweight

MalePh 1Completed1Aug 2025
NCT07493057Evaluate the Efficacy and Safety of GZR18 Injection in Obese Subjects With Obstructive Sleep Apnea Not Treated With Positive Airway Pressure (PAP) Therapy

GZR18

Obesity / overweight, Sleep apnea

BMI ≥28Ph 3Not yet recruiting1Nov 2027
NCT07501832Evaluate the Efficacy and Safety of GZR18 Injection in Obese Subjects With Obstructive Sleep Apnea Receiving Positive Airway Pressure (PAP) Therapy

GZR18

Obesity / overweight, Sleep apnea

BMI ≥28Ph 3Not yet recruiting1Sep 2028
NCT06554054A Study of GZR18 Tablet in Chinese Healthy Subjects

GZR18

Healthy volunteers

BMI ≤24.9Ph 1Active, not recruiting1Dec 2024
NCT06548997A Phase I Study of GZR18 Injection in Healthy Subjects

GZR18

Healthy volunteers

BMI ≤26Ph 1Completed1Oct 2022
NCT05328726Single, Ascending Dose, First Time in Human Study for GZR18 in Healthy Subjects

GZR18

Healthy volunteers

BMI 20-35Ph 1Completed1Feb 2023
Optimum 1A Phase III Clinical Study to Evaluate the Efficacy and Safety of GZR18 Injection in Subjects With Type 2 Diabetes Mellitus and Poor Blood Glucose Control by Diet and Exercise

GZR18

Type 2 diabetes

Ph 3Active, not recruiting1Aug 2026
NCT06256523A Study of GZR18 Injection in Chinese Adult Patients With Type 2 Diabetes Mellitus (T2DM)

GZR18

Type 2 diabetes

BMI 18.5-35Ph 1/2Completed1Sep 2023
NCT06256536A Study of GZR18 Injection in Chinese Obese/Overweight Patients

GZR18

Obesity / overweight

BMI ≥28Ph 1/2Completed1Oct 20231
NCT06256549A Study of GZR18 Injection in Chinese Patients With Type 2 Diabetes Mellitus

GZR18, Semaglutide

Type 2 diabetes

BMI ≥18.5Ph 2Unknown1Jul 2024
NCT07128888Study on Gastric Emptying Effect and Drug-Drug Interactions of GZR18 Injection

GZR18

Obesity / overweight

BMI 26-35Ph 1Recruiting1Jul 2026
NCT07055386A Study to Compare the Efficacy and Safety of GZR102 Injection and GZR18 Injection in Type 2 Diabetes Mellitus

GZR18

Type 2 diabetes

Ph 2Active, not recruiting1Jun 2026
NCT07355738Bioequivalence Study of GZR18 Injection Before and After CMC Change

GZR18

Healthy volunteers

BMI 19-26Ph 1Recruiting1May 2026
NCT07144098Study of Pharmacokinetics and Safety of GZR18 Injection in Subjects With Liver Insufficiency and Normal Liver Function

GZR18

Healthy volunteers, Hepatic impairment

BMI 19-32Ph 1Recruiting1Jul 2026
NCT06548945A Phase I Study of GZR18 Injection in Obese/Overweight Subjects

GZR18

Obesity / overweight

BMI ≥26Ph 1Completed1Aug 2023
Optimum 2A Phase III Clinical Study to Evaluate the Efficacy and Safety of GZR18 Injection in Adult Type 2 Diabetes Mellitus

GZR18, Semaglutide

Type 2 diabetes

Ph 3Active, not recruiting1Dec 2026
NCT07141030Study of Pharmacokinetics and Safety of GZR18 Injection in Subjects With Renal Impairment and Normal Renal Function

GZR18

Healthy volunteers, Renal impairment

BMI ≤40Ph 1Recruiting1Oct 2025
NCT06670209A Phase I Clinical Study to Evaluate the Effect of GZR18 Injection on the Pharmacokinetics of Oral Metformin Hydrochloride Tablets in Overweight/Obese Subjects

GZR18

Obesity / overweight

BMI 24-33Ph 1Not yet recruiting0Mar 2025