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Oral · GLP-1 agonist

HDM1002

13 trials in this molecule. Source: ClinicalTrials.gov, as of July 1, 2026.

Trials

13

Active

11

Recruiting

6

Completed

1

Sites

37

Countries

1

Endpoints

144

Composite endpoints

25

Distinct sites and countries across this molecule's trials. A site running several of its trials counts once, matching the map.

Development

Where the program stands

Trials by phase

Phase 1
8
Phase 2
2
Phase 3
3

Trials by status

Not yet recruiting
5
Recruiting
6
Completed
1
Unknown
1

Evidence coverage

What this asset has been measured on

Endpoints grouped into outcome categories, ranked by how often they are measured across this asset's trials.

Safety / tolerability / PK
88
Glycemic / diabetes
26
Weight & body composition
20
Cardiometabolic biomarkers
8
Patient-reported / QoL
2

Most-measured metrics

Top 20 metrics across this asset's endpoints

AUC₀–∞Safety/PK

23

Treatment-emergent AEs (any)Safety/PK

10

CmaxSafety/PK

10

TmaxSafety/PK

8

Half-lifeSafety/PK

7

HbA1c, changeGlycemic

6

Fasting glucose, changeGlycemic

4

Body weight, % changeWeight

4

≥10% weight-loss respondersWeight

4

HbA1c <7.0% achievementGlycemic

3

HOMA-IR (insulin sensitivity)Glycemic

3

Postprandial glucoseGlycemic

3

Body weight, absolute change (kg)Weight

3

Waist circumference, changeWeight

2

BMI, changeWeight

1

Plasma concentration (steady state)Safety/PK

1

≥5% weight-loss respondersWeight

1

≥15% weight-loss respondersWeight

1

Trials

Programs for this asset

Every trial for this molecule, with the same search, filters, and sort as the Trials tab.

13 of 13

Asset / PopulationKey I/E criterionEvidence
NCT06481085To Evaluate Efficacy and Safety of HDM1002 Tablets in Adults With Type 2 Diabetes Mellitus

HDM1002

Type 2 diabetes

BMI 22.5-40Ph 2Completed31May 2025
NCT07082114A Phase 3 Study to Evaluate Efficacy and Safety of HDM1002 Tablets in Adults With Type 2 Diabetes Mellitus

HDM1002

Type 2 diabetes

BMI 19-40Ph 3Recruiting1Feb 2027
NCT06985615A Study of HDM1002 in Subjects With And Without Varying Degrees Of Hepatic Impairement

HDM1002

Healthy volunteers, Hepatic impairment

BMI ≥50Ph 1Recruiting1Jan 2026
NCT06562088A Drug-Drug Interaction (DDI) Study of HDM1002 With Rifampicin and Itraconazole in Healthy Subjects

HDM1002

Healthy volunteers

BMI 19-32Ph 1Not yet recruiting1Nov 2024
NCT06576401A Study To Characterize Mass Balance Of [14C] HDM1002 in Chinese Healthy Subjects

HDM1002

Healthy volunteers

BMI 19-32Ph 1Recruiting1Oct 2024
NCT06520540HDM1002 Tablets in Chinese Overweight and Obese Adult Subjects

HDM1002

Obesity / overweight

BMI 24-36Ph 1Not yet recruiting1Nov 2024
NCT06608329A Relative Bioavailability and Food Effect Study of HDM1002 in Healthy Subjects

HDM1002

Healthy volunteers

BMI 19-30Ph 1Not yet recruiting1Nov 2024
NCT07594847A Study of HDM1002 Tablets on Cardiac Repolarization in Healthy Subjects

HDM1002

Healthy volunteers

BMI 19-28Ph 1Recruiting1Sep 2026
NCT07193459Study to Evaluate HDM1002 Tablets in Adults With Type 2 Diabetes Mellitus

HDM1002

Type 2 diabetes

BMI 22.5-40Ph 3Recruiting1Oct 2026
NCT06601517A Drug-Drug Interaction (DDI) Study of HDM1002 With Repaglinide, Atorvastatin, Digoxin and Rosuvastatin in Healthy Subjects and Overweight Subjects.

HDM1002

Healthy volunteers, Obesity / overweight

BMI 19-30Ph 1Not yet recruiting1Feb 2025
NCT07331389A Drug-Drug Interaction Study of HDM1002 and Metformin, Empagliflozin, Midazolam, Valsartan, and Warfarin

HDM1002

Obesity / overweight

BMI 24-35Ph 1Recruiting1Jan 2026
NCT06500299Evaluate the Safety and Efficacy of HDM1002 Tablets in Overweight and Obese Adults

HDM1002

Obesity / overweight

BMI ≥28Ph 2Unknown0Oct 2024
NCT06885021Evaluate the Safety and Efficacy of HDM1002 Tablets in Chinese Overweight and Obese Adults

HDM1002

Obesity / overweight

BMI ≥28Ph 3Not yet recruiting0May 2026