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Subcutaneous · GLP-1 / GIP dual

HDM1005

10 trials in this molecule. Source: ClinicalTrials.gov, as of July 1, 2026.

Trials

10

Active

8

Recruiting

5

Completed

2

Sites

6

Countries

1

Endpoints

75

Composite endpoints

1

Distinct sites and countries across this molecule's trials. A site running several of its trials counts once, matching the map.

Development

Where the program stands

Trials by phase

Phase 1
4
Phase 2
3
Phase 3
3

Trials by status

Not yet recruiting
3
Recruiting
5
Completed
2

Evidence coverage

What this asset has been measured on

Endpoints grouped into outcome categories, ranked by how often they are measured across this asset's trials.

Safety / tolerability / PK
24
Weight & body composition
19
Glycemic / diabetes
13
Cardiometabolic biomarkers
10
Other (unclassified)
9

Most-measured metrics

Top 20 metrics across this asset's endpoints

Body weight, absolute change (kg)Weight

4

HbA1c, changeGlycemic

4

Diastolic BP, changeBiomarker

2

Systolic BP, changeBiomarker

2

Body weight, % changeWeight

2

Waist circumference, changeWeight

2

BMI, changeWeight

2

Fasting glucose, changeGlycemic

2

Immunogenicity (ADA)Safety/PK

1

Treatment-emergent AEs (any)Safety/PK

1

≥15% weight-loss respondersWeight

1

HbA1c <7.0% achievementGlycemic

1

HbA1c <6.5% achievementGlycemic

1

Trials

Programs for this asset

Every trial for this molecule, with the same search, filters, and sort as the Trials tab.

10 of 10

Asset / PopulationKey I/E criterionEvidence
NCT07394114A Study of HDM1005 in Participants With Type 2 Diabetes Not Controlled With Diet and Exercise Alone

HDM1005

Type 2 diabetes

BMI ≥22.5Ph 3Recruiting1Aug 2027
NCT06637020Phase Ib Clinical Study of HDM1005 Injection

HDM1005

Obesity / overweight

BMI ≥27Ph 1Completed1Dec 2024
NCT07521631Efficacy and Safety of HDM1005 Compared to Tirzepatide in Obese Adults Without Diabetes

HDM1005, Tirzepatide

Obesity / overweight

BMI ≥28Ph 2Recruiting1Feb 2027
NCT07502001Influence of HDM1005 on Gastric Emptying and Pharmacokinetics of Metformin, Atorvastatin, Warfarin, and Digoxin

HDM1005

Obesity / overweight

BMI 24-35Ph 1Not yet recruiting1Dec 2026
NCT07279194Efficacy and Safety of HDM1005 in Chinese Obesity or Overweight Patients Without Diabetes

HDM1005

Obesity / overweight

BMI ≥28Ph 3Recruiting1Sep 2026
NCT06640647Phase Ia Clinical Study of HDM1005 Injection

HDM1005

Healthy volunteers

BMI 19-32Ph 1Completed1Aug 2024
NCT07559240A Pharmacokinetic Study of HDM1005 Injection in Participants With Impaired Renal Function and Healthy Participants

HDM1005

Healthy volunteers, Renal impairment

BMI 19-35Ph 1Not yet recruiting1Jun 2026
NCT07417306A Study of HDM1005 in Participants With T2DM Not Controlled With Metformin Alone or in Combination With a Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitor

HDM1005, Mazdutide

Type 2 diabetes

BMI ≥22.5Ph 3Not yet recruiting1Aug 2027
NCT06886126Phase II Clinical Study of HDM1005 Injection in Obese Adults Without Diabetes Mellitus

HDM1005

Obesity / overweight

BMI ≥28Ph 2Recruiting1Sep 2025
NCT07109700A Study of HDM1005 in Participants With T2DM Not Controlled With Diet/Exercise or Metformin

Dulaglutide, HDM1005

Type 2 diabetes

HbA1c 7.5-10.5%Ph 2Recruiting1Jan 2026