← All assets

Subcutaneous · GLP-1 agonist

Loxenatide / PEG-loxenatide

14 trials in this molecule. Source: ClinicalTrials.gov, as of July 1, 2026.

Trials

14

Active

2

Recruiting

2

Completed

8

Sites

10

Countries

1

Endpoints

60

Composite endpoints

0

Distinct sites and countries across this molecule's trials. A site running several of its trials counts once, matching the map.

Development

Where the program stands

Trials by phase

Phase 1
7
Phase 2
1
Phase 2/3
1
Phase 3
3
Phase 4
1
Not applicable
1

Trials by status

Recruiting
2
Completed
8
Unknown
4

Evidence coverage

What this asset has been measured on

Endpoints grouped into outcome categories, ranked by how often they are measured across this asset's trials.

Glycemic / diabetes
18
Safety / tolerability / PK
16
Other (unclassified)
11
Cardiometabolic biomarkers
7
Weight & body composition
5
Other clinical outcomes
3

Most-measured metrics

Top 20 metrics across this asset's endpoints

Trials

Programs for this asset

Every trial for this molecule, with the same search, filters, and sort as the Trials tab.

14 of 14

Asset / PopulationKey I/E criterionEvidence
NCT05172999Loxenatide Plus LNG-IUS in Endometrial Atypical Hyperplasia

Loxenatide / PEG-loxenatide

Obesity / overweight, Oncology, Reproductive / infertility

BMI ≥28Ph 2/3Completed1Dec 2025
NCT01965509A PK/PD Study of Polyethylene Glycol Loxenatide in Patients With Type 2 Diabetes

Loxenatide / PEG-loxenatide

Type 2 diabetes

BMI 19-35Ph 2Completed1Aug 2013
NCT02477969Efficacy and Safety Study of PEX168 in Combination Therapy Diabetes Mellitus Type 2 Patients With Metformin

Loxenatide / PEG-loxenatide

Type 2 diabetes

BMI 20-40Ph 3Unknown1Jun 2016
NCT06217887Efficacy Comparison of Polyethylene Glycol Loxenatide and Gliclazide on the Brain Function in T2DM Patients

Loxenatide / PEG-loxenatide

Alzheimer's / cognition, Type 2 diabetes

HbA1c 7-10%Not applicableUnknown1Feb 20242
NCT02447601Evaluate the Pharmacokinetics of Simvastatin When Coadministered With PEX168 in Healthy Adult Subjects

Loxenatide / PEG-loxenatide

Healthy volunteers

BMI 18-25Ph 1Completed1May 2015
NCT06825182Current Status of Islet Alpha Cell Function in Patients with Type 2 Diabetes

Loxenatide / PEG-loxenatide

Type 2 diabetes

Ph 3Recruiting1Aug 2025
NCT01965496A Phase I Study of Polyethylene Glycol Loxenatide in Patients With Type 2 Diabetes

Loxenatide / PEG-loxenatide

Type 2 diabetes

BMI 19-35Ph 1Completed1Mar 2013
NCT02451527The Pharmacokinetic Study of the Combination of Digoxin and Polythylene Glycol Loxenatide Injection in Healthy Subjects

Loxenatide / PEG-loxenatide

Healthy volunteers

BMI 19-25Ph 1Completed1Sep 2015
NCT02472236Evaluate the Pharmacokinetics of Digoxin When Coadministered With PEX168 in Healthy Adult Subjects

Loxenatide / PEG-loxenatide

Healthy volunteers

BMI 18-25Ph 1Completed1Sep 2015
GLP-1-CANEffect of GLP-1RA on Cardiac Autonomic Neuropathy in Type 2 Diabetes

GLP-1 / incretin class catch-all, Loxenatide / PEG-loxenatide, Semaglutide

Diabetic neuropathy, Obesity / overweight, Type 2 diabetes

BMI ≥24Ph 4Recruiting1Mar 202815
NCT02467790Polyethylene Glycol Loxenatide Pharmacokinetics Study in Subjects With Normal and Insufficiency Renal Function

Loxenatide / PEG-loxenatide

Healthy volunteers, Renal impairment

BMI ≤28Ph 1Unknown1Mar 20161
NCT01976858A Phase I Study of 8-week Continuous Treatment With Polyethylene Glycol Loxenatide in Patients With Type 2 Diabetes

Loxenatide / PEG-loxenatide

Type 2 diabetes

BMI 19-35Ph 1Completed1Sep 2011
NCT02477865Efficacy and Safety Study of PEX168 in Monotherapy Diabetes Mellitus Type 2 Patients

Loxenatide / PEG-loxenatide

Type 2 diabetes

BMI 20-40Ph 3Unknown0May 2016
NCT02461914Evaluate the Pharmacokinetics of Warfarin When Coadministered With PEX168 in Healthy Adult Subjects

Loxenatide / PEG-loxenatide

Healthy volunteers

BMI 18-25Ph 1Completed0Dec 2015