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Subcutaneous · GIP agonist

Macupatide

7 trials in this molecule. Source: ClinicalTrials.gov, as of July 1, 2026.

Trials

7

Active

3

Recruiting

2

Completed

4

Sites

93

Countries

6

Endpoints

37

Composite endpoints

6

Distinct sites and countries across this molecule's trials. A site running several of its trials counts once, matching the map.

Development

Where the program stands

Trials by phase

Phase 1
4
Phase 2
3

Trials by status

Not yet recruiting
1
Recruiting
2
Completed
4

Evidence coverage

What this asset has been measured on

Endpoints grouped into outcome categories, ranked by how often they are measured across this asset's trials.

Safety / tolerability / PK
14
Glycemic / diabetes
12
Weight & body composition
8
Other (unclassified)
3

Most-measured metrics

Top 20 metrics across this asset's endpoints

Treatment-emergent AEs (any)Safety/PK

4

CmaxSafety/PK

4

AUC₀–∞Safety/PK

4

Body weight, % changeWeight

3

Postprandial glucoseGlycemic

2

HbA1c, changeGlycemic

2

BMI, changeWeight

2

HOMA-IR (insulin sensitivity)Glycemic

1

Serious AEs (any)Safety/PK

1

TmaxSafety/PK

1

Body weight, absolute change (kg)Weight

1

≥5% weight-loss respondersWeight

1

≥10% weight-loss respondersWeight

1

Fasting glucose, changeGlycemic

1

Trials

Programs for this asset

Every trial for this molecule, with the same search, filters, and sort as the Trials tab.

7 of 7

Asset / PopulationKey I/E criterionEvidence
NCT06143956A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight

Eloralintide, Macupatide, Mazdutide, Tirzepatide

Obesity / overweight

Ph 2Recruiting53Sep 2027
NCT07589608A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight

Eloralintide, Macupatide

Obesity / overweight

Ph 2Not yet recruiting40Sep 2027
NCT07215559A Study of Macupatide (LY3532226) and Eloralintide (LY3841136), Alone or in Combination, in Adults With Obesity or Overweight and With Type 2 Diabetes

Eloralintide, Macupatide

Obesity / overweight, Type 2 diabetes

HbA1c 7.5-10.5%Ph 2Recruiting38Mar 2027
NCT06557356A Study of LY3532226 in Participants With Obesity

Macupatide

Obesity / overweight

BMI 30-40Ph 1Completed4Dec 2025
NCT04923269A Study of LY3532226 in Healthy Participants

Macupatide

Healthy volunteers

BMI 18.5-40Ph 1Completed1Oct 2021
NCT05887999A Study of LY3532226 in Participants With Type 1 Diabetes Mellitus

Macupatide

Type 1 diabetes

BMI 18.5-40Ph 1Completed1Feb 2024
NCT05407961A Study of LY3532226 in Participants With Type 2 Diabetes Mellitus

Dulaglutide, Macupatide

Type 2 diabetes

BMI 23-45Ph 1Completed1Jan 2024