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Subcutaneous · GLP-1 agonist

MET097 / PF-08653944

12 trials in this molecule. Source: ClinicalTrials.gov, as of July 1, 2026.

Trials

12

Active

9

Recruiting

5

Completed

3

Sites

243

Countries

11

Endpoints

203

Composite endpoints

0

Distinct sites and countries across this molecule's trials. A site running several of its trials counts once, matching the map.

Development

Where the program stands

Trials by phase

Phase 1
3
Phase 1/2
2
Phase 2
4
Phase 3
3

Trials by status

Not yet recruiting
2
Recruiting
5
Active, not recruiting
2
Completed
3

Evidence coverage

What this asset has been measured on

Endpoints grouped into outcome categories, ranked by how often they are measured across this asset's trials.

Weight & body composition
75
Safety / tolerability / PK
52
Cardiometabolic biomarkers
30
Glycemic / diabetes
21
Other (unclassified)
13
Patient-reported / QoL
12

Most-measured metrics

Top 20 metrics across this asset's endpoints

Trials

Programs for this asset

Every trial for this molecule, with the same search, filters, and sort as the Trials tab.

12 of 12

Asset / PopulationKey I/E criterionEvidence
VESPER-4Efficacy and Safety of MET097 Once-Weekly in People With Overweight or Obesity

MET097 / PF-08653944

Obesity / overweight

BMI 27-30Ph 3Recruiting195Sep 2027
NCT07400653A Study to Learn About the Study Medicine (PF-08653944) in People With Obesity or Overweight and Type 2 Diabetes (T2D)

MET097 / PF-08653944

Obesity / overweight, Type 2 diabetes

BMI ≥27Ph 3Recruiting183Oct 2027
VESPER-2A Study to Evaluate the Efficacy and Safety of Once-Weekly MET097 in Adults With Obesity or Overweight and T2DM

MET097 / PF-08653944

Obesity / overweight, Type 2 diabetes

BMI 27-50Ph 2Completed29Dec 2025
VESPER-3A Phase 2b Study to Evaluate the Efficacy and Safety of Once-Monthly MET097 in Adults With Obesity or Overweight

MET097 / PF-08653944

Obesity / overweight

Ph 2Active, not recruiting5Dec 2025
NCT06857617This Study Will Investigate the Safety, Tolerability, Pharmacokinetics, and Efficacy of MET097 in Adult Participants With Overweight or Obesity

MET097 / PF-08653944

Obesity / overweight

BMI 27-38Ph 1/2Completed3Jan 2025
NCT07519135A Study to Learn About the Medicine Called PF-08653944 in People With and Without Reduced Liver Function

MET097 / PF-08653944

Healthy volunteers, Hepatic impairment

BMI ≥21Ph 1Recruiting3Jul 2027
SOLIS-1A Study of PF-08653945 and PF-08653944 in Adults With Overweight or Obesity (SOLIS-1)

MET097 / PF-08653944

Obesity / overweight

BMI 30-50Ph 2Not yet recruiting3Aug 2027
VESPER-1A Phase 2b Study to Examine the Safety and Efficacy of Once-Weekly MET097 in Adults With Obesity or Overweight

MET097 / PF-08653944

Obesity / overweight

Ph 2Completed2Jul 2025
NCT07508241A Study to Learn About the Effect of Study Medicine Called PF-08653944 on How Quickly the Stomach Empties Its Content in Healthy Adults With Overweight or Obesity

MET097 / PF-08653944

Healthy volunteers, Obesity / overweight

BMI 27-45Ph 1Recruiting1Jan 2027
NCT06924320A Study of MET233 in Combination With MET097 in Individuals With Obesity or Overweight With or Without Diabetes

MET097 / PF-08653944, MET233

Obesity / overweight, Type 2 diabetes

BMI 27-38Ph 1/2Recruiting1Sep 2026
NCT07400679A Study to Learn How the Study Medicine Called PF-08653944 is Taken up Into the Blood in Adults With Overweight or Obesity

MET097 / PF-08653944

Obesity / overweight

BMI 27-45Ph 1Active, not recruiting1Sep 2026
NCT07595549A Study to Learn About the Study Medicine Called Berobenatide (PF-08653944) in People With Overweight or Obesity

MET097 / PF-08653944

Obesity / overweight

BMI 27-30Ph 3Not yet recruiting0May 2028