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Subcutaneous · FGF21 analog

NNC0194-0499

11 trials in this molecule. Source: ClinicalTrials.gov, as of July 1, 2026.

Trials

11

Active

1

Recruiting

0

Completed

10

Sites

308

Countries

28

Endpoints

118

Composite endpoints

0

Distinct sites and countries across this molecule's trials. A site running several of its trials counts once, matching the map.

Development

Where the program stands

Trials by phase

Phase 1
9
Phase 2
2

Trials by status

Active, not recruiting
1
Completed
10

Evidence coverage

What this asset has been measured on

Endpoints grouped into outcome categories, ranked by how often they are measured across this asset's trials.

Safety / tolerability / PK
67
MASH / liver
20
Cardiometabolic biomarkers
14
Glycemic / diabetes
11
Patient-reported / QoL
3
Weight & body composition
1
Other clinical outcomes
1
Other (unclassified)
1

Most-measured metrics

Top 20 metrics across this asset's endpoints

AUC₀–∞Safety/PK

13

CmaxSafety/PK

12

Treatment-emergent AEs (any)Safety/PK

9

TmaxSafety/PK

8

Half-lifeSafety/PK

5

Triglycerides, changeBiomarker

3

HDL-C, changeBiomarker

2

LDL-C, changeBiomarker

2

AST, changeMASH

2

ELF score, changeMASH

2

ALT, changeMASH

2

Fibrosis ≥1-stage improvement, no MASH worseningMASH

2

CGM time-in-rangeGlycemic

2

CGM time-above-rangeGlycemic

2

CGM time-below-rangeGlycemic

2

Alcohol consumption, changeOther clin.

1

Total cholesterol, changeBiomarker

1

Liver stiffness (VCTE), changeMASH

1

SF-36 physicalPRO/QoL

1

MASH resolution, no fibrosis worseningMASH

1

Trials

Programs for this asset

Every trial for this molecule, with the same search, filters, and sort as the Trials tab.

11 of 11

Asset / PopulationKey I/E criterionEvidence
NCT05016882Research Study on Whether a Combination of 2 Medicines (NNC0194 0499 and Semaglutide) Works in People With Non-alcoholic Steatohepatitis (NASH)

CagriSema / cagrilintide, NNC0194-0499, Semaglutide

MASH / NAFLD / liver fibrosis

Ph 2Completed255Dec 2024
NCT06409130Effects of NNC0194-0499, Cagrilintide, and Semaglutide Alone or in Combinations on Liver Damage and Alcohol Use in People With Alcohol-related Liver Disease

CagriSema / cagrilintide, NNC0194-0499, Semaglutide

Alcohol / substance use, MASH / NAFLD / liver fibrosis

Ph 2Completed102Nov 2025
NCT05917938A Research Study Looking at How a Single Dose of the Study Medicine NNC0194-0499 Behaves in Participants With Reduced Liver Function Compared to Participants With Normal Liver Function

NNC0194-0499

Healthy volunteers, Hepatic impairment

BMI 18.5-39.9Ph 1Completed5Dec 2024
NCT06188026A Research Study Looking at How the Compound NNC0194-0499 Works With Birth Control Pills in Women Not Able to Bear Children.

NNC0194-0499

Healthy volunteers

BMI 18.5-29.9Ph 1Completed1Dec 2024
NCT05742919A Research Study Looking at How a Single Dose of the Medicine NNC0194-0499 Behaves in Chinese Men

NNC0194-0499

Healthy volunteers

BMI 23-34.9Ph 1Completed1Jun 2023
NCT03015207First Human Dose Trial Investigating Safety, Tolerability and Pharmacokinetics of NNC0194-0499 in Male Subjects With Overweight or Obesity

NNC0194-0499

Obesity / overweight

BMI 25-34.9Ph 1Completed1Oct 20171
NCT05766709A Research Study Comparing Blood Levels of Medicines NNC0194-0499 and Semaglutide Administered as a Combination Formulation Versus Two Separate Formulations

NNC0194-0499, Semaglutide

Healthy volunteers, Obesity / overweight

BMI ≥25Ph 1Completed1Jan 2024
NCT05727644A Research Study Looking Into Blood and Urine Levels of the Medicine NNC0194-0499 in the Body and How Well it is Tolerated in Participants With Reduced Kidney Function and Normal Kidney Function

NNC0194-0499

Healthy volunteers, Renal impairment

BMI 18.5-39.9Ph 1Completed1Nov 2023
NCT04722653A Research Study Looking at How the Medicine NNC0194-0499 Behaves in Japanese and Non-Asian Men

NNC0194-0499

Healthy volunteers

BMI 23-34.9Ph 1Completed1Apr 20211
NCT07087795A Study to See the Effect of NNC0194-0499 Alone or in Combination With Semaglutide on Blood Sugar Control in People Living With Type 1 Diabetes

NNC0194-0499, Semaglutide

Type 1 diabetes

BMI 22-35Ph 1Active, not recruiting1Sep 2026
NCT03479892A Research Study Looking at a New Study Medicine (NNC0194-0499) for Weight Control in People With Overweight or Obesity

NNC0194-0499

Obesity / overweight

BMI 27-39.9Ph 1Completed1Jun 2019