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Subcutaneous · GIP agonist

NNC0480-0389

7 trials in this molecule. Source: ClinicalTrials.gov, as of July 1, 2026.

Trials

7

Active

0

Recruiting

0

Completed

7

Sites

132

Countries

12

Endpoints

62

Composite endpoints

0

Distinct sites and countries across this molecule's trials. A site running several of its trials counts once, matching the map.

Development

Where the program stands

Trials by phase

Phase 1
6
Phase 2
1

Trials by status

Completed
7

Evidence coverage

What this asset has been measured on

Endpoints grouped into outcome categories, ranked by how often they are measured across this asset's trials.

Safety / tolerability / PK
34
Cardiometabolic biomarkers
18
Weight & body composition
6
Glycemic / diabetes
4

Most-measured metrics

Top 20 metrics across this asset's endpoints

AUC₀–∞Safety/PK

15

CmaxSafety/PK

14

Treatment-emergent AEs (any)Safety/PK

5

HbA1c, changeGlycemic

2

Fasting glucose, changeGlycemic

2

Body weight, absolute change (kg)Weight

2

Body weight, % changeWeight

2

Waist circumference, changeWeight

2

Systolic BP, changeBiomarker

2

Total cholesterol, changeBiomarker

2

HDL-C, changeBiomarker

2

LDL-C, changeBiomarker

2

VLDL, changeBiomarker

2

Triglycerides, changeBiomarker

2

Free fatty acids, changeBiomarker

2

ApoB, changeBiomarker

2

hs-CRP, changeBiomarker

2

Trials

Programs for this asset

Every trial for this molecule, with the same search, filters, and sort as the Trials tab.

7 of 7

Asset / PopulationKey I/E criterionEvidence
NCT05144984A Research Study Looking at How Well a Combination of the Medicines Semaglutide and NNC0480-0389 Works in People With Type 2 Diabetes

NNC0480-0389, Semaglutide

Obesity / overweight, Type 2 diabetes

BMI ≥25Ph 2Completed129Feb 2023results
NCT05015894A Research Study Looking Into Blood Levels of the Medicine NNC0480-0389 in Participants With Reduced Kidney Function Compared to Participants With Normal Kidney Function

NNC0480-0389

Healthy volunteers, Renal impairment

BMI 20-39.9Ph 1Completed1Aug 2022
NCT04259801First Research Study to Look at How Two Medicines, NNC0480-0389 and Semaglutide, Work Together in Healthy People, in People With High Body Weight and in People With Diabetes

NNC0480-0389, Semaglutide

Healthy volunteers, Obesity / overweight, Type 2 diabetes

BMI 20-29.9Ph 1Completed1Mar 2022
NCT05046873A Research Study Looking Into Blood Levels of Semaglutide and NNC0480-0389 When Given in the Same Injection or in Two Separate Injections in Healthy People

NNC0480-0389, Semaglutide

Healthy volunteers

BMI 20-29.9Ph 1Completed1Jan 2022
NCT04878406A Research Study of How the Medicine NNC0480-0389 Taken With Semaglutide Works in the Body of Healthy Japanese Men

NNC0480-0389, Semaglutide

Healthy volunteers

BMI 20-24.9Ph 1Completed1Jul 2021
NCT05153564A Research Study Looking Into the Effect of Semaglutide and NNC0480 0389 on Blood Levels of a Birth Control Pill in Woman After Menopause

NNC0480-0389, Semaglutide

Healthy volunteers

BMI 20-29.9Ph 1Completed1Aug 2022
NCT05498610A Research Study of How the Medicine NNC0480-0389 Taken With Semaglutide Works in the Body of Healthy Chinese Men

NNC0480-0389, Semaglutide

Healthy volunteers

BMI 20-27.9Ph 1Completed1Oct 2022