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Subcutaneous · GLP-1 / glucagon dual

Pemvidutide

15 trials in this molecule. Source: ClinicalTrials.gov, as of July 1, 2026.

Trials

15

Active

2

Recruiting

1

Completed

10

Sites

158

Countries

3

Endpoints

89

Composite endpoints

10

Distinct sites and countries across this molecule's trials. A site running several of its trials counts once, matching the map.

Development

Where the program stands

Trials by phase

Phase 1
7
Phase 1/2
4
Phase 2
4

Trials by status

Recruiting
1
Active, not recruiting
1
Completed
10
Terminated
2
Withdrawn
1

Evidence coverage

What this asset has been measured on

Endpoints grouped into outcome categories, ranked by how often they are measured across this asset's trials.

Safety / tolerability / PK
30
MASH / liver
16
Other clinical outcomes
12
Glycemic / diabetes
11
Cardiometabolic biomarkers
8
Weight & body composition
6
Other (unclassified)
3
Cardiovascular outcomes
2
Patient-reported / QoL
1

Most-measured metrics

Top 20 metrics across this asset's endpoints

Treatment-emergent AEs (any)Safety/PK

11

HbA1c, changeGlycemic

5

MRI-PDFF, % changeMASH

4

Body weight, absolute change (kg)Weight

3

CmaxSafety/PK

3

AUC₀–∞Safety/PK

2

All-cause deathCV

2

Immunogenicity (ADA)Safety/PK

2

Body weight, % changeWeight

2

Fasting glucose, changeGlycemic

2

HOMA-IR (insulin sensitivity)Glycemic

2

ELF score, changeMASH

2

Liver stiffness (VCTE), changeMASH

2

Total cholesterol, changeBiomarker

1

Serious AEs (any)Safety/PK

1

Plasma concentration (steady state)Safety/PK

1

Heart rate, changeBiomarker

1

MASH resolution, no fibrosis worseningMASH

1

Fibrosis ≥1-stage improvement, no MASH worseningMASH

1

MASH resolution + fibrosis improvementMASH

1

Trials

Programs for this asset

Every trial for this molecule, with the same search, filters, and sort as the Trials tab.

15 of 15

Asset / PopulationKey I/E criterionEvidence
NCT07009860RESTORE TRIAL: A Phase 2 Study Evaluating the Efficacy and Safety of Pemvidutide in the Treatment of Alcohol-Associated Liver Disease (ALD)

Pemvidutide

Alcohol / substance use, MASH / NAFLD / liver fibrosis, Obesity / overweight

BMI ≥25Ph 2Recruiting43Mar 2027
IMPACTIMPACT TRIAL: Efficacy and Safety of Pemvidutide in Subjects With Nonalcoholic Steatohepatitis (NASH)

Pemvidutide

MASH / NAFLD / liver fibrosis, Metabolic syndrome, Obesity / overweight

BMI ≥27Ph 2Completed40Nov 20251
NCT05295875Efficacy and Safety of ALT-801 in the Treatment of Obesity

Pemvidutide

Obesity / overweight

BMI ≥30Ph 2Completed31Sep 2023
NCT01326871A Study of ALT-801 in Combination With Cisplatin and Gemcitabine in Muscle Invasive or Metastatic Urothelial Cancer

Pemvidutide

Oncology

Ph 1/2Completed16Apr 2016results
NCT05006885ALT-801 in Diabetic and Non-Diabetic Overweight and Obese Subjects With Non-alcoholic Fatty Liver Disease (NAFLD)

Pemvidutide

MASH / NAFLD / liver fibrosis, Obesity / overweight, Type 2 diabetes

Ph 1Completed15Aug 20221
NCT05292911Extension of ALT-801 in Diabetic and Non-Diabetic Overweight and Obese Subjects With (NAFLD)

Pemvidutide

MASH / NAFLD / liver fibrosis, Obesity / overweight, Type 2 diabetes

Ph 1Completed13Oct 20221
NCT06987513RECLAIM STUDY: A Phase 2 Evaluating the Efficacy and Safety of Pemvidutide in the Treatment of Alcohol Use Disorder (AUD) in Subjects With Obesity or Overweight

Pemvidutide

Alcohol / substance use, Obesity / overweight

BMI ≥25Ph 2Active, not recruiting12May 2026
NCT01029873QUILT-2.008: Study of ALT-801 With Cisplatin in Patients With Metastatic Melanoma

Pemvidutide

Oncology

Ph 1/2Completed8Nov 2011
NCT05134662ALT-801 in Overweight and Obese Subjects With Type 2 Diabetes Mellitus (T2DM)

Pemvidutide

Obesity / overweight, Type 2 diabetes

Ph 1Completed7Feb 2023
NCT01625260A Study of ALT-801 in Patients With Bacillus Calmette-Guerin (BCG) Failure Non-Muscle Invasive Bladder Cancer

Pemvidutide

Oncology

EF ≤50%Ph 1/2Terminated5Mar 2018results
NCT00496860Safety and Efficacy Study of ALT-801 to Treat Progressive Metastatic Malignancies

Pemvidutide

Oncology

Ph 1Completed4Oct 20091results
NCT04972396Pemvidutide (ALT-801) DDI Study in Healthy Volunteers

Pemvidutide

Healthy volunteers, Obesity / overweight

BMI 28-40Ph 1Completed2May 2022
NCT01670994QUILT-3.020: A Study of ALT-801 in Patients With Relapsed or Refractory Multiple Myeloma

Pemvidutide

Oncology

EF ≤50%Ph 1/2Terminated1Sep 2015results
NCT01478074ALT-801-activated Natural Killer Cells After FLAG Induction for Acute Myeloid Leukemia

Pemvidutide

Oncology

Ph 1Withdrawn1Oct 2013
NCT04561245ALT-801 (Pemvidutide) in Healthy Overweight and Obese Volunteers to Study Safety and Tolerability

Pemvidutide

Healthy volunteers, MASH / NAFLD / liver fibrosis, Obesity / overweight

BMI 25-40Ph 1Completed1Oct 2021