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Subcutaneous · Amylin analog

Petrelintide

8 trials in this molecule. Source: ClinicalTrials.gov, as of July 1, 2026.

Trials

8

Active

3

Recruiting

1

Completed

5

Sites

76

Countries

5

Endpoints

123

Composite endpoints

1

Distinct sites and countries across this molecule's trials. A site running several of its trials counts once, matching the map.

Development

Where the program stands

Trials by phase

Phase 1
4
Phase 2
4

Trials by status

Not yet recruiting
1
Recruiting
1
Active, not recruiting
1
Completed
5

Evidence coverage

What this asset has been measured on

Endpoints grouped into outcome categories, ranked by how often they are measured across this asset's trials.

Safety / tolerability / PK
61
Glycemic / diabetes
21
Weight & body composition
18
Cardiometabolic biomarkers
17
Other (unclassified)
5
Other clinical outcomes
1

Most-measured metrics

Top 20 metrics across this asset's endpoints

AUC₀–∞Safety/PK

14

TmaxSafety/PK

10

CmaxSafety/PK

7

Body weight, % changeWeight

6

Treatment-emergent AEs (any)Safety/PK

6

Half-lifeSafety/PK

4

Body weight, absolute change (kg)Weight

3

Waist circumference, changeWeight

3

HbA1c, changeGlycemic

3

Fasting glucose, changeGlycemic

3

hs-CRP, changeBiomarker

3

Postprandial glucoseGlycemic

3

≥5% weight-loss respondersWeight

2

≥10% weight-loss respondersWeight

2

Immunogenicity (ADA)Safety/PK

2

Systolic BP, changeBiomarker

2

Diastolic BP, changeBiomarker

2

BMI, changeWeight

1

HDL-C, changeBiomarker

1

LDL-C, changeBiomarker

1

Trials

Programs for this asset

Every trial for this molecule, with the same search, filters, and sort as the Trials tab.

8 of 8

Asset / PopulationKey I/E criterionEvidence
NCT06926842Efficacy and Safety of Petrelintide in Participants With Overweight or Obesity and Type 2 Diabetes (ZUPREME 2)

Petrelintide

Obesity / overweight, Type 2 diabetes

BMI ≥27Ph 2Active, not recruiting48Aug 2026
ZUPREMEOnce-weekly Petrelintide Versus Placebo for Obesity or Overweight With Co-morbidities

Petrelintide

Obesity / overweight

BMI ≥30Ph 2Completed32Sep 2025
NCT05613387A Research Study Looking at the Safety of Multiple Doses of ZP8396 and How it Works in the Body of Healthy Participants

Petrelintide

Healthy volunteers, Obesity / overweight

BMI 21-29.9Ph 1Completed1Jun 2024
NCT05096598A First-in-human Study Looking at the Safety of ZP8396 and How it Works in the Body of Healthy Trial Participants

Petrelintide

Healthy volunteers

BMI 21-29.9Ph 1Completed1Jan 2023
NCT07076030Pharmacokinetics of Petrelintide Following Administration to Participants With Impaired Renal Function

Petrelintide

Healthy volunteers, Renal impairment

BMI 21-40Ph 1Completed1Nov 2025
NCT07338214Investigating the Pharmacokinetics of Petrelintide Using Different Drug Product Concentrations

Petrelintide

Obesity / overweight

BMI ≥27Ph 1Completed1Mar 2026
NCT06951854Phase II Clinical Trial to Evaluate the Efficacy and Safety of NV01-A02 in Children With Autism Spectrum Disorder

Petrelintide

Age 6-15Ph 2Recruiting1Sep 2025
ZYNERGYA Dose-Finding Study of Petrelintide With Enicepatide (RO7795068) in Adults With Obesity or Overweight

CT-388, Petrelintide

Obesity / overweight

BMI ≥30Ph 2Not yet recruiting0Nov 2027