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Subcutaneous · GLP-1 / glucagon dual

SAR425899

6 trials in this molecule. Source: ClinicalTrials.gov, as of July 1, 2026.

Trials

6

Active

0

Recruiting

0

Completed

5

Sites

62

Countries

9

Endpoints

97

Composite endpoints

2

Distinct sites and countries across this molecule's trials. A site running several of its trials counts once, matching the map.

Development

Where the program stands

Trials by phase

Phase 1
4
Phase 2
2

Trials by status

Completed
5
Withdrawn
1

Evidence coverage

What this asset has been measured on

Endpoints grouped into outcome categories, ranked by how often they are measured across this asset's trials.

Safety / tolerability / PK
30
Glycemic / diabetes
24
Other (unclassified)
14
Weight & body composition
13
MASH / liver
9
Cardiometabolic biomarkers
6
Cardiovascular outcomes
1

Most-measured metrics

Top 20 metrics across this asset's endpoints

Fasting glucose, changeGlycemic

6

HbA1c, changeGlycemic

5

Body weight, absolute change (kg)Weight

5

Treatment-emergent AEs (any)Safety/PK

4

CmaxSafety/PK

4

Postprandial glucoseGlycemic

3

Waist circumference, changeWeight

3

AUC₀–∞Safety/PK

3

Half-lifeSafety/PK

3

HbA1c <6.5% achievementGlycemic

2

HOMA-IR (insulin sensitivity)Glycemic

2

TmaxSafety/PK

2

≥10% weight-loss respondersWeight

1

≥5% weight-loss respondersWeight

1

Total cholesterol, changeBiomarker

1

Free fatty acids, changeBiomarker

1

Triglycerides, changeBiomarker

1

Total fat massWeight

1

C-peptide AUCGlycemic

1

MASH resolution, no fibrosis worseningMASH

1

Trials

Programs for this asset

Every trial for this molecule, with the same search, filters, and sort as the Trials tab.

6 of 6

Asset / PopulationKey I/E criterionEvidence
NCT02973321A Study to Assess the Safety and Efficacy of SAR425899 in Patients With Type 2 Diabetes Mellitus

Liraglutide, SAR425899

Obesity / overweight, Type 2 diabetes

Ph 2Completed59Dec 20172results
NCT03414736A Study on Safety and Tolerability of SAR425899 in Overweight to Obese Subjects and Type 2 Diabetes Mellitus Patients Not Requiring Anti-Diabetic Pharmacotherapy With an Optional 6-month Safety Extension Period

SAR425899

Obesity / overweight, Type 2 diabetes

Ph 1Completed3Oct 2018
NCT03376802A Clinical Study to Investigate the Effect of SAR425899 on Energy Expenditure in Obese Subjects

SAR425899

Obesity / overweight

BMI 28-40Ph 1Completed2Dec 2018
NCT03350191A Clinical Study to Investigate if SAR425899 Binds to the Liver and Pancreas in Overweight to Obese Type 2 Diabetes Mellitus Patients

Exenatide, SAR425899

Obesity / overweight, Type 2 diabetes

BMI 28-38Ph 1Completed1Jun 20181
NCT02411825Multiple Ascending Dose Study in Healthy Male Subjects and Overweight to Obese Male and Female Type 2 Diabetes Mellitus (T2DM) Patients

SAR425899

Healthy volunteers, Obesity / overweight, Type 2 diabetes

BMI 20-30Ph 1Completed1Jan 20162
RestoreAssessment of the Safety and Effect of SAR425899 Versus Placebo for the Treatment of Non-alcoholic Fatty Liver Disease

SAR425899

MASH / NAFLD / liver fibrosis

HbA1c ≤6.5%Ph 2Withdrawn0Aug 2021