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Delfa

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Subcutaneous · GLP-1 / GIP dual

Brenipatide

18 trials in this molecule. Source: ClinicalTrials.gov, as of November 5, 2026.

Trials

18

Ongoing

15

Recruiting

13

Completed

3

Sites

784

Countries

28

Endpoints

133

Composite endpoints

0

Distinct sites and countries across this molecule's trials. A site running several of its trials counts once, matching the map.

Where the program stands

Trials by phase

Phase 1
6
Phase 2
8
Phase 3
4

Trials by status

Recruiting
13
Active, not recruiting
2
Completed
3

Evidence coverage

What this asset has been measured on

Endpoints grouped into outcome categories, ranked by how often they are measured across this asset's trials.

Other (unclassified)
48
Safety / tolerability / PK
37
Weight & body composition
18
Patient-reported / QoL
12
Other clinical outcomes
9
Glycemic / diabetes
5
Cardiometabolic biomarkers
4

Top 20 metrics across this asset's endpoints

Programs for this asset

Every trial for this molecule, with the same search, filters, and sort as the Trials tab.

18 of 18

GLP-1 and incretin trials
Asset / PopulationEligibility highlightEvidence
RENEW-MDD-1A Study of Brenipatide in Adult Participants With Major Depressive Disorder

Brenipatide

Mood Disorders, Psychiatric (schizophrenia / bipolar / depression)

-Ph 3Recruiting180Feb 2028-
RENEW-MDD- 2A Study of Brenipatide (LY3537031) in Adult Participants With Major Depressive Disorder

Brenipatide

Mood Disorders, Psychiatric (schizophrenia / bipolar / depression)

-Ph 3Recruiting170Dec 2028-
RENEW-COPDA Study of Brenipatide (LY3537031) in Adult Participants With Moderate-to-Severe Chronic Obstructive Pulmonary Disease (COPD)

Brenipatide

Pulmonary Disease, Chronic Obstructive

-Ph 2Recruiting127May 2028-
RENEW-AsthmaA Study to Evaluate Brenipatide Compared With Placebo in Adult Participants With Uncontrolled Moderate to Severe Asthma

Brenipatide

Asthma

-Ph 2Recruiting120Apr 2028-
RENEW-ALC-1A Study of Brenipatide in Participants With Moderate-to-Severe Alcohol Use Disorder

Brenipatide

Alcohol / substance use

-Ph 3Recruiting117Apr 2028-
RENEW-ALC-2A Study of Brenipatide in Participants With Alcohol Use Disorder

Brenipatide

Alcohol / substance use

-Ph 3Recruiting115Apr 2028-
RENEW-Scz-1A Study of Brenipatide in Adult Participants With Schizophrenia

Brenipatide

Psychiatric (schizophrenia / bipolar / depression)

-Ph 2Recruiting101Nov 2027-
RENEW-IBS-DA Study of Brenipatide (LY3537031) in Participants With Irritable Bowel Syndrome-Diarrhea (IBS-D)

Brenipatide

Diarrhea, Irritable Bowel Syndrome

-Ph 2Recruiting89Sep 2027-
NCT07286175A Study of Brenipatide in Adult Participants With Bipolar Disorder (RENEW-Bipolar-1)

Brenipatide

Psychiatric (schizophrenia / bipolar / depression)

-Ph 2Recruiting87Nov 2027-
RENEW-IBS-CA Study of Brenipatide (LY3537031) in Participants With Irritable Bowel Syndrome-Constipation (IBS-C)

Brenipatide

Constipation, Irritable Bowel Syndrome

-Ph 2Recruiting70Jul 2027-
RENEW-Op-1A Study of Brenipatide in Participants With Opioid Use Disorder

Brenipatide

Alcohol / substance use

-Ph 2Recruiting68Mar 2028-
RENEW-Smk-1A Study of Brenipatide in Adults Who Quit Smoking Cigarettes and Want to Avoid Relapse

Brenipatide

Alcohol / substance use

-Ph 2Recruiting29Feb 2027-
NCT06606106A Study of LY3537031 in Overweight, Obese, and Healthy Participants

Brenipatide

Obesity / overweight

-Ph 1Active, not recruiting5Nov 2026-
NCT07165015A Study of Pharmacokinetics and Safety of LY3537031 in Participants With Normal Renal Function and Participants With Renal Impairment

Brenipatide

Chronic kidney disease, Healthy volunteers, Renal impairment

BMI 19-40Ph 1Completed4Apr 2026-
NCT07165002A Study of the Pharmacokinetics and Safety of LY3537031 in Participants With Normal Liver Function and With Mild, Moderate, or Severe Liver Impairment

Brenipatide

Healthy volunteers, Hepatic impairment

BMI 19-40Ph 1Recruiting3Nov 2026-
NCT07476118A Study of Brenipatide (LY3537031) in Healthy Participants With Overweight or Obesity

Brenipatide

Obesity / overweight

Healthy volunteersPh 1Active, not recruiting3Feb 2027-
NCT04648865A Study of LY3537031 in Healthy Participants

Brenipatide

Healthy volunteers

BMI 19-35Ph 1Completed1Jun 2021-
NCT07202871A Study of How the Body Absorbs LY3537031

Brenipatide

Healthy volunteers

BMI 18.5-35Ph 1Completed1Jul 2026-

Showing 1-18 of 18 trials