| REDEFINE 3REDEFINE 3: A Research Study to See the Effects of CagriSema in People Living With Diseases in the Heart and Blood Vessels | CagriSema / cagrilintide, Semaglutide Cardiovascular disease, Obesity / overweight | HbA1c 6.5-10% | Ph 3 | Active, not recruiting | 631 | Sep 2027 | - | |
| REIMAGINE 2A Research Study to See How Well CagriSema Compared to Semaglutide, Cagrilintide and Placebo Lowers Blood Sugar and Body Weight in People With Type 2 Diabetes Treated With Metformin With or Without an SGLT2 Inhibitor | CagriSema / cagrilintide, Semaglutide Obesity / overweight, Type 2 diabetes | BMI ≥25 | Ph 3 | Completed | 405 | Nov 2025 | - | |
| NCT07564414A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose Weight | CagriSema / cagrilintide, Semaglutide Obesity / overweight | BMI ≥35 | Ph 3 | Recruiting | 303 | Feb 2028 | - | |
| NCT05016882Research Study on Whether a Combination of 2 Medicines (NNC0194 0499 and Semaglutide) Works in People With Non-alcoholic Steatohepatitis (NASH) | CagriSema / cagrilintide, NNC0194-0499, Semaglutide MASH / NAFLD / liver fibrosis | - | Ph 2 | Completed | 255 | Dec 2024 | - | |
| REDEFINE 1A Research Study to See How Well CagriSema Helps People With Excess Body Weight Lose Weight | CagriSema / cagrilintide, Semaglutide Obesity / overweight | BMI ≥30 | Ph 3 | Active, not recruiting | 254 | Oct 2024 | 2 | |
| NCT06221969A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Tirzepatide in People With Type 2 Diabetes Treated With Metformin With or Without an SGLT2 Inhibitor | CagriSema / cagrilintide, Semaglutide, Tirzepatide Obesity / overweight, Type 2 diabetes | BMI ≥30 | Ph 3 | Completed | 196 | Mar 2026 | - | |
| REDEFINE 2A Research Study to See How Well CagriSema Helps People With Type 2 Diabetes and Excess Body Weight Lose Weight | CagriSema / cagrilintide, Semaglutide Obesity / overweight, Type 2 diabetes | HbA1c 7-10% | Ph 3 | Completed | 179 | Jan 2025 | 1 | |
| REIMAGINE 5A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Tirzepatide in People With Type 2 Diabetes Treated With Metformin, SGLT2 Inhibitor or Both | CagriSema / cagrilintide, Semaglutide, Tirzepatide Obesity / overweight, Type 2 diabetes | BMI ≥30 | Ph 3 | Active, not recruiting | 163 | Jun 2026 | - | |
| NCT06131372A Research Study to See if Kidney Damage in People With Chronic Kidney Disease and Type 2 Diabetes Living With Overweight or Obesity Can be Reduced by CagriSema Compared to Semaglutide, Cagrilintide and Placebo | CagriSema / cagrilintide, Semaglutide Chronic kidney disease, Obesity / overweight, Type 2 diabetes | BMI ≥27 | Ph 2 | Completed | 128 | Sep 2025 | - | |
| NCT07253285A Research Study on How Well Cagrilintide and CagriSema Work in Children and Adolescents With Excess Body Weight | CagriSema / cagrilintide, Semaglutide Obesity / overweight | - | Ph 3 | Recruiting | 119 | Mar 2030 | - | |
| NCT07357766A Research Study to Compare Different Versions of Injectable CagriSema and Placebo in People With Excess Body Weight | CagriSema / cagrilintide, Semaglutide Obesity / overweight | - | Ph 3 | Not yet recruiting | 116 | Nov 2027 | - | |
| NCT06409130Effects of NNC0194-0499, Cagrilintide, and Semaglutide Alone or in Combinations on Liver Damage and Alcohol Use in People With Alcohol-related Liver Disease | CagriSema / cagrilintide, NNC0194-0499, Semaglutide Alcohol / substance use, MASH / NAFLD / liver fibrosis | - | Ph 2 | Completed | 102 | Nov 2025 | - | |
| RENEW 2Weight Loss in People Living With Overweight or Obesity and Type 2 Diabetes Following Treatment With Cagrilintide | CagriSema / cagrilintide Obesity / overweight, Type 2 diabetes | BMI ≥27 | Ph 3 | Active, not recruiting | 67 | May 2027 | - | |
| NCT07357740A Research Study to Compare Two Different Versions of Injectable CagriSema in People With Type 2 Diabetes | CagriSema / cagrilintide, Semaglutide Obesity / overweight, Type 2 diabetes | BMI 25-39.9 | Ph 2 | Not yet recruiting | 61 | Aug 2027 | - | |
| REIMAGINEYOUNGA Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Placebo in Children and Adolescents With Type 2 Diabetes | CagriSema / cagrilintide, Semaglutide Obesity / overweight, Type 2 diabetes | HbA1c 6.5-11% | Ph 3 | Not yet recruiting | 56 | Sep 2029 | - | |
| NCT06797869A Research Study to Investigate the Effects of CagriSema Compared to Placebo in People With Type 2 Diabetes and Painful Diabetic Peripheral Neuropathy | CagriSema / cagrilintide, Semaglutide Diabetic neuropathy, Type 2 diabetes | BMI ≥25 | Ph 2 | Active, not recruiting | 54 | Aug 2026 | - | |
| NCT03856047Research Study Investigating How Well NNC0174-0833 Works in People Suffering From Overweight or Obesity. | CagriSema / cagrilintide, Liraglutide Obesity / overweight | - | Ph 2 | Completed | 54 | Mar 2020 | 1 | results |
| REIMAGINE 3A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Placebo in People With Type 2 Diabetes Treated With Once-daily Basal Insulin With or Without Metformin | CagriSema / cagrilintide, Semaglutide Obesity / overweight, Type 2 diabetes | BMI ≥25 | Ph 3 | Completed | 53 | Sep 2025 | - | |
| REIMAGINE 1A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Placebo in People With Type 2 Diabetes Treated With Diet and Exercise | CagriSema / cagrilintide, Semaglutide Type 2 diabetes | BMI ≥23 | Ph 3 | Completed | 50 | Oct 2025 | - | |
| NCT07011667A Research Study to Look at How Well CagriSema Helps People Living With Obesity Lose Weight and Maintain Weight Loss in the Long-term | CagriSema / cagrilintide, Semaglutide Obesity / overweight | BMI ≥30 | Ph 3 | Active, not recruiting | 46 | Mar 2027 | - | |
| NCT06131437A Research Study to See How Well CagriSema Compared to Tirzepatide Helps People With Obesity Lose Weight | CagriSema / cagrilintide, Semaglutide, Tirzepatide Obesity / overweight | BMI ≥30 | Ph 3 | Completed | 46 | Dec 2025 | - | |
| RENEW 1Weight Loss in People Living With Overweight or Obesity Following Treatment With Cagrilintide | CagriSema / cagrilintide Obesity / overweight | BMI ≥30 | Ph 3 | Active, not recruiting | 40 | May 2027 | - | |
| REDEFINE 6A Research Study to See How Well CagriSema Helps People in China With Excess Body Weight Lose Weight | CagriSema / cagrilintide, Semaglutide Obesity / overweight | BMI ≥30 | Ph 3 | Completed | 37 | Jan 2025 | - | |
| NCT06780449A Research Study to Look Into the Long-term Effect on Weight Loss of CagriSema in People With Obesity | CagriSema / cagrilintide, Semaglutide Obesity / overweight | - | Ph 3 | Active, not recruiting | 36 | Aug 2028 | - | |
| NCT05813925A Research Study to See How Well CagriSema Helps People in East Asia With Excess Body Weight Lose Weight | CagriSema / cagrilintide, Semaglutide Obesity / overweight | BMI ≥27 | Ph 3 | Completed | 28 | Jan 2025 | 1 | |
