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Oral · GLP-1 agonist

CT-996 / RO7795081

6 trials in this molecule. Source: ClinicalTrials.gov, as of July 6, 2026.

Trials

6

Ongoing

4

Recruiting

2

Completed

2

Sites

72

Countries

8

Endpoints

76

Composite endpoints

1

Distinct sites and countries across this molecule's trials. A site running several of its trials counts once, matching the map.

Where the program stands

Trials by phase

Phase 1
4
Phase 2
2

Trials by status

Recruiting
2
Active, not recruiting
2
Completed
2

Evidence coverage

What this asset has been measured on

Endpoints grouped into outcome categories, ranked by how often they are measured across this asset's trials.

Safety / tolerability / PK
58
Weight & body composition
11
Glycemic / diabetes
4
Patient-reported / QoL
1
Other clinical outcomes
1
Other (unclassified)
1

Top 20 metrics across this asset's endpoints

HbA1c, changeGlycemic

2

HbA1c <5.7% achievementGlycemic

1

Fasting glucose, changeGlycemic

1

Body weight, % changeWeight

1

Body weight, absolute change (kg)Weight

1

≥15% weight-loss respondersWeight

1

Treatment-emergent AEs (any)Safety/PK

1

Documented hypoglycemiaSafety/PK

1

Plasma concentration (steady state)Safety/PK

1

Programs for this asset

Every trial for this molecule, with the same search, filters, and sort as the Trials tab.

6 of 6

GLP-1 and incretin trials
Asset / PopulationEligibility highlightEvidence
NCT07112872A Study to Compare Different Doses of RO7795081 With a Placebo or Semaglutide in People With Type 2 Diabetes

CT-996 / RO7795081, Semaglutide

Type 2 diabetes

BMI ≥23Ph 2Active, not recruiting50Nov 2026-
NCT07081958A Study Evaluating the Effect of Daily Oral RO7795081 in Participants With Obesity or Overweight With at Least One Weight-Related Comorbidity

CT-996 / RO7795081

Obesity / overweight

-Ph 2Active, not recruiting36Apr 2026-
NCT05814107Phase 1 Study of CT-996 in Overweight/Obese Participants and Patients With Type 2 Diabetes Mellitus

CT-996 / RO7795081

Obesity / overweight, Type 2 diabetes

BMI 25-40Ph 1Completed2Nov 2025-
NCT07499050A Study of Multiple Doses of Orally Administered RO7795081 in Otherwise Healthy Chinese Adult Participants With Obesity or Overweight

CT-996 / RO7795081

Obesity / overweight

BMI ≥24Ph 1Recruiting2Dec 2026-
NCT06982131A Study Investigating the Safety of RO7795081 and the Effect of RO7795081 on How the Body Processes Pitavastatin and Rosuvastatin in Otherwise Healthy Overweight or Obese Adult Participants

CT-996 / RO7795081

Healthy volunteers, Obesity / overweight

BMI ≥27Ph 1Recruiting1Dec 2026-
NCT06809608A Study Investigating the Effect of Different Approved Medications on How the Body Processes the Study Compound RO7795081

CT-996 / RO7795081

Healthy volunteers

BMI 18-32Ph 1Completed1Jun 2025-

Showing 1-6 of 6 trials