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Intravenous / Subcutaneous · GLP-1 agonist

Exenatide

387 trials in this molecule. Source: ClinicalTrials.gov, as of July 6, 2026.

Trials

387

Ongoing

21

Recruiting

12

Completed

280

Sites

3,307

Countries

60

Endpoints

3,043

Composite endpoints

141

Distinct sites and countries across this molecule's trials. A site running several of its trials counts once, matching the map.

Where the program stands

Trials by phase

Early Phase 1
5
Phase 1
48
Phase 1/2
14
Phase 2
52
Phase 2/3
9
Phase 3
84
Phase 4
89
Not applicable
86

Trials by status

Not yet recruiting
1
By invitation
1
Recruiting
12
Active, not recruiting
7
Completed
280
Terminated
24
Withdrawn
12
Unknown
50

Evidence coverage

What this asset has been measured on

Endpoints grouped into outcome categories, ranked by how often they are measured across this asset's trials.

Glycemic / diabetes
877
Safety / tolerability / PK
544
Cardiometabolic biomarkers
447
Weight & body composition
289
Other clinical outcomes
288
Other (unclassified)
268
Patient-reported / QoL
129
Cardiovascular outcomes
89
Renal / kidney
57
MASH / liver
30
Heart failure
25

Top 20 metrics across this asset's endpoints

HbA1c, changeGlycemic

179

Body weight, absolute change (kg)Weight

127

Fasting glucose, changeGlycemic

99

Postprandial glucoseGlycemic

97

Documented hypoglycemiaSafety/PK

88

HbA1c <7.0% achievementGlycemic

69

Treatment-emergent AEs (any)Safety/PK

67

Triglycerides, changeBiomarker

48

BMI, changeWeight

42

HOMA-IR (insulin sensitivity)Glycemic

40

Total cholesterol, changeBiomarker

39

HbA1c <6.5% achievementGlycemic

36

AUC₀-∞Safety/PK

35

HDL-C, changeBiomarker

34

Systolic BP, changeBiomarker

32

Plasma concentration (steady state)Safety/PK

28

Heart rate, changeBiomarker

26

Waist circumference, changeWeight

23

LDL-C, changeBiomarker

22

CmaxSafety/PK

21

Programs for this asset

Every trial for this molecule, with the same search, filters, and sort as the Trials tab.

387 of 387

GLP-1 and incretin trials
Asset / PopulationEligibility highlightEvidence
NCT01144338Exenatide Study of Cardiovascular Event Lowering Trial (EXSCEL): A Trial To Evaluate Cardiovascular Outcomes After Treatment With Exenatide Once Weekly In Patients With Type 2 Diabetes Mellitus

Exenatide

Type 2 diabetes

HbA1c 6.5-10%Ph 3Completed629Apr 201718results
NCT01789957Extension Study for 2993-112

Exenatide

Type 2 diabetes

-Ph 3Completed226Jun 2004-
NCT00717457A Study of Taspoglutide Versus Exenatide for the Treatment of Patients With Type 2 Diabetes Mellitus Inadequately Controlled With Metformin, Thiazolidinedione or a Combination of Both.

Exenatide, Taspoglutide

Type 2 diabetes

BMI ≥25Ph 3Completed216Mar 20111
NCT00518115Out-Patient Study in Patients With Type 2 Diabetes Mellitus Who Are Taking no Diabetes Medication or Metformin Only

Albiglutide, Exenatide

Type 2 diabetes

BMI 20-40Ph 2Completed163May 20082results
SUSTAIN™ 3Efficacy and Safety of Semaglutide Once-weekly Versus Exenatide ER 2.0 mg Once-weekly as add-on to 1-2 Oral Antidiabetic Drugs (OADs) in Subjects With Type 2 Diabetes

Exenatide, Semaglutide

Type 2 diabetes

HbA1c 7-10.5%Ph 3Completed146Jul 201518results
NCT02229396Phase 3 28-Week Study With 24-Week and 52-week Extension Phases to Evaluate Efficacy and Safety of Exenatide Once Weekly and Dapagliflozin Versus Exenatide and Dapagliflozin Matching Placebo

Exenatide

Type 2 diabetes

HbA1c 8-12%Ph 3Completed133Apr 20164results
NCT00039013Evaluation of the Effect on Glucose Control of AC2993 in Patients With Type 2 Diabetes Mellitus Treated With Metformin

Exenatide

Type 2 diabetes

BMI 27-45Ph 3Completed129Jun 20034
NCT00039026Evaluation of the Effect on Glucose Control of AC2993 in Patients With Type 2 Diabetes Mellitus Treated With a Sulfonylurea

Exenatide

Obesity / overweight, Type 2 diabetes

BMI 27-45Ph 3Completed126Aug 20033
LEAD-6Effect of Liraglutide or Exenatide Added to an Ongoing Treatment on Blood Glucose Control in Subjects With Type 2 Diabetes

Exenatide, Liraglutide

Type 2 diabetes

BMI ≤45Ph 3Completed125Apr 200816results
LixiLan-GEfficacy and Safety of the Insulin Glargine/Lixisenatide Fixed Ratio Combination (FRC) Versus GLP-1 Receptor Agonist in Patients With Type 2 Diabetes, With a FRC Extension Period

Albiglutide, Dulaglutide, Exenatide, GLP-1 / incretin class catch-all, Liraglutide, Lixisenatide

Type 2 diabetes

-Ph 3Completed124May 20185results
NCT02229383Phase III Study to Evaluate Safety and Efficacy of Added Exenatide Versus Placebo to Titrated Basal Insulin Glargine in Inadequately Controlled Patients With Type II Diabetes Mellitus

Exenatide

Type 2 diabetes

HbA1c 7.5-12%Ph 3Completed123Aug 20162results
NCT01455857A Study to Evaluate ITCA 650 for the Treatment of Type 2 Diabetes

Exenatide

Obesity / overweight, Type 2 diabetes

HbA1c 7.5-10%Ph 3Completed121Aug 20141
NCT00359762Exenatide Versus Glimepiride in Patients With Type 2 Diabetes

Exenatide

Obesity / overweight, Type 2 diabetes

BMI 25-40Ph 3Completed114Mar 20113results
DUAL™ IIIThe Efficacy of Insulin Degludec/Liraglutide in Controlling Glycaemia in Adults With Type 2 Diabetes Inadequately Controlled on GLP-1 Receptor Agonist and OAD Therapy

Exenatide, GLP-1 / incretin class catch-all, Liraglutide

Type 2 diabetes

BMI ≤40Ph 3Completed109Mar 20143results
NCT01029886Safety and Efficacy of Exenatide Once Weekly Versus Liraglutide in Subjects With Type 2 Diabetes

Exenatide, Liraglutide

Type 2 diabetes

BMI ≤45Ph 3Completed108Jan 20112results
NCT00676338Safety and Efficacy of Exenatide Once Weekly Injection Versus Metformin, Dipeptidyl Peptidase-4 Inhibitor, or Thiazolidinedione as Monotherapy in Drug-Naive Patients With Type 2 Diabetes (DURATION-4)

Exenatide

Type 2 diabetes

BMI 23-45Ph 3Completed106Jul 20105results
NCT03060980Comparison of Efficacy, Safety, and Tolerability of ITCA 650 to Empagliflozin and Glimepiride as add-on Metformin

Exenatide

Obesity / overweight, Type 2 diabetes

BMI 25-45Ph 3Terminated101Jan 2018-
NCT00035984Evaluation of the Effect on Glucose Control of AC2993 in Patients With Type 2 Diabetes Mellitus

Exenatide

Obesity / overweight, Type 2 diabetes

BMI 27-45Ph 3Completed100Aug 20033
NCT00635492CHOICE: CHanges to Treatment and Outcomes in Patients With Type 2 Diabetes Initiating InjeCtablE Therapy

Exenatide, GLP-1 / incretin class catch-all

Type 2 diabetes

--Completed96Dec 20112results
NCT00960661A Trial Comparing Two Therapies: Basal Insulin/Glargine, Exenatide and Metformin Therapy (BET) or Basal Insulin/Glargine, Bolus Insulin Lispro and Metformin Therapy (BBT) in Subjects With Type 2 Diabetes

Exenatide

Type 2 diabetes

BMI 25-45Ph 3Completed95Aug 20121results
NCT00082381Effect of AC2993 Compared With Insulin Glargine in Patients With Type 2 Diabetes Also Using Combination Therapy With Sulfonylurea and Metformin

Exenatide

Type 2 diabetes

HbA1c 7-10%Ph 3Completed91Jul 20083results
AWARD-1A Study in Participants With Type 2 Diabetes Mellitus

Dulaglutide, Exenatide

Type 2 diabetes

BMI 23-45Ph 3Completed89Nov 20113results
NCT00641056Efficacy of Exenatide Once Weekly and Once-Daily Insulin Glargine in Patients With Type 2 Diabetes Treated With Metformin Alone or in Combination With Sulfonylurea (DURATION - 3)

Exenatide

Type 2 diabetes

BMI 25-45Ph 3Completed75May 20097results
NCT00082407Exenatide Compared With Twice-Daily Biphasic Insulin Aspart in Patients With Type 2 Diabetes Using Sulfonylurea and Metformin

Exenatide

Type 2 diabetes

BMI 25-40Ph 3Completed69Jul 20083results
NCT00637273A Study to Compare the Glycemic Effects, Safety, and Tolerability of Exenatide Once Weekly to Those of Sitagliptin and Pioglitazone,in Subjects With Type 2 Diabetes Treated With Metformin (DURATION - 2)

Exenatide

Type 2 diabetes

BMI 25-45Ph 3Completed62Feb 20098results

Showing 1-25 of 387 trials