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Subcutaneous · GLP-1 / GIP / glucagon triple

HRS-4729 / KAI-4729

5 trials in this molecule. Source: ClinicalTrials.gov, as of November 5, 2026.

Trials

5

Ongoing

4

Recruiting

2

Completed

1

Sites

7

Countries

1

Endpoints

44

Composite endpoints

0

Distinct sites and countries across this molecule's trials. A site running several of its trials counts once, matching the map.

Where the program stands

Trials by phase

Phase 1
2
Phase 2
3

Trials by status

Not yet recruiting
2
Recruiting
2
Completed
1

Evidence coverage

What this asset has been measured on

Endpoints grouped into outcome categories, ranked by how often they are measured across this asset's trials.

Safety / tolerability / PK
20
Weight & body composition
8
Glycemic / diabetes
7
MASH / liver
5
Cardiometabolic biomarkers
3
Other (unclassified)
1

Top 20 metrics across this asset's endpoints

Treatment-emergent AEs (any)Safety/PK

1

CmaxSafety/PK

1

TmaxSafety/PK

1

Half-lifeSafety/PK

1

Immunogenicity (ADA)Safety/PK

1

Body weight, absolute change (kg)Weight

1

Fasting glucose, changeGlycemic

1

Total fat massWeight

1

Programs for this asset

Every trial for this molecule, with the same search, filters, and sort as the Trials tab.

5 of 5

GLP-1 and incretin trials
Asset / PopulationEligibility highlightEvidence
NCT07660848A Study of HRS-4729 Injection and HRS9531 Injection in Participants With Metabolic Dysfunction-Associated Steatohepatitis

HRS-4729 / KAI-4729, HRS9531

MASH / NAFLD / liver fibrosis

BMI ≥24Ph 2Recruiting2Mar 2028-
NCT07843862A Study of HRS-4729 Injection in Participants With Type 2 Diabetes

HRS-4729 / KAI-4729, Mazdutide

Type 2 diabetes

HbA1c 7.5-10.5%Ph 2Not yet recruiting2Apr 2027-
NCT07690826A Study to Evaluate the Efficacy and Safety of HRS-4729 Injection in Obesity

HRS-4729 / KAI-4729

Obesity / overweight

BMI 28-40Ph 2Not yet recruiting1Mar 2027-
NCT06762600A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of HRS-4729 Injection in Healthy Subjects

HRS-4729 / KAI-4729, HRS9531

Obesity / overweight

-Ph 1Completed1Mar 2026-
NCT07807059A Single-Dose Pharmacokinetic Study of HRS-4729 Injection in Healthy Participants and Patients With Renal Impairment

HRS-4729 / KAI-4729

Hepatic impairment, MASH / NAFLD / liver fibrosis, Obesity / overweight, Type 2 diabetes

BMI 19-40Ph 1Recruiting1Mar 2027-

Showing 1-5 of 5 trials