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Subcutaneous · GLP-1 agonist

Liraglutide

518 trials in this molecule. Source: ClinicalTrials.gov, as of July 6, 2026.

Trials

518

Ongoing

46

Recruiting

26

Completed

367

Sites

3,600

Countries

67

Endpoints

8,104

Composite endpoints

478

Distinct sites and countries across this molecule's trials. A site running several of its trials counts once, matching the map.

Where the program stands

Trials by phase

Early Phase 1
5
Phase 1
64
Phase 1/2
8
Phase 2
64
Phase 2/3
6
Phase 3
106
Phase 4
133
Not applicable
132

Trials by status

Not yet recruiting
5
By invitation
3
Recruiting
26
Active, not recruiting
12
Completed
367
Terminated
20
Withdrawn
17
Suspended
1
Unknown
67

Evidence coverage

What this asset has been measured on

Endpoints grouped into outcome categories, ranked by how often they are measured across this asset's trials.

Glycemic / diabetes
2,045
Safety / tolerability / PK
1,710
Cardiometabolic biomarkers
1,222
Weight & body composition
1,139
Other (unclassified)
617
Other clinical outcomes
597
Patient-reported / QoL
361
Renal / kidney
114
MASH / liver
105
Cardiovascular outcomes
101
Heart failure
93

Top 20 metrics across this asset's endpoints

HbA1c, changeGlycemic

366

Body weight, absolute change (kg)Weight

323

Fasting glucose, changeGlycemic

277

Postprandial glucoseGlycemic

252

Documented hypoglycemiaSafety/PK

244

HbA1c <7.0% achievementGlycemic

189

Treatment-emergent AEs (any)Safety/PK

180

Heart rate, changeBiomarker

133

Waist circumference, changeWeight

128

Body weight, % changeWeight

122

HbA1c <6.5% achievementGlycemic

109

AUC₀-∞Safety/PK

106

Systolic BP, changeBiomarker

97

Triglycerides, changeBiomarker

92

BMI, changeWeight

91

HOMA-IR (insulin sensitivity)Glycemic

87

Immunogenicity (ADA)Safety/PK

86

Total cholesterol, changeBiomarker

85

LDL-C, changeBiomarker

78

HDL-C, changeBiomarker

76

Programs for this asset

Every trial for this molecule, with the same search, filters, and sort as the Trials tab.

518 of 518

GLP-1 and incretin trials
Asset / PopulationEligibility highlightEvidence
LEADER®Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results

Liraglutide

Cardiovascular disease, Type 2 diabetes

-Ph 3Completed428Dec 201541results
DUAL™ IDual Action of Liraglutide and Insulin Degludec in Type 2 Diabetes: A Trial Comparing the Efficacy and Safety of Insulin Degludec/Liraglutide, Insulin Degludec and Liraglutide in Subjects With Type 2 Diabetes

Liraglutide

Type 2 diabetes

HbA1c 7-10%Ph 3Completed302May 20129results
NCT00856986The Effect of Insulin Detemir in Combination With Liraglutide and Metformin Compared to Liraglutide and Metformin in Subjects With Type 2 Diabetes

Liraglutide

Type 2 diabetes

HbA1c 7-10%Ph 3Completed233Apr 20103results
LIRA-PRIMEEfficacy in Controlling Glycaemia With Victoza® (Liraglutide) as add-on to Metformin vs. OADs as add-on to Metformin After up to 104 Weeks of Treatment in Subjects With Type 2 Diabetes

Liraglutide

Type 2 diabetes

HbA1c 7.5-9%Ph 4Completed232Aug 20192results
NCT01272219Effect of Liraglutide on Body Weight in Non-diabetic Obese Subjects or Overweight Subjects With Co-morbidities: SCALE™ - Obesity and Pre-diabetes

Liraglutide

Obesity / overweight, Prediabetes / glucose intolerance

-Ph 3Completed226Mar 201317results
LEAD-2To Compare the Effect of Liraglutide When Given Together With Metformin With the Effect of Metformin Given Alone and With the Effect of Glimepiride and Metformin Given Together

Liraglutide

Type 2 diabetes

HbA1c 7-11%Ph 3Completed190May 200718results
Ellipse™Efficacy and Safety of Liraglutide in Combination With Metformin Compared to Metformin Alone, in Children and Adolescents With Type 2 Diabetes

Liraglutide

Type 2 diabetes

HbA1c 7-11%Ph 3Completed185Nov 20172results
ADJUNCT ONE™The Efficacy and Safety of Liraglutide as Adjunct Therapy to Insulin in the Treatment of Type 1 Diabetes

Liraglutide

Type 1 diabetes

HbA1c 7-10%Ph 3Completed182Jun 20153results
NCT01128894A Study to Determine the Efficacy and Safety of Albiglutide as Compared With Liraglutide.

Albiglutide, Liraglutide

Type 2 diabetes

HbA1c 7-10%Ph 3Completed173Sep 20111results
NCT00700817The Effect of Liraglutide Compared to Sitagliptin, Both in Combination With Metformin on Glycaemic Control in Subjects With Type 2 Diabetes Mellitus

Liraglutide

Type 2 diabetes

BMI ≤45Ph 3Completed166Jun 200914results
NCT01272232Effect of Liraglutide on Body Weight in Overweight or Obese Subjects With Type 2 Diabetes: SCALE™ - Diabetes

Liraglutide

Obesity / overweight, Type 2 diabetes

BMI ≥27Ph 3Completed161Jan 201313results
NCT02461589Dose-finding of Semaglutide Administered Subcutaneously Once Daily Versus Placebo and Liraglutide in Subjects With Type 2 Diabetes

Liraglutide, Semaglutide

Type 2 diabetes

BMI 25-40Ph 2Completed150Oct 20161results
DUAL™ VIIIA 104 Week Clinical Trial Comparing Long Term Glycaemic Control of Insulin Degludec/Liraglutide (IDegLira) Versus Insulin Glargine Therapy in Subjects With Type 2 Diabetes Mellitus

Liraglutide

Type 2 diabetes

BMI ≥20Ph 3Completed143Oct 20182results
EAGLEEfficacy Assessment of Insulin Glargine Versus LiraglutidE After Oral Agents Failure

Liraglutide

Type 2 diabetes

BMI 25-40Ph 4Completed136Oct 2012-results
NCT01664247The Effect of Insulin Degludec in Combination With Liraglutide and Metformin in Subjects With Type 2 Diabetes Qualifying for Treatment Intensification

Liraglutide

Type 2 diabetes

HbA1c 7.5-10%Ph 3Completed132Dec 20131results
LEAD-1Effect of Liraglutide on Blood Glucose Control in Subjects With Type 2 Diabetes

Liraglutide

Type 2 diabetes

BMI ≤45Ph 3Completed127May 200715
LEAD-6Effect of Liraglutide or Exenatide Added to an Ongoing Treatment on Blood Glucose Control in Subjects With Type 2 Diabetes

Exenatide, Liraglutide

Type 2 diabetes

BMI ≤45Ph 3Completed125Apr 200816results
BEGIN™Comparison of the Efficacy and Safety of Two Intensification Strategies in Subjects With Type 2 Diabetes Inadequately Controlled on Basal Insulin and Metformin

Liraglutide

Type 2 diabetes

-Ph 3Completed124Jul 20121results
LixiLan-GEfficacy and Safety of the Insulin Glargine/Lixisenatide Fixed Ratio Combination (FRC) Versus GLP-1 Receptor Agonist in Patients With Type 2 Diabetes, With a FRC Extension Period

Albiglutide, Dulaglutide, Exenatide, GLP-1 / incretin class catch-all, Liraglutide, Lixisenatide

Type 2 diabetes

-Ph 3Completed124May 20185results
ADJUNCT TWO™The Efficacy and Safety of Liraglutide Adjunct to Insulin Treatment in Type 1 Diabetes

Liraglutide

Type 1 diabetes

HbA1c 7-10%Ph 3Completed120Apr 20154results
NCT03235050A Study to Evaluate the Efficacy and Safety of MEDI0382 in the Treatment of Overweight and Obese Subjects With Type 2 Diabetes

Cotadutide, Liraglutide

Obesity / overweight, Type 2 diabetes

BMI ≥25Ph 2Completed119May 20181results
LEAD-3To Evaluate the Effect of Liraglutide Versus Glimepiride (Amaryl®) on Haemoglobin A1c

Liraglutide

Type 2 diabetes

BMI ≤45Ph 3Terminated117Nov 200819results
NCT02420262A Clinical Trial Comparing Efficacy and Safety of Insulin Degludec/Liraglutide (IDegLira) Versus Basal-bolus Therapy in Subjects With Type 2 Diabetes Mellitus

Liraglutide

Type 2 diabetes

HbA1c 7-10%Ph 3Completed117Oct 20163results
LEAD-5Effect of Liraglutide on Blood Glucose Control in Subjects With Type 2 Diabetes

Liraglutide

Type 2 diabetes

BMI ≤45Ph 3Completed116Apr 200714
DUAL™ IIIThe Efficacy of Insulin Degludec/Liraglutide in Controlling Glycaemia in Adults With Type 2 Diabetes Inadequately Controlled on GLP-1 Receptor Agonist and OAD Therapy

Exenatide, GLP-1 / incretin class catch-all, Liraglutide

Type 2 diabetes

BMI ≤40Ph 3Completed109Mar 20143results

Showing 1-25 of 518 trials