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Oral / Subcutaneous · GLP-1 / GLP-2 dual

PG-102 / RT-114

5 trials in this molecule. Source: ClinicalTrials.gov, as of July 6, 2026.

Trials

5

Ongoing

4

Recruiting

1

Completed

1

Sites

16

Countries

2

Endpoints

50

Composite endpoints

2

Distinct sites and countries across this molecule's trials. A site running several of its trials counts once, matching the map.

Where the program stands

Trials by phase

Phase 1
2
Phase 2
3

Trials by status

Not yet recruiting
2
Recruiting
1
Active, not recruiting
1
Completed
1

Evidence coverage

What this asset has been measured on

Endpoints grouped into outcome categories, ranked by how often they are measured across this asset's trials.

Safety / tolerability / PK
27
Glycemic / diabetes
12
Weight & body composition
11

Top 20 metrics across this asset's endpoints

HbA1c, changeGlycemic

2

Treatment-emergent AEs (any)Safety/PK

2

Body weight, absolute change (kg)Weight

1

Body weight, % changeWeight

1

Fasting glucose, changeGlycemic

1

Immunogenicity (ADA)Safety/PK

1

CmaxSafety/PK

1

AUC₀-∞Safety/PK

1

TmaxSafety/PK

1

BMI, changeWeight

1

Waist circumference, changeWeight

1

Programs for this asset

Every trial for this molecule, with the same search, filters, and sort as the Trials tab.

5 of 5

GLP-1 and incretin trials
Asset / PopulationEligibility highlightEvidence
NCT06712615Phase II Study of PG-102(MG12) Compared With Placebo in Obesity and Type 2 Diabetes

PG-102 / RT-114

Obesity / overweight, Type 2 diabetes

HbA1c 7-10%Ph 2Active, not recruiting14Oct 2025-
NCT06309667A Study to Investigate the Safety, Tolerability, and Pharmacokinetics and Pharmacodynamics Following Subcutaneous Injections of PG-102 (MG12) in Healthy Adult and Obesity Participants.

PG-102 / RT-114

Healthy volunteers, Obesity / overweight

BMI 18-30Ph 1Completed1Feb 20251
NCT07187856Phase 2 Randomized Study of PG-102 vs Placebo and Semaglutide in Type 2 Diabetes Mellitus

PG-102 / RT-114, Semaglutide

Obesity / overweight, Type 2 diabetes

BMI 25-40Ph 2Not yet recruiting1Sep 2026-
NCT06891287An Early Phase Study of RT-114 (RaniPill Containing PG-102, a GLP-1/2 Dual Agonist) in Healthy Volunteers.

PG-102 / RT-114

Healthy volunteers, Obesity / overweight

-Ph 1Recruiting1Dec 2026-
NCT07677891Phase II Study of Switching From Dulaglutide to PG-102(MG12) in Type 2 Diabetes Mellitus

Dulaglutide, PG-102 / RT-114

Obesity / overweight, Type 2 diabetes

HbA1c ≤7.5%Ph 2Not yet recruiting0May 2027-

Showing 1-5 of 5 trials