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Intravenous / Subcutaneous · Amylin analog

Pramlintide

64 trials in this molecule. Source: ClinicalTrials.gov, as of July 6, 2026.

Trials

64

Ongoing

5

Recruiting

1

Completed

44

Sites

271

Countries

5

Endpoints

498

Composite endpoints

21

Distinct sites and countries across this molecule's trials. A site running several of its trials counts once, matching the map.

Where the program stands

Trials by phase

Early Phase 1
2
Phase 1
6
Phase 1/2
2
Phase 2
15
Phase 2/3
2
Phase 3
6
Phase 4
10
Not applicable
21

Trials by status

Not yet recruiting
3
Recruiting
1
Active, not recruiting
1
Completed
44
Terminated
4
Withdrawn
5
Unknown
6

Evidence coverage

What this asset has been measured on

Endpoints grouped into outcome categories, ranked by how often they are measured across this asset's trials.

Glycemic / diabetes
193
Safety / tolerability / PK
138
Other (unclassified)
54
Weight & body composition
48
Patient-reported / QoL
27
Cardiometabolic biomarkers
24
Other clinical outcomes
14

Top 20 metrics across this asset's endpoints

CGM time-in-rangeGlycemic

28

Postprandial glucoseGlycemic

21

Body weight, absolute change (kg)Weight

16

AUC₀-∞Safety/PK

15

CGM time-above-rangeGlycemic

13

Documented hypoglycemiaSafety/PK

11

Treatment-emergent AEs (any)Safety/PK

10

Severe hypoglycemiaSafety/PK

10

Body weight, % changeWeight

8

HbA1c, changeGlycemic

8

CmaxSafety/PK

7

CGM time-below-rangeGlycemic

7

CGM time-below-rangeSafety/PK

6

Waist circumference, changeWeight

6

Leptin, changeBiomarker

5

Heart rate, changeBiomarker

5

Immunogenicity (ADA)Safety/PK

5

Plasma concentration (steady state)Safety/PK

4

TmaxSafety/PK

3

Fasting glucose, changeGlycemic

3

Programs for this asset

Every trial for this molecule, with the same search, filters, and sort as the Trials tab.

64 of 64

GLP-1 and incretin trials
Asset / PopulationEligibility highlightEvidence
NCT00229658An Observational Study Evaluating SYMLIN® (Pramlintide Acetate) Injection Use in Insulin Using Patients With Type 2 and Type 1 Diabetes

Pramlintide

Type 1 diabetes, Type 2 diabetes

HbA1c ≤9%-Completed107May 20081results
NCT00108004Clinical Utility and Safety of Pramlintide in Subjects With Type 1 and Type 2 Diabetes Mellitus

Pramlintide

Type 1 diabetes, Type 2 diabetes

HbA1c 7-11%Ph 3Completed48Jun 20053
NCT00467649A Study to Characterize Regimens of Basal Insulin Intensified With Either Symlin® or Rapid Acting Insulin in Patients With Type 2 Diabetes

Pramlintide

Obesity / overweight, Type 2 diabetes

BMI 25-50Ph 4Completed37Apr 20081results
NCT00673387Study to Examine Safety, Tolerability, and Effect on Body Weight of Metreleptin Administered in Conjunction With Pramlintide in Obese and Overweight Subjects

Pramlintide

Obesity / overweight

BMI 30-35Ph 2Completed36Apr 20091results
NCT00240253A Study Evaluating the Efficacy and Safety of Adding Symlin® to Lantus® (Insulin Glargine) in Subjects With Type 2 Diabetes

Pramlintide

Obesity / overweight, Type 2 diabetes

BMI 25-45Ph 4Completed34Jun 20063
NCT00042458Evaluation of Dose-titration of Pramlintide During Initiation of Therapy in Patients Trying to Improve Glucose Control

Pramlintide

Type 1 diabetes

HbA1c 7.5-9%Ph 3Completed33Mar 20031
NCT00819234Extension Study of Protocol DFA102 to Examine the Long-Term Safety, Tolerability, and Effect on Body Weight of Pramlintide Administered in Combination With Metreleptin

Pramlintide

Obesity / overweight

-Ph 2Completed33Oct 20091results
NCT00107107Study of the Long-Term Safety of Pramlintide in Subjects With Type 1 Diabetes Mellitus

Pramlintide

Type 1 diabetes

-Ph 3Completed25Jun 20051
NCT00112021A Study to Examine the Effect of Pramlintide on Body Weight and Its Safety and Tolerability in Obese Subjects

Pramlintide

Obesity / overweight

BMI 30-50Ph 2Completed21Nov 20051
NCT00189514A Study to Examine the Long Term Effect of Pramlintide on Body Weight and Its Safety and Tolerability in Obese Subjects

Pramlintide

Obesity / overweight

-Ph 2Completed21Jun 20071
NCT01235741A Study To Examine The Efficacy And Safety Of Pramlintide+Metreleptin In Obese Subjects

Pramlintide

Obesity / overweight

BMI 35-45Ph 2Terminated18Sep 2011-results
NCT00402077A Study to Examine the Safety, Tolerability, and Body Weight Effect of Pramlintide Alone and in Combination With Oral Antiobesity Agents in Overweight and Obese Subjects

Pramlintide

Obesity / overweight

BMI 30-50Ph 2Completed16Aug 2007-
NCT00392925A Study to Evaluate the Effect on Body Weight of Leptin Administered in Conjunction With Pramlintide in Overweight and Obese Subjects

Pramlintide

Obesity / overweight

BMI 30-35Ph 2Completed12Sep 20071results
NCT00444561Exploratory Study to Evaluate Various Pharmacodynamic Effects of Subcutaneously Infused or Injected Pramlintide in Obese Subjects

Pramlintide

Obesity / overweight

BMI 30-45Ph 2Completed10May 2005-
NCT00042471Evaluation of the Bioavailability of Pramlintide

Pramlintide

Obesity / overweight, Type 1 diabetes, Type 2 diabetes

BMI 30-45Ph 2Completed4Dec 2002-
NCT01137695Efficacy Study of High Dose Symlin to Treat Type 2 Diabetes Mellitus

Pramlintide

Obesity / overweight, Type 2 diabetes

BMI ≥30Ph 3Unknown3Jan 2012-
NCT02500979Effect of a Fixed Pramlintide: Insulin Dose Ratio on Postprandial Glucose in Type 1 Diabetes Mellitus

Pramlintide

Type 1 diabetes

BMI ≤30Ph 1Completed3Aug 20161results
NCT00313183A Study to Evaluate Symlin in Adolescent Subjects With Type 1 Diabetes Mellitus

Pramlintide

Type 1 diabetes

HbA1c 6-10%Ph 2Completed3Aug 2007-
DTADMulti-Center Development of a Novel Diagnostic Test for Alzheimer's Disease

Pramlintide

Alzheimer's / cognition, Healthy volunteers

BMI 20-35Early Ph 1Active, not recruiting3Nov 2026-
APPPancreatic Polypeptide as a Modulator of Amylin- Induced Satiety in Healthy Humans

Pramlintide

Healthy volunteers

BMI 18-27Not applicableRecruiting1Oct 2026-
NCT00206258The Role of Amylin and Glucagon in T1DM

Pramlintide

Type 1 diabetes

HbA1c ≤8%Ph 3Completed1Aug 20051
NCT00291772Continuous Subcutaneous Infusion of Pramlintide and Insulin

Pramlintide

Type 1 diabetes

HbA1c ≤8.5%Ph 4Completed1Nov 20072
NCT00442767Post-meal Insulin Dosing With Adjuvant Pre-meal Pramlintide in Children With Type 1 Diabetes Mellitus

Pramlintide

Type 1 diabetes

HbA1c ≤8.5%Ph 4Completed1Feb 20091results
NCT00502138A Pilot Study of Continuous Subcutaneous Pramlintide Infusion Therapy in Patients With Type 1 Diabetes

Pramlintide

Type 1 diabetes

BMI ≤35Ph 4Completed1Jan 20081
NCT00690235Demonstrate the Effects of Pramlintide on Weight Reduction in Schizophrenia

Pramlintide

Obesity / overweight, Psychiatric (schizophrenia / bipolar / depression)

BMI ≥27Ph 4Completed1Aug 2011-results

Showing 1-25 of 64 trials