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Subcutaneous · GLP-1 agonist

Visepegenatide

10 trials in this molecule. Source: ClinicalTrials.gov, as of November 5, 2026.

Trials

10

Ongoing

0

Recruiting

0

Completed

9

Sites

10

Countries

2

Endpoints

53

Composite endpoints

0

Distinct sites and countries across this molecule's trials. A site running several of its trials counts once, matching the map.

Where the program stands

Trials by phase

Phase 1
5
Phase 1/2
1
Phase 2
2
Phase 3
2

Trials by status

Completed
9
Unknown
1

Evidence coverage

What this asset has been measured on

Endpoints grouped into outcome categories, ranked by how often they are measured across this asset's trials.

Safety / tolerability / PK
21
Glycemic / diabetes
18
Weight & body composition
6
Other (unclassified)
6
Cardiometabolic biomarkers
2

Top 20 metrics across this asset's endpoints

AUC₀-∞Safety/PK

3

HbA1c, changeGlycemic

2

HbA1c <7.0% achievementGlycemic

2

Body weight, absolute change (kg)Weight

2

Fasting glucose, changeGlycemic

2

BMI, changeWeight

2

Treatment-emergent AEs (any)Safety/PK

1

Plasma concentration (steady state)Safety/PK

1

CmaxSafety/PK

1

TmaxSafety/PK

1

Half-lifeSafety/PK

1

Programs for this asset

Every trial for this molecule, with the same search, filters, and sort as the Trials tab.

10 of 10

GLP-1 and incretin trials
Asset / PopulationEligibility highlightEvidence
NCT03072407MAD Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of PB-119 to Subjects With T2DM

Visepegenatide

Type 2 diabetes

BMI 22-40Ph 1Completed2Nov 2016-
NCT03059719Clinical Trial for PB-119 in Subjects With Type 2 Diabetes Mellitus

Exenatide, Visepegenatide

Type 2 diabetes

-Ph 1Completed1Sep 2016-
NCT03604419Dose-finding of PB-119 Administered Subcutaneously Once Weekly Versus Placebo in Subjects With Type 2 Diabetes

Visepegenatide

Type 2 diabetes

BMI 18.5-40Ph 2Completed1Jul 20191
NCT02084251Clinical Trial for PB-119 in Healthy Subjects (Phase I)

Visepegenatide

Type 2 diabetes

BMI 19-24Ph 1Completed1Nov 20141
NCT06350812A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of PB-119 Injection in Chinese Obese Subjects

Visepegenatide

Obesity / overweight

-Ph 1/2Completed1Nov 2024-
NCT05328843Study to Evaluate the Pharmacokinetic Characteristics of Pegylated Exenatide Injection (PB-119) in Subjects With Different Degrees of Renal Insufficiency and Matched Subjects With Normal Renal Function

Visepegenatide

Type 2 diabetes

BMI 18-30Ph 1Unknown1Oct 2022-
PB119Safety and Efficacy of Pegylated Exenatine Injection (PB-119) in Drug-naïve T2DM Subjects

Visepegenatide

Type 2 diabetes

BMI ≤40Ph 3Completed1Mar 20221
NCT04504396Safety and Efficacy of PB-119 in Subjects With Type 2 Diabetes and Not Well-controlled by Metformin Monotherapy

Visepegenatide

Type 2 diabetes

BMI ≤40Ph 3Completed1Sep 2022-
NCT03062774Continuous Multiple Dose PB-119 Injection in Health Volunteers

Visepegenatide

Type 2 diabetes

-Ph 1Completed1Sep 20161
NCT03520972Dose-finding of PB-119 Administered Subcutaneously Once-weekly Versus Placebo in Drug-naïve T2DM Subjects

Visepegenatide

Type 2 diabetes

BMI 18.5-35Ph 2Completed1Jul 20192

Showing 1-10 of 10 trials