CompletedPhase 1

Incretin Regulation of Insulin Secretion in Monogenic Diabetes

Lead sponsor

University of Chicago

Asset

Avexitide

Listed sites

Recruiting sites

Actual enrollment

Study population

Eligibility highlights

•Healthy volunteers

Primary endpoint

Registered trial locations

Locations reported to ClinicalTrials.gov for this trial snapshot. Site count is not enrollment count; per-site enrollment is not available from source.

Identifiers

Registered as

NCT IDNCT01795144

Org study ID12-1517

Timeline

Milestones

Study first posted2013-02-20estimated

Last update posted2017-04-10actual

Study start2014-01 (month precision)

Primary completion2017-03actual (month precision)

Study completion2017-03actual (month precision)

Assets

Investigational agents

Avexitide

Who can enroll

Minimum age18 Years

Maximum age89 Years

SexAll

Healthy volunteersAccepted

Inclusion criteria

Monogenic Diabetes Subjects:

Inclusion Criteria:

•Diagnosis of monogenic diabetes

•Previously participated in US Neonatal Diabetes Registry (IRB 15617B) or Genetics of diabetes mellitus (IRB 6858)

•Age: 18 years +

Exclusion criteria

•Pregnancy

•Acute medical illness or chronic conditions including: cardiac failure, renal insufficiency (estimated glomerular filtration rate <50 ml/min), hepatic insufficiency (known cirrhosis or hepatitis), chronic obstructive pulmonary disease, gastrointestinal disorders causing malabsorption, anemia (Hct < 36%), or uncontrolled hypertension

Healthy Controls:

Inclusion Criteria:

•Good general health

•Stable weight for 6 months

•Age: 18 years +

Exclusion Criteria:

•Pregnancy

Endpoints (0)

What's being measured

Protocol endpoints and posted registry outcome measures, grouped into outcome categories. Composite endpoints show their component event types. Standard codes (LOINC, SNOMED CT) are shown where available.

No endpoints recorded for this trial.

Provenance

Sources

Trial identity, design, statusClinicalTrials.gov API v2

Snapshot dateJuly 6, 2026

Endpoint classificationDelfa endpoint taxonomy v2 (May 13, 2026)

Results tableno registry results posted yet

Trial facts come from public ClinicalTrials.gov records. Endpoint categories are Delfa's classification of those records, not a ClinicalTrials.gov field. All figures reflect the July 6, 2026 snapshot.