The Effect of Bariatric Surgery on Metabolism, the Metabolome and Microbiome in Patients With Type 2 Diabetes

The Effect of Bariatric Surgery on Metabolism, the Metabolome and the Microbiome in Patients With Type 2 Diabetes

Lead sponsor

Mayo Clinic

Asset

Avexitide

Listed sites

Recruiting sites

Actual enrollment

Study population

Obesity / overweight, Type 2 diabetes

Eligibility highlights

•BMI ≥35

Primary endpoint

Registered trial locations

Locations reported to ClinicalTrials.gov for this trial snapshot. Site count is not enrollment count; per-site enrollment is not available from source.

Identifiers

Registered as

NCT IDNCT02762708

Org study ID15-000179

Timeline

Milestones

Study first posted2016-05-05estimated

Primary completion2018-01-06actual

Study completion2018-01-06actual

Last update posted2022-05-03actual

Results first posted2022-05-03actual

Study start2016-03 (month precision)

Assets

Investigational agents

Avexitide

Who this study enrolls

Obesity / overweightType 2 diabetes

Who can enroll

Minimum age20 Years

Maximum age65 Years

SexAll

Healthy volunteersAccepted

Inclusion criteria

•Age 20-65 years of age.

•Seen at Mayo Clinic Nutrition Clinic and have received authorization for RYGB surgery.

•Type 2 Diabetes Mellitus or impaired fasting glucose with BMI >35 AND not interested in surgery but are interested in supervised caloric restriction.

Exclusion criteria

•Previous treatment with thiazolidinediones.

•Chronic antibiotic therapy.

•Active microvascular or macrovascular complications of diabetes.

Endpoints (0)

What's being measured

Protocol endpoints and posted registry outcome measures, grouped into outcome categories. Composite endpoints show their component event types. Standard codes (LOINC, SNOMED CT) are shown where available.

No endpoints recorded for this trial.

Provenance

Sources

Trial identity, design, statusClinicalTrials.gov API v2

Snapshot dateJuly 6, 2026

Endpoint classificationDelfa endpoint taxonomy v2 (May 13, 2026)

Results tableClinicalTrials.gov results section

Trial facts come from public ClinicalTrials.gov records. Endpoint categories are Delfa's classification of those records, not a ClinicalTrials.gov field. All figures reflect the July 6, 2026 snapshot.