CompletedPhase 2Results posted
A 12-WEEK TITRATE STUDY TO EVALUATE SAFETY, TOLERABILITY AND PHARMACODYNAMICS OF PF-06882961 IN ADULTS WITH TYPE 2 DIABETES MELLITUS AND IN NON-DIABETIC ADULTS WITH OBESITY
A 12-WEEK, PHASE 2A, RANDOMIZED, DOUBLE-BLIND, SPONSOR-OPEN, PLACEBO-CONTROLLED, PARALLEL GROUP STUDY TO ASSESS THE SAFETY, TOLERABILITY, AND PHARMACODYNAMICS OF PF-06882961 TITRATION IN ADULTS WITH TYPE 2 DIABETES MELLITUS TREATED WITH METFORMIN AND IN NON-DIABETIC ADULTS WITH OBESITY
Lead sponsor
Asset
Danuglipron
Oral · GLP-1 agonist
Listed sites
38
Recruiting sites
-
Actual enrollment
151
Study population
Obesity / overweight, Type 2 diabetes
Eligibility highlights
-
Primary endpoints
•Treatment Emergent Adverse Events (AEs) by Severity•Treatment-emergent AEs (any)
Registered trial locations
Locations reported to ClinicalTrials.gov for this trial snapshot. Site count is not enrollment count; per-site enrollment is not available from source.
Identifiers
Registered as
NCT IDNCT04617275
Org study IDC3421008
Secondary IDGLP-1Ra Ph 2 Titration StudyAlias Study Number
Timeline
Milestones
Study first posted2020-11-05actual
Study start2021-01-06actual
Primary completion2021-11-17actual
Study completion2021-11-17actual
Last update posted2022-12-08actual
Results first posted2022-12-08actual
Assets
Investigational agents
Who this study enrolls
Obesity / overweightType 2 diabetes
Who can enroll
Minimum age18 Years
Maximum age75 Years
SexAll
Healthy volunteersNot accepted
Inclusion criteria
•Male or female participants between the ages of 18 and 75 years, inclusive, at Visit 1 (screening).
Exclusion criteria
•Diagnosis of type 1 diabetes mellitus or secondary forms of diabetes.
•History of myocardial infarction, unstable angina, arterial revascularization, stroke, New York Heart Association Functional Class II IV heart failure, or transient ischemic attack within 6 months of screening (Visit 1).
•Participants with a known medical history of active liver disease (other than non alcoholic hepatic steatosis), including chronic active hepatitis B or C, or primary biliary cirrhosis.
•History of major depressive disorder or history of other severe psychiatric disorders (eg, schizophrenia or bipolar disorder) within the last 2 years.
•Any lifetime history of a suicide attempt.
Endpoints (60)
What's being measured
Protocol endpoints and posted registry outcome measures, grouped into outcome categories. Composite endpoints show their component event types. Standard codes (LOINC, SNOMED CT) are shown where available.
Coverage by outcome category
Weight & body composition
24
Glycemic / diabetes
24
Safety / tolerability / PK
10
Patient-reported / QoL
2
Weight & body composition
24 endpointsSecondary/registry result
CFB in Body Weight at Week 2 (Participants With T2DM)
Time frame:Baseline, Week 2
descriptive
Posted result
| Group | Least-squares mean · kg | 95% CI |
|---|---|---|
| Placebo (T2DM) | -0.14 | -0.72 - 0.44 |
| PF-06882961 80 mg BID Low, Slow (T2DM) | -0.40 | -0.89 - 0.08 |
| PF-06882961 80 mg BID High, Slow (T2DM) | -0.22 | -0.70 - 0.26 |
| PF-06882961 120 mg BID Low, Fast (T2DM) | -0.46 | -0.94 - 0.02 |
| PF-06882961 120 mg BID High, Fast (T2DM) | -0.63 | -1.11 - -0.16 |
| PF-06882961 200 mg BID (T2DM) | -0.21 | -0.72 - 0.30 |
Mean difference (final values)-0.2690% CI-1.02 - 0.50p0.2843Mixed Models Analysis
Mean difference (final values)-0.0890% CI-0.84 - 0.68p0.4310Mixed Models Analysis
Mean difference (final values)-0.3290% CI-1.07 - 0.43p0.2402Mixed Models Analysis
Mean difference (final values)-0.4990% CI-1.24 - 0.26p0.1397Mixed Models Analysis
Mean difference (final values)-0.0790% CI-0.85 - 0.71p0.4393Mixed Models Analysis
Secondary/registry result
CFB in Body Weight at Week 4 (Participants With T2DM)
Time frame:Baseline, Week 4
descriptive
Posted result
| Group | Least-squares mean · kg | 95% CI |
|---|---|---|
| Placebo (T2DM) | -0.46 | -1.40 - 0.47 |
| PF-06882961 80 mg BID Low, Slow (T2DM) | -1.23 | -2.03 - -0.44 |
| PF-06882961 80 mg BID High, Slow (T2DM) | -0.34 | -1.11 - 0.43 |
| PF-06882961 120 mg BID Low, Fast (T2DM) | -1.58 | -2.35 - -0.81 |
| PF-06882961 120 mg BID High, Fast (T2DM) | -1.47 | -2.25 - -0.70 |
| PF-06882961 200 mg BID (T2DM) | -0.41 | -1.23 - 0.41 |
Mean difference (final values)-0.7790% CI-2.00 - 0.45p0.1491Mixed Models Analysis
Median difference (final values)0.1290% CI-1.09 - 1.34p0.5664Mixed Models Analysis
Median difference (final values)-1.1290% CI-2.33 - 0.09p0.0632Mixed Models Analysis
Median difference (final values)-1.0190% CI-2.23 - 0.20p0.0847Mixed Models Analysis
Mean difference (final values)0.0590% CI-1.20 - 1.30p0.5264Mixed Models Analysis
Secondary/registry result
CFB in Body Weight at Week 6 (Participants With T2DM)
Time frame:Baseline, Week 6
descriptive
Posted result
| Group | Least-squares mean · kg | 95% CI |
|---|---|---|
| Placebo (T2DM) | -0.38 | -1.42 - 0.66 |
| PF-06882961 80 mg BID Low, Slow (T2DM) | -1.86 | -2.77 - -0.95 |
| PF-06882961 80 mg BID High, Slow (T2DM) | -0.65 | -1.52 - 0.23 |
| PF-06882961 120 mg BID Low, Fast (T2DM) | -2.74 | -3.65 - -1.83 |
| PF-06882961 120 mg BID High, Fast (T2DM) | -2.23 | -3.13 - -1.33 |
| PF-06882961 200 mg BID (T2DM) | -1.16 | -2.10 - -0.21 |
Mean difference (final values)-1.4890% CI-2.86 - -0.10p0.0395Mixed Models Analysis
Mean difference (final values)-0.2790% CI-1.63 - 1.10p0.3726Mixed Models Analysis
Mean difference (final values)-2.3690% CI-3.74 - -0.98p0.0028Mixed Models Analysis
Mean difference (final values)-1.8590% CI-3.23 - -0.47p0.0139Mixed Models Analysis
Mean difference (final values)-0.7890% CI-2.19 - 0.64p0.1815Mixed Models Analysis
Secondary/registry result
CFB in Body Weight at Week 8 (Participants With T2DM)
Time frame:Baseline, Week 8
descriptive
Posted result
| Group | Least-squares mean · kg | 95% CI |
|---|---|---|
| Placebo (T2DM) | -0.36 | -1.51 - 0.80 |
| PF-06882961 80 mg BID Low, Slow (T2DM) | -2.52 | -3.55 - -1.48 |
| PF-06882961 80 mg BID High, Slow (T2DM) | -1.08 | -2.07 - -0.09 |
| PF-06882961 120 mg BID Low, Fast (T2DM) | -3.82 | -4.86 - -2.79 |
| PF-06882961 120 mg BID High, Fast (T2DM) | -2.41 | -3.43 - -1.38 |
| PF-06882961 200 mg BID (T2DM) | -3.32 | -4.42 - -2.23 |
Mean difference (final values)-2.1690% CI-3.71 - -0.61p0.0112Mixed Models Analysis
Mean difference (final values)-0.7290% CI-2.24 - 0.80p0.2161Mixed Models Analysis
Mean difference (final values)-3.4790% CI-5.02 - -1.92p0.0002Mixed Models Analysis
Mean difference (final values)-2.0590% CI-3.59 - -0.51p0.0147Mixed Models Analysis
Mean difference (final values)-2.9790% CI-4.56 - -1.37p0.0013Mixed Models Analysis
Secondary/registry result
CFB in Body Weight at Week 10 (Participants With T2DM)
Time frame:Baseline, Week 10
descriptive
Posted result
| Group | Least-squares mean · kg | 95% CI |
|---|---|---|
| Placebo (T2DM) | -0.67 | -1.96 - 0.61 |
| PF-06882961 80 mg BID Low, Slow (T2DM) | -3.14 | -4.34 - -1.93 |
| PF-06882961 80 mg BID High, Slow (T2DM) | -1.71 | -2.83 - -0.58 |
| PF-06882961 120 mg BID Low, Fast (T2DM) | -4.95 | -6.15 - -3.75 |
| PF-06882961 120 mg BID High, Fast (T2DM) | -3.35 | -4.53 - -2.18 |
| PF-06882961 200 mg BID (T2DM) | -4.38 | -5.64 - -3.12 |
Mean difference (final values)-2.4690% CI-4.22 - -0.70p0.0111Mixed Models Analysis
Mean difference (final values)-1.0390% CI-2.75 - 0.68p0.1600Mixed Models Analysis
Mean difference (final values)-4.2790% CI-6.03 - -2.52p<0.0001Mixed Models Analysis
Mean difference (final values)-2.6890% CI-4.42 - -0.94p0.0061Mixed Models Analysis
Mean difference (final values)-3.7190% CI-5.52 - -1.89p0.0005Mixed Models Analysis
Secondary/registry result
CFB in Body Weight at Week 12 (Participants With T2DM)
Time frame:Baseline, Week 12
descriptive
Posted result
| Group | Least-squares mean · kg | 95% CI |
|---|---|---|
| Placebo (T2DM) | -0.42 | -1.87 - 1.03 |
| PF-06882961 80 mg BID Low, Slow (T2DM) | -3.64 | -5.03 - -2.24 |
| PF-06882961 80 mg BID High, Slow (T2DM) | -1.93 | -3.22 - -0.64 |
| PF-06882961 120 mg BID Low, Fast (T2DM) | -5.38 | -6.77 - -3.98 |
| PF-06882961 120 mg BID High, Fast (T2DM) | -2.93 | -4.29 - -1.56 |
| PF-06882961 200 mg BID (T2DM) | -5.37 | -6.86 - -3.88 |
Mean difference (final values)-3.2190% CI-5.22 - -1.20p0.0047Mixed Models Analysis
Mean difference (final values)-1.5190% CI-3.45 - 0.44p0.1003Mixed Models Analysis
Mean difference (final values)-4.9590% CI-6.96 - -2.95p<0.0001Mixed Models Analysis
Mean difference (final values)-2.5090% CI-4.49 - -0.51p0.0197Mixed Models Analysis
Mean difference (final values)-4.9490% CI-7.03 - -2.85p<0.0001Mixed Models Analysis
Secondary/registry result
CFB in Body Weight at Week 2 (Non-diabetic Participants With Obesity)
Time frame:Baseline, Week 2
descriptive
Posted result
| Group | Least-squares mean · kg | 95% CI |
|---|---|---|
| Placebo (Non-diabetic Obesity) | 0.23 | -0.81 - 1.26 |
| PF-06882961 200 mg BID (Non-diabetic Obesity) | -0.73 | -1.34 - -0.13 |
Mean difference (final values)-0.9690% CI-2.12 - 0.19p0.0836Mixed Models Analysis
Secondary/registry result
CFB in Body Weight at Week 4 (Non-diabetic Participants With Obesity)
Time frame:Baseline, Week 4
descriptive
Posted result
| Group | Least-squares mean · kg | 95% CI |
|---|---|---|
| Placebo (Non-diabetic Obesity) | 0.09 | -1.21 - 1.40 |
| PF-06882961 200 mg BID (Non-diabetic Obesity) | -1.50 | -2.25 - -0.74 |
Mean difference (final values)-1.5990% CI-3.07 - -0.12p0.0386Mixed Models Analysis
Secondary/registry result
CFB in Body Weight at Week 6 (Non-diabetic Participants With Obesity)
Time frame:Baseline, Week 6
descriptive
Posted result
| Group | Least-squares mean · kg | 95% CI |
|---|---|---|
| Placebo (Non-diabetic Obesity) | -0.10 | -2.28 - 2.08 |
| PF-06882961 200 mg BID (Non-diabetic Obesity) | -1.59 | -2.86 - -0.33 |
Mean difference (final values)-1.5090% CI-3.99 - 1.00p0.1566Mixed Models Analysis
Secondary/registry result
CFB in Body Weight at Week 8 (Non-diabetic Participants With Obesity)
Time frame:Baseline, Week 8
descriptive
Posted result
| Group | Least-squares mean · kg | 95% CI |
|---|---|---|
| Placebo (Non-diabetic Obesity) | 0.26 | -2.57 - 3.09 |
| PF-06882961 200 mg BID (Non-diabetic Obesity) | -2.36 | -4.08 - -0.65 |
Mean difference (final values)-2.6290% CI-5.91 - 0.67p0.0916Mixed Models Analysis
Secondary/registry result
CFB in Body Weight at Week 10 (Non-diabetic Participants With Obesity)
Time frame:Baseline, Week 10
descriptive
Posted result
| Group | Least-squares mean · kg | 95% CI |
|---|---|---|
| Placebo (Non-diabetic Obesity) | -0.40 | -3.17 - 2.37 |
| PF-06882961 200 mg BID (Non-diabetic Obesity) | -3.47 | -5.21 - -1.73 |
Mean difference (final values)-3.0790% CI-6.31 - 0.17p0.0590Mixed Models Analysis
Secondary/registry result
CFB in Body Weight at Week 12 (Non-diabetic Participants With Obesity)
Time frame:Baseline, Week 12
descriptive
Posted result
| Group | Least-squares mean · kg | 95% CI |
|---|---|---|
| Placebo (Non-diabetic Obesity) | -0.11 | -3.93 - 3.72 |
| PF-06882961 200 mg BID (Non-diabetic Obesity) | -3.85 | -6.25 - -1.44 |
Mean difference (final values)-3.7490% CI-8.23 - 0.75p0.0826Mixed Models Analysis
Secondary/protocol endpoint
CFB in Body Weight at Week 2 (Participants With T2DM)
Time frame:Baseline, Week 2
Body weight, absolute change (kg)
change from baseline, improvement
Secondary/protocol endpoint
CFB in Body Weight at Week 4 (Participants With T2DM)
Time frame:Baseline, Week 4
Body weight, absolute change (kg)
change from baseline, improvement
Secondary/protocol endpoint
CFB in Body Weight at Week 6 (Participants With T2DM)
Time frame:Baseline, Week 6
Body weight, absolute change (kg)
change from baseline, improvement
Secondary/protocol endpoint
CFB in Body Weight at Week 8 (Participants With T2DM)
Time frame:Baseline, Week 8
Body weight, absolute change (kg)
change from baseline, improvement
Secondary/protocol endpoint
CFB in Body Weight at Week 10 (Participants With T2DM)
Time frame:Baseline, Week 10
Body weight, absolute change (kg)
change from baseline, improvement
Secondary/protocol endpoint
CFB in Body Weight at Week 12 (Participants With T2DM)
Time frame:Baseline, Week 12
Body weight, absolute change (kg)
change from baseline, improvement
Secondary/protocol endpoint
CFB in Body Weight at Week 2 (Non-diabetic Participants With Obesity)
Time frame:Baseline, Week 2
Body weight, absolute change (kg)
change from baseline, improvement
Secondary/protocol endpoint
CFB in Body Weight at Week 4 (Non-diabetic Participants With Obesity)
Time frame:Baseline, Week 4
Body weight, absolute change (kg)
change from baseline, improvement
Secondary/protocol endpoint
CFB in Body Weight at Week 6 (Non-diabetic Participants With Obesity)
Time frame:Baseline, Week 6
Body weight, absolute change (kg)
change from baseline, improvement
Secondary/protocol endpoint
CFB in Body Weight at Week 8 (Non-diabetic Participants With Obesity)
Time frame:Baseline, Week 8
Body weight, absolute change (kg)
change from baseline, improvement
Secondary/protocol endpoint
CFB in Body Weight at Week 10 (Non-diabetic Participants With Obesity)
Time frame:Baseline, Week 10
Body weight, absolute change (kg)
change from baseline, improvement
Secondary/protocol endpoint
CFB in Body Weight at Week 12 (Non-diabetic Participants With Obesity)
Time frame:Baseline, Week 12
Body weight, absolute change (kg)
change from baseline, improvement
Glycemic / diabetes
24 endpointsSecondary/registry result
Change From Baseline (CFB) in Fasting Plasma Glucose at Week 2
Time frame:Baseline, Week 2
change from baseline, improvement
Posted result
| Group | Least-squares mean · mg/dL | 95% CI |
|---|---|---|
| Placebo (T2DM) | -5.63 | -19.00 - 7.74 |
| PF-06882961 80 mg BID Low, Slow (T2DM) | -3.32 | -14.62 - 7.97 |
| PF-06882961 80 mg BID High, Slow (T2DM) | -23.04 | -34.05 - -12.03 |
| PF-06882961 120 mg BID Low, Fast (T2DM) | -36.48 | -47.44 - -25.52 |
| PF-06882961 120 mg BID High, Fast (T2DM) | -39.29 | -50.23 - -28.35 |
| PF-06882961 200 mg BID (T2DM) | -25.15 | -36.59 - -13.72 |
Mean difference (final values)2.3190% CI-15.23 - 19.85p0.5863Mixed Models Analysis
Mean difference (final values)-17.4190% CI-34.75 - -0.06p0.0494Mixed Models Analysis
Mean difference (final values)-30.8590% CI-48.09 - -13.61p0.0019Mixed Models Analysis
Mean difference (final values)-33.6690% CI-51.00 - -16.32p0.0009Mixed Models Analysis
Mean difference (final values)-19.5290% CI-37.12 - -1.92p0.0343Mixed Models Analysis
Secondary/registry result
CFB in Fasting Plasma Glucose at Week 4
Time frame:Baseline, Week 4
concentration, descriptive
Posted result
| Group | Least-squares mean · mg/dL | 95% CI |
|---|---|---|
| Placebo (T2DM) | -13.12 | -26.88 - 0.64 |
| PF-06882961 80 mg BID Low, Slow (T2DM) | -16.45 | -28.11 - -4.79 |
| PF-06882961 80 mg BID High, Slow (T2DM) | -32.77 | -43.98 - -21.55 |
| PF-06882961 120 mg BID Low, Fast (T2DM) | -45.92 | -57.20 - -34.64 |
| PF-06882961 120 mg BID High, Fast (T2DM) | -48.97 | -60.52 - -37.42 |
| PF-06882961 200 mg BID (T2DM) | -41.60 | -53.38 - -29.83 |
Mean difference (final values)-3.3390% CI-21.41 - 14.76p0.3804Mixed Models Analysis
Mean difference (final values)-19.6590% CI-37.44 - -1.87p0.0348Mixed Models Analysis
Mean difference (final values)-32.8090% CI-50.54 - -15.05p0.0014Mixed Models Analysis
Mean difference (final values)-35.8590% CI-53.90 - -17.81p0.0007Mixed Models Analysis
Mean difference (final values)-28.4990% CI-46.60 - -10.37p0.0052Mixed Models Analysis
Secondary/registry result
CFB in Fasting Plasma Glucose at Week 6
Time frame:Baseline, Week 6
concentration, descriptive
Posted result
| Group | Least-squares mean · mg/dL | 95% CI |
|---|---|---|
| Placebo (T2DM) | -3.75 | -19.85 - 12.35 |
| PF-06882961 80 mg BID Low, Slow (T2DM) | -29.33 | -43.35 - -15.31 |
| PF-06882961 80 mg BID High, Slow (T2DM) | -36.70 | -50.13 - -23.27 |
| PF-06882961 120 mg BID Low, Fast (T2DM) | -43.82 | -57.90 - -29.75 |
| PF-06882961 120 mg BID High, Fast (T2DM) | -49.22 | -63.14 - -35.31 |
| PF-06882961 200 mg BID (T2DM) | -37.38 | -51.77 - -22.99 |
Mean difference (final values)-25.5890% CI-46.97 - -4.18p0.0250Mixed Models Analysis
Mean difference (final values)-32.9590% CI-53.95 - -11.95p0.0053Mixed Models Analysis
Mean difference (final values)-40.0790% CI-61.41 - -18.73p0.0012Mixed Models Analysis
Mean difference (final values)-45.4790% CI-66.85 - -24.10p0.0003Mixed Models Analysis
Mean difference (final values)-33.6390% CI-55.19 - -12.08p0.0055Mixed Models Analysis
Secondary/registry result
CFB in Fasting Plasma Glucose at Week 8
Time frame:Baseline, Week 8
concentration, descriptive
Posted result
| Group | Least-squares mean · mg/dL | 95% CI |
|---|---|---|
| Placebo (T2DM) | -5.90 | -20.83 - 9.04 |
| PF-06882961 80 mg BID Low, Slow (T2DM) | -33.69 | -47.42 - -19.96 |
| PF-06882961 80 mg BID High, Slow (T2DM) | -31.57 | -44.56 - -18.58 |
| PF-06882961 120 mg BID Low, Fast (T2DM) | -52.84 | -66.55 - -39.13 |
| PF-06882961 120 mg BID High, Fast (T2DM) | -39.69 | -53.63 - -25.75 |
| PF-06882961 200 mg BID (T2DM) | -48.02 | -62.47 - -33.57 |
Mean difference (final values)-27.7990% CI-48.12 - -7.47p0.0127Mixed Models Analysis
Mean difference (final values)-25.6790% CI-45.51 - -5.83p0.0171Mixed Models Analysis
Mean difference (final values)-46.9490% CI-67.16 - -26.72p0.0001Mixed Models Analysis
Mean difference (final values)-33.7990% CI-54.32 - -13.27p0.0037Mixed Models Analysis
Mean difference (final values)-42.1390% CI-62.85 - -21.40p0.0005Mixed Models Analysis
Secondary/registry result
CFB in Fasting Plasma Glucose at Week 10
Time frame:Baseline, Week 10
concentration, descriptive
Posted result
| Group | Least-squares mean · mg/dL | 95% CI |
|---|---|---|
| Placebo (T2DM) | -23.39 | -39.07 - -7.71 |
| PF-06882961 80 mg BID Low, Slow (T2DM) | -36.24 | -51.69 - -20.78 |
| PF-06882961 80 mg BID High, Slow (T2DM) | -38.21 | -52.17 - -24.26 |
| PF-06882961 120 mg BID Low, Fast (T2DM) | -57.36 | -72.43 - -42.29 |
| PF-06882961 120 mg BID High, Fast (T2DM) | -22.08 | -36.88 - -7.29 |
| PF-06882961 200 mg BID (T2DM) | -37.81 | -53.52 - -22.11 |
Mean difference (final values)-12.8590% CI-34.90 - 9.21p0.1678Mixed Models Analysis
Mean difference (final values)-14.8290% CI-35.85 - 6.21p0.1223Mixed Models Analysis
Mean difference (final values)-33.9790% CI-55.66 - -12.28p0.0054Mixed Models Analysis
Mean difference (final values)1.3190% CI-20.38 - 22.99p0.5398Mixed Models Analysis
Mean difference (final values)-14.4290% CI-36.56 - 7.72p0.1409Mixed Models Analysis
Secondary/registry result
CFB in Fasting Plasma Glucose at Week 12
Time frame:Baseline, Week 12
concentration, descriptive
Posted result
| Group | Least-squares mean · mg/dL | 95% CI |
|---|---|---|
| Placebo (T2DM) | -13.09 | -29.75 - 3.57 |
| PF-06882961 80 mg BID Low, Slow (T2DM) | -41.74 | -58.49 - -25.00 |
| PF-06882961 80 mg BID High, Slow (T2DM) | -40.41 | -55.25 - -25.57 |
| PF-06882961 120 mg BID Low, Fast (T2DM) | -53.94 | -70.26 - -37.63 |
| PF-06882961 120 mg BID High, Fast (T2DM) | -23.34 | -39.52 - -7.17 |
| PF-06882961 200 mg BID (T2DM) | -37.48 | -55.27 - -19.69 |
Mean difference (final values)-28.6590% CI-52.31 - -4.99p0.0236Mixed Models Analysis
Mean difference (final values)-27.3290% CI-49.67 - -4.97p0.0226Mixed Models Analysis
Mean difference (final values)-40.8590% CI-64.11 - -17.59p0.0022Mixed Models Analysis
Mean difference (final values)-10.2590% CI-33.59 - 13.08p0.2335Mixed Models Analysis
Mean difference (final values)-24.3890% CI-48.69 - -0.08p0.0494Mixed Models Analysis
Secondary/registry result
CFB in Glycolated Hemoglobin A1c (HbA1c) at Week 2
Time frame:Baseline, Week 2
descriptive
Posted result
| Group | Least-squares mean · Percentage | 95% CI |
|---|---|---|
| Placebo (T2DM) | -0.03 | -0.20 - 0.14 |
| PF-06882961 80 mg BID Low, Slow (T2DM) | -0.12 | -0.26 - 0.02 |
| PF-06882961 80 mg BID High, Slow (T2DM) | -0.29 | -0.43 - -0.15 |
| PF-06882961 120 mg BID Low, Fast (T2DM) | -0.37 | -0.51 - -0.24 |
| PF-06882961 120 mg BID High, Fast (T2DM) | -0.35 | -0.49 - -0.21 |
| PF-06882961 200 mg BID (T2DM) | -0.20 | -0.34 - -0.05 |
Mean difference (final values)-0.0990% CI-0.31 - 0.13p0.2485Mixed Models Analysis
Mean difference (final values)-0.2690% CI-0.48 - -0.04p0.0252Mixed Models Analysis
Mean difference (final values)-0.3490% CI-0.56 - -0.12p0.0053Mixed Models Analysis
Mean difference (final values)-0.3290% CI-0.54 - -0.10p0.0090Mixed Models Analysis
Mean difference (final values)-0.1790% CI-0.39 - 0.05p0.1066Mixed Models Analysis
Secondary/registry result
CFB in Glycolated HbA1c at Week 4
Time frame:Baseline, Week 4
descriptive
Posted result
| Group | Least-squares mean · Percentage | 95% CI |
|---|---|---|
| Placebo (T2DM) | -0.22 | -0.45 - 0.00 |
| PF-06882961 80 mg BID Low, Slow (T2DM) | -0.33 | -0.52 - -0.14 |
| PF-06882961 80 mg BID High, Slow (T2DM) | -0.59 | -0.77 - -0.41 |
| PF-06882961 120 mg BID Low, Fast (T2DM) | -0.81 | -1.00 - -0.63 |
| PF-06882961 120 mg BID High, Fast (T2DM) | -0.75 | -0.94 - -0.56 |
| PF-06882961 200 mg BID (T2DM) | -0.58 | -0.78 - -0.39 |
Mean difference (final values)-0.1190% CI-0.40 - 0.19p0.2740Mixed Models Analysis
Mean difference (final values)-0.3790% CI-0.66 - -0.08p0.0196Mixed Models Analysis
Mean difference (final values)-0.5990% CI-0.88 - -0.30p0.0006Mixed Models Analysis
Mean difference (final values)-0.5390% CI-0.82 - -0.23p0.0019Mixed Models Analysis
Mean difference (final values)-0.3690% CI-0.66 - -0.06p0.0243Mixed Models Analysis
Secondary/registry result
CFB in Glycolated HbA1c at Week 6
Time frame:Baseline, Week 6
descriptive
Posted result
| Group | Least-squares mean · Percentage | 95% CI |
|---|---|---|
| Placebo (T2DM) | -0.26 | -0.56 - 0.04 |
| PF-06882961 80 mg BID Low, Slow (T2DM) | -0.49 | -0.75 - -0.24 |
| PF-06882961 80 mg BID High, Slow (T2DM) | -0.92 | -1.16 - -0.67 |
| PF-06882961 120 mg BID Low, Fast (T2DM) | -1.11 | -1.36 - -0.86 |
| PF-06882961 120 mg BID High, Fast (T2DM) | -0.97 | -1.22 - -0.72 |
| PF-06882961 200 mg BID (T2DM) | -0.93 | -1.19 - -0.68 |
Mean difference (final values)-0.2390% CI-0.62 - 0.15p0.1587Mixed Models Analysis
Mean difference (final values)-0.6690% CI-1.04 - -0.27p0.0027Mixed Models Analysis
Mean difference (final values)-0.8590% CI-1.24 - -0.47p0.0002Mixed Models Analysis
Mean difference (final values)-0.7190% CI-1.10 - -0.32p0.0016Mixed Models Analysis
Mean difference (final values)-0.6790% CI-1.07 - -0.28p0.0027Mixed Models Analysis
Secondary/registry result
CFB in Glycolated HbA1c at Week 8
Time frame:Baseline, Week 8
descriptive
Posted result
| Group | Least-squares mean · Percentage | 95% CI |
|---|---|---|
| Placebo (T2DM) | -0.27 | -0.60 - 0.05 |
| PF-06882961 80 mg BID Low, Slow (T2DM) | -0.71 | -0.99 - -0.43 |
| PF-06882961 80 mg BID High, Slow (T2DM) | -1.14 | -1.41 - -0.88 |
| PF-06882961 120 mg BID Low, Fast (T2DM) | -1.38 | -1.65 - -1.10 |
| PF-06882961 120 mg BID High, Fast (T2DM) | -1.20 | -1.48 - -0.92 |
| PF-06882961 200 mg BID (T2DM) | -1.18 | -1.47 - -0.89 |
Mean difference (final values)-0.4390% CI-0.86 - -0.01p0.0472Mixed Models Analysis
Mean difference (final values)-0.8790% CI-1.29 - -0.45p0.0004Mixed Models Analysis
Mean difference (final values)-1.1090% CI-1.53 - -0.68p<0.0001Mixed Models Analysis
Mean difference (final values)-0.9390% CI-1.36 - -0.50p0.0003Mixed Models Analysis
Mean difference (final values)-0.9190% CI-1.34 - -0.47p0.0004Mixed Models Analysis
Secondary/registry result
CFB in Glycolated HbA1c at Week 10
Time frame:Baseline, Week 10
descriptive
Posted result
| Group | Least-squares mean · Percentage | 95% CI |
|---|---|---|
| Placebo (T2DM) | -0.32 | -0.69 - 0.05 |
| PF-06882961 80 mg BID Low, Slow (T2DM) | -1.00 | -1.33 - -0.67 |
| PF-06882961 80 mg BID High, Slow (T2DM) | -1.26 | -1.57 - -0.95 |
| PF-06882961 120 mg BID Low, Fast (T2DM) | -1.48 | -1.81 - -1.16 |
| PF-06882961 120 mg BID High, Fast (T2DM) | -1.22 | -1.55 - -0.89 |
| PF-06882961 200 mg BID (T2DM) | -1.36 | -1.70 - -1.03 |
Mean difference (final values)-0.6990% CI-1.18 - -0.19p0.0116Mixed Models Analysis
Mean difference (final values)-0.9490% CI-1.43 - -0.46p0.0008Mixed Models Analysis
Mean difference (final values)-1.1690% CI-1.66 - -0.67p<0.0001Mixed Models Analysis
Mean difference (final values)-0.9090% CI-1.40 - -0.40p0.0017Mixed Models Analysis
Mean difference (final values)-1.0590% CI-1.55 - -0.55p0.0004Mixed Models Analysis
Secondary/registry result
CFB in Glycolated HbA1c at Week 12
Time frame:Baseline, Week 12
descriptive
Posted result
| Group | Least-squares mean · Percentage | 95% CI |
|---|---|---|
| Placebo (T2DM) | -0.32 | -0.73 - 0.10 |
| PF-06882961 80 mg BID Low, Slow (T2DM) | -1.07 | -1.45 - -0.70 |
| PF-06882961 80 mg BID High, Slow (T2DM) | -1.32 | -1.67 - -0.97 |
| PF-06882961 120 mg BID Low, Fast (T2DM) | -1.56 | -1.94 - -1.19 |
| PF-06882961 120 mg BID High, Fast (T2DM) | -1.04 | -1.42 - -0.67 |
| PF-06882961 200 mg BID (T2DM) | -1.57 | -1.96 - -1.18 |
Mean difference (final values)-0.7690% CI-1.32 - -0.20p0.0132Mixed Models Analysis
Mean difference (final values)-1.0090% CI-1.55 - -0.46p0.0014Mixed Models Analysis
Mean difference (final values)-1.2590% CI-1.80 - -0.69p0.0002Mixed Models Analysis
Mean difference (final values)-0.7390% CI-1.29 - -0.16p0.0174Mixed Models Analysis
Mean difference (final values)-1.2590% CI-1.82 - -0.69p0.0002Mixed Models Analysis
Secondary/protocol endpoint
Change From Baseline (CFB) in Fasting Plasma Glucose at Week 2
Time frame:Baseline, Week 2
Fasting glucose, change
change from baseline, improvement
LOINC 1558-6
Secondary/protocol endpoint
CFB in Fasting Plasma Glucose at Week 4
Time frame:Baseline, Week 4
Fasting glucose, change
change from baseline, improvement
LOINC 1558-6
Secondary/protocol endpoint
CFB in Fasting Plasma Glucose at Week 6
Time frame:Baseline, Week 6
Fasting glucose, change
change from baseline, improvement
LOINC 1558-6
Secondary/protocol endpoint
CFB in Fasting Plasma Glucose at Week 8
Time frame:Baseline, Week 8
Fasting glucose, change
change from baseline, improvement
LOINC 1558-6
Secondary/protocol endpoint
CFB in Fasting Plasma Glucose at Week 10
Time frame:Baseline, Week 10
Fasting glucose, change
change from baseline, improvement
LOINC 1558-6
Secondary/protocol endpoint
CFB in Fasting Plasma Glucose at Week 12
Time frame:Baseline, Week 12
Fasting glucose, change
change from baseline, improvement
LOINC 1558-6
Secondary/protocol endpoint
CFB in Glycolated Hemoglobin A1c (HbA1c) at Week 2
Time frame:Baseline, Week 2
HbA1c, change
change from baseline, improvement
LOINC 4548-4
Secondary/protocol endpoint
CFB in Glycolated HbA1c at Week 4
Time frame:Baseline, Week 4
HbA1c, change
change from baseline, improvement
LOINC 4548-4
Secondary/protocol endpoint
CFB in Glycolated HbA1c at Week 6
Time frame:Baseline, Week 6
HbA1c, change
change from baseline, improvement
LOINC 4548-4
Secondary/protocol endpoint
CFB in Glycolated HbA1c at Week 8
Time frame:Baseline, Week 8
HbA1c, change
change from baseline, improvement
LOINC 4548-4
Secondary/protocol endpoint
CFB in Glycolated HbA1c at Week 10
Time frame:Baseline, Week 10
HbA1c, change
change from baseline, improvement
LOINC 4548-4
Secondary/protocol endpoint
CFB in Glycolated HbA1c at Week 12
Time frame:Baseline, Week 12
HbA1c, change
change from baseline, improvement
LOINC 4548-4
Patient-reported / QoL
2 endpointsSecondary/registry result
Number of Participants With Response to Patient Health Questionnaire-9 (PHQ-9)
Time frame:Week 0, 2, 4, 6, 8, 10, 12, 13-14.
event count, event
Posted result
| Group | Participants | 95% CI |
|---|---|---|
| Placebo (T2DM)Week 0 - Little Interest/Pleasure in Things - Not At All | 15 | - |
| Week 0 - Little Interest/Pleasure in Things - Several Days | 1 | - |
| Week 0 - Little Interest/Pleasure in Things - More Than Half the Days | 0 | - |
| Week 0 - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 0 - Feeling Down Depressed or Hopeless - Not At All | 14 | - |
| Week 0 - Feeling Down Depressed or Hopeless - Several Days | 2 | - |
| Week 0 - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 0 - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 0 - Trouble Falling or Staying Asleep - Not At All | 15 | - |
| Week 0 - Trouble Falling or Staying Asleep - Several Days | 1 | - |
| Week 0 - Trouble Falling or Staying Asleep - More Than Half the Days | 0 | - |
| Week 0 - Trouble Falling or Staying Asleep - Nearly Every Day | 0 | - |
| Week 0 - Feeling Tired or Little Energy - Not At All | 13 | - |
| Week 0 - Feeling Tired or Little Energy - Several Days | 3 | - |
| Week 0 - Feeling Tired or Little Energy - More Than Half the Days | 0 | - |
| Week 0 - Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Week 0 - Poor Appetite or Overeating - Not At All | 15 | - |
| Week 0 - Poor Appetite or Overeating - Several Days | 1 | - |
| Week 0 - Poor Appetite or Overeating - More Than Half the Days | 0 | - |
| Week 0 - Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Week 0 - Feeling Bad About Yourself - Not At All | 16 | - |
| Week 0 - Feeling Bad About Yourself - Several Days | 0 | - |
| Week 0 - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 0 - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 0 - Trouble Concentrating on Things - Not At All | 16 | - |
| Week 0 - Trouble Concentrating on Things - Several Days | 0 | - |
| Week 0 - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 0 - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 0 - Moving Slowly or Fidgety/Restless - Not At All | 16 | - |
| Week 0 - Moving Slowly or Fidgety/Restless - Several Days | 0 | - |
| Week 0 - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 0 - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 0 - Thoughts You Be Better Off Dead - Not At All | 16 | - |
| Week 0 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 0 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 0 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Week 2 - Little Interest/Pleasure in Things - Not At All | 13 | - |
| Week 2 - Little Interest/Pleasure in Things - Several Days | 1 | - |
| Week 2 - Little Interest/Pleasure in Things - More Than Half the Days | 0 | - |
| Week 2 - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 2 - Feeling Down Depressed or Hopeless - Not At All | 12 | - |
| Week 2 - Feeling Down Depressed or Hopeless - Several Days | 2 | - |
| Week 2 - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 2 - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 2 - Trouble Falling or Staying Asleep - Not At All | 14 | - |
| Week 2 - Trouble Falling or Staying Asleep - Several Days | 0 | - |
| Week 2 - Trouble Falling or Staying Asleep - More Than Half the Days | 0 | - |
| Week 2 - Trouble Falling or Staying Asleep - Nearly Every Day | 0 | - |
| Week 2 - Feeling Tired or Little Energy - Not At All | 11 | - |
| Week 2 - Feeling Tired or Little Energy - Several Days | 3 | - |
| Week 2 - Feeling Tired or Little Energy - More Than Half the Days | 0 | - |
| Week 2 - Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Week 2 - Poor Appetite or Overeating - Not At All | 12 | - |
| Week 2 - Poor Appetite or Overeating - Several Days | 2 | - |
| Week 2 - Poor Appetite or Overeating - More Than Half the Days | 0 | - |
| Week 2 - Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Week 2 - Feeling Bad About Yourself - Not At All | 14 | - |
| Week 2 - Feeling Bad About Yourself - Several Days | 0 | - |
| Week 2 - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 2 - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 2 - Trouble Concentrating on Things - Not At All | 14 | - |
| Week 2 - Trouble Concentrating on Things - Several Days | 0 | - |
| Week 2 - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 2 - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 2 - Moving Slowly or Fidgety/Restless - Not At All | 14 | - |
| Week 2 - Moving Slowly or Fidgety/Restless - Several Days | 0 | - |
| Week 2 - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 2 - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 2 - Thoughts You Be Better Off Dead - Not At All | 14 | - |
| Week 2 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 2 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 2 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Week 4 - Little Interest/Pleasure in Things - Not At All | 12 | - |
| Week 4 - Little Interest/Pleasure in Things - Several Days | 2 | - |
| Week 4 - Little Interest/Pleasure in Things - More Than Half the Days | 0 | - |
| Week 4 - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 4 -Feeling Down Depressed or Hopeless - Not At All | 13 | - |
| Week 4 - Feeling Down Depressed or Hopeless - Several Days | 1 | - |
| Week 4 - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 4 - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 4 - Trouble Falling or Staying Asleep - Not At All | 13 | - |
| Week 4 - Trouble Falling or Staying Asleep - Several Days | 1 | - |
| Week 4 - Trouble Falling or Staying Asleep - More Than Half the Days | 0 | - |
| Week 4 - Trouble Falling or Staying Asleep - Nearly Every Day | 0 | - |
| Week 4 - Feeling Tired or Little Energy - Not At All | 11 | - |
| Week 4 - Feeling Tired or Little Energy - Several Days | 3 | - |
| Week 4 - Feeling Tired or Little Energy - More Than Half the Days | 0 | - |
| Week 4 - Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Week 4 - Poor Appetite or Overeating - Not At All | 11 | - |
| Week 4 - Poor Appetite or Overeating - Several Days | 3 | - |
| Week 4 - Poor Appetite or Overeating - More Than Half the Days | 0 | - |
| Week 4 - Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Week 4 - Feeling Bad About Yourself - Not At All | 14 | - |
| Week 4 - Feeling Bad About Yourself - Several Days | 0 | - |
| Week 4 - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 4 - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 4 - Trouble Concentrating on Things - Not At All | 13 | - |
| Week 4 - Trouble Concentrating on Things - Several Days | 1 | - |
| Week 4 - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 4 - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 4 - Moving Slowly or Fidgety/Restless - Not At All | 14 | - |
| Week 4 - Moving Slowly or Fidgety/Restless - Several Days | 0 | - |
| Week 4 - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 4 - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 4 - Thoughts You Be Better Off Dead - Not At All | 14 | - |
| Week 4 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 4 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 4 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Week 6 -Little Interest/Pleasure in Things - Not At All | 12 | - |
| Week 6 -Little Interest/Pleasure in Things - Several Days | 2 | - |
| Week 6 -Little Interest/Pleasure in Things - More Than Half the Days | 0 | - |
| Week 6 -Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 6 -Feeling Down Depressed or Hopeless - Not At All | 12 | - |
| Week 6 -Feeling Down Depressed or Hopeless - Several Days | 2 | - |
| Week 6 -Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 6 -Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 6 -Trouble Falling or Staying Asleep - Not At All | 12 | - |
| Week 6 -Trouble Falling or Staying Asleep - Several Days | 1 | - |
| Week 6 -Trouble Falling or Staying Asleep - More Than Half the Days | 1 | - |
| Week 6 -Trouble Falling or Staying Asleep - Nearly Every Day | 0 | - |
| Week 6 -Feeling Tired or Little Energy - Not At All | 12 | - |
| Week 6 -Feeling Tired or Little Energy - Several Days | 2 | - |
| Week 6 -Feeling Tired or Little Energy - More Than Half the Days | 0 | - |
| Week 6 -Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Week 6 -Poor Appetite or Overeating - Not At All | 12 | - |
| Week 6 -Poor Appetite or Overeating - Several Days | 2 | - |
| Week 6 -Poor Appetite or Overeating - More Than Half the Days | 0 | - |
| Week 6 -Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Week 6 -Feeling Bad About Yourself - Not At All | 14 | - |
| Week 6 -Feeling Bad About Yourself - Several Days | 0 | - |
| Week 6 -Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 6 -Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 6 -Trouble Concentrating on Things - Not At All | 13 | - |
| Week 6 -Trouble Concentrating on Things - Several Days | 1 | - |
| Week 6 -Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 6 -Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 6 -Moving Slowly or Fidgety/Restless - Not At All | 14 | - |
| Week 6 -Moving Slowly or Fidgety/Restless - Several Days | 0 | - |
| Week 6 -Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 6 -Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 6 - Thoughts You Be Better Off Dead - Not At All | 14 | - |
| Week 6 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 6 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 6 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Week 8 - Little Interest/Pleasure in Things - Not At All | 13 | - |
| Week 8 - Little Interest/Pleasure in Things - Several Days | 1 | - |
| Week 8 - Little Interest/Pleasure in Things - More Than Half the Days | 0 | - |
| Week 8 - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 8 - Feeling Down Depressed or Hopeless - Not At All | 14 | - |
| Week 8 - Feeling Down Depressed or Hopeless - Several Days | 0 | - |
| Week 8 - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 8 - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 8 - Trouble Falling or Staying Asleep - Not At All | 13 | - |
| Week 8 - Trouble Falling or Staying Asleep - Several Days | 1 | - |
| Week 8 - Trouble Falling or Staying Asleep - More Than Half the Days | 0 | - |
| Week 8 - Trouble Falling or Staying Asleep - Nearly Every Day | 0 | - |
| Week 8 - Feeling Tired or Little Energy - Not At All | 11 | - |
| Week 8 - Feeling Tired or Little Energy - Several Days | 3 | - |
| Week 8 - Feeling Tired or Little Energy - More Than Half the Days | 0 | - |
| Week 8 - Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Week 8 - Poor Appetite or Overeating - Not At All | 11 | - |
| Week 8 - Poor Appetite or Overeating - Several Days | 3 | - |
| Week 8 - Poor Appetite or Overeating - More Than Half the Days | 0 | - |
| Week 8 - Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Week 8 - Feeling Bad About Yourself - Not At All | 14 | - |
| Week 8 - Feeling Bad About Yourself - Several Days | 0 | - |
| Week 8 - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 8 - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 8 - Trouble Concentrating on Things - Not At All | 13 | - |
| Week 8 - Trouble Concentrating on Things - Several Days | 1 | - |
| Week 8 - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 8 - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 8 - Moving Slowly or Fidgety/Restless - Not At All | 14 | - |
| Week 8 - Moving Slowly or Fidgety/Restless - Several Days | 0 | - |
| Week 8 - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 8 - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 8 - Thoughts You Be Better Off Dead - Not At All | 14 | - |
| Week 8 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 8 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 8 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Week 10 - Little Interest/Pleasure in Things - Not At All | 13 | - |
| Week 10 - Little Interest/Pleasure in Things - Several Days | 1 | - |
| Week 10 - Little Interest/Pleasure in Things - More Than Half the Days | 0 | - |
| Week 10 - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 10 - Feeling Down Depressed or Hopeless - Not At All | 13 | - |
| Week 10 - Feeling Down Depressed or Hopeless - Several Days | 1 | - |
| Week 10 - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 10 - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 10 - Trouble Falling or Staying Asleep - Not At All | 13 | - |
| Week 10 - Trouble Falling or Staying Asleep - Several Days | 1 | - |
| Week 10 - Trouble Falling or Staying Asleep - More Than Half the Days | 0 | - |
| Week 10 - Trouble Falling or Staying Asleep - Nearly Every Day | 0 | - |
| Week 10 - Feeling Tired or Little Energy - Not At All | 11 | - |
| Week 10 - Feeling Tired or Little Energy - Several Days | 3 | - |
| Week 10 - Feeling Tired or Little Energy - More Than Half the Days | 0 | - |
| Week 10 - Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Week 10 - Poor Appetite or Overeating - Not At All | 10 | - |
| Week 10 - Poor Appetite or Overeating - Several Days | 4 | - |
| Week 10 - Poor Appetite or Overeating - More Than Half the Days | 0 | - |
| Week 10 - Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Week 10 - Feeling Bad About Yourself - Not At All | 14 | - |
| Week 10 - Feeling Bad About Yourself - Several Days | 0 | - |
| Week 10 - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 10 - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 10 - Trouble Concentrating on Things - Not At All | 13 | - |
| Week 10 - Trouble Concentrating on Things - Several Days | 1 | - |
| Week 10 - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 10 - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 10 - Moving Slowly or Fidgety/Restless - Not At All | 14 | - |
| Week 10 - Moving Slowly or Fidgety/Restless - Several Days | 0 | - |
| Week 10 - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 10 - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 10 - Thoughts You Be Better Off Dead - Not At All | 14 | - |
| Week 10 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 10 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 10 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Week 12 - Little Interest/Pleasure in Things - Not At All | 11 | - |
| Week 12 - Little Interest/Pleasure in Things - Several Days | 2 | - |
| Week 12 - Little Interest/Pleasure in Things - More Than Half the Days | 0 | - |
| Week 12 - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 12 - Feeling Down Depressed or Hopeless - Not At All | 11 | - |
| Week 12 - Feeling Down Depressed or Hopeless - Several Days | 2 | - |
| Week 12 - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 12 - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 12 - Trouble Falling or Staying Asleep - Not At All | 11 | - |
| Week 12 - Trouble Falling or Staying Asleep - Several Days | 2 | - |
| Week 12 - Trouble Falling or Staying Asleep - More Than Half the Days | 0 | - |
| Week 12 - Trouble Falling or Staying Asleep - Nearly Every Day | 0 | - |
| Week 12 - Feeling Tired or Little Energy - Not At All | 10 | - |
| Week 12 - Feeling Tired or Little Energy - Several Days | 3 | - |
| Week 12 - Feeling Tired or Little Energy - More Than Half the Days | 0 | - |
| Week 12 - Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Week 12 - Poor Appetite or Overeating - Not At All | 10 | - |
| Week 12 - Poor Appetite or Overeating - Several Days | 3 | - |
| Week 12 - Poor Appetite or Overeating - More Than Half the Days | 0 | - |
| Week 12 - Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Week 12 - Feeling Bad About Yourself - Not At All | 13 | - |
| Week 12 - Feeling Bad About Yourself - Several Days | 0 | - |
| Week 12 - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 12 - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 12 - Trouble Concentrating on Things - Not At All | 11 | - |
| Week 12 - Trouble Concentrating on Things - Several Days | 2 | - |
| Week 12 - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 12 - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 12 - Moving Slowly or Fidgety/Restless - Not At All | 12 | - |
| Week 12 - Moving Slowly or Fidgety/Restless - Several Days | 1 | - |
| Week 12 - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 12 - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 12 - Thoughts You Be Better Off Dead - Not At All | 13 | - |
| Week 12 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 12 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 12 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Follow-Up - Little Interest/Pleasure in Things - Not At All | 11 | - |
| Follow-Up - Little Interest/Pleasure in Things - Several Days | 2 | - |
| Follow-Up - Little Interest/Pleasure in Things - More Than Half the Days | 0 | - |
| Follow-Up - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Follow-Up - Feeling Down Depressed or Hopeless - Not At All | 13 | - |
| Follow-Up - Feeling Down Depressed or Hopeless - Several Days | 0 | - |
| Follow-Up - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Follow-Up - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Follow-Up - Trouble Falling or Staying Asleep - Not At All | 12 | - |
| Follow-Up - Trouble Falling or Staying Asleep - Several Days | 0 | - |
| Follow-Up - Trouble Falling or Staying Asleep - More Than Half the Days | 1 | - |
| Follow-Up - Trouble Falling or Staying Asleep - Nearly Every Day | 0 | - |
| Follow-Up - Feeling Tired or Little Energy - Not At All | 11 | - |
| Follow-Up - Feeling Tired or Little Energy - Several Days | 2 | - |
| Follow-Up - Feeling Tired or Little Energy - More Than Half the Days | 0 | - |
| Follow-Up - Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Follow-Up - Poor Appetite or Overeating - Not At All | 11 | - |
| Follow-Up - Poor Appetite or Overeating - Several Days | 2 | - |
| Follow-Up - Poor Appetite or Overeating - More Than Half the Days | 0 | - |
| Follow-Up - Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Follow-Up - Feeling Bad About Yourself - Not At All | 13 | - |
| Follow-Up - Feeling Bad About Yourself - Several Days | 0 | - |
| Follow-Up - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Follow-Up - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Follow-Up - Trouble Concentrating on Things - Not At All | 12 | - |
| Follow-Up - Trouble Concentrating on Things - Several Days | 1 | - |
| Follow-Up - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Follow-Up - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Follow-Up - Moving Slowly or Fidgety/Restless - Not At All | 12 | - |
| Follow-Up - Moving Slowly or Fidgety/Restless - Several Days | 1 | - |
| Follow-Up - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Follow-Up - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Follow-Up - Thoughts You Be Better Off Dead - Not At All | 13 | - |
| Follow-Up - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Follow-Up - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Follow-Up - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Placebo (Non-diabetic Obesity)Week 0 - Little Interest/Pleasure in Things - Not At All | 6 | - |
| Week 0 - Little Interest/Pleasure in Things - Several Days | 0 | - |
| Week 0 - Little Interest/Pleasure in Things - More Than Half the Days | 0 | - |
| Week 0 - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 0 - Feeling Down Depressed or Hopeless - Not At All | 6 | - |
| Week 0 - Feeling Down Depressed or Hopeless - Several Days | 0 | - |
| Week 0 - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 0 - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 0 - Trouble Falling or Staying Asleep - Not At All | 5 | - |
| Week 0 - Trouble Falling or Staying Asleep - Several Days | 0 | - |
| Week 0 - Trouble Falling or Staying Asleep - More Than Half the Days | 1 | - |
| Week 0 - Trouble Falling or Staying Asleep - Nearly Every Day | 0 | - |
| Week 0 - Feeling Tired or Little Energy - Not At All | 3 | - |
| Week 0 - Feeling Tired or Little Energy - Several Days | 2 | - |
| Week 0 - Feeling Tired or Little Energy - More Than Half the Days | 1 | - |
| Week 0 - Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Week 0 - Poor Appetite or Overeating - Not At All | 3 | - |
| Week 0 - Poor Appetite or Overeating - Several Days | 2 | - |
| Week 0 - Poor Appetite or Overeating - More Than Half the Days | 1 | - |
| Week 0 - Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Week 0 - Feeling Bad About Yourself - Not At All | 6 | - |
| Week 0 - Feeling Bad About Yourself - Several Days | 0 | - |
| Week 0 - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 0 - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 0 - Trouble Concentrating on Things - Not At All | 5 | - |
| Week 0 - Trouble Concentrating on Things - Several Days | 1 | - |
| Week 0 - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 0 - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 0 - Moving Slowly or Fidgety/Restless - Not At All | 6 | - |
| Week 0 - Moving Slowly or Fidgety/Restless - Several Days | 0 | - |
| Week 0 - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 0 - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 0 - Thoughts You Be Better Off Dead - Not At All | 6 | - |
| Week 0 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 0 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 0 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Week 2 - Little Interest/Pleasure in Things - Not At All | 5 | - |
| Week 2 - Little Interest/Pleasure in Things - Several Days | 1 | - |
| Week 2 - Little Interest/Pleasure in Things - More Than Half the Days | 0 | - |
| Week 2 - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 2 - Feeling Down Depressed or Hopeless - Not At All | 6 | - |
| Week 2 - Feeling Down Depressed or Hopeless - Several Days | 0 | - |
| Week 2 - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 2 - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 2 - Trouble Falling or Staying Asleep - Not At All | 4 | - |
| Week 2 - Trouble Falling or Staying Asleep - Several Days | 1 | - |
| Week 2 - Trouble Falling or Staying Asleep - More Than Half the Days | 1 | - |
| Week 2 - Trouble Falling or Staying Asleep - Nearly Every Day | 0 | - |
| Week 2 - Feeling Tired or Little Energy - Not At All | 3 | - |
| Week 2 - Feeling Tired or Little Energy - Several Days | 2 | - |
| Week 2 - Feeling Tired or Little Energy - More Than Half the Days | 1 | - |
| Week 2 - Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Week 2 - Poor Appetite or Overeating - Not At All | 2 | - |
| Week 2 - Poor Appetite or Overeating - Several Days | 3 | - |
| Week 2 - Poor Appetite or Overeating - More Than Half the Days | 1 | - |
| Week 2 - Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Week 2 - Feeling Bad About Yourself - Not At All | 6 | - |
| Week 2 - Feeling Bad About Yourself - Several Days | 0 | - |
| Week 2 - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 2 - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 2 - Trouble Concentrating on Things - Not At All | 5 | - |
| Week 2 - Trouble Concentrating on Things - Several Days | 0 | - |
| Week 2 - Trouble Concentrating on Things - More Than Half the Days | 1 | - |
| Week 2 - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 2 - Moving Slowly or Fidgety/Restless - Not At All | 5 | - |
| Week 2 - Moving Slowly or Fidgety/Restless - Several Days | 0 | - |
| Week 2 - Moving Slowly or Fidgety/Restless - More Than Half the Days | 1 | - |
| Week 2 - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 2 - Thoughts You Be Better Off Dead - Not At All | 6 | - |
| Week 2 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 2 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 2 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Week 4 - Little Interest/Pleasure in Things - Not At All | 4 | - |
| Week 4 - Little Interest/Pleasure in Things - Several Days | 0 | - |
| Week 4 - Little Interest/Pleasure in Things - More Than Half the Days | 1 | - |
| Week 4 - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 4 -Feeling Down Depressed or Hopeless - Not At All | 5 | - |
| Week 4 - Feeling Down Depressed or Hopeless - Several Days | 0 | - |
| Week 4 - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 4 - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 4 - Trouble Falling or Staying Asleep - Not At All | 3 | - |
| Week 4 - Trouble Falling or Staying Asleep - Several Days | 1 | - |
| Week 4 - Trouble Falling or Staying Asleep - More Than Half the Days | 0 | - |
| Week 4 - Trouble Falling or Staying Asleep - Nearly Every Day | 1 | - |
| Week 4 - Feeling Tired or Little Energy - Not At All | 2 | - |
| Week 4 - Feeling Tired or Little Energy - Several Days | 1 | - |
| Week 4 - Feeling Tired or Little Energy - More Than Half the Days | 2 | - |
| Week 4 - Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Week 4 - Poor Appetite or Overeating - Not At All | 3 | - |
| Week 4 - Poor Appetite or Overeating - Several Days | 2 | - |
| Week 4 - Poor Appetite or Overeating - More Than Half the Days | 0 | - |
| Week 4 - Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Week 4 - Feeling Bad About Yourself - Not At All | 5 | - |
| Week 4 - Feeling Bad About Yourself - Several Days | 0 | - |
| Week 4 - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 4 - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 4 - Trouble Concentrating on Things - Not At All | 4 | - |
| Week 4 - Trouble Concentrating on Things - Several Days | 1 | - |
| Week 4 - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 4 - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 4 - Moving Slowly or Fidgety/Restless - Not At All | 4 | - |
| Week 4 - Moving Slowly or Fidgety/Restless - Several Days | 1 | - |
| Week 4 - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 4 - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 4 - Thoughts You Be Better Off Dead - Not At All | 5 | - |
| Week 4 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 4 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 4 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Week 6 -Little Interest/Pleasure in Things - Not At All | 4 | - |
| Week 6 -Little Interest/Pleasure in Things - Several Days | 1 | - |
| Week 6 -Little Interest/Pleasure in Things - More Than Half the Days | 0 | - |
| Week 6 -Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 6 -Feeling Down Depressed or Hopeless - Not At All | 5 | - |
| Week 6 -Feeling Down Depressed or Hopeless - Several Days | 0 | - |
| Week 6 -Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 6 -Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 6 -Trouble Falling or Staying Asleep - Not At All | 4 | - |
| Week 6 -Trouble Falling or Staying Asleep - Several Days | 0 | - |
| Week 6 -Trouble Falling or Staying Asleep - More Than Half the Days | 1 | - |
| Week 6 -Trouble Falling or Staying Asleep - Nearly Every Day | 0 | - |
| Week 6 -Feeling Tired or Little Energy - Not At All | 2 | - |
| Week 6 -Feeling Tired or Little Energy - Several Days | 2 | - |
| Week 6 -Feeling Tired or Little Energy - More Than Half the Days | 1 | - |
| Week 6 -Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Week 6 -Poor Appetite or Overeating - Not At All | 2 | - |
| Week 6 -Poor Appetite or Overeating - Several Days | 2 | - |
| Week 6 -Poor Appetite or Overeating - More Than Half the Days | 1 | - |
| Week 6 -Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Week 6 -Feeling Bad About Yourself - Not At All | 5 | - |
| Week 6 -Feeling Bad About Yourself - Several Days | 0 | - |
| Week 6 -Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 6 -Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 6 -Trouble Concentrating on Things - Not At All | 4 | - |
| Week 6 -Trouble Concentrating on Things - Several Days | 1 | - |
| Week 6 -Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 6 -Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 6 -Moving Slowly or Fidgety/Restless - Not At All | 5 | - |
| Week 6 -Moving Slowly or Fidgety/Restless - Several Days | 0 | - |
| Week 6 -Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 6 -Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 6 - Thoughts You Be Better Off Dead - Not At All | 5 | - |
| Week 6 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 6 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 6 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Week 8 - Little Interest/Pleasure in Things - Not At All | 5 | - |
| Week 8 - Little Interest/Pleasure in Things - Several Days | 0 | - |
| Week 8 - Little Interest/Pleasure in Things - More Than Half the Days | 0 | - |
| Week 8 - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 8 - Feeling Down Depressed or Hopeless - Not At All | 5 | - |
| Week 8 - Feeling Down Depressed or Hopeless - Several Days | 0 | - |
| Week 8 - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 8 - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 8 - Trouble Falling or Staying Asleep - Not At All | 3 | - |
| Week 8 - Trouble Falling or Staying Asleep - Several Days | 1 | - |
| Week 8 - Trouble Falling or Staying Asleep - More Than Half the Days | 1 | - |
| Week 8 - Trouble Falling or Staying Asleep - Nearly Every Day | 0 | - |
| Week 8 - Feeling Tired or Little Energy - Not At All | 3 | - |
| Week 8 - Feeling Tired or Little Energy - Several Days | 2 | - |
| Week 8 - Feeling Tired or Little Energy - More Than Half the Days | 0 | - |
| Week 8 - Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Week 8 - Poor Appetite or Overeating - Not At All | 2 | - |
| Week 8 - Poor Appetite or Overeating - Several Days | 2 | - |
| Week 8 - Poor Appetite or Overeating - More Than Half the Days | 1 | - |
| Week 8 - Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Week 8 - Feeling Bad About Yourself - Not At All | 5 | - |
| Week 8 - Feeling Bad About Yourself - Several Days | 0 | - |
| Week 8 - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 8 - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 8 - Trouble Concentrating on Things - Not At All | 4 | - |
| Week 8 - Trouble Concentrating on Things - Several Days | 1 | - |
| Week 8 - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 8 - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 8 - Moving Slowly or Fidgety/Restless - Not At All | 5 | - |
| Week 8 - Moving Slowly or Fidgety/Restless - Several Days | 0 | - |
| Week 8 - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 8 - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 8 - Thoughts You Be Better Off Dead - Not At All | 5 | - |
| Week 8 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 8 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 8 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Week 10 - Little Interest/Pleasure in Things - Not At All | 5 | - |
| Week 10 - Little Interest/Pleasure in Things - Several Days | 0 | - |
| Week 10 - Little Interest/Pleasure in Things - More Than Half the Days | 0 | - |
| Week 10 - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 10 - Feeling Down Depressed or Hopeless - Not At All | 5 | - |
| Week 10 - Feeling Down Depressed or Hopeless - Several Days | 0 | - |
| Week 10 - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 10 - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 10 - Trouble Falling or Staying Asleep - Not At All | 3 | - |
| Week 10 - Trouble Falling or Staying Asleep - Several Days | 1 | - |
| Week 10 - Trouble Falling or Staying Asleep - More Than Half the Days | 1 | - |
| Week 10 - Trouble Falling or Staying Asleep - Nearly Every Day | 0 | - |
| Week 10 - Feeling Tired or Little Energy - Not At All | 2 | - |
| Week 10 - Feeling Tired or Little Energy - Several Days | 2 | - |
| Week 10 - Feeling Tired or Little Energy - More Than Half the Days | 1 | - |
| Week 10 - Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Week 10 - Poor Appetite or Overeating - Not At All | 2 | - |
| Week 10 - Poor Appetite or Overeating - Several Days | 3 | - |
| Week 10 - Poor Appetite or Overeating - More Than Half the Days | 0 | - |
| Week 10 - Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Week 10 - Feeling Bad About Yourself - Not At All | 5 | - |
| Week 10 - Feeling Bad About Yourself - Several Days | 0 | - |
| Week 10 - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 10 - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 10 - Trouble Concentrating on Things - Not At All | 5 | - |
| Week 10 - Trouble Concentrating on Things - Several Days | 0 | - |
| Week 10 - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 10 - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 10 - Moving Slowly or Fidgety/Restless - Not At All | 5 | - |
| Week 10 - Moving Slowly or Fidgety/Restless - Several Days | 0 | - |
| Week 10 - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 10 - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 10 - Thoughts You Be Better Off Dead - Not At All | 5 | - |
| Week 10 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 10 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 10 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Week 12 - Little Interest/Pleasure in Things - Not At All | 5 | - |
| Week 12 - Little Interest/Pleasure in Things - Several Days | 0 | - |
| Week 12 - Little Interest/Pleasure in Things - More Than Half the Days | 0 | - |
| Week 12 - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 12 - Feeling Down Depressed or Hopeless - Not At All | 5 | - |
| Week 12 - Feeling Down Depressed or Hopeless - Several Days | 0 | - |
| Week 12 - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 12 - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 12 - Trouble Falling or Staying Asleep - Not At All | 3 | - |
| Week 12 - Trouble Falling or Staying Asleep - Several Days | 2 | - |
| Week 12 - Trouble Falling or Staying Asleep - More Than Half the Days | 0 | - |
| Week 12 - Trouble Falling or Staying Asleep - Nearly Every Day | 0 | - |
| Week 12 - Feeling Tired or Little Energy - Not At All | 3 | - |
| Week 12 - Feeling Tired or Little Energy - Several Days | 2 | - |
| Week 12 - Feeling Tired or Little Energy - More Than Half the Days | 0 | - |
| Week 12 - Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Week 12 - Poor Appetite or Overeating - Not At All | 2 | - |
| Week 12 - Poor Appetite or Overeating - Several Days | 3 | - |
| Week 12 - Poor Appetite or Overeating - More Than Half the Days | 0 | - |
| Week 12 - Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Week 12 - Feeling Bad About Yourself - Not At All | 5 | - |
| Week 12 - Feeling Bad About Yourself - Several Days | 0 | - |
| Week 12 - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 12 - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 12 - Trouble Concentrating on Things - Not At All | 5 | - |
| Week 12 - Trouble Concentrating on Things - Several Days | 0 | - |
| Week 12 - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 12 - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 12 - Moving Slowly or Fidgety/Restless - Not At All | 5 | - |
| Week 12 - Moving Slowly or Fidgety/Restless - Several Days | 0 | - |
| Week 12 - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 12 - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 12 - Thoughts You Be Better Off Dead - Not At All | 5 | - |
| Week 12 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 12 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 12 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Follow-Up - Little Interest/Pleasure in Things - Not At All | 5 | - |
| Follow-Up - Little Interest/Pleasure in Things - Several Days | 0 | - |
| Follow-Up - Little Interest/Pleasure in Things - More Than Half the Days | 0 | - |
| Follow-Up - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Follow-Up - Feeling Down Depressed or Hopeless - Not At All | 5 | - |
| Follow-Up - Feeling Down Depressed or Hopeless - Several Days | 0 | - |
| Follow-Up - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Follow-Up - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Follow-Up - Trouble Falling or Staying Asleep - Not At All | 4 | - |
| Follow-Up - Trouble Falling or Staying Asleep - Several Days | 1 | - |
| Follow-Up - Trouble Falling or Staying Asleep - More Than Half the Days | 0 | - |
| Follow-Up - Trouble Falling or Staying Asleep - Nearly Every Day | 0 | - |
| Follow-Up - Feeling Tired or Little Energy - Not At All | 2 | - |
| Follow-Up - Feeling Tired or Little Energy - Several Days | 3 | - |
| Follow-Up - Feeling Tired or Little Energy - More Than Half the Days | 0 | - |
| Follow-Up - Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Follow-Up - Poor Appetite or Overeating - Not At All | 3 | - |
| Follow-Up - Poor Appetite or Overeating - Several Days | 2 | - |
| Follow-Up - Poor Appetite or Overeating - More Than Half the Days | 0 | - |
| Follow-Up - Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Follow-Up - Feeling Bad About Yourself - Not At All | 5 | - |
| Follow-Up - Feeling Bad About Yourself - Several Days | 0 | - |
| Follow-Up - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Follow-Up - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Follow-Up - Trouble Concentrating on Things - Not At All | 5 | - |
| Follow-Up - Trouble Concentrating on Things - Several Days | 0 | - |
| Follow-Up - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Follow-Up - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Follow-Up - Moving Slowly or Fidgety/Restless - Not At All | 5 | - |
| Follow-Up - Moving Slowly or Fidgety/Restless - Several Days | 0 | - |
| Follow-Up - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Follow-Up - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Follow-Up - Thoughts You Be Better Off Dead - Not At All | 5 | - |
| Follow-Up - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Follow-Up - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Follow-Up - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| PF-06882961 80 mg BID Low, Slow (T2DM)Week 0 - Little Interest/Pleasure in Things - Not At All | 16 | - |
| Week 0 - Little Interest/Pleasure in Things - Several Days | 3 | - |
| Week 0 - Little Interest/Pleasure in Things - More Than Half the Days | 1 | - |
| Week 0 - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 0 - Feeling Down Depressed or Hopeless - Not At All | 19 | - |
| Week 0 - Feeling Down Depressed or Hopeless - Several Days | 1 | - |
| Week 0 - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 0 - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 0 - Trouble Falling or Staying Asleep - Not At All | 13 | - |
| Week 0 - Trouble Falling or Staying Asleep - Several Days | 5 | - |
| Week 0 - Trouble Falling or Staying Asleep - More Than Half the Days | 2 | - |
| Week 0 - Trouble Falling or Staying Asleep - Nearly Every Day | 0 | - |
| Week 0 - Feeling Tired or Little Energy - Not At All | 13 | - |
| Week 0 - Feeling Tired or Little Energy - Several Days | 5 | - |
| Week 0 - Feeling Tired or Little Energy - More Than Half the Days | 2 | - |
| Week 0 - Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Week 0 - Poor Appetite or Overeating - Not At All | 13 | - |
| Week 0 - Poor Appetite or Overeating - Several Days | 6 | - |
| Week 0 - Poor Appetite or Overeating - More Than Half the Days | 1 | - |
| Week 0 - Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Week 0 - Feeling Bad About Yourself - Not At All | 20 | - |
| Week 0 - Feeling Bad About Yourself - Several Days | 0 | - |
| Week 0 - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 0 - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 0 - Trouble Concentrating on Things - Not At All | 16 | - |
| Week 0 - Trouble Concentrating on Things - Several Days | 3 | - |
| Week 0 - Trouble Concentrating on Things - More Than Half the Days | 1 | - |
| Week 0 - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 0 - Moving Slowly or Fidgety/Restless - Not At All | 19 | - |
| Week 0 - Moving Slowly or Fidgety/Restless - Several Days | 1 | - |
| Week 0 - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 0 - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 0 - Thoughts You Be Better Off Dead - Not At All | 20 | - |
| Week 0 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 0 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 0 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Week 2 - Little Interest/Pleasure in Things - Not At All | 16 | - |
| Week 2 - Little Interest/Pleasure in Things - Several Days | 4 | - |
| Week 2 - Little Interest/Pleasure in Things - More Than Half the Days | 0 | - |
| Week 2 - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 2 - Feeling Down Depressed or Hopeless - Not At All | 18 | - |
| Week 2 - Feeling Down Depressed or Hopeless - Several Days | 2 | - |
| Week 2 - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 2 - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 2 - Trouble Falling or Staying Asleep - Not At All | 14 | - |
| Week 2 - Trouble Falling or Staying Asleep - Several Days | 5 | - |
| Week 2 - Trouble Falling or Staying Asleep - More Than Half the Days | 1 | - |
| Week 2 - Trouble Falling or Staying Asleep - Nearly Every Day | 0 | - |
| Week 2 - Feeling Tired or Little Energy - Not At All | 13 | - |
| Week 2 - Feeling Tired or Little Energy - Several Days | 6 | - |
| Week 2 - Feeling Tired or Little Energy - More Than Half the Days | 0 | - |
| Week 2 - Feeling Tired or Little Energy - Nearly Every Day | 1 | - |
| Week 2 - Poor Appetite or Overeating - Not At All | 15 | - |
| Week 2 - Poor Appetite or Overeating - Several Days | 4 | - |
| Week 2 - Poor Appetite or Overeating - More Than Half the Days | 0 | - |
| Week 2 - Poor Appetite or Overeating - Nearly Every Day | 1 | - |
| Week 2 - Feeling Bad About Yourself - Not At All | 18 | - |
| Week 2 - Feeling Bad About Yourself - Several Days | 1 | - |
| Week 2 - Feeling Bad About Yourself - More Than Half the Days | 1 | - |
| Week 2 - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 2 - Trouble Concentrating on Things - Not At All | 17 | - |
| Week 2 - Trouble Concentrating on Things - Several Days | 2 | - |
| Week 2 - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 2 - Trouble Concentrating on Things - Nearly Every Day | 1 | - |
| Week 2 - Moving Slowly or Fidgety/Restless - Not At All | 19 | - |
| Week 2 - Moving Slowly or Fidgety/Restless - Several Days | 0 | - |
| Week 2 - Moving Slowly or Fidgety/Restless - More Than Half the Days | 1 | - |
| Week 2 - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 2 - Thoughts You Be Better Off Dead - Not At All | 20 | - |
| Week 2 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 2 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 2 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Week 4 - Little Interest/Pleasure in Things - Not At All | 16 | - |
| Week 4 - Little Interest/Pleasure in Things - Several Days | 3 | - |
| Week 4 - Little Interest/Pleasure in Things - More Than Half the Days | 0 | - |
| Week 4 - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 4 -Feeling Down Depressed or Hopeless - Not At All | 18 | - |
| Week 4 - Feeling Down Depressed or Hopeless - Several Days | 1 | - |
| Week 4 - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 4 - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 4 - Trouble Falling or Staying Asleep - Not At All | 11 | - |
| Week 4 - Trouble Falling or Staying Asleep - Several Days | 8 | - |
| Week 4 - Trouble Falling or Staying Asleep - More Than Half the Days | 0 | - |
| Week 4 - Trouble Falling or Staying Asleep - Nearly Every Day | 0 | - |
| Week 4 - Feeling Tired or Little Energy - Not At All | 10 | - |
| Week 4 - Feeling Tired or Little Energy - Several Days | 8 | - |
| Week 4 - Feeling Tired or Little Energy - More Than Half the Days | 1 | - |
| Week 4 - Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Week 4 - Poor Appetite or Overeating - Not At All | 14 | - |
| Week 4 - Poor Appetite or Overeating - Several Days | 3 | - |
| Week 4 - Poor Appetite or Overeating - More Than Half the Days | 1 | - |
| Week 4 - Poor Appetite or Overeating - Nearly Every Day | 1 | - |
| Week 4 - Feeling Bad About Yourself - Not At All | 19 | - |
| Week 4 - Feeling Bad About Yourself - Several Days | 0 | - |
| Week 4 - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 4 - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 4 - Trouble Concentrating on Things - Not At All | 16 | - |
| Week 4 - Trouble Concentrating on Things - Several Days | 3 | - |
| Week 4 - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 4 - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 4 - Moving Slowly or Fidgety/Restless - Not At All | 18 | - |
| Week 4 - Moving Slowly or Fidgety/Restless - Several Days | 1 | - |
| Week 4 - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 4 - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 4 - Thoughts You Be Better Off Dead - Not At All | 19 | - |
| Week 4 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 4 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 4 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Week 6 -Little Interest/Pleasure in Things - Not At All | 15 | - |
| Week 6 -Little Interest/Pleasure in Things - Several Days | 4 | - |
| Week 6 -Little Interest/Pleasure in Things - More Than Half the Days | 0 | - |
| Week 6 -Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 6 -Feeling Down Depressed or Hopeless - Not At All | 18 | - |
| Week 6 -Feeling Down Depressed or Hopeless - Several Days | 1 | - |
| Week 6 -Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 6 -Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 6 -Trouble Falling or Staying Asleep - Not At All | 12 | - |
| Week 6 -Trouble Falling or Staying Asleep - Several Days | 7 | - |
| Week 6 -Trouble Falling or Staying Asleep - More Than Half the Days | 0 | - |
| Week 6 -Trouble Falling or Staying Asleep - Nearly Every Day | 0 | - |
| Week 6 -Feeling Tired or Little Energy - Not At All | 11 | - |
| Week 6 -Feeling Tired or Little Energy - Several Days | 7 | - |
| Week 6 -Feeling Tired or Little Energy - More Than Half the Days | 0 | - |
| Week 6 -Feeling Tired or Little Energy - Nearly Every Day | 1 | - |
| Week 6 -Poor Appetite or Overeating - Not At All | 14 | - |
| Week 6 -Poor Appetite or Overeating - Several Days | 4 | - |
| Week 6 -Poor Appetite or Overeating - More Than Half the Days | 0 | - |
| Week 6 -Poor Appetite or Overeating - Nearly Every Day | 1 | - |
| Week 6 -Feeling Bad About Yourself - Not At All | 18 | - |
| Week 6 -Feeling Bad About Yourself - Several Days | 1 | - |
| Week 6 -Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 6 -Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 6 -Trouble Concentrating on Things - Not At All | 14 | - |
| Week 6 -Trouble Concentrating on Things - Several Days | 5 | - |
| Week 6 -Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 6 -Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 6 -Moving Slowly or Fidgety/Restless - Not At All | 18 | - |
| Week 6 -Moving Slowly or Fidgety/Restless - Several Days | 1 | - |
| Week 6 -Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 6 -Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 6 - Thoughts You Be Better Off Dead - Not At All | 18 | - |
| Week 6 - Thoughts You Be Better Off Dead - Several Days | 1 | - |
| Week 6 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 6 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Week 8 - Little Interest/Pleasure in Things - Not At All | 16 | - |
| Week 8 - Little Interest/Pleasure in Things - Several Days | 2 | - |
| Week 8 - Little Interest/Pleasure in Things - More Than Half the Days | 0 | - |
| Week 8 - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 8 - Feeling Down Depressed or Hopeless - Not At All | 18 | - |
| Week 8 - Feeling Down Depressed or Hopeless - Several Days | 0 | - |
| Week 8 - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 8 - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 8 - Trouble Falling or Staying Asleep - Not At All | 12 | - |
| Week 8 - Trouble Falling or Staying Asleep - Several Days | 5 | - |
| Week 8 - Trouble Falling or Staying Asleep - More Than Half the Days | 1 | - |
| Week 8 - Trouble Falling or Staying Asleep - Nearly Every Day | 0 | - |
| Week 8 - Feeling Tired or Little Energy - Not At All | 13 | - |
| Week 8 - Feeling Tired or Little Energy - Several Days | 4 | - |
| Week 8 - Feeling Tired or Little Energy - More Than Half the Days | 1 | - |
| Week 8 - Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Week 8 - Poor Appetite or Overeating - Not At All | 15 | - |
| Week 8 - Poor Appetite or Overeating - Several Days | 3 | - |
| Week 8 - Poor Appetite or Overeating - More Than Half the Days | 0 | - |
| Week 8 - Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Week 8 - Feeling Bad About Yourself - Not At All | 18 | - |
| Week 8 - Feeling Bad About Yourself - Several Days | 0 | - |
| Week 8 - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 8 - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 8 - Trouble Concentrating on Things - Not At All | 14 | - |
| Week 8 - Trouble Concentrating on Things - Several Days | 3 | - |
| Week 8 - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 8 - Trouble Concentrating on Things - Nearly Every Day | 1 | - |
| Week 8 - Moving Slowly or Fidgety/Restless - Not At All | 17 | - |
| Week 8 - Moving Slowly or Fidgety/Restless - Several Days | 1 | - |
| Week 8 - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 8 - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 8 - Thoughts You Be Better Off Dead - Not At All | 18 | - |
| Week 8 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 8 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 8 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Week 10 - Little Interest/Pleasure in Things - Not At All | 17 | - |
| Week 10 - Little Interest/Pleasure in Things - Several Days | 1 | - |
| Week 10 - Little Interest/Pleasure in Things - More Than Half the Days | 0 | - |
| Week 10 - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 10 - Feeling Down Depressed or Hopeless - Not At All | 18 | - |
| Week 10 - Feeling Down Depressed or Hopeless - Several Days | 0 | - |
| Week 10 - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 10 - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 10 - Trouble Falling or Staying Asleep - Not At All | 13 | - |
| Week 10 - Trouble Falling or Staying Asleep - Several Days | 5 | - |
| Week 10 - Trouble Falling or Staying Asleep - More Than Half the Days | 0 | - |
| Week 10 - Trouble Falling or Staying Asleep - Nearly Every Day | 0 | - |
| Week 10 - Feeling Tired or Little Energy - Not At All | 11 | - |
| Week 10 - Feeling Tired or Little Energy - Several Days | 7 | - |
| Week 10 - Feeling Tired or Little Energy - More Than Half the Days | 0 | - |
| Week 10 - Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Week 10 - Poor Appetite or Overeating - Not At All | 15 | - |
| Week 10 - Poor Appetite or Overeating - Several Days | 3 | - |
| Week 10 - Poor Appetite or Overeating - More Than Half the Days | 0 | - |
| Week 10 - Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Week 10 - Feeling Bad About Yourself - Not At All | 18 | - |
| Week 10 - Feeling Bad About Yourself - Several Days | 0 | - |
| Week 10 - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 10 - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 10 - Trouble Concentrating on Things - Not At All | 17 | - |
| Week 10 - Trouble Concentrating on Things - Several Days | 1 | - |
| Week 10 - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 10 - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 10 - Moving Slowly or Fidgety/Restless - Not At All | 17 | - |
| Week 10 - Moving Slowly or Fidgety/Restless - Several Days | 1 | - |
| Week 10 - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 10 - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 10 - Thoughts You Be Better Off Dead - Not At All | 18 | - |
| Week 10 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 10 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 10 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Week 12 - Little Interest/Pleasure in Things - Not At All | 15 | - |
| Week 12 - Little Interest/Pleasure in Things - Several Days | 3 | - |
| Week 12 - Little Interest/Pleasure in Things - More Than Half the Days | 0 | - |
| Week 12 - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 12 - Feeling Down Depressed or Hopeless - Not At All | 18 | - |
| Week 12 - Feeling Down Depressed or Hopeless - Several Days | 0 | - |
| Week 12 - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 12 - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 12 - Trouble Falling or Staying Asleep - Not At All | 12 | - |
| Week 12 - Trouble Falling or Staying Asleep - Several Days | 6 | - |
| Week 12 - Trouble Falling or Staying Asleep - More Than Half the Days | 0 | - |
| Week 12 - Trouble Falling or Staying Asleep - Nearly Every Day | 0 | - |
| Week 12 - Feeling Tired or Little Energy - Not At All | 12 | - |
| Week 12 - Feeling Tired or Little Energy - Several Days | 6 | - |
| Week 12 - Feeling Tired or Little Energy - More Than Half the Days | 0 | - |
| Week 12 - Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Week 12 - Poor Appetite or Overeating - Not At All | 14 | - |
| Week 12 - Poor Appetite or Overeating - Several Days | 3 | - |
| Week 12 - Poor Appetite or Overeating - More Than Half the Days | 0 | - |
| Week 12 - Poor Appetite or Overeating - Nearly Every Day | 1 | - |
| Week 12 - Feeling Bad About Yourself - Not At All | 18 | - |
| Week 12 - Feeling Bad About Yourself - Several Days | 0 | - |
| Week 12 - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 12 - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 12 - Trouble Concentrating on Things - Not At All | 17 | - |
| Week 12 - Trouble Concentrating on Things - Several Days | 1 | - |
| Week 12 - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 12 - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 12 - Moving Slowly or Fidgety/Restless - Not At All | 17 | - |
| Week 12 - Moving Slowly or Fidgety/Restless - Several Days | 1 | - |
| Week 12 - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 12 - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 12 - Thoughts You Be Better Off Dead - Not At All | 18 | - |
| Week 12 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 12 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 12 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Follow-Up - Little Interest/Pleasure in Things - Not At All | 14 | - |
| Follow-Up - Little Interest/Pleasure in Things - Several Days | 3 | - |
| Follow-Up - Little Interest/Pleasure in Things - More Than Half the Days | 0 | - |
| Follow-Up - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Follow-Up - Feeling Down Depressed or Hopeless - Not At All | 17 | - |
| Follow-Up - Feeling Down Depressed or Hopeless - Several Days | 0 | - |
| Follow-Up - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Follow-Up - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Follow-Up - Trouble Falling or Staying Asleep - Not At All | 12 | - |
| Follow-Up - Trouble Falling or Staying Asleep - Several Days | 5 | - |
| Follow-Up - Trouble Falling or Staying Asleep - More Than Half the Days | 0 | - |
| Follow-Up - Trouble Falling or Staying Asleep - Nearly Every Day | 0 | - |
| Follow-Up - Feeling Tired or Little Energy - Not At All | 11 | - |
| Follow-Up - Feeling Tired or Little Energy - Several Days | 5 | - |
| Follow-Up - Feeling Tired or Little Energy - More Than Half the Days | 1 | - |
| Follow-Up - Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Follow-Up - Poor Appetite or Overeating - Not At All | 13 | - |
| Follow-Up - Poor Appetite or Overeating - Several Days | 4 | - |
| Follow-Up - Poor Appetite or Overeating - More Than Half the Days | 0 | - |
| Follow-Up - Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Follow-Up - Feeling Bad About Yourself - Not At All | 17 | - |
| Follow-Up - Feeling Bad About Yourself - Several Days | 0 | - |
| Follow-Up - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Follow-Up - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Follow-Up - Trouble Concentrating on Things - Not At All | 17 | - |
| Follow-Up - Trouble Concentrating on Things - Several Days | 0 | - |
| Follow-Up - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Follow-Up - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Follow-Up - Moving Slowly or Fidgety/Restless - Not At All | 17 | - |
| Follow-Up - Moving Slowly or Fidgety/Restless - Several Days | 0 | - |
| Follow-Up - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Follow-Up - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Follow-Up - Thoughts You Be Better Off Dead - Not At All | 17 | - |
| Follow-Up - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Follow-Up - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Follow-Up - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| PF-06882961 80 mg BID High, Slow (T2DM)Week 0 - Little Interest/Pleasure in Things - Not At All | 20 | - |
| Week 0 - Little Interest/Pleasure in Things - Several Days | 1 | - |
| Week 0 - Little Interest/Pleasure in Things - More Than Half the Days | 1 | - |
| Week 0 - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 0 - Feeling Down Depressed or Hopeless - Not At All | 18 | - |
| Week 0 - Feeling Down Depressed or Hopeless - Several Days | 3 | - |
| Week 0 - Feeling Down Depressed or Hopeless - More Than Half the Days | 1 | - |
| Week 0 - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 0 - Trouble Falling or Staying Asleep - Not At All | 16 | - |
| Week 0 - Trouble Falling or Staying Asleep - Several Days | 4 | - |
| Week 0 - Trouble Falling or Staying Asleep - More Than Half the Days | 1 | - |
| Week 0 - Trouble Falling or Staying Asleep - Nearly Every Day | 1 | - |
| Week 0 - Feeling Tired or Little Energy - Not At All | 15 | - |
| Week 0 - Feeling Tired or Little Energy - Several Days | 4 | - |
| Week 0 - Feeling Tired or Little Energy - More Than Half the Days | 2 | - |
| Week 0 - Feeling Tired or Little Energy - Nearly Every Day | 1 | - |
| Week 0 - Poor Appetite or Overeating - Not At All | 19 | - |
| Week 0 - Poor Appetite or Overeating - Several Days | 1 | - |
| Week 0 - Poor Appetite or Overeating - More Than Half the Days | 2 | - |
| Week 0 - Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Week 0 - Feeling Bad About Yourself - Not At All | 22 | - |
| Week 0 - Feeling Bad About Yourself - Several Days | 0 | - |
| Week 0 - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 0 - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 0 - Trouble Concentrating on Things - Not At All | 21 | - |
| Week 0 - Trouble Concentrating on Things - Several Days | 1 | - |
| Week 0 - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 0 - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 0 - Moving Slowly or Fidgety/Restless - Not At All | 22 | - |
| Week 0 - Moving Slowly or Fidgety/Restless - Several Days | 0 | - |
| Week 0 - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 0 - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 0 - Thoughts You Be Better Off Dead - Not At All | 22 | - |
| Week 0 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 0 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 0 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Week 2 - Little Interest/Pleasure in Things - Not At All | 17 | - |
| Week 2 - Little Interest/Pleasure in Things - Several Days | 2 | - |
| Week 2 - Little Interest/Pleasure in Things - More Than Half the Days | 1 | - |
| Week 2 - Little Interest/Pleasure in Things - Nearly Every Day | 1 | - |
| Week 2 - Feeling Down Depressed or Hopeless - Not At All | 20 | - |
| Week 2 - Feeling Down Depressed or Hopeless - Several Days | 1 | - |
| Week 2 - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 2 - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 2 - Trouble Falling or Staying Asleep - Not At All | 16 | - |
| Week 2 - Trouble Falling or Staying Asleep - Several Days | 2 | - |
| Week 2 - Trouble Falling or Staying Asleep - More Than Half the Days | 2 | - |
| Week 2 - Trouble Falling or Staying Asleep - Nearly Every Day | 1 | - |
| Week 2 - Feeling Tired or Little Energy - Not At All | 17 | - |
| Week 2 - Feeling Tired or Little Energy - Several Days | 2 | - |
| Week 2 - Feeling Tired or Little Energy - More Than Half the Days | 2 | - |
| Week 2 - Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Week 2 - Poor Appetite or Overeating - Not At All | 15 | - |
| Week 2 - Poor Appetite or Overeating - Several Days | 6 | - |
| Week 2 - Poor Appetite or Overeating - More Than Half the Days | 0 | - |
| Week 2 - Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Week 2 - Feeling Bad About Yourself - Not At All | 21 | - |
| Week 2 - Feeling Bad About Yourself - Several Days | 0 | - |
| Week 2 - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 2 - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 2 - Trouble Concentrating on Things - Not At All | 20 | - |
| Week 2 - Trouble Concentrating on Things - Several Days | 1 | - |
| Week 2 - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 2 - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 2 - Moving Slowly or Fidgety/Restless - Not At All | 20 | - |
| Week 2 - Moving Slowly or Fidgety/Restless - Several Days | 1 | - |
| Week 2 - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 2 - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 2 - Thoughts You Be Better Off Dead - Not At All | 21 | - |
| Week 2 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 2 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 2 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Week 4 - Little Interest/Pleasure in Things - Not At All | 20 | - |
| Week 4 - Little Interest/Pleasure in Things - Several Days | 0 | - |
| Week 4 - Little Interest/Pleasure in Things - More Than Half the Days | 1 | - |
| Week 4 - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 4 -Feeling Down Depressed or Hopeless - Not At All | 18 | - |
| Week 4 - Feeling Down Depressed or Hopeless - Several Days | 3 | - |
| Week 4 - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 4 - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 4 - Trouble Falling or Staying Asleep - Not At All | 14 | - |
| Week 4 - Trouble Falling or Staying Asleep - Several Days | 4 | - |
| Week 4 - Trouble Falling or Staying Asleep - More Than Half the Days | 3 | - |
| Week 4 - Trouble Falling or Staying Asleep - Nearly Every Day | 0 | - |
| Week 4 - Feeling Tired or Little Energy - Not At All | 17 | - |
| Week 4 - Feeling Tired or Little Energy - Several Days | 2 | - |
| Week 4 - Feeling Tired or Little Energy - More Than Half the Days | 2 | - |
| Week 4 - Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Week 4 - Poor Appetite or Overeating - Not At All | 18 | - |
| Week 4 - Poor Appetite or Overeating - Several Days | 3 | - |
| Week 4 - Poor Appetite or Overeating - More Than Half the Days | 0 | - |
| Week 4 - Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Week 4 - Feeling Bad About Yourself - Not At All | 21 | - |
| Week 4 - Feeling Bad About Yourself - Several Days | 0 | - |
| Week 4 - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 4 - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 4 - Trouble Concentrating on Things - Not At All | 20 | - |
| Week 4 - Trouble Concentrating on Things - Several Days | 1 | - |
| Week 4 - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 4 - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 4 - Moving Slowly or Fidgety/Restless - Not At All | 20 | - |
| Week 4 - Moving Slowly or Fidgety/Restless - Several Days | 1 | - |
| Week 4 - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 4 - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 4 - Thoughts You Be Better Off Dead - Not At All | 21 | - |
| Week 4 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 4 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 4 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Week 6 -Little Interest/Pleasure in Things - Not At All | 17 | - |
| Week 6 -Little Interest/Pleasure in Things - Several Days | 2 | - |
| Week 6 -Little Interest/Pleasure in Things - More Than Half the Days | 1 | - |
| Week 6 -Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 6 -Feeling Down Depressed or Hopeless - Not At All | 20 | - |
| Week 6 -Feeling Down Depressed or Hopeless - Several Days | 0 | - |
| Week 6 -Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 6 -Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 6 -Trouble Falling or Staying Asleep - Not At All | 14 | - |
| Week 6 -Trouble Falling or Staying Asleep - Several Days | 6 | - |
| Week 6 -Trouble Falling or Staying Asleep - More Than Half the Days | 0 | - |
| Week 6 -Trouble Falling or Staying Asleep - Nearly Every Day | 0 | - |
| Week 6 -Feeling Tired or Little Energy - Not At All | 16 | - |
| Week 6 -Feeling Tired or Little Energy - Several Days | 3 | - |
| Week 6 -Feeling Tired or Little Energy - More Than Half the Days | 1 | - |
| Week 6 -Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Week 6 -Poor Appetite or Overeating - Not At All | 14 | - |
| Week 6 -Poor Appetite or Overeating - Several Days | 6 | - |
| Week 6 -Poor Appetite or Overeating - More Than Half the Days | 0 | - |
| Week 6 -Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Week 6 -Feeling Bad About Yourself - Not At All | 20 | - |
| Week 6 -Feeling Bad About Yourself - Several Days | 0 | - |
| Week 6 -Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 6 -Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 6 -Trouble Concentrating on Things - Not At All | 19 | - |
| Week 6 -Trouble Concentrating on Things - Several Days | 1 | - |
| Week 6 -Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 6 -Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 6 -Moving Slowly or Fidgety/Restless - Not At All | 20 | - |
| Week 6 -Moving Slowly or Fidgety/Restless - Several Days | 0 | - |
| Week 6 -Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 6 -Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 6 - Thoughts You Be Better Off Dead - Not At All | 20 | - |
| Week 6 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 6 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 6 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Week 8 - Little Interest/Pleasure in Things - Not At All | 16 | - |
| Week 8 - Little Interest/Pleasure in Things - Several Days | 2 | - |
| Week 8 - Little Interest/Pleasure in Things - More Than Half the Days | 0 | - |
| Week 8 - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 8 - Feeling Down Depressed or Hopeless - Not At All | 17 | - |
| Week 8 - Feeling Down Depressed or Hopeless - Several Days | 1 | - |
| Week 8 - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 8 - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 8 - Trouble Falling or Staying Asleep - Not At All | 13 | - |
| Week 8 - Trouble Falling or Staying Asleep - Several Days | 5 | - |
| Week 8 - Trouble Falling or Staying Asleep - More Than Half the Days | 0 | - |
| Week 8 - Trouble Falling or Staying Asleep - Nearly Every Day | 0 | - |
| Week 8 - Feeling Tired or Little Energy - Not At All | 16 | - |
| Week 8 - Feeling Tired or Little Energy - Several Days | 1 | - |
| Week 8 - Feeling Tired or Little Energy - More Than Half the Days | 1 | - |
| Week 8 - Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Week 8 - Poor Appetite or Overeating - Not At All | 13 | - |
| Week 8 - Poor Appetite or Overeating - Several Days | 5 | - |
| Week 8 - Poor Appetite or Overeating - More Than Half the Days | 0 | - |
| Week 8 - Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Week 8 - Feeling Bad About Yourself - Not At All | 18 | - |
| Week 8 - Feeling Bad About Yourself - Several Days | 0 | - |
| Week 8 - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 8 - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 8 - Trouble Concentrating on Things - Not At All | 16 | - |
| Week 8 - Trouble Concentrating on Things - Several Days | 2 | - |
| Week 8 - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 8 - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 8 - Moving Slowly or Fidgety/Restless - Not At All | 18 | - |
| Week 8 - Moving Slowly or Fidgety/Restless - Several Days | 0 | - |
| Week 8 - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 8 - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 8 - Thoughts You Be Better Off Dead - Not At All | 18 | - |
| Week 8 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 8 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 8 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Week 10 - Little Interest/Pleasure in Things - Not At All | 15 | - |
| Week 10 - Little Interest/Pleasure in Things - Several Days | 1 | - |
| Week 10 - Little Interest/Pleasure in Things - More Than Half the Days | 2 | - |
| Week 10 - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 10 - Feeling Down Depressed or Hopeless - Not At All | 16 | - |
| Week 10 - Feeling Down Depressed or Hopeless - Several Days | 2 | - |
| Week 10 - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 10 - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 10 - Trouble Falling or Staying Asleep - Not At All | 14 | - |
| Week 10 - Trouble Falling or Staying Asleep - Several Days | 3 | - |
| Week 10 - Trouble Falling or Staying Asleep - More Than Half the Days | 1 | - |
| Week 10 - Trouble Falling or Staying Asleep - Nearly Every Day | 0 | - |
| Week 10 - Feeling Tired or Little Energy - Not At All | 14 | - |
| Week 10 - Feeling Tired or Little Energy - Several Days | 3 | - |
| Week 10 - Feeling Tired or Little Energy - More Than Half the Days | 0 | - |
| Week 10 - Feeling Tired or Little Energy - Nearly Every Day | 1 | - |
| Week 10 - Poor Appetite or Overeating - Not At All | 16 | - |
| Week 10 - Poor Appetite or Overeating - Several Days | 2 | - |
| Week 10 - Poor Appetite or Overeating - More Than Half the Days | 0 | - |
| Week 10 - Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Week 10 - Feeling Bad About Yourself - Not At All | 18 | - |
| Week 10 - Feeling Bad About Yourself - Several Days | 0 | - |
| Week 10 - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 10 - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 10 - Trouble Concentrating on Things - Not At All | 17 | - |
| Week 10 - Trouble Concentrating on Things - Several Days | 1 | - |
| Week 10 - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 10 - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 10 - Moving Slowly or Fidgety/Restless - Not At All | 17 | - |
| Week 10 - Moving Slowly or Fidgety/Restless - Several Days | 0 | - |
| Week 10 - Moving Slowly or Fidgety/Restless - More Than Half the Days | 1 | - |
| Week 10 - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 10 - Thoughts You Be Better Off Dead - Not At All | 18 | - |
| Week 10 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 10 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 10 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Week 12 - Little Interest/Pleasure in Things - Not At All | 14 | - |
| Week 12 - Little Interest/Pleasure in Things - Several Days | 2 | - |
| Week 12 - Little Interest/Pleasure in Things - More Than Half the Days | 2 | - |
| Week 12 - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 12 - Feeling Down Depressed or Hopeless - Not At All | 17 | - |
| Week 12 - Feeling Down Depressed or Hopeless - Several Days | 1 | - |
| Week 12 - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 12 - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 12 - Trouble Falling or Staying Asleep - Not At All | 12 | - |
| Week 12 - Trouble Falling or Staying Asleep - Several Days | 5 | - |
| Week 12 - Trouble Falling or Staying Asleep - More Than Half the Days | 1 | - |
| Week 12 - Trouble Falling or Staying Asleep - Nearly Every Day | 0 | - |
| Week 12 - Feeling Tired or Little Energy - Not At All | 14 | - |
| Week 12 - Feeling Tired or Little Energy - Several Days | 3 | - |
| Week 12 - Feeling Tired or Little Energy - More Than Half the Days | 0 | - |
| Week 12 - Feeling Tired or Little Energy - Nearly Every Day | 1 | - |
| Week 12 - Poor Appetite or Overeating - Not At All | 13 | - |
| Week 12 - Poor Appetite or Overeating - Several Days | 5 | - |
| Week 12 - Poor Appetite or Overeating - More Than Half the Days | 0 | - |
| Week 12 - Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Week 12 - Feeling Bad About Yourself - Not At All | 18 | - |
| Week 12 - Feeling Bad About Yourself - Several Days | 0 | - |
| Week 12 - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 12 - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 12 - Trouble Concentrating on Things - Not At All | 17 | - |
| Week 12 - Trouble Concentrating on Things - Several Days | 0 | - |
| Week 12 - Trouble Concentrating on Things - More Than Half the Days | 1 | - |
| Week 12 - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 12 - Moving Slowly or Fidgety/Restless - Not At All | 18 | - |
| Week 12 - Moving Slowly or Fidgety/Restless - Several Days | 0 | - |
| Week 12 - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 12 - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 12 - Thoughts You Be Better Off Dead - Not At All | 18 | - |
| Week 12 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 12 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 12 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Follow-Up - Little Interest/Pleasure in Things - Not At All | 17 | - |
| Follow-Up - Little Interest/Pleasure in Things - Several Days | 1 | - |
| Follow-Up - Little Interest/Pleasure in Things - More Than Half the Days | 0 | - |
| Follow-Up - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Follow-Up - Feeling Down Depressed or Hopeless - Not At All | 17 | - |
| Follow-Up - Feeling Down Depressed or Hopeless - Several Days | 1 | - |
| Follow-Up - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Follow-Up - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Follow-Up - Trouble Falling or Staying Asleep - Not At All | 13 | - |
| Follow-Up - Trouble Falling or Staying Asleep - Several Days | 5 | - |
| Follow-Up - Trouble Falling or Staying Asleep - More Than Half the Days | 0 | - |
| Follow-Up - Trouble Falling or Staying Asleep - Nearly Every Day | 0 | - |
| Follow-Up - Feeling Tired or Little Energy - Not At All | 14 | - |
| Follow-Up - Feeling Tired or Little Energy - Several Days | 4 | - |
| Follow-Up - Feeling Tired or Little Energy - More Than Half the Days | 0 | - |
| Follow-Up - Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Follow-Up - Poor Appetite or Overeating - Not At All | 16 | - |
| Follow-Up - Poor Appetite or Overeating - Several Days | 2 | - |
| Follow-Up - Poor Appetite or Overeating - More Than Half the Days | 0 | - |
| Follow-Up - Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Follow-Up - Feeling Bad About Yourself - Not At All | 18 | - |
| Follow-Up - Feeling Bad About Yourself - Several Days | 0 | - |
| Follow-Up - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Follow-Up - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Follow-Up - Trouble Concentrating on Things - Not At All | 16 | - |
| Follow-Up - Trouble Concentrating on Things - Several Days | 2 | - |
| Follow-Up - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Follow-Up - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Follow-Up - Moving Slowly or Fidgety/Restless - Not At All | 18 | - |
| Follow-Up - Moving Slowly or Fidgety/Restless - Several Days | 0 | - |
| Follow-Up - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Follow-Up - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Follow-Up - Thoughts You Be Better Off Dead - Not At All | 18 | - |
| Follow-Up - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Follow-Up - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Follow-Up - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| PF-06882961 120 mg BID Low, Fast (T2DM)Week 0 - Little Interest/Pleasure in Things - Not At All | 20 | - |
| Week 0 - Little Interest/Pleasure in Things - Several Days | 1 | - |
| Week 0 - Little Interest/Pleasure in Things - More Than Half the Days | 0 | - |
| Week 0 - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 0 - Feeling Down Depressed or Hopeless - Not At All | 19 | - |
| Week 0 - Feeling Down Depressed or Hopeless - Several Days | 1 | - |
| Week 0 - Feeling Down Depressed or Hopeless - More Than Half the Days | 1 | - |
| Week 0 - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 0 - Trouble Falling or Staying Asleep - Not At All | 17 | - |
| Week 0 - Trouble Falling or Staying Asleep - Several Days | 2 | - |
| Week 0 - Trouble Falling or Staying Asleep - More Than Half the Days | 2 | - |
| Week 0 - Trouble Falling or Staying Asleep - Nearly Every Day | 0 | - |
| Week 0 - Feeling Tired or Little Energy - Not At All | 17 | - |
| Week 0 - Feeling Tired or Little Energy - Several Days | 4 | - |
| Week 0 - Feeling Tired or Little Energy - More Than Half the Days | 0 | - |
| Week 0 - Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Week 0 - Poor Appetite or Overeating - Not At All | 18 | - |
| Week 0 - Poor Appetite or Overeating - Several Days | 3 | - |
| Week 0 - Poor Appetite or Overeating - More Than Half the Days | 0 | - |
| Week 0 - Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Week 0 - Feeling Bad About Yourself - Not At All | 20 | - |
| Week 0 - Feeling Bad About Yourself - Several Days | 1 | - |
| Week 0 - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 0 - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 0 - Trouble Concentrating on Things - Not At All | 19 | - |
| Week 0 - Trouble Concentrating on Things - Several Days | 1 | - |
| Week 0 - Trouble Concentrating on Things - More Than Half the Days | 1 | - |
| Week 0 - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 0 - Moving Slowly or Fidgety/Restless - Not At All | 21 | - |
| Week 0 - Moving Slowly or Fidgety/Restless - Several Days | 0 | - |
| Week 0 - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 0 - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 0 - Thoughts You Be Better Off Dead - Not At All | 21 | - |
| Week 0 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 0 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 0 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Week 2 - Little Interest/Pleasure in Things - Not At All | 21 | - |
| Week 2 - Little Interest/Pleasure in Things - Several Days | 0 | - |
| Week 2 - Little Interest/Pleasure in Things - More Than Half the Days | 0 | - |
| Week 2 - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 2 - Feeling Down Depressed or Hopeless - Not At All | 21 | - |
| Week 2 - Feeling Down Depressed or Hopeless - Several Days | 0 | - |
| Week 2 - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 2 - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 2 - Trouble Falling or Staying Asleep - Not At All | 19 | - |
| Week 2 - Trouble Falling or Staying Asleep - Several Days | 2 | - |
| Week 2 - Trouble Falling or Staying Asleep - More Than Half the Days | 0 | - |
| Week 2 - Trouble Falling or Staying Asleep - Nearly Every Day | 0 | - |
| Week 2 - Feeling Tired or Little Energy - Not At All | 18 | - |
| Week 2 - Feeling Tired or Little Energy - Several Days | 3 | - |
| Week 2 - Feeling Tired or Little Energy - More Than Half the Days | 0 | - |
| Week 2 - Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Week 2 - Poor Appetite or Overeating - Not At All | 19 | - |
| Week 2 - Poor Appetite or Overeating - Several Days | 2 | - |
| Week 2 - Poor Appetite or Overeating - More Than Half the Days | 0 | - |
| Week 2 - Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Week 2 - Feeling Bad About Yourself - Not At All | 21 | - |
| Week 2 - Feeling Bad About Yourself - Several Days | 0 | - |
| Week 2 - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 2 - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 2 - Trouble Concentrating on Things - Not At All | 20 | - |
| Week 2 - Trouble Concentrating on Things - Several Days | 1 | - |
| Week 2 - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 2 - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 2 - Moving Slowly or Fidgety/Restless - Not At All | 21 | - |
| Week 2 - Moving Slowly or Fidgety/Restless - Several Days | 0 | - |
| Week 2 - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 2 - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 2 - Thoughts You Be Better Off Dead - Not At All | 21 | - |
| Week 2 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 2 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 2 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Week 4 - Little Interest/Pleasure in Things - Not At All | 21 | - |
| Week 4 - Little Interest/Pleasure in Things - Several Days | 0 | - |
| Week 4 - Little Interest/Pleasure in Things - More Than Half the Days | 0 | - |
| Week 4 - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 4 -Feeling Down Depressed or Hopeless - Not At All | 21 | - |
| Week 4 - Feeling Down Depressed or Hopeless - Several Days | 0 | - |
| Week 4 - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 4 - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 4 - Trouble Falling or Staying Asleep - Not At All | 20 | - |
| Week 4 - Trouble Falling or Staying Asleep - Several Days | 1 | - |
| Week 4 - Trouble Falling or Staying Asleep - More Than Half the Days | 0 | - |
| Week 4 - Trouble Falling or Staying Asleep - Nearly Every Day | 0 | - |
| Week 4 - Feeling Tired or Little Energy - Not At All | 18 | - |
| Week 4 - Feeling Tired or Little Energy - Several Days | 1 | - |
| Week 4 - Feeling Tired or Little Energy - More Than Half the Days | 2 | - |
| Week 4 - Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Week 4 - Poor Appetite or Overeating - Not At All | 20 | - |
| Week 4 - Poor Appetite or Overeating - Several Days | 0 | - |
| Week 4 - Poor Appetite or Overeating - More Than Half the Days | 1 | - |
| Week 4 - Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Week 4 - Feeling Bad About Yourself - Not At All | 21 | - |
| Week 4 - Feeling Bad About Yourself - Several Days | 0 | - |
| Week 4 - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 4 - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 4 - Trouble Concentrating on Things - Not At All | 20 | - |
| Week 4 - Trouble Concentrating on Things - Several Days | 1 | - |
| Week 4 - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 4 - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 4 - Moving Slowly or Fidgety/Restless - Not At All | 21 | - |
| Week 4 - Moving Slowly or Fidgety/Restless - Several Days | 0 | - |
| Week 4 - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 4 - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 4 - Thoughts You Be Better Off Dead - Not At All | 21 | - |
| Week 4 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 4 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 4 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Week 6 -Little Interest/Pleasure in Things - Not At All | 19 | - |
| Week 6 -Little Interest/Pleasure in Things - Several Days | 0 | - |
| Week 6 -Little Interest/Pleasure in Things - More Than Half the Days | 0 | - |
| Week 6 -Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 6 -Feeling Down Depressed or Hopeless - Not At All | 18 | - |
| Week 6 -Feeling Down Depressed or Hopeless - Several Days | 1 | - |
| Week 6 -Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 6 -Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 6 -Trouble Falling or Staying Asleep - Not At All | 16 | - |
| Week 6 -Trouble Falling or Staying Asleep - Several Days | 3 | - |
| Week 6 -Trouble Falling or Staying Asleep - More Than Half the Days | 0 | - |
| Week 6 -Trouble Falling or Staying Asleep - Nearly Every Day | 0 | - |
| Week 6 -Feeling Tired or Little Energy - Not At All | 15 | - |
| Week 6 -Feeling Tired or Little Energy - Several Days | 4 | - |
| Week 6 -Feeling Tired or Little Energy - More Than Half the Days | 0 | - |
| Week 6 -Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Week 6 -Poor Appetite or Overeating - Not At All | 15 | - |
| Week 6 -Poor Appetite or Overeating - Several Days | 3 | - |
| Week 6 -Poor Appetite or Overeating - More Than Half the Days | 1 | - |
| Week 6 -Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Week 6 -Feeling Bad About Yourself - Not At All | 19 | - |
| Week 6 -Feeling Bad About Yourself - Several Days | 0 | - |
| Week 6 -Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 6 -Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 6 -Trouble Concentrating on Things - Not At All | 19 | - |
| Week 6 -Trouble Concentrating on Things - Several Days | 0 | - |
| Week 6 -Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 6 -Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 6 -Moving Slowly or Fidgety/Restless - Not At All | 19 | - |
| Week 6 -Moving Slowly or Fidgety/Restless - Several Days | 0 | - |
| Week 6 -Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 6 -Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 6 - Thoughts You Be Better Off Dead - Not At All | 19 | - |
| Week 6 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 6 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 6 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Week 8 - Little Interest/Pleasure in Things - Not At All | 18 | - |
| Week 8 - Little Interest/Pleasure in Things - Several Days | 0 | - |
| Week 8 - Little Interest/Pleasure in Things - More Than Half the Days | 0 | - |
| Week 8 - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 8 - Feeling Down Depressed or Hopeless - Not At All | 16 | - |
| Week 8 - Feeling Down Depressed or Hopeless - Several Days | 2 | - |
| Week 8 - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 8 - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 8 - Trouble Falling or Staying Asleep - Not At All | 15 | - |
| Week 8 - Trouble Falling or Staying Asleep - Several Days | 3 | - |
| Week 8 - Trouble Falling or Staying Asleep - More Than Half the Days | 0 | - |
| Week 8 - Trouble Falling or Staying Asleep - Nearly Every Day | 0 | - |
| Week 8 - Feeling Tired or Little Energy - Not At All | 16 | - |
| Week 8 - Feeling Tired or Little Energy - Several Days | 2 | - |
| Week 8 - Feeling Tired or Little Energy - More Than Half the Days | 0 | - |
| Week 8 - Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Week 8 - Poor Appetite or Overeating - Not At All | 15 | - |
| Week 8 - Poor Appetite or Overeating - Several Days | 3 | - |
| Week 8 - Poor Appetite or Overeating - More Than Half the Days | 0 | - |
| Week 8 - Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Week 8 - Feeling Bad About Yourself - Not At All | 18 | - |
| Week 8 - Feeling Bad About Yourself - Several Days | 0 | - |
| Week 8 - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 8 - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 8 - Trouble Concentrating on Things - Not At All | 18 | - |
| Week 8 - Trouble Concentrating on Things - Several Days | 0 | - |
| Week 8 - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 8 - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 8 - Moving Slowly or Fidgety/Restless - Not At All | 18 | - |
| Week 8 - Moving Slowly or Fidgety/Restless - Several Days | 0 | - |
| Week 8 - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 8 - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 8 - Thoughts You Be Better Off Dead - Not At All | 18 | - |
| Week 8 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 8 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 8 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Week 10 - Little Interest/Pleasure in Things - Not At All | 16 | - |
| Week 10 - Little Interest/Pleasure in Things - Several Days | 0 | - |
| Week 10 - Little Interest/Pleasure in Things - More Than Half the Days | 0 | - |
| Week 10 - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 10 - Feeling Down Depressed or Hopeless - Not At All | 15 | - |
| Week 10 - Feeling Down Depressed or Hopeless - Several Days | 1 | - |
| Week 10 - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 10 - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 10 - Trouble Falling or Staying Asleep - Not At All | 14 | - |
| Week 10 - Trouble Falling or Staying Asleep - Several Days | 2 | - |
| Week 10 - Trouble Falling or Staying Asleep - More Than Half the Days | 0 | - |
| Week 10 - Trouble Falling or Staying Asleep - Nearly Every Day | 0 | - |
| Week 10 - Feeling Tired or Little Energy - Not At All | 14 | - |
| Week 10 - Feeling Tired or Little Energy - Several Days | 2 | - |
| Week 10 - Feeling Tired or Little Energy - More Than Half the Days | 0 | - |
| Week 10 - Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Week 10 - Poor Appetite or Overeating - Not At All | 14 | - |
| Week 10 - Poor Appetite or Overeating - Several Days | 1 | - |
| Week 10 - Poor Appetite or Overeating - More Than Half the Days | 1 | - |
| Week 10 - Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Week 10 - Feeling Bad About Yourself - Not At All | 16 | - |
| Week 10 - Feeling Bad About Yourself - Several Days | 0 | - |
| Week 10 - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 10 - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 10 - Trouble Concentrating on Things - Not At All | 16 | - |
| Week 10 - Trouble Concentrating on Things - Several Days | 0 | - |
| Week 10 - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 10 - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 10 - Moving Slowly or Fidgety/Restless - Not At All | 16 | - |
| Week 10 - Moving Slowly or Fidgety/Restless - Several Days | 0 | - |
| Week 10 - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 10 - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 10 - Thoughts You Be Better Off Dead - Not At All | 16 | - |
| Week 10 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 10 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 10 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Week 12 - Little Interest/Pleasure in Things - Not At All | 16 | - |
| Week 12 - Little Interest/Pleasure in Things - Several Days | 0 | - |
| Week 12 - Little Interest/Pleasure in Things - More Than Half the Days | 0 | - |
| Week 12 - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 12 - Feeling Down Depressed or Hopeless - Not At All | 16 | - |
| Week 12 - Feeling Down Depressed or Hopeless - Several Days | 0 | - |
| Week 12 - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 12 - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 12 - Trouble Falling or Staying Asleep - Not At All | 15 | - |
| Week 12 - Trouble Falling or Staying Asleep - Several Days | 1 | - |
| Week 12 - Trouble Falling or Staying Asleep - More Than Half the Days | 0 | - |
| Week 12 - Trouble Falling or Staying Asleep - Nearly Every Day | 0 | - |
| Week 12 - Feeling Tired or Little Energy - Not At All | 14 | - |
| Week 12 - Feeling Tired or Little Energy - Several Days | 2 | - |
| Week 12 - Feeling Tired or Little Energy - More Than Half the Days | 0 | - |
| Week 12 - Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Week 12 - Poor Appetite or Overeating - Not At All | 14 | - |
| Week 12 - Poor Appetite or Overeating - Several Days | 2 | - |
| Week 12 - Poor Appetite or Overeating - More Than Half the Days | 0 | - |
| Week 12 - Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Week 12 - Feeling Bad About Yourself - Not At All | 16 | - |
| Week 12 - Feeling Bad About Yourself - Several Days | 0 | - |
| Week 12 - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 12 - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 12 - Trouble Concentrating on Things - Not At All | 16 | - |
| Week 12 - Trouble Concentrating on Things - Several Days | 0 | - |
| Week 12 - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 12 - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 12 - Moving Slowly or Fidgety/Restless - Not At All | 16 | - |
| Week 12 - Moving Slowly or Fidgety/Restless - Several Days | 0 | - |
| Week 12 - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 12 - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 12 - Thoughts You Be Better Off Dead - Not At All | 16 | - |
| Week 12 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 12 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 12 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Follow-Up - Little Interest/Pleasure in Things - Not At All | 16 | - |
| Follow-Up - Little Interest/Pleasure in Things - Several Days | 0 | - |
| Follow-Up - Little Interest/Pleasure in Things - More Than Half the Days | 0 | - |
| Follow-Up - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Follow-Up - Feeling Down Depressed or Hopeless - Not At All | 16 | - |
| Follow-Up - Feeling Down Depressed or Hopeless - Several Days | 0 | - |
| Follow-Up - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Follow-Up - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Follow-Up - Trouble Falling or Staying Asleep - Not At All | 14 | - |
| Follow-Up - Trouble Falling or Staying Asleep - Several Days | 2 | - |
| Follow-Up - Trouble Falling or Staying Asleep - More Than Half the Days | 0 | - |
| Follow-Up - Trouble Falling or Staying Asleep - Nearly Every Day | 0 | - |
| Follow-Up - Feeling Tired or Little Energy - Not At All | 14 | - |
| Follow-Up - Feeling Tired or Little Energy - Several Days | 2 | - |
| Follow-Up - Feeling Tired or Little Energy - More Than Half the Days | 0 | - |
| Follow-Up - Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Follow-Up - Poor Appetite or Overeating - Not At All | 15 | - |
| Follow-Up - Poor Appetite or Overeating - Several Days | 1 | - |
| Follow-Up - Poor Appetite or Overeating - More Than Half the Days | 0 | - |
| Follow-Up - Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Follow-Up - Feeling Bad About Yourself - Not At All | 16 | - |
| Follow-Up - Feeling Bad About Yourself - Several Days | 0 | - |
| Follow-Up - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Follow-Up - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Follow-Up - Trouble Concentrating on Things - Not At All | 16 | - |
| Follow-Up - Trouble Concentrating on Things - Several Days | 0 | - |
| Follow-Up - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Follow-Up - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Follow-Up - Moving Slowly or Fidgety/Restless - Not At All | 16 | - |
| Follow-Up - Moving Slowly or Fidgety/Restless - Several Days | 0 | - |
| Follow-Up - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Follow-Up - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Follow-Up - Thoughts You Be Better Off Dead - Not At All | 16 | - |
| Follow-Up - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Follow-Up - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Follow-Up - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| PF-06882961 120 mg BID High, Fast (T2DM)Week 0 - Little Interest/Pleasure in Things - Not At All | 20 | - |
| Week 0 - Little Interest/Pleasure in Things - Several Days | 1 | - |
| Week 0 - Little Interest/Pleasure in Things - More Than Half the Days | 1 | - |
| Week 0 - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 0 - Feeling Down Depressed or Hopeless - Not At All | 22 | - |
| Week 0 - Feeling Down Depressed or Hopeless - Several Days | 0 | - |
| Week 0 - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 0 - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 0 - Trouble Falling or Staying Asleep - Not At All | 17 | - |
| Week 0 - Trouble Falling or Staying Asleep - Several Days | 4 | - |
| Week 0 - Trouble Falling or Staying Asleep - More Than Half the Days | 1 | - |
| Week 0 - Trouble Falling or Staying Asleep - Nearly Every Day | 0 | - |
| Week 0 - Feeling Tired or Little Energy - Not At All | 16 | - |
| Week 0 - Feeling Tired or Little Energy - Several Days | 4 | - |
| Week 0 - Feeling Tired or Little Energy - More Than Half the Days | 2 | - |
| Week 0 - Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Week 0 - Poor Appetite or Overeating - Not At All | 19 | - |
| Week 0 - Poor Appetite or Overeating - Several Days | 2 | - |
| Week 0 - Poor Appetite or Overeating - More Than Half the Days | 1 | - |
| Week 0 - Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Week 0 - Feeling Bad About Yourself - Not At All | 22 | - |
| Week 0 - Feeling Bad About Yourself - Several Days | 0 | - |
| Week 0 - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 0 - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 0 - Trouble Concentrating on Things - Not At All | 20 | - |
| Week 0 - Trouble Concentrating on Things - Several Days | 2 | - |
| Week 0 - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 0 - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 0 - Moving Slowly or Fidgety/Restless - Not At All | 21 | - |
| Week 0 - Moving Slowly or Fidgety/Restless - Several Days | 1 | - |
| Week 0 - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 0 - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 0 - Thoughts You Be Better Off Dead - Not At All | 22 | - |
| Week 0 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 0 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 0 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Week 2 - Little Interest/Pleasure in Things - Not At All | 19 | - |
| Week 2 - Little Interest/Pleasure in Things - Several Days | 2 | - |
| Week 2 - Little Interest/Pleasure in Things - More Than Half the Days | 0 | - |
| Week 2 - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 2 - Feeling Down Depressed or Hopeless - Not At All | 21 | - |
| Week 2 - Feeling Down Depressed or Hopeless - Several Days | 0 | - |
| Week 2 - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 2 - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 2 - Trouble Falling or Staying Asleep - Not At All | 17 | - |
| Week 2 - Trouble Falling or Staying Asleep - Several Days | 3 | - |
| Week 2 - Trouble Falling or Staying Asleep - More Than Half the Days | 0 | - |
| Week 2 - Trouble Falling or Staying Asleep - Nearly Every Day | 1 | - |
| Week 2 - Feeling Tired or Little Energy - Not At All | 17 | - |
| Week 2 - Feeling Tired or Little Energy - Several Days | 3 | - |
| Week 2 - Feeling Tired or Little Energy - More Than Half the Days | 1 | - |
| Week 2 - Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Week 2 - Poor Appetite or Overeating - Not At All | 18 | - |
| Week 2 - Poor Appetite or Overeating - Several Days | 2 | - |
| Week 2 - Poor Appetite or Overeating - More Than Half the Days | 1 | - |
| Week 2 - Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Week 2 - Feeling Bad About Yourself - Not At All | 20 | - |
| Week 2 - Feeling Bad About Yourself - Several Days | 1 | - |
| Week 2 - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 2 - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 2 - Trouble Concentrating on Things - Not At All | 19 | - |
| Week 2 - Trouble Concentrating on Things - Several Days | 2 | - |
| Week 2 - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 2 - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 2 - Moving Slowly or Fidgety/Restless - Not At All | 21 | - |
| Week 2 - Moving Slowly or Fidgety/Restless - Several Days | 0 | - |
| Week 2 - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 2 - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 2 - Thoughts You Be Better Off Dead - Not At All | 21 | - |
| Week 2 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 2 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 2 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Week 4 - Little Interest/Pleasure in Things - Not At All | 19 | - |
| Week 4 - Little Interest/Pleasure in Things - Several Days | 3 | - |
| Week 4 - Little Interest/Pleasure in Things - More Than Half the Days | 0 | - |
| Week 4 - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 4 -Feeling Down Depressed or Hopeless - Not At All | 22 | - |
| Week 4 - Feeling Down Depressed or Hopeless - Several Days | 0 | - |
| Week 4 - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 4 - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 4 - Trouble Falling or Staying Asleep - Not At All | 18 | - |
| Week 4 - Trouble Falling or Staying Asleep - Several Days | 4 | - |
| Week 4 - Trouble Falling or Staying Asleep - More Than Half the Days | 0 | - |
| Week 4 - Trouble Falling or Staying Asleep - Nearly Every Day | 0 | - |
| Week 4 - Feeling Tired or Little Energy - Not At All | 17 | - |
| Week 4 - Feeling Tired or Little Energy - Several Days | 5 | - |
| Week 4 - Feeling Tired or Little Energy - More Than Half the Days | 0 | - |
| Week 4 - Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Week 4 - Poor Appetite or Overeating - Not At All | 16 | - |
| Week 4 - Poor Appetite or Overeating - Several Days | 3 | - |
| Week 4 - Poor Appetite or Overeating - More Than Half the Days | 3 | - |
| Week 4 - Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Week 4 - Feeling Bad About Yourself - Not At All | 22 | - |
| Week 4 - Feeling Bad About Yourself - Several Days | 0 | - |
| Week 4 - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 4 - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 4 - Trouble Concentrating on Things - Not At All | 21 | - |
| Week 4 - Trouble Concentrating on Things - Several Days | 1 | - |
| Week 4 - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 4 - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 4 - Moving Slowly or Fidgety/Restless - Not At All | 21 | - |
| Week 4 - Moving Slowly or Fidgety/Restless - Several Days | 1 | - |
| Week 4 - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 4 - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 4 - Thoughts You Be Better Off Dead - Not At All | 22 | - |
| Week 4 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 4 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 4 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Week 6 -Little Interest/Pleasure in Things - Not At All | 16 | - |
| Week 6 -Little Interest/Pleasure in Things - Several Days | 3 | - |
| Week 6 -Little Interest/Pleasure in Things - More Than Half the Days | 0 | - |
| Week 6 -Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 6 -Feeling Down Depressed or Hopeless - Not At All | 18 | - |
| Week 6 -Feeling Down Depressed or Hopeless - Several Days | 1 | - |
| Week 6 -Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 6 -Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 6 -Trouble Falling or Staying Asleep - Not At All | 18 | - |
| Week 6 -Trouble Falling or Staying Asleep - Several Days | 1 | - |
| Week 6 -Trouble Falling or Staying Asleep - More Than Half the Days | 0 | - |
| Week 6 -Trouble Falling or Staying Asleep - Nearly Every Day | 0 | - |
| Week 6 -Feeling Tired or Little Energy - Not At All | 15 | - |
| Week 6 -Feeling Tired or Little Energy - Several Days | 4 | - |
| Week 6 -Feeling Tired or Little Energy - More Than Half the Days | 0 | - |
| Week 6 -Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Week 6 -Poor Appetite or Overeating - Not At All | 13 | - |
| Week 6 -Poor Appetite or Overeating - Several Days | 3 | - |
| Week 6 -Poor Appetite or Overeating - More Than Half the Days | 3 | - |
| Week 6 -Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Week 6 -Feeling Bad About Yourself - Not At All | 19 | - |
| Week 6 -Feeling Bad About Yourself - Several Days | 0 | - |
| Week 6 -Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 6 -Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 6 -Trouble Concentrating on Things - Not At All | 18 | - |
| Week 6 -Trouble Concentrating on Things - Several Days | 1 | - |
| Week 6 -Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 6 -Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 6 -Moving Slowly or Fidgety/Restless - Not At All | 18 | - |
| Week 6 -Moving Slowly or Fidgety/Restless - Several Days | 1 | - |
| Week 6 -Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 6 -Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 6 - Thoughts You Be Better Off Dead - Not At All | 19 | - |
| Week 6 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 6 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 6 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Week 8 - Little Interest/Pleasure in Things - Not At All | 17 | - |
| Week 8 - Little Interest/Pleasure in Things - Several Days | 1 | - |
| Week 8 - Little Interest/Pleasure in Things - More Than Half the Days | 0 | - |
| Week 8 - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 8 - Feeling Down Depressed or Hopeless - Not At All | 18 | - |
| Week 8 - Feeling Down Depressed or Hopeless - Several Days | 0 | - |
| Week 8 - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 8 - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 8 - Trouble Falling or Staying Asleep - Not At All | 17 | - |
| Week 8 - Trouble Falling or Staying Asleep - Several Days | 1 | - |
| Week 8 - Trouble Falling or Staying Asleep - More Than Half the Days | 0 | - |
| Week 8 - Trouble Falling or Staying Asleep - Nearly Every Day | 0 | - |
| Week 8 - Feeling Tired or Little Energy - Not At All | 16 | - |
| Week 8 - Feeling Tired or Little Energy - Several Days | 2 | - |
| Week 8 - Feeling Tired or Little Energy - More Than Half the Days | 0 | - |
| Week 8 - Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Week 8 - Poor Appetite or Overeating - Not At All | 13 | - |
| Week 8 - Poor Appetite or Overeating - Several Days | 3 | - |
| Week 8 - Poor Appetite or Overeating - More Than Half the Days | 2 | - |
| Week 8 - Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Week 8 - Feeling Bad About Yourself - Not At All | 18 | - |
| Week 8 - Feeling Bad About Yourself - Several Days | 0 | - |
| Week 8 - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 8 - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 8 - Trouble Concentrating on Things - Not At All | 17 | - |
| Week 8 - Trouble Concentrating on Things - Several Days | 1 | - |
| Week 8 - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 8 - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 8 - Moving Slowly or Fidgety/Restless - Not At All | 18 | - |
| Week 8 - Moving Slowly or Fidgety/Restless - Several Days | 0 | - |
| Week 8 - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 8 - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 8 - Thoughts You Be Better Off Dead - Not At All | 18 | - |
| Week 8 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 8 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 8 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Week 10 - Little Interest/Pleasure in Things - Not At All | 16 | - |
| Week 10 - Little Interest/Pleasure in Things - Several Days | 1 | - |
| Week 10 - Little Interest/Pleasure in Things - More Than Half the Days | 0 | - |
| Week 10 - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 10 - Feeling Down Depressed or Hopeless - Not At All | 17 | - |
| Week 10 - Feeling Down Depressed or Hopeless - Several Days | 0 | - |
| Week 10 - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 10 - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 10 - Trouble Falling or Staying Asleep - Not At All | 15 | - |
| Week 10 - Trouble Falling or Staying Asleep - Several Days | 1 | - |
| Week 10 - Trouble Falling or Staying Asleep - More Than Half the Days | 1 | - |
| Week 10 - Trouble Falling or Staying Asleep - Nearly Every Day | 0 | - |
| Week 10 - Feeling Tired or Little Energy - Not At All | 13 | - |
| Week 10 - Feeling Tired or Little Energy - Several Days | 2 | - |
| Week 10 - Feeling Tired or Little Energy - More Than Half the Days | 2 | - |
| Week 10 - Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Week 10 - Poor Appetite or Overeating - Not At All | 11 | - |
| Week 10 - Poor Appetite or Overeating - Several Days | 5 | - |
| Week 10 - Poor Appetite or Overeating - More Than Half the Days | 1 | - |
| Week 10 - Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Week 10 - Feeling Bad About Yourself - Not At All | 17 | - |
| Week 10 - Feeling Bad About Yourself - Several Days | 0 | - |
| Week 10 - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 10 - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 10 - Trouble Concentrating on Things - Not At All | 16 | - |
| Week 10 - Trouble Concentrating on Things - Several Days | 1 | - |
| Week 10 - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 10 - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 10 - Moving Slowly or Fidgety/Restless - Not At All | 16 | - |
| Week 10 - Moving Slowly or Fidgety/Restless - Several Days | 1 | - |
| Week 10 - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 10 - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 10 - Thoughts You Be Better Off Dead - Not At All | 17 | - |
| Week 10 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 10 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 10 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Week 12 - Little Interest/Pleasure in Things - Not At All | 16 | - |
| Week 12 - Little Interest/Pleasure in Things - Several Days | 0 | - |
| Week 12 - Little Interest/Pleasure in Things - More Than Half the Days | 0 | - |
| Week 12 - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 12 - Feeling Down Depressed or Hopeless - Not At All | 16 | - |
| Week 12 - Feeling Down Depressed or Hopeless - Several Days | 0 | - |
| Week 12 - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 12 - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 12 - Trouble Falling or Staying Asleep - Not At All | 14 | - |
| Week 12 - Trouble Falling or Staying Asleep - Several Days | 1 | - |
| Week 12 - Trouble Falling or Staying Asleep - More Than Half the Days | 1 | - |
| Week 12 - Trouble Falling or Staying Asleep - Nearly Every Day | 0 | - |
| Week 12 - Feeling Tired or Little Energy - Not At All | 14 | - |
| Week 12 - Feeling Tired or Little Energy - Several Days | 2 | - |
| Week 12 - Feeling Tired or Little Energy - More Than Half the Days | 0 | - |
| Week 12 - Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Week 12 - Poor Appetite or Overeating - Not At All | 14 | - |
| Week 12 - Poor Appetite or Overeating - Several Days | 2 | - |
| Week 12 - Poor Appetite or Overeating - More Than Half the Days | 0 | - |
| Week 12 - Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Week 12 - Feeling Bad About Yourself - Not At All | 16 | - |
| Week 12 - Feeling Bad About Yourself - Several Days | 0 | - |
| Week 12 - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 12 - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 12 - Trouble Concentrating on Things - Not At All | 16 | - |
| Week 12 - Trouble Concentrating on Things - Several Days | 0 | - |
| Week 12 - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 12 - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 12 - Moving Slowly or Fidgety/Restless - Not At All | 16 | - |
| Week 12 - Moving Slowly or Fidgety/Restless - Several Days | 0 | - |
| Week 12 - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 12 - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 12 - Thoughts You Be Better Off Dead - Not At All | 16 | - |
| Week 12 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 12 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 12 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Follow-Up - Little Interest/Pleasure in Things - Not At All | 17 | - |
| Follow-Up - Little Interest/Pleasure in Things - Several Days | 0 | - |
| Follow-Up - Little Interest/Pleasure in Things - More Than Half the Days | 0 | - |
| Follow-Up - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Follow-Up - Feeling Down Depressed or Hopeless - Not At All | 16 | - |
| Follow-Up - Feeling Down Depressed or Hopeless - Several Days | 1 | - |
| Follow-Up - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Follow-Up - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Follow-Up - Trouble Falling or Staying Asleep - Not At All | 15 | - |
| Follow-Up - Trouble Falling or Staying Asleep - Several Days | 2 | - |
| Follow-Up - Trouble Falling or Staying Asleep - More Than Half the Days | 0 | - |
| Follow-Up - Trouble Falling or Staying Asleep - Nearly Every Day | 0 | - |
| Follow-Up - Feeling Tired or Little Energy - Not At All | 17 | - |
| Follow-Up - Feeling Tired or Little Energy - Several Days | 0 | - |
| Follow-Up - Feeling Tired or Little Energy - More Than Half the Days | 0 | - |
| Follow-Up - Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Follow-Up - Poor Appetite or Overeating - Not At All | 16 | - |
| Follow-Up - Poor Appetite or Overeating - Several Days | 1 | - |
| Follow-Up - Poor Appetite or Overeating - More Than Half the Days | 0 | - |
| Follow-Up - Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Follow-Up - Feeling Bad About Yourself - Not At All | 17 | - |
| Follow-Up - Feeling Bad About Yourself - Several Days | 0 | - |
| Follow-Up - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Follow-Up - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Follow-Up - Trouble Concentrating on Things - Not At All | 17 | - |
| Follow-Up - Trouble Concentrating on Things - Several Days | 0 | - |
| Follow-Up - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Follow-Up - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Follow-Up - Moving Slowly or Fidgety/Restless - Not At All | 17 | - |
| Follow-Up - Moving Slowly or Fidgety/Restless - Several Days | 0 | - |
| Follow-Up - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Follow-Up - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Follow-Up - Thoughts You Be Better Off Dead - Not At All | 17 | - |
| Follow-Up - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Follow-Up - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Follow-Up - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| PF-06882961 200 mg BID (T2DM)Week 0 - Little Interest/Pleasure in Things - Not At All | 19 | - |
| Week 0 - Little Interest/Pleasure in Things - Several Days | 1 | - |
| Week 0 - Little Interest/Pleasure in Things - More Than Half the Days | 1 | - |
| Week 0 - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 0 - Feeling Down Depressed or Hopeless - Not At All | 19 | - |
| Week 0 - Feeling Down Depressed or Hopeless - Several Days | 2 | - |
| Week 0 - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 0 - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 0 - Trouble Falling or Staying Asleep - Not At All | 17 | - |
| Week 0 - Trouble Falling or Staying Asleep - Several Days | 2 | - |
| Week 0 - Trouble Falling or Staying Asleep - More Than Half the Days | 1 | - |
| Week 0 - Trouble Falling or Staying Asleep - Nearly Every Day | 1 | - |
| Week 0 - Feeling Tired or Little Energy - Not At All | 14 | - |
| Week 0 - Feeling Tired or Little Energy - Several Days | 6 | - |
| Week 0 - Feeling Tired or Little Energy - More Than Half the Days | 1 | - |
| Week 0 - Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Week 0 - Poor Appetite or Overeating - Not At All | 21 | - |
| Week 0 - Poor Appetite or Overeating - Several Days | 0 | - |
| Week 0 - Poor Appetite or Overeating - More Than Half the Days | 0 | - |
| Week 0 - Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Week 0 - Feeling Bad About Yourself - Not At All | 21 | - |
| Week 0 - Feeling Bad About Yourself - Several Days | 0 | - |
| Week 0 - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 0 - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 0 - Trouble Concentrating on Things - Not At All | 21 | - |
| Week 0 - Trouble Concentrating on Things - Several Days | 0 | - |
| Week 0 - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 0 - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 0 - Moving Slowly or Fidgety/Restless - Not At All | 21 | - |
| Week 0 - Moving Slowly or Fidgety/Restless - Several Days | 0 | - |
| Week 0 - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 0 - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 0 - Thoughts You Be Better Off Dead - Not At All | 21 | - |
| Week 0 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 0 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 0 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Week 2 - Little Interest/Pleasure in Things - Not At All | 16 | - |
| Week 2 - Little Interest/Pleasure in Things - Several Days | 2 | - |
| Week 2 - Little Interest/Pleasure in Things - More Than Half the Days | 1 | - |
| Week 2 - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 2 - Feeling Down Depressed or Hopeless - Not At All | 17 | - |
| Week 2 - Feeling Down Depressed or Hopeless - Several Days | 2 | - |
| Week 2 - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 2 - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 2 - Trouble Falling or Staying Asleep - Not At All | 13 | - |
| Week 2 - Trouble Falling or Staying Asleep - Several Days | 4 | - |
| Week 2 - Trouble Falling or Staying Asleep - More Than Half the Days | 0 | - |
| Week 2 - Trouble Falling or Staying Asleep - Nearly Every Day | 2 | - |
| Week 2 - Feeling Tired or Little Energy - Not At All | 16 | - |
| Week 2 - Feeling Tired or Little Energy - Several Days | 2 | - |
| Week 2 - Feeling Tired or Little Energy - More Than Half the Days | 1 | - |
| Week 2 - Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Week 2 - Poor Appetite or Overeating - Not At All | 17 | - |
| Week 2 - Poor Appetite or Overeating - Several Days | 2 | - |
| Week 2 - Poor Appetite or Overeating - More Than Half the Days | 0 | - |
| Week 2 - Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Week 2 - Feeling Bad About Yourself - Not At All | 19 | - |
| Week 2 - Feeling Bad About Yourself - Several Days | 0 | - |
| Week 2 - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 2 - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 2 - Trouble Concentrating on Things - Not At All | 18 | - |
| Week 2 - Trouble Concentrating on Things - Several Days | 1 | - |
| Week 2 - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 2 - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 2 - Moving Slowly or Fidgety/Restless - Not At All | 18 | - |
| Week 2 - Moving Slowly or Fidgety/Restless - Several Days | 1 | - |
| Week 2 - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 2 - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 2 - Thoughts You Be Better Off Dead - Not At All | 19 | - |
| Week 2 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 2 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 2 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Week 4 - Little Interest/Pleasure in Things - Not At All | 18 | - |
| Week 4 - Little Interest/Pleasure in Things - Several Days | 1 | - |
| Week 4 - Little Interest/Pleasure in Things - More Than Half the Days | 0 | - |
| Week 4 - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 4 -Feeling Down Depressed or Hopeless - Not At All | 18 | - |
| Week 4 - Feeling Down Depressed or Hopeless - Several Days | 1 | - |
| Week 4 - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 4 - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 4 - Trouble Falling or Staying Asleep - Not At All | 16 | - |
| Week 4 - Trouble Falling or Staying Asleep - Several Days | 2 | - |
| Week 4 - Trouble Falling or Staying Asleep - More Than Half the Days | 0 | - |
| Week 4 - Trouble Falling or Staying Asleep - Nearly Every Day | 1 | - |
| Week 4 - Feeling Tired or Little Energy - Not At All | 14 | - |
| Week 4 - Feeling Tired or Little Energy - Several Days | 4 | - |
| Week 4 - Feeling Tired or Little Energy - More Than Half the Days | 0 | - |
| Week 4 - Feeling Tired or Little Energy - Nearly Every Day | 1 | - |
| Week 4 - Poor Appetite or Overeating - Not At All | 16 | - |
| Week 4 - Poor Appetite or Overeating - Several Days | 2 | - |
| Week 4 - Poor Appetite or Overeating - More Than Half the Days | 1 | - |
| Week 4 - Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Week 4 - Feeling Bad About Yourself - Not At All | 18 | - |
| Week 4 - Feeling Bad About Yourself - Several Days | 1 | - |
| Week 4 - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 4 - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 4 - Trouble Concentrating on Things - Not At All | 19 | - |
| Week 4 - Trouble Concentrating on Things - Several Days | 0 | - |
| Week 4 - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 4 - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 4 - Moving Slowly or Fidgety/Restless - Not At All | 19 | - |
| Week 4 - Moving Slowly or Fidgety/Restless - Several Days | 0 | - |
| Week 4 - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 4 - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 4 - Thoughts You Be Better Off Dead - Not At All | 19 | - |
| Week 4 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 4 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 4 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Week 6 -Little Interest/Pleasure in Things - Not At All | 14 | - |
| Week 6 -Little Interest/Pleasure in Things - Several Days | 1 | - |
| Week 6 -Little Interest/Pleasure in Things - More Than Half the Days | 1 | - |
| Week 6 -Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 6 -Feeling Down Depressed or Hopeless - Not At All | 15 | - |
| Week 6 -Feeling Down Depressed or Hopeless - Several Days | 1 | - |
| Week 6 -Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 6 -Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 6 -Trouble Falling or Staying Asleep - Not At All | 12 | - |
| Week 6 -Trouble Falling or Staying Asleep - Several Days | 3 | - |
| Week 6 -Trouble Falling or Staying Asleep - More Than Half the Days | 0 | - |
| Week 6 -Trouble Falling or Staying Asleep - Nearly Every Day | 1 | - |
| Week 6 -Feeling Tired or Little Energy - Not At All | 10 | - |
| Week 6 -Feeling Tired or Little Energy - Several Days | 5 | - |
| Week 6 -Feeling Tired or Little Energy - More Than Half the Days | 1 | - |
| Week 6 -Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Week 6 -Poor Appetite or Overeating - Not At All | 9 | - |
| Week 6 -Poor Appetite or Overeating - Several Days | 6 | - |
| Week 6 -Poor Appetite or Overeating - More Than Half the Days | 1 | - |
| Week 6 -Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Week 6 -Feeling Bad About Yourself - Not At All | 16 | - |
| Week 6 -Feeling Bad About Yourself - Several Days | 0 | - |
| Week 6 -Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 6 -Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 6 -Trouble Concentrating on Things - Not At All | 16 | - |
| Week 6 -Trouble Concentrating on Things - Several Days | 0 | - |
| Week 6 -Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 6 -Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 6 -Moving Slowly or Fidgety/Restless - Not At All | 16 | - |
| Week 6 -Moving Slowly or Fidgety/Restless - Several Days | 0 | - |
| Week 6 -Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 6 -Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 6 - Thoughts You Be Better Off Dead - Not At All | 16 | - |
| Week 6 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 6 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 6 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Week 8 - Little Interest/Pleasure in Things - Not At All | 15 | - |
| Week 8 - Little Interest/Pleasure in Things - Several Days | 1 | - |
| Week 8 - Little Interest/Pleasure in Things - More Than Half the Days | 0 | - |
| Week 8 - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 8 - Feeling Down Depressed or Hopeless - Not At All | 15 | - |
| Week 8 - Feeling Down Depressed or Hopeless - Several Days | 1 | - |
| Week 8 - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 8 - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 8 - Trouble Falling or Staying Asleep - Not At All | 13 | - |
| Week 8 - Trouble Falling or Staying Asleep - Several Days | 2 | - |
| Week 8 - Trouble Falling or Staying Asleep - More Than Half the Days | 0 | - |
| Week 8 - Trouble Falling or Staying Asleep - Nearly Every Day | 1 | - |
| Week 8 - Feeling Tired or Little Energy - Not At All | 9 | - |
| Week 8 - Feeling Tired or Little Energy - Several Days | 6 | - |
| Week 8 - Feeling Tired or Little Energy - More Than Half the Days | 1 | - |
| Week 8 - Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Week 8 - Poor Appetite or Overeating - Not At All | 9 | - |
| Week 8 - Poor Appetite or Overeating - Several Days | 4 | - |
| Week 8 - Poor Appetite or Overeating - More Than Half the Days | 2 | - |
| Week 8 - Poor Appetite or Overeating - Nearly Every Day | 1 | - |
| Week 8 - Feeling Bad About Yourself - Not At All | 15 | - |
| Week 8 - Feeling Bad About Yourself - Several Days | 1 | - |
| Week 8 - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 8 - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 8 - Trouble Concentrating on Things - Not At All | 15 | - |
| Week 8 - Trouble Concentrating on Things - Several Days | 1 | - |
| Week 8 - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 8 - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 8 - Moving Slowly or Fidgety/Restless - Not At All | 16 | - |
| Week 8 - Moving Slowly or Fidgety/Restless - Several Days | 0 | - |
| Week 8 - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 8 - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 8 - Thoughts You Be Better Off Dead - Not At All | 16 | - |
| Week 8 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 8 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 8 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Week 10 - Little Interest/Pleasure in Things - Not At All | 14 | - |
| Week 10 - Little Interest/Pleasure in Things - Several Days | 1 | - |
| Week 10 - Little Interest/Pleasure in Things - More Than Half the Days | 0 | - |
| Week 10 - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 10 - Feeling Down Depressed or Hopeless - Not At All | 14 | - |
| Week 10 - Feeling Down Depressed or Hopeless - Several Days | 1 | - |
| Week 10 - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 10 - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 10 - Trouble Falling or Staying Asleep - Not At All | 12 | - |
| Week 10 - Trouble Falling or Staying Asleep - Several Days | 2 | - |
| Week 10 - Trouble Falling or Staying Asleep - More Than Half the Days | 0 | - |
| Week 10 - Trouble Falling or Staying Asleep - Nearly Every Day | 1 | - |
| Week 10 - Feeling Tired or Little Energy - Not At All | 12 | - |
| Week 10 - Feeling Tired or Little Energy - Several Days | 2 | - |
| Week 10 - Feeling Tired or Little Energy - More Than Half the Days | 0 | - |
| Week 10 - Feeling Tired or Little Energy - Nearly Every Day | 1 | - |
| Week 10 - Poor Appetite or Overeating - Not At All | 10 | - |
| Week 10 - Poor Appetite or Overeating - Several Days | 2 | - |
| Week 10 - Poor Appetite or Overeating - More Than Half the Days | 2 | - |
| Week 10 - Poor Appetite or Overeating - Nearly Every Day | 1 | - |
| Week 10 - Feeling Bad About Yourself - Not At All | 14 | - |
| Week 10 - Feeling Bad About Yourself - Several Days | 1 | - |
| Week 10 - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 10 - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 10 - Trouble Concentrating on Things - Not At All | 15 | - |
| Week 10 - Trouble Concentrating on Things - Several Days | 0 | - |
| Week 10 - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 10 - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 10 - Moving Slowly or Fidgety/Restless - Not At All | 15 | - |
| Week 10 - Moving Slowly or Fidgety/Restless - Several Days | 0 | - |
| Week 10 - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 10 - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 10 - Thoughts You Be Better Off Dead - Not At All | 15 | - |
| Week 10 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 10 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 10 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Week 12 - Little Interest/Pleasure in Things - Not At All | 13 | - |
| Week 12 - Little Interest/Pleasure in Things - Several Days | 1 | - |
| Week 12 - Little Interest/Pleasure in Things - More Than Half the Days | 0 | - |
| Week 12 - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 12 - Feeling Down Depressed or Hopeless - Not At All | 13 | - |
| Week 12 - Feeling Down Depressed or Hopeless - Several Days | 1 | - |
| Week 12 - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 12 - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 12 - Trouble Falling or Staying Asleep - Not At All | 12 | - |
| Week 12 - Trouble Falling or Staying Asleep - Several Days | 1 | - |
| Week 12 - Trouble Falling or Staying Asleep - More Than Half the Days | 0 | - |
| Week 12 - Trouble Falling or Staying Asleep - Nearly Every Day | 1 | - |
| Week 12 - Feeling Tired or Little Energy - Not At All | 11 | - |
| Week 12 - Feeling Tired or Little Energy - Several Days | 3 | - |
| Week 12 - Feeling Tired or Little Energy - More Than Half the Days | 0 | - |
| Week 12 - Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Week 12 - Poor Appetite or Overeating - Not At All | 9 | - |
| Week 12 - Poor Appetite or Overeating - Several Days | 4 | - |
| Week 12 - Poor Appetite or Overeating - More Than Half the Days | 0 | - |
| Week 12 - Poor Appetite or Overeating - Nearly Every Day | 1 | - |
| Week 12 - Feeling Bad About Yourself - Not At All | 13 | - |
| Week 12 - Feeling Bad About Yourself - Several Days | 1 | - |
| Week 12 - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 12 - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 12 - Trouble Concentrating on Things - Not At All | 14 | - |
| Week 12 - Trouble Concentrating on Things - Several Days | 0 | - |
| Week 12 - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 12 - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 12 - Moving Slowly or Fidgety/Restless - Not At All | 14 | - |
| Week 12 - Moving Slowly or Fidgety/Restless - Several Days | 0 | - |
| Week 12 - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 12 - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 12 - Thoughts You Be Better Off Dead - Not At All | 14 | - |
| Week 12 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 12 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 12 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Follow-Up - Little Interest/Pleasure in Things - Not At All | 13 | - |
| Follow-Up - Little Interest/Pleasure in Things - Several Days | 1 | - |
| Follow-Up - Little Interest/Pleasure in Things - More Than Half the Days | 0 | - |
| Follow-Up - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Follow-Up - Feeling Down Depressed or Hopeless - Not At All | 13 | - |
| Follow-Up - Feeling Down Depressed or Hopeless - Several Days | 1 | - |
| Follow-Up - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Follow-Up - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Follow-Up - Trouble Falling or Staying Asleep - Not At All | 12 | - |
| Follow-Up - Trouble Falling or Staying Asleep - Several Days | 1 | - |
| Follow-Up - Trouble Falling or Staying Asleep - More Than Half the Days | 0 | - |
| Follow-Up - Trouble Falling or Staying Asleep - Nearly Every Day | 1 | - |
| Follow-Up - Feeling Tired or Little Energy - Not At All | 12 | - |
| Follow-Up - Feeling Tired or Little Energy - Several Days | 2 | - |
| Follow-Up - Feeling Tired or Little Energy - More Than Half the Days | 0 | - |
| Follow-Up - Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Follow-Up - Poor Appetite or Overeating - Not At All | 12 | - |
| Follow-Up - Poor Appetite or Overeating - Several Days | 2 | - |
| Follow-Up - Poor Appetite or Overeating - More Than Half the Days | 0 | - |
| Follow-Up - Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Follow-Up - Feeling Bad About Yourself - Not At All | 13 | - |
| Follow-Up - Feeling Bad About Yourself - Several Days | 1 | - |
| Follow-Up - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Follow-Up - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Follow-Up - Trouble Concentrating on Things - Not At All | 14 | - |
| Follow-Up - Trouble Concentrating on Things - Several Days | 0 | - |
| Follow-Up - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Follow-Up - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Follow-Up - Moving Slowly or Fidgety/Restless - Not At All | 14 | - |
| Follow-Up - Moving Slowly or Fidgety/Restless - Several Days | 0 | - |
| Follow-Up - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Follow-Up - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Follow-Up - Thoughts You Be Better Off Dead - Not At All | 14 | - |
| Follow-Up - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Follow-Up - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Follow-Up - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| PF-06882961 200 mg BID (Non-diabetic Obesity)Week 0 - Little Interest/Pleasure in Things - Not At All | 21 | - |
| Week 0 - Little Interest/Pleasure in Things - Several Days | 1 | - |
| Week 0 - Little Interest/Pleasure in Things - More Than Half the Days | 0 | - |
| Week 0 - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 0 - Feeling Down Depressed or Hopeless - Not At All | 19 | - |
| Week 0 - Feeling Down Depressed or Hopeless - Several Days | 3 | - |
| Week 0 - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 0 - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 0 - Trouble Falling or Staying Asleep - Not At All | 15 | - |
| Week 0 - Trouble Falling or Staying Asleep - Several Days | 7 | - |
| Week 0 - Trouble Falling or Staying Asleep - More Than Half the Days | 0 | - |
| Week 0 - Trouble Falling or Staying Asleep - Nearly Every Day | 0 | - |
| Week 0 - Feeling Tired or Little Energy - Not At All | 15 | - |
| Week 0 - Feeling Tired or Little Energy - Several Days | 7 | - |
| Week 0 - Feeling Tired or Little Energy - More Than Half the Days | 0 | - |
| Week 0 - Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Week 0 - Poor Appetite or Overeating - Not At All | 20 | - |
| Week 0 - Poor Appetite or Overeating - Several Days | 1 | - |
| Week 0 - Poor Appetite or Overeating - More Than Half the Days | 1 | - |
| Week 0 - Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Week 0 - Feeling Bad About Yourself - Not At All | 21 | - |
| Week 0 - Feeling Bad About Yourself - Several Days | 1 | - |
| Week 0 - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 0 - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 0 - Trouble Concentrating on Things - Not At All | 20 | - |
| Week 0 - Trouble Concentrating on Things - Several Days | 2 | - |
| Week 0 - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 0 - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 0 - Moving Slowly or Fidgety/Restless - Not At All | 21 | - |
| Week 0 - Moving Slowly or Fidgety/Restless - Several Days | 1 | - |
| Week 0 - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 0 - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 0 - Thoughts You Be Better Off Dead - Not At All | 22 | - |
| Week 0 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 0 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 0 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Week 2 - Little Interest/Pleasure in Things - Not At All | 18 | - |
| Week 2 - Little Interest/Pleasure in Things - Several Days | 1 | - |
| Week 2 - Little Interest/Pleasure in Things - More Than Half the Days | 0 | - |
| Week 2 - Little Interest/Pleasure in Things - Nearly Every Day | 1 | - |
| Week 2 - Feeling Down Depressed or Hopeless - Not At All | 18 | - |
| Week 2 - Feeling Down Depressed or Hopeless - Several Days | 2 | - |
| Week 2 - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 2 - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 2 - Trouble Falling or Staying Asleep - Not At All | 15 | - |
| Week 2 - Trouble Falling or Staying Asleep - Several Days | 5 | - |
| Week 2 - Trouble Falling or Staying Asleep - More Than Half the Days | 0 | - |
| Week 2 - Trouble Falling or Staying Asleep - Nearly Every Day | 0 | - |
| Week 2 - Feeling Tired or Little Energy - Not At All | 14 | - |
| Week 2 - Feeling Tired or Little Energy - Several Days | 5 | - |
| Week 2 - Feeling Tired or Little Energy - More Than Half the Days | 1 | - |
| Week 2 - Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Week 2 - Poor Appetite or Overeating - Not At All | 17 | - |
| Week 2 - Poor Appetite or Overeating - Several Days | 2 | - |
| Week 2 - Poor Appetite or Overeating - More Than Half the Days | 1 | - |
| Week 2 - Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Week 2 - Feeling Bad About Yourself - Not At All | 19 | - |
| Week 2 - Feeling Bad About Yourself - Several Days | 1 | - |
| Week 2 - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 2 - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 2 - Trouble Concentrating on Things - Not At All | 18 | - |
| Week 2 - Trouble Concentrating on Things - Several Days | 2 | - |
| Week 2 - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 2 - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 2 - Moving Slowly or Fidgety/Restless - Not At All | 20 | - |
| Week 2 - Moving Slowly or Fidgety/Restless - Several Days | 0 | - |
| Week 2 - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 2 - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 2 - Thoughts You Be Better Off Dead - Not At All | 20 | - |
| Week 2 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 2 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 2 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Week 4 - Little Interest/Pleasure in Things - Not At All | 16 | - |
| Week 4 - Little Interest/Pleasure in Things - Several Days | 1 | - |
| Week 4 - Little Interest/Pleasure in Things - More Than Half the Days | 0 | - |
| Week 4 - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 4 -Feeling Down Depressed or Hopeless - Not At All | 15 | - |
| Week 4 - Feeling Down Depressed or Hopeless - Several Days | 2 | - |
| Week 4 - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 4 - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 4 - Trouble Falling or Staying Asleep - Not At All | 14 | - |
| Week 4 - Trouble Falling or Staying Asleep - Several Days | 3 | - |
| Week 4 - Trouble Falling or Staying Asleep - More Than Half the Days | 0 | - |
| Week 4 - Trouble Falling or Staying Asleep - Nearly Every Day | 0 | - |
| Week 4 - Feeling Tired or Little Energy - Not At All | 9 | - |
| Week 4 - Feeling Tired or Little Energy - Several Days | 8 | - |
| Week 4 - Feeling Tired or Little Energy - More Than Half the Days | 0 | - |
| Week 4 - Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Week 4 - Poor Appetite or Overeating - Not At All | 13 | - |
| Week 4 - Poor Appetite or Overeating - Several Days | 2 | - |
| Week 4 - Poor Appetite or Overeating - More Than Half the Days | 1 | - |
| Week 4 - Poor Appetite or Overeating - Nearly Every Day | 1 | - |
| Week 4 - Feeling Bad About Yourself - Not At All | 17 | - |
| Week 4 - Feeling Bad About Yourself - Several Days | 0 | - |
| Week 4 - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 4 - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 4 - Trouble Concentrating on Things - Not At All | 16 | - |
| Week 4 - Trouble Concentrating on Things - Several Days | 1 | - |
| Week 4 - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 4 - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 4 - Moving Slowly or Fidgety/Restless - Not At All | 17 | - |
| Week 4 - Moving Slowly or Fidgety/Restless - Several Days | 0 | - |
| Week 4 - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 4 - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 4 - Thoughts You Be Better Off Dead - Not At All | 17 | - |
| Week 4 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 4 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 4 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Week 6 -Little Interest/Pleasure in Things - Not At All | 14 | - |
| Week 6 -Little Interest/Pleasure in Things - Several Days | 1 | - |
| Week 6 -Little Interest/Pleasure in Things - More Than Half the Days | 0 | - |
| Week 6 -Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 6 -Feeling Down Depressed or Hopeless - Not At All | 13 | - |
| Week 6 -Feeling Down Depressed or Hopeless - Several Days | 2 | - |
| Week 6 -Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 6 -Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 6 -Trouble Falling or Staying Asleep - Not At All | 10 | - |
| Week 6 -Trouble Falling or Staying Asleep - Several Days | 4 | - |
| Week 6 -Trouble Falling or Staying Asleep - More Than Half the Days | 1 | - |
| Week 6 -Trouble Falling or Staying Asleep - Nearly Every Day | 0 | - |
| Week 6 -Feeling Tired or Little Energy - Not At All | 10 | - |
| Week 6 -Feeling Tired or Little Energy - Several Days | 5 | - |
| Week 6 -Feeling Tired or Little Energy - More Than Half the Days | 0 | - |
| Week 6 -Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Week 6 -Poor Appetite or Overeating - Not At All | 12 | - |
| Week 6 -Poor Appetite or Overeating - Several Days | 3 | - |
| Week 6 -Poor Appetite or Overeating - More Than Half the Days | 0 | - |
| Week 6 -Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Week 6 -Feeling Bad About Yourself - Not At All | 15 | - |
| Week 6 -Feeling Bad About Yourself - Several Days | 0 | - |
| Week 6 -Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 6 -Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 6 -Trouble Concentrating on Things - Not At All | 14 | - |
| Week 6 -Trouble Concentrating on Things - Several Days | 1 | - |
| Week 6 -Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 6 -Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 6 -Moving Slowly or Fidgety/Restless - Not At All | 15 | - |
| Week 6 -Moving Slowly or Fidgety/Restless - Several Days | 0 | - |
| Week 6 -Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 6 -Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 6 - Thoughts You Be Better Off Dead - Not At All | 15 | - |
| Week 6 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 6 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 6 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Week 8 - Little Interest/Pleasure in Things - Not At All | 13 | - |
| Week 8 - Little Interest/Pleasure in Things - Several Days | 2 | - |
| Week 8 - Little Interest/Pleasure in Things - More Than Half the Days | 0 | - |
| Week 8 - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 8 - Feeling Down Depressed or Hopeless - Not At All | 14 | - |
| Week 8 - Feeling Down Depressed or Hopeless - Several Days | 1 | - |
| Week 8 - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 8 - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 8 - Trouble Falling or Staying Asleep - Not At All | 10 | - |
| Week 8 - Trouble Falling or Staying Asleep - Several Days | 5 | - |
| Week 8 - Trouble Falling or Staying Asleep - More Than Half the Days | 0 | - |
| Week 8 - Trouble Falling or Staying Asleep - Nearly Every Day | 0 | - |
| Week 8 - Feeling Tired or Little Energy - Not At All | 10 | - |
| Week 8 - Feeling Tired or Little Energy - Several Days | 4 | - |
| Week 8 - Feeling Tired or Little Energy - More Than Half the Days | 1 | - |
| Week 8 - Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Week 8 - Poor Appetite or Overeating - Not At All | 12 | - |
| Week 8 - Poor Appetite or Overeating - Several Days | 3 | - |
| Week 8 - Poor Appetite or Overeating - More Than Half the Days | 0 | - |
| Week 8 - Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Week 8 - Feeling Bad About Yourself - Not At All | 14 | - |
| Week 8 - Feeling Bad About Yourself - Several Days | 1 | - |
| Week 8 - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 8 - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 8 - Trouble Concentrating on Things - Not At All | 14 | - |
| Week 8 - Trouble Concentrating on Things - Several Days | 1 | - |
| Week 8 - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 8 - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 8 - Moving Slowly or Fidgety/Restless - Not At All | 15 | - |
| Week 8 - Moving Slowly or Fidgety/Restless - Several Days | 0 | - |
| Week 8 - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 8 - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 8 - Thoughts You Be Better Off Dead - Not At All | 15 | - |
| Week 8 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 8 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 8 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Week 10 - Little Interest/Pleasure in Things - Not At All | 13 | - |
| Week 10 - Little Interest/Pleasure in Things - Several Days | 2 | - |
| Week 10 - Little Interest/Pleasure in Things - More Than Half the Days | 0 | - |
| Week 10 - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 10 - Feeling Down Depressed or Hopeless - Not At All | 14 | - |
| Week 10 - Feeling Down Depressed or Hopeless - Several Days | 1 | - |
| Week 10 - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 10 - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 10 - Trouble Falling or Staying Asleep - Not At All | 10 | - |
| Week 10 - Trouble Falling or Staying Asleep - Several Days | 5 | - |
| Week 10 - Trouble Falling or Staying Asleep - More Than Half the Days | 0 | - |
| Week 10 - Trouble Falling or Staying Asleep - Nearly Every Day | 0 | - |
| Week 10 - Feeling Tired or Little Energy - Not At All | 9 | - |
| Week 10 - Feeling Tired or Little Energy - Several Days | 5 | - |
| Week 10 - Feeling Tired or Little Energy - More Than Half the Days | 1 | - |
| Week 10 - Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Week 10 - Poor Appetite or Overeating - Not At All | 12 | - |
| Week 10 - Poor Appetite or Overeating - Several Days | 3 | - |
| Week 10 - Poor Appetite or Overeating - More Than Half the Days | 0 | - |
| Week 10 - Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Week 10 - Feeling Bad About Yourself - Not At All | 15 | - |
| Week 10 - Feeling Bad About Yourself - Several Days | 0 | - |
| Week 10 - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 10 - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 10 - Trouble Concentrating on Things - Not At All | 15 | - |
| Week 10 - Trouble Concentrating on Things - Several Days | 0 | - |
| Week 10 - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 10 - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 10 - Moving Slowly or Fidgety/Restless - Not At All | 15 | - |
| Week 10 - Moving Slowly or Fidgety/Restless - Several Days | 0 | - |
| Week 10 - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 10 - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 10 - Thoughts You Be Better Off Dead - Not At All | 15 | - |
| Week 10 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 10 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 10 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Week 12 - Little Interest/Pleasure in Things - Not At All | 14 | - |
| Week 12 - Little Interest/Pleasure in Things - Several Days | 0 | - |
| Week 12 - Little Interest/Pleasure in Things - More Than Half the Days | 0 | - |
| Week 12 - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Week 12 - Feeling Down Depressed or Hopeless - Not At All | 14 | - |
| Week 12 - Feeling Down Depressed or Hopeless - Several Days | 0 | - |
| Week 12 - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Week 12 - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Week 12 - Trouble Falling or Staying Asleep - Not At All | 9 | - |
| Week 12 - Trouble Falling or Staying Asleep - Several Days | 4 | - |
| Week 12 - Trouble Falling or Staying Asleep - More Than Half the Days | 1 | - |
| Week 12 - Trouble Falling or Staying Asleep - Nearly Every Day | 0 | - |
| Week 12 - Feeling Tired or Little Energy - Not At All | 9 | - |
| Week 12 - Feeling Tired or Little Energy - Several Days | 5 | - |
| Week 12 - Feeling Tired or Little Energy - More Than Half the Days | 0 | - |
| Week 12 - Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Week 12 - Poor Appetite or Overeating - Not At All | 12 | - |
| Week 12 - Poor Appetite or Overeating - Several Days | 1 | - |
| Week 12 - Poor Appetite or Overeating - More Than Half the Days | 0 | - |
| Week 12 - Poor Appetite or Overeating - Nearly Every Day | 1 | - |
| Week 12 - Feeling Bad About Yourself - Not At All | 14 | - |
| Week 12 - Feeling Bad About Yourself - Several Days | 0 | - |
| Week 12 - Feeling Bad About Yourself - More Than Half the Days | 0 | - |
| Week 12 - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Week 12 - Trouble Concentrating on Things - Not At All | 14 | - |
| Week 12 - Trouble Concentrating on Things - Several Days | 0 | - |
| Week 12 - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Week 12 - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Week 12 - Moving Slowly or Fidgety/Restless - Not At All | 14 | - |
| Week 12 - Moving Slowly or Fidgety/Restless - Several Days | 0 | - |
| Week 12 - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Week 12 - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Week 12 - Thoughts You Be Better Off Dead - Not At All | 14 | - |
| Week 12 - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Week 12 - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Week 12 - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
| Follow-Up - Little Interest/Pleasure in Things - Not At All | 12 | - |
| Follow-Up - Little Interest/Pleasure in Things - Several Days | 1 | - |
| Follow-Up - Little Interest/Pleasure in Things - More Than Half the Days | 1 | - |
| Follow-Up - Little Interest/Pleasure in Things - Nearly Every Day | 0 | - |
| Follow-Up - Feeling Down Depressed or Hopeless - Not At All | 12 | - |
| Follow-Up - Feeling Down Depressed or Hopeless - Several Days | 2 | - |
| Follow-Up - Feeling Down Depressed or Hopeless - More Than Half the Days | 0 | - |
| Follow-Up - Feeling Down Depressed or Hopeless - Nearly Every Day | 0 | - |
| Follow-Up - Trouble Falling or Staying Asleep - Not At All | 9 | - |
| Follow-Up - Trouble Falling or Staying Asleep - Several Days | 4 | - |
| Follow-Up - Trouble Falling or Staying Asleep - More Than Half the Days | 0 | - |
| Follow-Up - Trouble Falling or Staying Asleep - Nearly Every Day | 1 | - |
| Follow-Up - Feeling Tired or Little Energy - Not At All | 9 | - |
| Follow-Up - Feeling Tired or Little Energy - Several Days | 4 | - |
| Follow-Up - Feeling Tired or Little Energy - More Than Half the Days | 1 | - |
| Follow-Up - Feeling Tired or Little Energy - Nearly Every Day | 0 | - |
| Follow-Up - Poor Appetite or Overeating - Not At All | 12 | - |
| Follow-Up - Poor Appetite or Overeating - Several Days | 1 | - |
| Follow-Up - Poor Appetite or Overeating - More Than Half the Days | 1 | - |
| Follow-Up - Poor Appetite or Overeating - Nearly Every Day | 0 | - |
| Follow-Up - Feeling Bad About Yourself - Not At All | 13 | - |
| Follow-Up - Feeling Bad About Yourself - Several Days | 0 | - |
| Follow-Up - Feeling Bad About Yourself - More Than Half the Days | 1 | - |
| Follow-Up - Feeling Bad About Yourself - Nearly Every Day | 0 | - |
| Follow-Up - Trouble Concentrating on Things - Not At All | 13 | - |
| Follow-Up - Trouble Concentrating on Things - Several Days | 1 | - |
| Follow-Up - Trouble Concentrating on Things - More Than Half the Days | 0 | - |
| Follow-Up - Trouble Concentrating on Things - Nearly Every Day | 0 | - |
| Follow-Up - Moving Slowly or Fidgety/Restless - Not At All | 14 | - |
| Follow-Up - Moving Slowly or Fidgety/Restless - Several Days | 0 | - |
| Follow-Up - Moving Slowly or Fidgety/Restless - More Than Half the Days | 0 | - |
| Follow-Up - Moving Slowly or Fidgety/Restless - Nearly Every Day | 0 | - |
| Follow-Up - Thoughts You Be Better Off Dead - Not At All | 14 | - |
| Follow-Up - Thoughts You Be Better Off Dead - Several Days | 0 | - |
| Follow-Up - Thoughts You Be Better Off Dead - More Than Half the Days | 0 | - |
| Follow-Up - Thoughts You Be Better Off Dead - Nearly Every Day | 0 | - |
Secondary/protocol endpoint
Number of Participants With Response to Patient Health Questionnaire-9 (PHQ-9)
Time frame:Week 0, 2, 4, 6, 8, 10, 12, 13-14.
threshold achievement, improvement
Safety / tolerability / PK
10 endpointsPrimary/registry result
Number of Participants With Treatment Emergent Adverse Events (AEs) by Severity
Time frame:Baseline through follow-up (Day 112)
event count, event
Posted result
| Group | Participants | 95% CI |
|---|---|---|
| Placebo (T2DM)All Causality - Mild | 5 | - |
| All Causality - Moderate | 3 | - |
| All Causality - Severe | 0 | - |
| Treatment Related - Mild | 2 | - |
| Treatment Related - Moderate | 2 | - |
| Treatment Related - Severe | 0 | - |
| PF-06882961 80 mg BID Low, Slow (T2DM)All Causality - Mild | 4 | - |
| All Causality - Moderate | 8 | - |
| All Causality - Severe | 0 | - |
| Treatment Related - Mild | 4 | - |
| Treatment Related - Moderate | 4 | - |
| Treatment Related - Severe | 0 | - |
| PF-06882961 80 mg BID High, Slow (T2DM)All Causality - Mild | 10 | - |
| All Causality - Moderate | 3 | - |
| All Causality - Severe | 1 | - |
| Treatment Related - Mild | 8 | - |
| Treatment Related - Moderate | 2 | - |
| Treatment Related - Severe | 0 | - |
| PF-06882961 120 mg BID Low, Fast (T2DM)All Causality - Mild | 9 | - |
| All Causality - Moderate | 5 | - |
| All Causality - Severe | 2 | - |
| Treatment Related - Mild | 3 | - |
| Treatment Related - Moderate | 3 | - |
| Treatment Related - Severe | 2 | - |
| PF-06882961 120 mg BID High, Fast (T2DM)All Causality - Mild | 8 | - |
| All Causality - Moderate | 6 | - |
| All Causality - Severe | 1 | - |
| Treatment Related - Mild | 7 | - |
| Treatment Related - Moderate | 7 | - |
| Treatment Related - Severe | 0 | - |
| PF-06882961 200 mg BID (T2DM)All Causality - Mild | 10 | - |
| All Causality - Moderate | 3 | - |
| All Causality - Severe | 1 | - |
| Treatment Related - Mild | 9 | - |
| Treatment Related - Moderate | 3 | - |
| Treatment Related - Severe | 1 | - |
| Placebo (Non-diabetic Obesity)All Causality - Mild | 1 | - |
| All Causality - Moderate | 3 | - |
| All Causality - Severe | 0 | - |
| Treatment Related - Mild | 0 | - |
| Treatment Related - Moderate | 1 | - |
| Treatment Related - Severe | 0 | - |
| PF-06882961 200 mg BID (Non-diabetic Obesity)All Causality - Mild | 6 | - |
| All Causality - Moderate | 11 | - |
| All Causality - Severe | 1 | - |
| Treatment Related - Mild | 5 | - |
| Treatment Related - Moderate | 11 | - |
| Treatment Related - Severe | 1 | - |
Primary/protocol endpoint
Number of Participants With Treatment Emergent Adverse Events (AEs) by Severity
Time frame:Baseline through follow-up (Day 112)
Treatment-emergent AEs (any)
event count, event
Secondary/registry result
Number of Participants With Laboratory Abnormalities (Without Regard to Baseline Abnormality)
Time frame:Baseline through Visit 10 (Day 91)
event count, event
Posted result
| Group | Participants | 95% CI |
|---|---|---|
| Placebo (T2DM) | 12 | - |
| PF-06882961 80 mg BID Low, Slow (T2DM) | 16 | - |
| PF-06882961 80 mg BID High, Slow (T2DM) | 17 | - |
| PF-06882961 120 mg BID Low, Fast (T2DM) | 20 | - |
| PF-06882961 120 mg BID High, Fast (T2DM) | 17 | - |
| PF-06882961 200 mg BID (T2DM) | 14 | - |
| Placebo (Non-diabetic Obesity) | 4 | - |
| PF-06882961 200 mg BID (Non-diabetic Obesity) | 9 | - |
Secondary/registry result
Number of Participants With Vital Signs Meeting the Pre-defined Categorical Summarization Criteria
Time frame:Baseline through Visit 10 (Day 91)
event count, event
Posted result
| Group | Participants | 95% CI |
|---|---|---|
| Placebo (T2DM)Supine SBP <90 mmHg | 0 | - |
| Supine SBP Increase >=30 mmHg | 0 | - |
| Supine SBP Decrease >=30 mmHg | 0 | - |
| Supine DBP <50 mmHg | 0 | - |
| Supine DBP Increase >=20 mmHg | 1 | - |
| Supine DBP Decrease >=20 mmHg | 0 | - |
| Supine Pulse Rate <40 bpm | 0 | - |
| Supine Pulse Rate >120 bpm | 0 | - |
| PF-06882961 80 mg BID Low, Slow (T2DM)Supine SBP <90 mmHg | 0 | - |
| Supine SBP Increase >=30 mmHg | 0 | - |
| Supine SBP Decrease >=30 mmHg | 2 | - |
| Supine DBP <50 mmHg | 0 | - |
| Supine DBP Increase >=20 mmHg | 0 | - |
| Supine DBP Decrease >=20 mmHg | 1 | - |
| Supine Pulse Rate <40 bpm | 0 | - |
| Supine Pulse Rate >120 bpm | 0 | - |
| PF-06882961 80 mg BID High, Slow (T2DM)Supine SBP <90 mmHg | 0 | - |
| Supine SBP Increase >=30 mmHg | 2 | - |
| Supine SBP Decrease >=30 mmHg | 1 | - |
| Supine DBP <50 mmHg | 0 | - |
| Supine DBP Increase >=20 mmHg | 2 | - |
| Supine DBP Decrease >=20 mmHg | 1 | - |
| Supine Pulse Rate <40 bpm | 0 | - |
| Supine Pulse Rate >120 bpm | 0 | - |
| PF-06882961 120 mg BID Low, Fast (T2DM)Supine SBP <90 mmHg | 0 | - |
| Supine SBP Increase >=30 mmHg | 0 | - |
| Supine SBP Decrease >=30 mmHg | 3 | - |
| Supine DBP <50 mmHg | 0 | - |
| Supine DBP Increase >=20 mmHg | 0 | - |
| Supine DBP Decrease >=20 mmHg | 1 | - |
| Supine Pulse Rate <40 bpm | 0 | - |
| Supine Pulse Rate >120 bpm | 0 | - |
| PF-06882961 120 mg BID High, Fast (T2DM)Supine SBP <90 mmHg | 0 | - |
| Supine SBP Increase >=30 mmHg | 4 | - |
| Supine SBP Decrease >=30 mmHg | 2 | - |
| Supine DBP <50 mmHg | 0 | - |
| Supine DBP Increase >=20 mmHg | 2 | - |
| Supine DBP Decrease >=20 mmHg | 1 | - |
| Supine Pulse Rate <40 bpm | 0 | - |
| Supine Pulse Rate >120 bpm | 0 | - |
| PF-06882961 200 mg BID (T2DM)Supine SBP <90 mmHg | 0 | - |
| Supine SBP Increase >=30 mmHg | 1 | - |
| Supine SBP Decrease >=30 mmHg | 1 | - |
| Supine DBP <50 mmHg | 0 | - |
| Supine DBP Increase >=20 mmHg | 1 | - |
| Supine DBP Decrease >=20 mmHg | 1 | - |
| Supine Pulse Rate <40 bpm | 0 | - |
| Supine Pulse Rate >120 bpm | 0 | - |
| Placebo (Non-diabetic Obesity)Supine SBP <90 mmHg | 0 | - |
| Supine SBP Increase >=30 mmHg | 0 | - |
| Supine SBP Decrease >=30 mmHg | 1 | - |
| Supine DBP <50 mmHg | 0 | - |
| Supine DBP Increase >=20 mmHg | 0 | - |
| Supine DBP Decrease >=20 mmHg | 1 | - |
| Supine Pulse Rate <40 bpm | 0 | - |
| Supine Pulse Rate >120 bpm | 0 | - |
| PF-06882961 200 mg BID (Non-diabetic Obesity)Supine SBP <90 mmHg | 0 | - |
| Supine SBP Increase >=30 mmHg | 0 | - |
| Supine SBP Decrease >=30 mmHg | 2 | - |
| Supine DBP <50 mmHg | 0 | - |
| Supine DBP Increase >=20 mmHg | 0 | - |
| Supine DBP Decrease >=20 mmHg | 1 | - |
| Supine Pulse Rate <40 bpm | 0 | - |
| Supine Pulse Rate >120 bpm | 0 | - |
Secondary/registry result
Number of Participants With Electrocardiogram (ECG) Data Meeting the Pre-defined Categorical Summarization Criteria
Time frame:Baseline through Visit 10 (Day 91)
event count, event
Posted result
| Group | Participants | 95% CI |
|---|---|---|
| Placebo (T2DM)PR interval >=300 msec | 0 | - |
| %Change in PR interval >=25/50% | 0 | - |
| QRS interval >=140 msec | 0 | - |
| %Change in QRS interval >=50% | 0 | - |
| QTcF interval >450 and <=480 msec | 1 | - |
| QTcF interval >480 and <=500 msec | 0 | - |
| QTcF interval >500 msec | 0 | - |
| Change in QTcF interval >30 and <=60 msec | 2 | - |
| Change in QTcF interval >60 msec | 0 | - |
| PF-06882961 80 mg BID Low, Slow (T2DM)PR interval >=300 msec | 0 | - |
| %Change in PR interval >=25/50% | 0 | - |
| QRS interval >=140 msec | 0 | - |
| %Change in QRS interval >=50% | 0 | - |
| QTcF interval >450 and <=480 msec | 0 | - |
| QTcF interval >480 and <=500 msec | 0 | - |
| QTcF interval >500 msec | 0 | - |
| Change in QTcF interval >30 and <=60 msec | 0 | - |
| Change in QTcF interval >60 msec | 0 | - |
| PF-06882961 80 mg BID High, Slow (T2DM)PR interval >=300 msec | 0 | - |
| %Change in PR interval >=25/50% | 0 | - |
| QRS interval >=140 msec | 0 | - |
| %Change in QRS interval >=50% | 0 | - |
| QTcF interval >450 and <=480 msec | 0 | - |
| QTcF interval >480 and <=500 msec | 0 | - |
| QTcF interval >500 msec | 0 | - |
| Change in QTcF interval >30 and <=60 msec | 0 | - |
| Change in QTcF interval >60 msec | 0 | - |
| PF-06882961 120 mg BID Low, Fast (T2DM)PR interval >=300 msec | 0 | - |
| %Change in PR interval >=25/50% | 0 | - |
| QRS interval >=140 msec | 0 | - |
| %Change in QRS interval >=50% | 0 | - |
| QTcF interval >450 and <=480 msec | 2 | - |
| QTcF interval >480 and <=500 msec | 0 | - |
| QTcF interval >500 msec | 0 | - |
| Change in QTcF interval >30 and <=60 msec | 1 | - |
| Change in QTcF interval >60 msec | 0 | - |
| PF-06882961 120 mg BID High, Fast (T2DM)PR interval >=300 msec | 0 | - |
| %Change in PR interval >=25/50% | 0 | - |
| QRS interval >=140 msec | 0 | - |
| %Change in QRS interval >=50% | 0 | - |
| QTcF interval >450 and <=480 msec | 0 | - |
| QTcF interval >480 and <=500 msec | 0 | - |
| QTcF interval >500 msec | 0 | - |
| Change in QTcF interval >30 and <=60 msec | 3 | - |
| Change in QTcF interval >60 msec | 0 | - |
| PF-06882961 200 mg BID (T2DM)PR interval >=300 msec | 0 | - |
| %Change in PR interval >=25/50% | 0 | - |
| QRS interval >=140 msec | 0 | - |
| %Change in QRS interval >=50% | 0 | - |
| QTcF interval >450 and <=480 msec | 0 | - |
| QTcF interval >480 and <=500 msec | 0 | - |
| QTcF interval >500 msec | 0 | - |
| Change in QTcF interval >30 and <=60 msec | 0 | - |
| Change in QTcF interval >60 msec | 0 | - |
| Placebo (Non-diabetic Obesity)PR interval >=300 msec | 0 | - |
| %Change in PR interval >=25/50% | 0 | - |
| QRS interval >=140 msec | 0 | - |
| %Change in QRS interval >=50% | 0 | - |
| QTcF interval >450 and <=480 msec | 1 | - |
| QTcF interval >480 and <=500 msec | 1 | - |
| QTcF interval >500 msec | 0 | - |
| Change in QTcF interval >30 and <=60 msec | 0 | - |
| Change in QTcF interval >60 msec | 1 | - |
| PF-06882961 200 mg BID (Non-diabetic Obesity)PR interval >=300 msec | 0 | - |
| %Change in PR interval >=25/50% | 0 | - |
| QRS interval >=140 msec | 0 | - |
| %Change in QRS interval >=50% | 0 | - |
| QTcF interval >450 and <=480 msec | 1 | - |
| QTcF interval >480 and <=500 msec | 0 | - |
| QTcF interval >500 msec | 0 | - |
| Change in QTcF interval >30 and <=60 msec | 0 | - |
| Change in QTcF interval >60 msec | 0 | - |
Secondary/registry result
Number of Participants With Categorical Scores on the Columbia Suicide Severity Rating Scale (C-SSRS)
Time frame:Week 0, 2, 4, 6, 8, 10, 12, 13-14
event count, event
Posted result
| Group | Participants | 95% CI |
|---|---|---|
| Placebo (T2DM)Week 0 - <1> Completed Suicide | 0 | - |
| Week 0 - <2> Suicide Attempt | 0 | - |
| Week 0 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 0 - <4> Suicidal Ideation | 0 | - |
| Week 0 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Week 2 - <1> Completed Suicide | 0 | - |
| Week 2 - <2> Suicide Attempt | 0 | - |
| Week 2 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 2 - <4> Suicidal Ideation | 0 | - |
| Week 2 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Week 4 - <1> Completed Suicide | 0 | - |
| Week 4 - <2> Suicide Attempt | 0 | - |
| Week 4 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 4 - <4> Suicidal Ideation | 0 | - |
| Week 4 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Week 6 - <1> Completed Suicide | 0 | - |
| Week 6 - <2> Suicide Attempt | 0 | - |
| Week 6 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 6 - <4> Suicidal Ideation | 0 | - |
| Week 6 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Week 8 - <1> Completed Suicide | 0 | - |
| Week 8 - <2> Suicide Attempt | 0 | - |
| Week 8 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 8 - <4> Suicidal Ideation | 0 | - |
| Week 8 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Week 10 - <1> Completed Suicide | 0 | - |
| Week 10 - <2> Suicide Attempt | 0 | - |
| Week 10 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 10 - <4> Suicidal Ideation | 0 | - |
| Week 10 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Week 12 - <1> Completed Suicide | 0 | - |
| Week 12 - <2> Suicide Attempt | 0 | - |
| Week 12 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 12 - <4> Suicidal Ideation | 0 | - |
| Week 12 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Follow-Up - <1> Completed Suicide | 0 | - |
| Follow-Up - <2> Suicide Attempt | 0 | - |
| Follow-Up - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Follow-Up - <4> Suicidal Ideation | 0 | - |
| Follow-Up - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Placebo (Non-diabetic Obesity)Week 0 - <1> Completed Suicide | 0 | - |
| Week 0 - <2> Suicide Attempt | 0 | - |
| Week 0 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 0 - <4> Suicidal Ideation | 0 | - |
| Week 0 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Week 2 - <1> Completed Suicide | 0 | - |
| Week 2 - <2> Suicide Attempt | 0 | - |
| Week 2 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 2 - <4> Suicidal Ideation | 0 | - |
| Week 2 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Week 4 - <1> Completed Suicide | 0 | - |
| Week 4 - <2> Suicide Attempt | 0 | - |
| Week 4 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 4 - <4> Suicidal Ideation | 0 | - |
| Week 4 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Week 6 - <1> Completed Suicide | 0 | - |
| Week 6 - <2> Suicide Attempt | 0 | - |
| Week 6 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 6 - <4> Suicidal Ideation | 0 | - |
| Week 6 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Week 8 - <1> Completed Suicide | 0 | - |
| Week 8 - <2> Suicide Attempt | 0 | - |
| Week 8 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 8 - <4> Suicidal Ideation | 0 | - |
| Week 8 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Week 10 - <1> Completed Suicide | 0 | - |
| Week 10 - <2> Suicide Attempt | 0 | - |
| Week 10 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 10 - <4> Suicidal Ideation | 0 | - |
| Week 10 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Week 12 - <1> Completed Suicide | 0 | - |
| Week 12 - <2> Suicide Attempt | 0 | - |
| Week 12 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 12 - <4> Suicidal Ideation | 0 | - |
| Week 12 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Follow-Up - <1> Completed Suicide | 0 | - |
| Follow-Up - <2> Suicide Attempt | 0 | - |
| Follow-Up - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Follow-Up - <4> Suicidal Ideation | 0 | - |
| Follow-Up - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| PF-06882961 80 mg BID Low, Slow (T2DM)Week 0 - <1> Completed Suicide | 0 | - |
| Week 0 - <2> Suicide Attempt | 0 | - |
| Week 0 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 0 - <4> Suicidal Ideation | 0 | - |
| Week 0 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Week 2 - <1> Completed Suicide | 0 | - |
| Week 2 - <2> Suicide Attempt | 0 | - |
| Week 2 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 2 - <4> Suicidal Ideation | 0 | - |
| Week 2 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Week 4 - <1> Completed Suicide | 0 | - |
| Week 4 - <2> Suicide Attempt | 0 | - |
| Week 4 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 4 - <4> Suicidal Ideation | 0 | - |
| Week 4 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Week 6 - <1> Completed Suicide | 0 | - |
| Week 6 - <2> Suicide Attempt | 0 | - |
| Week 6 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 6 - <4> Suicidal Ideation | 0 | - |
| Week 6 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Week 8 - <1> Completed Suicide | 0 | - |
| Week 8 - <2> Suicide Attempt | 0 | - |
| Week 8 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 8 - <4> Suicidal Ideation | 0 | - |
| Week 8 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Week 10 - <1> Completed Suicide | 0 | - |
| Week 10 - <2> Suicide Attempt | 0 | - |
| Week 10 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 10 - <4> Suicidal Ideation | 0 | - |
| Week 10 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Week 12 - <1> Completed Suicide | 0 | - |
| Week 12 - <2> Suicide Attempt | 0 | - |
| Week 12 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 12 - <4> Suicidal Ideation | 0 | - |
| Week 12 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Follow-Up - <1> Completed Suicide | 0 | - |
| Follow-Up - <2> Suicide Attempt | 0 | - |
| Follow-Up - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Follow-Up - <4> Suicidal Ideation | 0 | - |
| Follow-Up - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| PF-06882961 80 mg BID High, Slow (T2DM)Week 0 - <1> Completed Suicide | 0 | - |
| Week 0 - <2> Suicide Attempt | 0 | - |
| Week 0 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 0 - <4> Suicidal Ideation | 0 | - |
| Week 0 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Week 2 - <1> Completed Suicide | 0 | - |
| Week 2 - <2> Suicide Attempt | 0 | - |
| Week 2 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 2 - <4> Suicidal Ideation | 0 | - |
| Week 2 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Week 4 - <1> Completed Suicide | 0 | - |
| Week 4 - <2> Suicide Attempt | 0 | - |
| Week 4 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 4 - <4> Suicidal Ideation | 0 | - |
| Week 4 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Week 6 - <1> Completed Suicide | 0 | - |
| Week 6 - <2> Suicide Attempt | 0 | - |
| Week 6 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 6 - <4> Suicidal Ideation | 0 | - |
| Week 6 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Week 8 - <1> Completed Suicide | 0 | - |
| Week 8 - <2> Suicide Attempt | 0 | - |
| Week 8 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 8 - <4> Suicidal Ideation | 0 | - |
| Week 8 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Week 10 - <1> Completed Suicide | 0 | - |
| Week 10 - <2> Suicide Attempt | 0 | - |
| Week 10 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 10 - <4> Suicidal Ideation | 0 | - |
| Week 10 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Week 12 - <1> Completed Suicide | 0 | - |
| Week 12 - <2> Suicide Attempt | 0 | - |
| Week 12 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 12 - <4> Suicidal Ideation | 0 | - |
| Week 12 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Follow-Up - <1> Completed Suicide | 0 | - |
| Follow-Up - <2> Suicide Attempt | 0 | - |
| Follow-Up - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Follow-Up - <4> Suicidal Ideation | 0 | - |
| Follow-Up - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| PF-06882961 120 mg BID Low, Fast (T2DM)Week 0 - <1> Completed Suicide | 0 | - |
| Week 0 - <2> Suicide Attempt | 0 | - |
| Week 0 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 0 - <4> Suicidal Ideation | 0 | - |
| Week 0 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Week 2 - <1> Completed Suicide | 0 | - |
| Week 2 - <2> Suicide Attempt | 0 | - |
| Week 2 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 2 - <4> Suicidal Ideation | 0 | - |
| Week 2 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Week 4 - <1> Completed Suicide | 0 | - |
| Week 4 - <2> Suicide Attempt | 0 | - |
| Week 4 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 4 - <4> Suicidal Ideation | 0 | - |
| Week 4 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Week 6 - <1> Completed Suicide | 0 | - |
| Week 6 - <2> Suicide Attempt | 0 | - |
| Week 6 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 6 - <4> Suicidal Ideation | 0 | - |
| Week 6 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Week 8 - <1> Completed Suicide | 0 | - |
| Week 8 - <2> Suicide Attempt | 0 | - |
| Week 8 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 8 - <4> Suicidal Ideation | 0 | - |
| Week 8 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Week 10 - <1> Completed Suicide | 0 | - |
| Week 10 - <2> Suicide Attempt | 0 | - |
| Week 10 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 10 - <4> Suicidal Ideation | 0 | - |
| Week 10 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Week 12 - <1> Completed Suicide | 0 | - |
| Week 12 - <2> Suicide Attempt | 0 | - |
| Week 12 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 12 - <4> Suicidal Ideation | 0 | - |
| Week 12 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Follow-Up - <1> Completed Suicide | 0 | - |
| Follow-Up - <2> Suicide Attempt | 0 | - |
| Follow-Up - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Follow-Up - <4> Suicidal Ideation | 0 | - |
| Follow-Up - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| PF-06882961 120 mg BID High, Fast (T2DM)Week 0 - <1> Completed Suicide | 0 | - |
| Week 0 - <2> Suicide Attempt | 0 | - |
| Week 0 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 0 - <4> Suicidal Ideation | 0 | - |
| Week 0 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Week 2 - <1> Completed Suicide | 0 | - |
| Week 2 - <2> Suicide Attempt | 0 | - |
| Week 2 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 2 - <4> Suicidal Ideation | 0 | - |
| Week 2 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Week 4 - <1> Completed Suicide | 0 | - |
| Week 4 - <2> Suicide Attempt | 0 | - |
| Week 4 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 4 - <4> Suicidal Ideation | 0 | - |
| Week 4 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Week 6 - <1> Completed Suicide | 0 | - |
| Week 6 - <2> Suicide Attempt | 0 | - |
| Week 6 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 6 - <4> Suicidal Ideation | 0 | - |
| Week 6 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Week 8 - <1> Completed Suicide | 0 | - |
| Week 8 - <2> Suicide Attempt | 0 | - |
| Week 8 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 8 - <4> Suicidal Ideation | 0 | - |
| Week 8 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Week 10 - <1> Completed Suicide | 0 | - |
| Week 10 - <2> Suicide Attempt | 0 | - |
| Week 10 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 10 - <4> Suicidal Ideation | 0 | - |
| Week 10 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Week 12 - <1> Completed Suicide | 0 | - |
| Week 12 - <2> Suicide Attempt | 0 | - |
| Week 12 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 12 - <4> Suicidal Ideation | 0 | - |
| Week 12 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Follow-Up - <1> Completed Suicide | 0 | - |
| Follow-Up - <2> Suicide Attempt | 0 | - |
| Follow-Up - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Follow-Up - <4> Suicidal Ideation | 0 | - |
| Follow-Up - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| PF-06882961 200 mg BID (T2DM)Week 0 - <1> Completed Suicide | 0 | - |
| Week 0 - <2> Suicide Attempt | 0 | - |
| Week 0 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 0 - <4> Suicidal Ideation | 0 | - |
| Week 0 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Week 2 - <1> Completed Suicide | 0 | - |
| Week 2 - <2> Suicide Attempt | 0 | - |
| Week 2 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 2 - <4> Suicidal Ideation | 0 | - |
| Week 2 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Week 4 - <1> Completed Suicide | 0 | - |
| Week 4 - <2> Suicide Attempt | 0 | - |
| Week 4 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 4 - <4> Suicidal Ideation | 0 | - |
| Week 4 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Week 6 - <1> Completed Suicide | 0 | - |
| Week 6 - <2> Suicide Attempt | 0 | - |
| Week 6 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 6 - <4> Suicidal Ideation | 0 | - |
| Week 6 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Week 8 - <1> Completed Suicide | 0 | - |
| Week 8 - <2> Suicide Attempt | 0 | - |
| Week 8 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 8 - <4> Suicidal Ideation | 0 | - |
| Week 8 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Week 10 - <1> Completed Suicide | 0 | - |
| Week 10 - <2> Suicide Attempt | 0 | - |
| Week 10 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 10 - <4> Suicidal Ideation | 0 | - |
| Week 10 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Week 12 - <1> Completed Suicide | 0 | - |
| Week 12 - <2> Suicide Attempt | 0 | - |
| Week 12 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 12 - <4> Suicidal Ideation | 0 | - |
| Week 12 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Follow-Up - <1> Completed Suicide | 0 | - |
| Follow-Up - <2> Suicide Attempt | 0 | - |
| Follow-Up - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Follow-Up - <4> Suicidal Ideation | 0 | - |
| Follow-Up - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| PF-06882961 200 mg BID (Non-diabetic Obesity)Week 0 - <1> Completed Suicide | 0 | - |
| Week 0 - <2> Suicide Attempt | 0 | - |
| Week 0 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 0 - <4> Suicidal Ideation | 0 | - |
| Week 0 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Week 2 - <1> Completed Suicide | 0 | - |
| Week 2 - <2> Suicide Attempt | 0 | - |
| Week 2 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 2 - <4> Suicidal Ideation | 0 | - |
| Week 2 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Week 4 - <1> Completed Suicide | 0 | - |
| Week 4 - <2> Suicide Attempt | 0 | - |
| Week 4 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 4 - <4> Suicidal Ideation | 0 | - |
| Week 4 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Week 6 - <1> Completed Suicide | 0 | - |
| Week 6 - <2> Suicide Attempt | 0 | - |
| Week 6 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 6 - <4> Suicidal Ideation | 0 | - |
| Week 6 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Week 8 - <1> Completed Suicide | 0 | - |
| Week 8 - <2> Suicide Attempt | 0 | - |
| Week 8 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 8 - <4> Suicidal Ideation | 0 | - |
| Week 8 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Week 10 - <1> Completed Suicide | 0 | - |
| Week 10 - <2> Suicide Attempt | 0 | - |
| Week 10 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 10 - <4> Suicidal Ideation | 0 | - |
| Week 10 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Week 12 - <1> Completed Suicide | 0 | - |
| Week 12 - <2> Suicide Attempt | 0 | - |
| Week 12 - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Week 12 - <4> Suicidal Ideation | 0 | - |
| Week 12 - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
| Follow-Up - <1> Completed Suicide | 0 | - |
| Follow-Up - <2> Suicide Attempt | 0 | - |
| Follow-Up - <3> Preparatory Acts Towards Imminent Suicidal Behavior | 0 | - |
| Follow-Up - <4> Suicidal Ideation | 0 | - |
| Follow-Up - <7> Self-injurious Behavior, No Suicidal Intent | 0 | - |
Secondary/protocol endpoint
Number of Participants With Laboratory Abnormalities (Without Regard to Baseline Abnormality)
Time frame:Baseline through Visit 10 (Day 91)
descriptive
Secondary/protocol endpoint
Number of Participants With Vital Signs Meeting the Pre-defined Categorical Summarization Criteria
Time frame:Baseline through Visit 10 (Day 91)
threshold achievement, event
componentsSystolic BP, change, Diastolic BP, change, Heart rate, change
Secondary/protocol endpoint
Number of Participants With Electrocardiogram (ECG) Data Meeting the Pre-defined Categorical Summarization Criteria
Time frame:Baseline through Visit 10 (Day 91)
threshold achievement, event
Secondary/protocol endpoint
Number of Participants With Categorical Scores on the Columbia Suicide Severity Rating Scale (C-SSRS)
Time frame:Week 0, 2, 4, 6, 8, 10, 12, 13-14
descriptive
Publications (1)
Bibliography
Records linked to this trial through ClinicalTrials.gov references, PubMed NCT search, and curated study seeds. 'Canonical' marks design/result papers; others are registry references or candidates.
Registry references + supporting bibliography
- Diabetes, obesity & metabolism2023 Oct (month)PMID37311722doi:10.1111/dom.15168via clinicaltrials gov reference derived + pubmed nct search
Provenance
Sources
Trial identity, design, statusClinicalTrials.gov API v2
Snapshot dateJuly 6, 2026
Endpoint classificationDelfa endpoint taxonomy v2 (May 13, 2026)
Results tableClinicalTrials.gov results section
Trial facts come from public ClinicalTrials.gov records. Endpoint categories are Delfa's classification of those records, not a ClinicalTrials.gov field. All figures reflect the July 6, 2026 snapshot.