TerminatedPhase 1

A Study to Assess Safety, Tolerability, and Pharmacokinetics of AZD0186

A Phase 1 Randomized, Single-blind, Placebo-controlled, First-in-Human and Sequential Group Study to Assess Safety, Tolerability, and Pharmacokinetics of AZD0186 Following Single Ascending Doses Via Oral Administration

Lead sponsor

AstraZeneca

Asset

AZD0186

Oral · GLP-1 agonist

Listed sites

Recruiting sites

Actual enrollment

Study population

Prediabetes / glucose intolerance, Type 2 diabetes

Eligibility highlights

•Healthy volunteers

Primary endpoint

•Adverse Events (AEs), and Serious Adverse Events (SAEs)

Registered trial locations

Locations reported to ClinicalTrials.gov for this trial snapshot. Site count is not enrollment count; per-site enrollment is not available from source.

Identifiers

Registered as

NCT IDNCT05694741

Org study IDD8740C00001

Timeline

Milestones

Study start2022-12-20actual

Study first posted2023-01-23actual

Primary completion2023-05-10actual

Study completion2023-05-10actual

Last update posted2024-12-13actual

Assets

Investigational agents

AZD0186

Who this study enrolls

Prediabetes / glucose intoleranceType 2 diabetes

Who can enroll

Minimum age18 Years

Maximum age55 Years

SexAll

Healthy volunteersAccepted

Inclusion criteria

•Provision of signed and dated, written informed consent prior to any study specific procedures.

•Healthy male and female subjects aged 18 to 55 years with suitable veins for cannulation or repeated venipuncture.

•Females must have a negative pregnancy test at the Screening Visit and on admission to the Clinical Unit, must not be lactating and must be of non-childbearing potential, confirmed at the Screening Visit.

•Have a BMI between:

1. Part 1: 18 to 32 kg/m2 inclusive,

2. Part 2 and Part 3: 18 to 32 kg/m2 inclusive,

3. and weigh at least 50 kg (males and females).

•Provision of signed, written, and dated informed consent for optional genetic/biomarker research.

•For the healthy Japanese cohort (Part 2): healthy subjects are to be Japanese (eg, natives of Japan or Japanese Americans), defined as having both parents and 4 grandparents who are Japanese.

•For the healthy Chinese cohort (Part 3): healthy male and female (of non-childbearing potential) healthy Chinese subjects for whom both parents and all grandparents are Chinese and not lived outside of China for more than 10 years.

Exclusion criteria

•History of any clinically important disease or disorder which may either put the healthy subject at risk because of participation in the study,or influence the results or the healthy subject's ability to participate in the study.

•History or presence of gastrointestinal, hepatic, or renal disease, or any other condition known to interfere with absorption, distribution, metabolism or excretion of drugs.

•Any clinically important illness, medical/surgical procedure or trauma within 4 weeks of the first administration of IMP.

•Presence of any retinal (including intraretinal) abnormality detected by ophthalmological examination including indirect ophthalmoscopy, fundoscopy or OCT.

•Presence of any factors that predispose to retinal detachment including lattice degeneration, retinal hole, or high myopia (-10 diopters or higher) found on ophthalmological examination.

•History of retinal detachment in either eye.

•History of treated or untreated retinal holes.

•Any clinically important abnormalities across the ophthalmological examinations.

•Any laboratory values with the following deviations:

1. Alanine aminotransferase > ULN

2. Aspartate aminotransferase > ULN

3. eGFR < 90 mL/minute/1.73 m2 (calculated using the Chronic Kidney Disease Epidemiology Collaboration formula)

4. White blood cell count < LLN

5. Hemoglobin < LLN

•Any clinically important abnormalities in clinical chemistry, hematology or urinalysis results.

•Any positive result on screening for serum hepatitis B surface antigen, hepatitis C antibody and HIV.

•Abnormal vital signs, after 10 minutes supine rest, defined as any of the following:

1. Systolic BP < 90 mmHg or > 140 mmHg.

2. Diastolic BP < 50 mmHg or > 90 mmHg.

3. Heart rate < 45 or > 85 bpm.

•Any clinically important abnormalities in rhythm, conduction or morphology of the resting ECG and any clinically important abnormalities in the 12-lead ECG that may interfere with the interpretation of QTc interval changes, including abnormal ST and T-wave morphology, particularly in the protocol defined primary lead or left ventricular hypertrophy.

•Known or suspected history of drug abuse.

•Current smokers or those who have smoked or used nicotine products within the previous 3 months.

•History of alcohol abuse or excessive intake of alcohol.

•Positive screen for drugs of abuse or cotinine at screening or admission to the Clinical Unit or positive screen for alcohol on admission to the Clinical Unit prior to the first administration of the IMP.

•History of severe allergy/hypersensitivity or ongoing clinically important allergy/hypersensitivity, as judged by the Investigator or history of hypersensitivity to drugs with a similar chemical structure or class to GLP-1 RA.

•Any condition that would have interfered with the evaluation of the IMP or interpretation of subject safety or study results.

•Lifetime history of schizophrenia or other psychosis or bipolar disorder or suicide attempts, major depressive disorder, or self-reported suicidal ideation.

•Healthy subjects with a history of MTC, multiple endocrine neoplasia syndrome type 2, or healthy subjects with a screening/baseline serum calcitonin ≥ 50 pg/mL.

•History of gastrointestinal abnormality that could affect gastrointestinal motility.

•Excessive intake of caffeine containing drinks or food.

•Plasma donation within one month of the Screening Visit or any blood donation/blood loss > 500 mL during the 3 months prior to the Screening Visit.

•Has received another new chemical entity within 30 days or 5 half-lives of the first administration of IMP in this study.

•Previous bone marrow transplant.

•Non-leukocyte depleted whole blood transfusion within 120 days of the date of the genetic sample collection.

Endpoints (4)

What's being measured

Protocol endpoints and posted registry outcome measures, grouped into outcome categories. Composite endpoints show their component event types. Standard codes (LOINC, SNOMED CT) are shown where available.

Safety / tolerability / PK

4 endpoints

Primary/protocol endpoint

Adverse Events (AEs), and Serious Adverse Events (SAEs)

Time frame:Up to the Follow-up Visit (approximately 6 weeks)

descriptive

Secondary/protocol endpoint

Area under plasma concentration-time curve from zero to infinity (AUCinf)

Time frame:Day 1 to Day 3

concentration, descriptive

Secondary/protocol endpoint

Area under the plasma concentration-time curve from 0 to the last quantifiable concentration (AUClast)

Time frame:Day 1 to Day 3

concentration, descriptive

Secondary/protocol endpoint

Maximum observed concentration (Cmax)

Time frame:Day 1 to Day 3

concentration, descriptive

Provenance

Sources

Trial identity, design, statusClinicalTrials.gov API v2

Snapshot dateNovember 5, 2026

Endpoint classificationDelfa endpoint taxonomy v2 (May 13, 2026)

Results tableno registry results posted yet

Trial facts come from public ClinicalTrials.gov records. Endpoint categories are Delfa's classification of those records, not a ClinicalTrials.gov field. All figures reflect the November 5, 2026 snapshot.