DRIVE
CompletedPhase 4Results postedDiabetes Remote Intervention to improVe Use of Evidence-based Medications
DRIVE Program: Diabetes Remote Intervention to improVe Use of Evidence-based Medications
Lead sponsor
Asset
GLP-1 / incretin class catch-all
Listed sites
1
Recruiting sites
-
Actual enrollment
200
Study population
Cardiovascular disease
Eligibility highlights
•BMI ≥30•HbA1c 6.5-8.9%•eGFR ≤60
Primary endpoint
•Prescriptions of SGLT2i or GLP1-RA at Any Time
Registered trial locations
Locations reported to ClinicalTrials.gov for this trial snapshot. Site count is not enrollment count; per-site enrollment is not available from source.
Identifiers
Registered as
Timeline
Milestones
Assets
Investigational agents
Who this study enrolls
Who can enroll
Inclusion criteria
1. Aged 27 - 79 years at the time of agreeing to participate in the program
2. Presence of type 2 diabetes (treated with metformin unless intolerant, may also be treated with DPP4i, sulfonylurea, pioglitazone, and/or basal insulin)
3. HbA1c 6.5-8.9%; AND
4. At elevated cardiovascular and/or renal risk defined as any diagnosed ASCVD, estimated ASCVD risk >10%, congestive heart failure, non-alcoholic fatty liver disease, estimated glomerular filtration rate (eGFR) <60 mL/min/1.73m2, albuminuria above 300mg/g; and those aged 60 years or older with at least two of: active tobacco use, dyslipidemia (LDL-c above 160 mg/dL or 4.1 mmol/L, non-HDL-C above 190 mg/dL or 4.9 mmol/L, triglycerides above 175 mg/dL,) hypertension (2 systolic blood pressure values above 130 mmHg and/or 2 diastolic blood pressure values above 90 mmHg within 12 months,) or BMI above 30
5. Has seen a primary care provider within the Mass General Brigham network within the last year
Exclusion criteria
1. Type 1 diabetes
2. Currently or previously prescribed an SGLT2i or GLP1-RA
3. Taking any short-acting insulin
4. History of diabetic ketoacidosis
5. History of hypoglycemia requiring hospitalization
6. Frequent (more than two times in 1 week) episodes of symptomatic hypoglycemia with blood glucose <70 mg/dL
7. eGFR below 15 ml/min/m2
8. Mental incapacity, unwillingness, or language barriers precluding adequate understanding or cooperation, OR
9. Life expectancy less than 1 year or utilizing palliative care
Endpoints (7)
What's being measured
Protocol endpoints and posted registry outcome measures, grouped into outcome categories. Composite endpoints show their component event types. Standard codes (LOINC, SNOMED CT) are shown where available.
Coverage by outcome category
Weight & body composition
2 endpointsChange in Body Weight (kg)
Time frame:From 0-months (baseline) to 6-months following enrollment
change from baseline, improvement
Change in Body Weight (%)
Time frame:From 0-months (baseline) to 6-months following enrollment
change from baseline, improvement
Glycemic / diabetes
1 endpointChange in Laboratory Measured HbA1c
Time frame:From 0-months (baseline) to 6-months following enrollment
change from baseline, improvement
Other (unclassified)
4 endpointsNumber of Patients With Prescriptions of SGLT2i or GLP1-RA at Any Time
Time frame:Any time between 0-months (baseline) to 6-months following enrollment
event count, event
Number of Patients With Prescriptions of SGLT2i or GLP1-RA at 2-months
Time frame:2-months following enrollment
event count, event
Number of Patients With Prescriptions of SGLT2i or GLP1-RA at 6-months
Time frame:At 6-months following enrollment
event count, event
Change in Short-form Patient Activation Measure (PAM)
Time frame:From 0-months (baseline) to 6-months following enrollment
change from baseline, improvement
Provenance
Sources
Trial facts come from public ClinicalTrials.gov records. Endpoint categories are Delfa's classification of those records, not a ClinicalTrials.gov field. All figures reflect the July 6, 2026 snapshot.