GENETIC VARIABILITY TO GLP1 TREATMENT

1. Diagnosed with type 2 diabetes (for participant in Cohort A) or Obese (for participant in Cohort B) and treated with Ozempic (Semaglutide) S.C. injection for at least 24 weeks.

2. Subject is male/female between 18 to 80 years old (both inclusive) at the time of enrollment.

3. Subject BMI above 30 kg/m2 at treatment initiation.

4. Subject does not belong to any vulnerable population, is willing and able to provide written informed consent prior to any study procedure.

5. Participant understands the nature of the procedure and is willing and able to comply with all requirement of the protocol.

1. Subject falls under contraindications to Ozempic (Semaglutide) label

2. Subject known or suspected for hypersensitivity to any GLP-1RA or related products, or allergic constitution

3. Subjects suffers from any other condition affecting body weight.

4. Subject with history of chronic or acute pancreatitis

5. Subject have a history of a major cardiovascular and/or cerebrovascular disease within the 6 months before screening.

6. Presence or history of malignant neoplasm within 5 years prior to screening day.

7. Subject suffers from any renal impairment (Cr > 2 mg/dl).

8. Subject suffers from any impaired hepatic function (ALT, AST or GGT 2-fold higher than normal upper limit).

9. Any disorder, which in the investigator's opinion might jeopardize patient's safety or compliance with the protocol.

10. Subject is a female who is pregnant, breastfeeding or intends to become pregnant or is of child bearing potential without medically acceptable methods of contraception.

11. Participation in another clinical study in prior 4 weeks.