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Delfa

← All trials/NCT07755085

Not yet recruitingPhase 4

GLP-1s in Hip and Knee Arthroplasty

Does the Preoperative Use of GLP-1 Agonists Change Outcomes in Patients Waiting for Total Hip and Knee Arthroplasty: A Pilot Randomized Control Trial

Asset

Semaglutide

GLP-1 agonist

Listed sites

1

Recruiting sites

-

Estimated enrollment

100

Study population

Arthritis, Obesity / overweight

Eligibility highlights

-

Primary endpoint

•Wound Complication after Joint Arthroplasty

Registered trial locations

Locations reported to ClinicalTrials.gov for this trial snapshot. Site count is not enrollment count; per-site enrollment is not available from source.

Identifiers

Registered as

NCT IDNCT07755085
Org study IDGLP1

Timeline

Milestones

Study first posted2026-08-10actual
Last update posted2026-08-10actual
Study start2026-10-01estimated
Primary completion2028-06-01estimated
Study completion2028-12estimated (month precision)

Assets

Investigational agents

Semaglutide

Who this study enrolls

ArthritisObesity / overweight

Who can enroll

Minimum age18 Years
Maximum age90 Years
SexAll
Healthy volunteersNot accepted

Inclusion criteria

•Patients with a diagnosis of hip or knee arthritis and are a deemed candidate for THA or TKA by an orthopaedic surgeon
•Diagnosis of BMI 35+ with an obesity-related health condition (Coronary vascular disease, previous stroke, type 2 diabetes, hypertension, dyslipidemia, obstructive sleep apnea, asthma) or BMI 40+
•Patients must be between 18-90 years of age
•Able to provide informed consent

Exclusion criteria

•Cognitive impairment that precludes study participation and compliance
•Patients unwilling to undergo smoking cessation prior to surgery
•Patients currently taking biologic medications that suppress the immune system
•Patients currently taking GLP-1 medications
•Patients with a contraindication to GLP-1 medication

Endpoints (13)

What's being measured

Protocol endpoints and posted registry outcome measures, grouped into outcome categories. Composite endpoints show their component event types. Standard codes (LOINC, SNOMED CT) are shown where available.

Coverage by outcome category

Other (unclassified)
5
Other clinical outcomes
3
Weight & body composition
2
Patient-reported / QoL
2
Safety / tolerability / PK
1

Weight & body composition

2 endpoints
Secondary/protocol endpoint

Body weight

Time frame:6 months

descriptive

Secondary/protocol endpoint

Body composition analysis by DEXA

Time frame:6 months

descriptive

Patient-reported / QoL

2 endpoints
Secondary/protocol endpoint

Patient reported outcome measure - Quality of Life

Time frame:1 year

descriptive

Secondary/protocol endpoint

Patient reported outcome measure - Patient Satisfaction

Time frame:1 year

descriptive

Safety / tolerability / PK

1 endpoint
Secondary/protocol endpoint

Adverse Events

Time frame:9 months

descriptive

Other clinical outcomes

3 endpoints
Primary/protocol endpoint

Incidence of Wound Complication after Joint Arthroplasty

Time frame:90 days

event count, event

Secondary/protocol endpoint

Incidence of Superficial wound infections

Time frame:1 year

event count, event

Secondary/protocol endpoint

Incidence of deep periprosthetic infections

Time frame:1 year

event count, event

Other (unclassified)

5 endpoints
Secondary/protocol endpoint/low confidence

Gait

Time frame:1 year

descriptive

Secondary/protocol endpoint/low confidence

Patient reported outcome measures - Joint function

Time frame:1 year

descriptive

Secondary/protocol endpoint/low confidence

Surgical Complications

Time frame:1 year

descriptive

Other/protocol endpoint/low confidence

Return to work

Time frame:1 year

descriptive

Other/protocol endpoint/low confidence

Surgery Delayed / Cancelled

Time frame:6 months

descriptive

Publications (1)

Bibliography

Records linked to this trial through ClinicalTrials.gov references, PubMed NCT search, and curated study seeds. 'Canonical' marks design/result papers; others are registry references or candidates.

Registry references + supporting bibliography

Provenance

Sources

Trial identity, design, statusClinicalTrials.gov API v2
Snapshot dateNovember 5, 2026
Endpoint classificationDelfa endpoint taxonomy v2 (May 13, 2026)
Results tableno registry results posted yet

Trial facts come from public ClinicalTrials.gov records. Endpoint categories are Delfa's classification of those records, not a ClinicalTrials.gov field. All figures reflect the November 5, 2026 snapshot.