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Not yet recruiting

Comparing Facial Aging Between Identical Twins With 3D Imaging

A Prospective Observational Study of Facial Aging in Identical Twins Using Three-Dimensional Imaging

Assets

Semaglutide / Tirzepatide

Listed sites

1

Recruiting sites

-

Estimated enrollment

200

Study population

-

Eligibility highlights

-

Primary endpoint

•Within-pair difference in quantitative three-dimensional facial surface

Registered trial locations

Locations reported to ClinicalTrials.gov for this trial snapshot. Site count is not enrollment count; per-site enrollment is not available from source.

Identifiers

Registered as

NCT IDNCT07760532
Org study IDTwinsStudy_2026-0412
Secondary ID2026-0412Pearl IRB

Timeline

Milestones

Study start2026-08-08estimated
Study first posted2026-08-12actual
Last update posted2026-08-12actual
Primary completion2026-09estimated (month precision)
Study completion2026-09estimated (month precision)

Assets

Investigational agents

SemaglutideTirzepatide

Who can enroll

Minimum age18 Years
SexAll
Healthy volunteersAccepted
Sampling methodNon probability sample

Study population text

Adult twin pairs attending the Twins Days Festival in Twinsburg, Ohio (August 8-9, 2026), the largest annual gathering of twins in the world. Participants are recruited on-site through a study booth and printed festival materials, and in advance through a study information page on the practice website. Anticipated enrollment is approximately 50 to 100 twin pairs (up to approximately 200 individual participants).

Inclusion criteria

•Adults aged 18 years or older
•Members of a monozygotic (identical) twin pair, with both twins present and willing to participate
•Able to provide written informed consent in English

Exclusion criteria

•Age under 18 years
•Inability or unwillingness to provide informed consent
•Facial conditions or recent facial surgery that, in the investigator's judgment, would prevent standardized imaging
•Pregnancy, by self-report

Note: Zygosity is established by participant self-report, supported where available by prior DNA testing or physician confirmation. No genetic testing is performed and no biological specimens are collected. Pairs who self-report as dizygotic or are uncertain of their zygosity are recorded as such and analyzed separately from the confirmed monozygotic cohort.

Endpoints (2)

What's being measured

Protocol endpoints and posted registry outcome measures, grouped into outcome categories. Composite endpoints show their component event types. Standard codes (LOINC, SNOMED CT) are shown where available.

Other (unclassified)

2 endpoints
Primary/protocol endpoint/low confidence

Within-pair difference in quantitative three-dimensional facial surface measurements

Time frame:Day 1 (single study visit; all data collected at enrollment)

descriptive

Secondary/protocol endpoint/low confidence

Within-pair difference in midface and lower-face volume and contour among twin pairs discordant for GLP-1 receptor agonist use

Time frame:Day 1 (single study visit; all data collected at enrollment)

descriptive

Publications (1)

Bibliography

Records linked to this trial through ClinicalTrials.gov references, PubMed NCT search, and curated study seeds. 'Canonical' marks design/result papers; others are registry references or candidates.

Registry references + supporting bibliography

Provenance

Sources

Trial identity, design, statusClinicalTrials.gov API v2
Snapshot dateNovember 5, 2026
Endpoint classificationDelfa endpoint taxonomy v2 (May 13, 2026)
Results tableno registry results posted yet

Trial facts come from public ClinicalTrials.gov records. Endpoint categories are Delfa's classification of those records, not a ClinicalTrials.gov field. All figures reflect the November 5, 2026 snapshot.