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Liraglutide In Overweight Patients With Type 1 Diabetes
LIRAGLUTIDE IN OVERWEIGHT PATIENTS WITH TYPE 1 DIABETES
Lead sponsor
Asset
Liraglutide
Subcutaneous · GLP-1 agonist
Listed sites
2
Recruiting sites
—
Enrollment
84
actual
Study population
Obesity / overweight, Type 1 diabetes
Key I/E criterion
•BMI ≥25
Primary endpoint
•HbA1c, change
Footprint
Where this trial recruits
Site locations as reported to ClinicalTrials.gov. Site count is not enrollment count; per-site enrollment is not available from source.
Identifiers
Registered as
Timeline
Milestones
Assets
Investigational agents
Study populations
Who this study enrolls
Eligibility
Who can enroll
Inclusion criteria
1) Type 1 Diabetes on continuous subcutaneous insulin infusion (CSII; also known as insulin pump) or multiple (four or more) injections of insulin per day. 2) Using a continuous glucose monitoring device (CGM) or regularly measuring their blood sugars four times daily. 3) HbA1c of less than 8.5%. 4) Well versed with carbohydrate counting. 5) Age 18-75 years 6) BMI≥ 25kg/m2 7) Age at diagnosis of type 1 diabetes should be <30 years. 8) evidence of auto-immunity to beta cells (GAD-65 and islet cell antibody screen)
Exclusion criteria
1)Type 1 diabetes for less than 6 months; 2)Coronary event or procedure (myocardial infarction, unstable angina, coronary artery bypass, surgery or coronary angioplasty) in the previous four weeks; 3)Hepatic disease (transaminase > 3 times normal) or cirrhosis; 4)Renal impairment (serum eGFR <30ml/min/1.73m2); 5)HIV or Hepatitis B or C positive status; 6)Participation in any other concurrent clinical trial; 7)Any other life-threatening, non-cardiac disease; 8)Use of an investigational agent or therapeutic regimen within 30 days of study. 9) history of pancreatitis 10) pregnancy 11) inability to give informed consent 12) history of gastroparesis 13)history of medullary thyroid carcinoma or MEN 2 syndrome. 14) Smokers will be advised not to change their amount of smoking for the duration of the study; 15) Use of any agent other than insulin for treatment of diabetes (metformin, pramlintide or thiazolidinediones.
Endpoints (4)
What's being measured
Protocol endpoints and posted registry outcome measures, grouped into outcome categories. Composite endpoints show their component event types. Standard codes (LOINC, SNOMED CT) are shown where available.
Glycemic / diabetes
4 endpointsHbA1c
Time frame:26 weeks
HbA1c, change
change from baseline, improvement
LOINC 4548-4
Posted result
| Group | Value (mean), percent | 95% CI |
|---|---|---|
| Placebobaseline | 7.77 | — |
| 26 week | 7.64 | — |
| Liraglutidebaseline | 7.94 | — |
| 26 week | 7.60 | — |
HbA1c
Time frame:26 weeks
HbA1c, change
change from baseline, improvement
LOINC 4548-4
Glucose Concentrations
Time frame:26 weeks
descriptive
Posted result
| Group | Value (mean), mg/dL | 95% CI |
|---|---|---|
| Placebobaseline | 183 | — |
| 26 week | 172 | — |
| Liraglutidebaseline | 173 | — |
| 26 week | 171 | — |
Glucose Concentrations
Time frame:26 weeks
Fasting glucose, change
change from baseline, improvement
LOINC 1558-6
Provenance
Sources
Trial facts come from public ClinicalTrials.gov records. Endpoint categories are Delfa's classification of those records, not a ClinicalTrials.gov field. All figures reflect the July 1, 2026 snapshot.