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CompletedPhase 3Results posted

Liraglutide In Overweight Patients With Type 1 Diabetes

LIRAGLUTIDE IN OVERWEIGHT PATIENTS WITH TYPE 1 DIABETES

Asset

Liraglutide

Subcutaneous · GLP-1 agonist

Listed sites

2

Recruiting sites

Enrollment

84

actual

Study population

Obesity / overweight, Type 1 diabetes

Key I/E criterion

BMI ≥25

Primary endpoint

HbA1c, change

Footprint

Where this trial recruits

Site locations as reported to ClinicalTrials.gov. Site count is not enrollment count; per-site enrollment is not available from source.

Identifiers

Registered as

NCT IDNCT01753362
Org study ID1965

Timeline

Milestones

Study first posted2012-12-20estimated
Last update posted2019-12-17actual
Results first posted2019-12-17actual
Study start2012-12 (month precision)
Primary completion2017-12actual (month precision)
Study completion2018-02actual (month precision)

Assets

Investigational agents

Study populations

Who this study enrolls

Obesity / overweightType 1 diabetes

Eligibility

Who can enroll

Minimum age18 Years
Maximum age75 Years
SexAll
Healthy volunteersNot accepted

Inclusion criteria

1) Type 1 Diabetes on continuous subcutaneous insulin infusion (CSII; also known as insulin pump) or multiple (four or more) injections of insulin per day. 2) Using a continuous glucose monitoring device (CGM) or regularly measuring their blood sugars four times daily. 3) HbA1c of less than 8.5%. 4) Well versed with carbohydrate counting. 5) Age 18-75 years 6) BMI≥ 25kg/m2 7) Age at diagnosis of type 1 diabetes should be <30 years. 8) evidence of auto-immunity to beta cells (GAD-65 and islet cell antibody screen)

Exclusion criteria

1)Type 1 diabetes for less than 6 months; 2)Coronary event or procedure (myocardial infarction, unstable angina, coronary artery bypass, surgery or coronary angioplasty) in the previous four weeks; 3)Hepatic disease (transaminase > 3 times normal) or cirrhosis; 4)Renal impairment (serum eGFR <30ml/min/1.73m2); 5)HIV or Hepatitis B or C positive status; 6)Participation in any other concurrent clinical trial; 7)Any other life-threatening, non-cardiac disease; 8)Use of an investigational agent or therapeutic regimen within 30 days of study. 9) history of pancreatitis 10) pregnancy 11) inability to give informed consent 12) history of gastroparesis 13)history of medullary thyroid carcinoma or MEN 2 syndrome. 14) Smokers will be advised not to change their amount of smoking for the duration of the study; 15) Use of any agent other than insulin for treatment of diabetes (metformin, pramlintide or thiazolidinediones.

Endpoints (4)

What's being measured

Protocol endpoints and posted registry outcome measures, grouped into outcome categories. Composite endpoints show their component event types. Standard codes (LOINC, SNOMED CT) are shown where available.

Glycemic / diabetes

4 endpoints
Primary/registry result

HbA1c

Time frame:26 weeks

HbA1c, change

change from baseline, improvement

LOINC 4548-4

Posted result

GroupValue (mean), percent95% CI
Placebobaseline7.77
26 week7.64
Liraglutidebaseline7.94
26 week7.60
Primary/protocol endpoint

HbA1c

Time frame:26 weeks

HbA1c, change

change from baseline, improvement

LOINC 4548-4

Secondary/registry result

Glucose Concentrations

Time frame:26 weeks

descriptive

Posted result

GroupValue (mean), mg/dL95% CI
Placebobaseline183
26 week172
Liraglutidebaseline173
26 week171
Secondary/protocol endpoint

Glucose Concentrations

Time frame:26 weeks

Fasting glucose, change

change from baseline, improvement

LOINC 1558-6

Provenance

Sources

Trial identity, design, statusClinicalTrials.gov API v2
Snapshot dateJuly 1, 2026
Endpoint classificationDelfa endpoint taxonomy v2 (May 13, 2026)
Results tableClinicalTrials.gov results section

Trial facts come from public ClinicalTrials.gov records. Endpoint categories are Delfa's classification of those records, not a ClinicalTrials.gov field. All figures reflect the July 1, 2026 snapshot.