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Effects of Glucagon Like Peptide-1 on No-reflow
Effects of Glucagon Like Peptide-1 on No-reflow in Patients With ST-segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
Lead sponsor
Asset
Liraglutide
Subcutaneous · GLP-1 agonist
Listed sites
1
Recruiting sites
1
Enrollment
190
estimated
Study population
Cardiovascular disease
Key I/E criterion
—
Primary endpoint
•A change in the prevalence of no-reflow
Footprint
Where this trial recruits
Site locations as reported to ClinicalTrials.gov. Site count is not enrollment count; per-site enrollment is not available from source.
Identifiers
Registered as
Timeline
Milestones
Assets
Investigational agents
Study populations
Who this study enrolls
Eligibility
Who can enroll
Inclusion criteria
Patients with ST-segment elevation myocardial infarction were eligible for the study.
Exclusion criteria
Patients were excluded for the following reasons: unconscious at presentation; had cardiogenic shock, hypoglycaemia, or diabetic ketoacidosis; had a history of myocardial infarction, stent thrombosis, or renal insufficiency; or had previously undergone coronary artery bypass surgery.
Endpoints (5)
What's being measured
Protocol endpoints and posted registry outcome measures, grouped into outcome categories. Composite endpoints show their component event types. Standard codes (LOINC, SNOMED CT) are shown where available.
Coverage by outcome category
Cardiovascular outcomes
1 endpointa change in the prevalence of no-reflow
Time frame:immediately after PCI
categorical status, improvement
Cardiometabolic biomarkers
1 endpointa change in high-sensitivity C-reactive protein (hsCRP)
Time frame:immediately after PCI, at 1,3,5 days after PCI
hs-CRP, change
change from baseline, improvement
LOINC 30522-7
Safety / tolerability / PK
1 endpointdifferences in the incidences of treatment-emergent adverse events
Time frame:immediately after PCI, at 1,3,5 days after PCI
Treatment-emergent AEs (any)
event count, event
Other (unclassified)
2 endpointsa change in troponin T
Time frame:immediately after PCI, at 1,3,5 days after PCI
change from baseline, improvement
a change in superoxide dismutase (SOD)
Time frame:immediately after PCI, at 1,3,5 days after PCI
change from baseline, improvement
Publications (5)
Bibliography
Records linked to this trial through ClinicalTrials.gov references, PubMed NCT search, and curated study seeds. 'Canonical' marks design/result papers; others are registry references or candidates.
Registry references + supporting bibliography
- Current vascular pharmacology2013 Mar 1PMID23506504via CT.gov background
- Journal of the American College of Cardiology2009 Feb 10PMID19195607doi:10.1016/j.jacc.2008.10.033via CT.gov background
- Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions2008 Dec 1PMID19021281doi:10.1002/ccd.21715via CT.gov background
- Lancet (London, England)2003 Jan 4PMID12517460doi:10.1016/S0140-6736(03)12113-7via CT.gov background
Provenance
Sources
Trial facts come from public ClinicalTrials.gov records. Endpoint categories are Delfa's classification of those records, not a ClinicalTrials.gov field. All figures reflect the July 1, 2026 snapshot.