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Effect of GLP-1 Receptor Agonism After Sleeve Gastrectomy
Effect of GLP-1 Receptor Agonism on Weight and Caloric Intake in Subjects After Sleeve Gastrectomy
Lead sponsor
Assets
GLP-1 / incretin class catch-all / Liraglutide
Listed sites
1
Recruiting sites
—
Enrollment
46
actual
Study population
Bariatric Surgery, Obesity / overweight
Key I/E criterion
—
Primary endpoint
•Body weight, absolute change (kg)
Footprint
Where this trial recruits
Site locations as reported to ClinicalTrials.gov. Site count is not enrollment count; per-site enrollment is not available from source.
Identifiers
Registered as
Timeline
Milestones
Assets
Investigational agents
Study populations
Who this study enrolls
Eligibility
Who can enroll
Inclusion criteria
1. Age 20-65 years of age
2. Seen at Mayo Clinic Nutrition Clinic and have received authorization for bariatric surgery.
3. No active physical illness which will interfere with mobility or weight loss after bariatric surgery.
4. Females who are sexually active and able to become pregnant must agree to use birth control for duration of study if randomized to Saxenda/Placebo.
Exclusion criteria
1. Prior use of glucose lowering medication in the 3 months prior to screening.
2. A fasting glucose ≥ 126mg/dl or an HbA1c ≥ 6.5% will be taken as evidence of type 2 diabetes and therefore patients will be deemed ineligible for participation.
3. Prior abdominal surgery other than cholecystectomy, appendectomy or hysterectomy.
4. Pregnancy or active consideration of pregnancy during the period of study. Subjects will be discontinued if they become pregnant during the study.
5. Hypersensitivity to liraglutide or any product components.
6. Personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia type 2.
7. Prior history of pancreatitis, cholelithiasis or cholecystitis.
8. Concurrent use of insulin or any other GLP-1 receptor agonist.
9. Active, severe psychiatric disease
Endpoints (8)
What's being measured
Protocol endpoints and posted registry outcome measures, grouped into outcome categories. Composite endpoints show their component event types. Standard codes (LOINC, SNOMED CT) are shown where available.
Coverage by outcome category
Weight & body composition
2 endpointsWeight
Time frame:baseline and 36 months
Body weight, absolute change (kg)
change from baseline, improvement
Posted result
| Group | Value (mean), kilograms | 95% CI |
|---|---|---|
| Sleeve Gastrectomy Saxendabaseline | 127 | — |
| 36 months | 75 | — |
| Sleeve Gastrectomy Placebobaseline | 130 | — |
| 36 months | 107 | — |
| Roux-en-Y Gastric (RYGB)baseline | 126 | — |
| 36 months | 98 | — |
Weight
Time frame:baseline and 36 months
Body weight, absolute change (kg)
change from baseline, improvement
Cardiometabolic biomarkers
6 endpointsSystolic Blood Pressure
Time frame:baseline and 36 months
Systolic BP, change
change from baseline, improvement
LOINC 8480-6
Posted result
| Group | Value (mean), Millimeters of Mercury | 95% CI |
|---|---|---|
| Sleeve Gastrectomy Saxendabaseline | 129 | — |
| 36 months | 112 | — |
| Sleeve Gastrectomy Placebobaseline | 130 | — |
| 36 months | 128 | — |
| Roux-en-Y Gastric (RYGB)baseline | 123 | — |
| 36 months | 122 | — |
Diastolic Blood Pressure
Time frame:baseline and 36 months
Diastolic BP, change
change from baseline, improvement
LOINC 8462-4
Posted result
| Group | Value (mean), Millimeters of Mercury | 95% CI |
|---|---|---|
| Sleeve Gastrectomy Saxendabaseline | 86 | — |
| 36 months | 84 | — |
| Sleeve Gastrectomy Placebobaseline | 83 | — |
| 36 months | 93 | — |
| Roux-en-Y Gastric (RYGB)baseline | 76 | — |
| 36 months | 82 | — |
Low-density Lipoprotein (LDL)
Time frame:baseline and 36 months
LDL-C, change
change from baseline, improvement
LOINC 13457-7
Posted result
| Group | Value (mean), mg/dL | 95% CI |
|---|---|---|
| Sleeve Gastrectomy Saxendabaseline | 114 | — |
| 36 months | 106 | — |
| Sleeve Gastrectomy Placebobaseline | 101 | — |
| 36 months | 68 | — |
| Roux-en-Y Gastric (RYGB)baseline | 99 | — |
| 36 months | 90 | — |
Systolic Blood Pressure
Time frame:baseline and 36 months
Systolic BP, change
change from baseline, improvement
LOINC 8480-6
Diastolic Blood Pressure
Time frame:baseline and 36 months
Diastolic BP, change
change from baseline, improvement
LOINC 8462-4
Low-density Lipoprotein (LDL)
Time frame:baseline and 36 months
LDL-C, change
change from baseline, improvement
LOINC 13457-7
Provenance
Sources
Trial facts come from public ClinicalTrials.gov records. Endpoint categories are Delfa's classification of those records, not a ClinicalTrials.gov field. All figures reflect the July 1, 2026 snapshot.