GLP-1 Peptide Atlas, by Delfa

← Trials/Trial dossier/NCT03795701

CompletedPhase NA

To Predict Weight Loss Response to Liraglutide (Saxenda®), From fMRI-based Determination of Food Cue Reactivity

Lead sponsor

Texas Tech University

Asset

Liraglutide

Subcutaneous · GLP-1 agonist

Listed sites

Recruiting sites

—

Enrollment

actual

Study population

Obesity / overweight

Key I/E criterion

•BMI 30-50

Primary endpoints

•Compare the changes of pre-prandial fMRI-FCR in Liraglutide 3.0•Compare the changes of post-prandial fMRI-FCR in Liraglutide 3.0•Compare the changes of energy intake in Liraglutide 3.0

Footprint

Where this trial recruits

Site locations as reported to ClinicalTrials.gov. Site count is not enrollment count; per-site enrollment is not available from source.

Identifiers

Registered as

NCT IDNCT03795701

Org study IDTTUIRB2018-824

Timeline

Milestones

Study first posted2019-01-08actual

Study start2019-01-08actual

Primary completion2022-05-01actual

Study completion2022-05-01actual

Last update posted2023-12-04actual

Assets

Investigational agents

Liraglutide

Study populations

Who this study enrolls

Obesity / overweight

Eligibility

Who can enroll

Minimum age18 Years

Maximum age60 Years

SexAll

Healthy volunteersAccepted

Inclusion criteria

•Age 18-60 years

•BMI 30-50 kg/m2

Exclusion criteria

•Participants unable or unwilling to provide informed consent.

•Participants with motor, visual or hearing impairment.

•Females with irregular menstrual cycles (onset of menstruation greater than 1 week from expected data during the last 3 months).

•Females who are currently breastfeeding or intend to start breastfeeding.

•Participants with diagnosed diabetes mellitus (type 1 or type 2) or uncontrolled hypertension, history of ischemic heart disease, stroke, neurological disease.

•Participants with current severe psychiatric illnesses (e.g. psychosis, schizophrenia, bipolar disorders, depression).

•Participants experiencing current suicidal ideation, and recent or past suicide attempts.

•Participants with history of psychiatric hospitalization.

•Participants who are currently on (or have been on within the past 4 weeks) any medication in the broader drug classes of anti-depressant, anti-epileptic, or anti-anxiety medicines will be excluded (as these affect fMRI-FCR in the brain).

•Participants with contraindications for MRI scanning.

1. aneurism clips

2. any implanted medical devices (pacemaker, neurostimulator)

3. known pregnancy

4. shrapnel in body or any injury to eye involving metal

5. any ferrous metal in body

•Participants with a history of diagnosed eating disorders such as bulimia nervosa, anorexia nervosa and severe binge eating disorder.

•Participants with a history of diagnosed substance abuse or alcohol abuse.

•Patients experiencing persistent loss of appetite, nausea or vomiting within the last 4 weeks without known cause (e.g. flu, food poisoning).

•Participants who have been involved in a weight loss intervention program (including anti-obesity medication) within the past 3 months (and or loss >10% of body weight) or who have ever had bariatric surgery or have weight loss devices implanted.

•Current smokers (smoked within the last 30 days).

•The receipt of any investigational drug within (3 months) prior to this trial.

•Previous participation in this trial (i.e. randomized).

•Unable or unwilling to consume required study meals for any reason (e.g. dietary restrictions, allergies, or aversions to any of the food items used in the study).

•Contraindications to study medications,

–Subject with a personal or family history of medullary thyroid carcinoma (MTC).

–Subject with multiple endocrine neoplasia syndrome 2 (MEN 2).

–Allergic to Liraglutide or any of the ingredients in Saxenda® (i.e. Active ingredient: liraglutide; Inactive ingredients: disodium phosphate dehydrate, propylene glycol, phenol and water for injection)

–Women who are pregnant, or have the intention of becoming pregnant.

•Taking other GLP-1 receptor agonists (currently or in the past 3 months).

•Current severe problems with stomach, such as slowed emptying of the stomach (gastroparesis) or problems with digesting food.

•Current or past known serious chronic illness of liver, kidney and pancreas.

•Current or recent (30 days) depression or suicidal thoughts.

•Current fasting plasma glucose 126mg/dL or higher or HbA1c 6.5% or higher, or alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine, blood urea nitrogen (BUN) 10% above normal range for the assay.

Endpoints (24)

What's being measured

Protocol endpoints and posted registry outcome measures, grouped into outcome categories. Composite endpoints show their component event types. Standard codes (LOINC, SNOMED CT) are shown where available.

Coverage by outcome category

Other (unclassified)

Cardiometabolic biomarkers

Patient-reported / QoL