ZQL007

Registry references + supporting bibliography

• Increased skeletal muscle capillarization enhances insulin sensitivity.

  American journal of physiology. Endocrinology and metabolism2014 Dec 15PMID25352432doi:10.1152/ajpendo.00020.2014via CT.gov background

• Effect of treadmill training on endothelial function and walking abilities in patients with peripheral arterial disease.

  Journal of cardiology2014 Aug (month)PMID24438856doi:10.1016/j.jjcc.2013.12.002via CT.gov background

• Exercise-induced capillary growth in human skeletal muscle and the dynamics of VEGF.

  Microcirculation (New York, N.Y. : 1994)2014 May (month)PMID24450403doi:10.1111/micc.12117via CT.gov background

• Muscle-specific vascular endothelial growth factor deletion induces muscle capillary rarefaction creating muscle insulin resistance.

  Diabetes2013 Feb (month)PMID23002035doi:10.2337/db12-0354via CT.gov background

• Systematic review of the efficacy of cilostazol, naftidrofuryl oxalate and pentoxifylline for the treatment of intermittent claudication.

  The British journal of surgery2012 Dec (month)PMID23034699doi:10.1002/bjs.8895via CT.gov background

• Supervised walking therapy in patients with intermittent claudication.

  Journal of vascular surgery2012 Oct (month)PMID23026425doi:10.1016/j.jvs.2012.04.046via CT.gov background

• Microvascular blood flow responses to muscle contraction are not altered by high-fat feeding in rats.

  Diabetes, obesity & metabolism2012 Aug (month)PMID22429614doi:10.1111/j.1463-1326.2012.01598.xvia CT.gov background

• Relationship between leg muscle capillary density and peak hyperemic blood flow with endurance capacity in peripheral artery disease.

  Journal of applied physiology (Bethesda, Md. : 1985)2011 Jul (month)PMID21512146doi:10.1152/japplphysiol.00141.2011via CT.gov background

• Salsalate attenuates free fatty acid-induced microvascular and metabolic insulin resistance in humans.

  Diabetes care2011 Jul (month)PMID21617098doi:10.2337/dc10-2345via CT.gov background

• Exercise training increases endothelial progenitor cells and decreases asymmetric dimethylarginine in peripheral arterial disease: a randomized controlled trial.

  Atherosclerosis2011 Jul (month)PMID21481871doi:10.1016/j.atherosclerosis.2011.03.018via CT.gov background

• Free fatty acids induce insulin resistance in both cardiac and skeletal muscle microvasculature in humans.

  The Journal of clinical endocrinology and metabolism2011 Feb (month)PMID21047922doi:10.1210/jc.2010-1174via CT.gov background

• Exercise rehabilitation in peripheral artery disease: functional impact and mechanisms of benefits.

  Circulation2011 Jan 4PMID21200015doi:10.1161/CIRCULATIONAHA.109.881888via CT.gov background

• Angiotensin II type 1 and type 2 receptors regulate basal skeletal muscle microvascular volume and glucose use.

  Hypertension (Dallas, Tex. : 1979)2010 Feb (month)PMID19996061doi:10.1161/HYPERTENSIONAHA.109.145409via CT.gov background

• Infusing lipid raises plasma free fatty acids and induces insulin resistance in muscle microvasculature.

  The Journal of clinical endocrinology and metabolism2009 Sep (month)PMID19567533doi:10.1210/jc.2009-0027via CT.gov background

• The vascular actions of insulin control its delivery to muscle and regulate the rate-limiting step in skeletal muscle insulin action.

  Diabetologia2009 May (month)PMID19283361doi:10.1007/s00125-009-1313-zvia CT.gov background

• Muscle-specific VEGF deficiency greatly reduces exercise endurance in mice.

  The Journal of physiology2009 Apr 15PMID19237429doi:10.1113/jphysiol.2008.164384via CT.gov background

• Limb stress-rest perfusion imaging with contrast ultrasound for the assessment of peripheral arterial disease severity.

  JACC. Cardiovascular imaging2008 May (month)PMID19356447doi:10.1016/j.jcmg.2008.04.001via CT.gov background

• Hyperinsulinemia rapidly increases human muscle microvascular perfusion but fails to increase muscle insulin clearance: evidence that a saturable process mediates muscle insulin uptake.

  Diabetes2007 Dec (month)PMID17720897doi:10.2337/db07-0670via CT.gov background

• Impaired angiogenesis after hindlimb ischemia in type 2 diabetes mellitus: differential regulation of vascular endothelial growth factor receptor 1 and soluble vascular endothelial growth factor receptor 1.

  Circulation research2007 Oct 26PMID17823371doi:10.1161/CIRCRESAHA.107.160630via CT.gov background

• Contraction stimulates nitric oxide independent microvascular recruitment and increases muscle insulin uptake.

  Diabetes2007 Sep (month)PMID17563063doi:10.2337/db07-0020via CT.gov background

• Mixed meal and light exercise each recruit muscle capillaries in healthy humans.

  American journal of physiology. Endocrinology and metabolism2006 Jun (month)PMID16682488doi:10.1152/ajpendo.00497.2005via CT.gov background

• Direct effects of glucagon-like peptide-1 on myocardial contractility and glucose uptake in normal and postischemic isolated rat hearts.

  The Journal of pharmacology and experimental therapeutics2006 Jun (month)PMID16489128doi:10.1124/jpet.106.100982via CT.gov background

• Obesity blunts insulin-mediated microvascular recruitment in human forearm muscle.

  Diabetes2006 May (month)PMID16644702doi:10.2337/db05-1373via CT.gov background

• VEGF receptor signalling - in control of vascular function.

  Nature reviews. Molecular cell biology2006 May (month)PMID16633338doi:10.1038/nrm1911via CT.gov background

• Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms.

  Circulation2006 Apr 18PMID16618833doi:10.1161/CIRCULATIONAHA.105.563213via CT.gov background

• Insulin resistance in spontaneously hypertensive rats is associated with endothelial dysfunction characterized by imbalance between NO and ET-1 production.

  American journal of physiology. Heart and circulatory physiology2005 Aug (month)PMID15792994doi:10.1152/ajpheart.00092.2005via CT.gov background

• The union of vascular and metabolic actions of insulin in sickness and in health.

  Arteriosclerosis, thrombosis, and vascular biology2005 May (month)PMID15863720doi:10.1161/01.ATV.0000164044.42910.6bvia CT.gov background

• Lower capillary density but no difference in VEGF expression in obese vs. lean young skeletal muscle in humans.

  Journal of applied physiology (Bethesda, Md. : 1985)2005 Jan (month)PMID15298982doi:10.1152/japplphysiol.00353.2004via CT.gov background

• Vasoconstrictor effects of insulin in skeletal muscle arterioles are mediated by ERK1/2 activation in endothelium.

  American journal of physiology. Heart and circulatory physiology2004 Nov (month)PMID15059773doi:10.1152/ajpheart.00067.2004via CT.gov background

• Skeletal muscle contraction stimulates capillary recruitment and glucose uptake in insulin-resistant obese Zucker rats.

  American journal of physiology. Endocrinology and metabolism2004 Oct (month)PMID15213062doi:10.1152/ajpendo.00077.2004via CT.gov background

• Capillary regression in vascular endothelial growth factor-deficient skeletal muscle.

  Physiological genomics2004 Jun 17PMID15084712doi:10.1152/physiolgenomics.00023.2004via CT.gov background

• Microvascular recruitment is an early insulin effect that regulates skeletal muscle glucose uptake in vivo.

  Diabetes2004 Jun (month)PMID15161743doi:10.2337/diabetes.53.6.1418via CT.gov background

• Inhibiting NOS blocks microvascular recruitment and blunts muscle glucose uptake in response to insulin.

  American journal of physiology. Endocrinology and metabolism2003 Jul (month)PMID12791603doi:10.1152/ajpendo.00021.2003via CT.gov background

• Insulin-mediated hemodynamic changes are impaired in muscle of Zucker obese rats.

  Diabetes2002 Dec (month)PMID12453905doi:10.2337/diabetes.51.12.3492via CT.gov background

• Physiological concentrations of insulin induce endothelin-mediated vasoconstriction during inhibition of NOS or PI3-kinase in skeletal muscle arterioles.

  Cardiovascular research2002 Dec (month)PMID12445887doi:10.1016/s0008-6363(02)00593-xvia CT.gov background

• Lipid infusion impairs physiologic insulin-mediated capillary recruitment and muscle glucose uptake in vivo.

  Diabetes2002 Apr (month)PMID11916937doi:10.2337/diabetes.51.4.1138via CT.gov background

• Effects of exercise rehabilitation on endothelial reactivity in older patients with peripheral arterial disease.

  The American journal of cardiology2001 Feb 1PMID11165969doi:10.1016/s0002-9149(00)01367-9via CT.gov background

• Acute impairment of insulin-mediated capillary recruitment and glucose uptake in rat skeletal muscle in vivo by TNF-alpha.

  Diabetes2000 Nov (month)PMID11078458doi:10.2337/diabetes.49.11.1904via CT.gov background

• Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats.

  The Journal of clinical investigation1999 Aug (month)PMID10449437doi:10.1172/JCI5971via CT.gov background

• Acute vasoconstriction-induced insulin resistance in rat muscle in vivo.

  Diabetes1999 Mar (month)PMID10078557doi:10.2337/diabetes.48.3.564via CT.gov background

• Superiority of treadmill walking exercise versus strength training for patients with peripheral arterial disease. Implications for the mechanism of the training response.

  Circulation1994 Oct (month)PMID7923674doi:10.1161/01.cir.90.4.1866via CT.gov background

• Intermittent claudication, exercise, and blood rheology.

  Circulation1987 Nov (month)PMID3499255doi:10.1161/01.cir.76.5.1110via CT.gov background

• Skeletal muscle capillary density and fiber type are possible determinants of in vivo insulin resistance in man.

  The Journal of clinical investigation1987 Aug (month)PMID3301899doi:10.1172/JCI113088via CT.gov background

• Active and passive capillary control in red muscle at rest and in exercise.

  The American journal of physiology1982 Aug (month)PMID7114231doi:10.1152/ajpheart.1982.243.2.H196via CT.gov background