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The Effects of Glucose Control and Weight Loss Between Beinaglutide and Dulaglutide in Type 2 Diabetes With Overweight or Obesity.
A Randomized Controlled, Open-label, Multi-center Study With 16-week Beinaglutide or Dulaglutide Assessing Effects on Glucose Control and Weight Loss in Type 2 Diabetes With Overweight or Obesity.
Assets
Beinaglutide / Dulaglutide / GLP-1 / incretin class catch-all
Listed sites
4
Recruiting sites
4
Enrollment
120
estimated
Study population
Obesity / overweight, Type 2 diabetes
Key I/E criteria
•BMI 24-35•HbA1c 7-10%
Primary endpoint
•HbA1c, change
Footprint
Where this trial recruits
Site locations as reported to ClinicalTrials.gov. Site count is not enrollment count; per-site enrollment is not available from source.
Identifiers
Registered as
Timeline
Milestones
Assets
Investigational agents
Study populations
Who this study enrolls
Eligibility
Who can enroll
Inclusion criteria
1. Age between 18 to 70 years old from all sex;
2. Diagnosed with type 2 diabetes and HbA1c between 7% to 10%;
3. BMI from 24 to 35kg/m² or waistline longger than 90cm(male)/85cm(female);
4. Volunteer to participate in the study with informed consent;
Exclusion criteria
1. Type 1 diabetes or other specific types of diabetes;
2. Taking drugs of GLP-1 receptor agonist、TZDs and SGLT2 inhibitor within 3 months of screening;
3. Taking insulin or insulin analogues more than 7 days within 3 months of screening;
4. Pregnancy, breastfeeding or planned pregnancy;
5. History of acute or chronic pancreatitis;
6. Taking glucocorticoids(oral or intravenous) continuously more than 7 days within 6 months of screening;
7. Alanine aminotransferase or aspartate transaminase more than 3 times of the normal upper limit, total bilirubin more than 2 times of the normal upper limit;
8. renal impairment (estimated glomerular filtration rate<60mL/min per 1.73 m²);
9. History of gastrointestinal disease;
10. History of malignant tumor within 5 years of screening;
11. History of organ transplantation or AIDS;
12. History of glaucoma;
13. History of hyperthyroidism or hypothyroidism;
14. History of medullary thyroid carcinoma or multiple endocrine neoplasia II;
15. History of abnormal of Calcitonin or thyroid tumor;
16. History of alcohol abuse;
17. Recruited by other clinical trials within 3 months of screening;
18. Taking drugs of weight loss within 3 months of screening;
19. History of bariatric surgery;
20. History of mental disorders;
21. History of rheumatic diseases or autoimmune diseases;
22. Allergic to beinaglutide or dulaglutide;
23. Participants who estimated would not be suitable for the study by the investigators.
Endpoints (13)
What's being measured
Protocol endpoints and posted registry outcome measures, grouped into outcome categories. Composite endpoints show their component event types. Standard codes (LOINC, SNOMED CT) are shown where available.
Coverage by outcome category
Weight & body composition
4 endpointsWeight loss
Time frame:From baseline to 16 week.
≥5% weight-loss responders
threshold achievement, improvement
Body Mass Index(BMI)
Time frame:From baseline to 16 week.
BMI, change
change from baseline, improvement
Waistline
Time frame:From baseline to 16 week.
Waist circumference, change
change from baseline, improvement
Hipline
Time frame:From baseline to 16 week.
change from baseline, improvement
Glycemic / diabetes
4 endpointshaemoglobin A1c(HbA1c)
Time frame:From baseline to 16 week.
HbA1c, change
change from baseline, improvement
LOINC 4548-4
GLucose
Time frame:From baseline to 16 week.
Fasting glucose, change
change from baseline, improvement
LOINC 1558-6
Homeostasis model assessment for insulin resistance(HOMA-IR)
Time frame:From baseline to 16 week.
HOMA-IR (insulin sensitivity)
change from baseline, improvement
Homeostasis model assessment for β cell(HOMA-β)
Time frame:From baseline to 16 week.
change from baseline, improvement
MASH / liver
1 endpointAdipose tissue of liver
Time frame:From baseline to 16 week.
change from baseline, improvement
Cardiometabolic biomarkers
4 endpointsSerum total cholesterol
Time frame:From baseline to 16 week.
Total cholesterol, change
change from baseline, improvement
LOINC 2093-3
Serum triglycerides
Time frame:From baseline to 16 week.
Triglycerides, change
change from baseline, improvement
LOINC 2571-8
Serum Low Density Lipoprotein-Cholesterol(LDL-C)
Time frame:From baseline to 16 week.
LDL-C, change
change from baseline, improvement
LOINC 13457-7
Serum High Density Lipoprotein-Cholesterol(HDL-C)
Time frame:From baseline to 16 week.
HDL-C, change
change from baseline, improvement
LOINC 2085-9
Provenance
Sources
Trial facts come from public ClinicalTrials.gov records. Endpoint categories are Delfa's classification of those records, not a ClinicalTrials.gov field. All figures reflect the July 1, 2026 snapshot.